{"id":"https://openalex.org/W2007135310","doi":"https://doi.org/10.1007/s00415-004-0619-5","title":"Hepatic injury, liver monitoring and the beta-interferons for multiple sclerosis","display_name":"Hepatic injury, liver monitoring and the beta-interferons for multiple sclerosis","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W2007135310","doi":"https://doi.org/10.1007/s00415-004-0619-5","mag":"2007135310","pmid":"https://pubmed.ncbi.nlm.nih.gov/15592724"},"language":"en","primary_location":{"id":"doi:10.1007/s00415-004-0619-5","doi":"https://doi.org/10.1007/s00415-004-0619-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00415-004-0619-5","pdf_url":null,"source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025037775","display_name":"Helen L. Tremlett","orcid":"https://orcid.org/0000-0001-5804-2535","observed_orcids":["https://orcid.org/0000-0001-5804-2535"]},"institutions":[{"id":"https://openalex.org/I1287378978","display_name":"University of British Columbia Hospital","ror":"https://ror.org/00frst980","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1287378978","https://openalex.org/I141074466","https://openalex.org/I141945490","https://openalex.org/I2799475292"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2799475292","display_name":"Vancouver Hospital and Health Sciences Centre","ror":"https://ror.org/05p83my93","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I141074466","https://openalex.org/I2799475292"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Helen Tremlett","raw_affiliation_strings":["Department of Medicine (Neurology) rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. tremlett@interchange.ubc.ca","Department of Medicine (Neurology) rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, BC, V6T 2B5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Neurology) rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada. tremlett@interchange.ubc.ca","institution_ids":["https://openalex.org/I1287378978","https://openalex.org/I141945490","https://openalex.org/I2799475292"]},{"raw_affiliation_string":"Department of Medicine (Neurology) rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, BC, V6T 2B5, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2799475292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111686685","display_name":"Jo\u00ebl Oger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2799475292","display_name":"Vancouver Hospital and Health Sciences Centre","ror":"https://ror.org/05p83my93","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I141074466","https://openalex.org/I2799475292"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joel Oger","raw_affiliation_strings":["Department of Medicine (Neurology) rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, BC, V6T 2B5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Neurology) rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, BC, V6T 2B5, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2799475292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025037775"],"corresponding_institution_ids":["https://openalex.org/I1287378978","https://openalex.org/I141945490","https://openalex.org/I2799475292"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.4469,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.3,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"251","issue":"11","first_page":"1297","last_page":"1303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.38530001044273376,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.8939999938011169},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/aminotransferases","display_name":"transaminases","score":0.8949999809265137},{"id":"https://openalex.org/keywords/liver-function-monitoring","display_name":"liver function monitoring","score":0.7730000019073486},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8550000190734863},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.984000027179718},{"id":"https://openalex.org/keywords/dose-dependent-liver-injury","display_name":"dose-dependent liver injury","score":0.5580000281333923},{"id":"https://openalex.org/keywords/sex-differences-in-drug-response","display_name":"sex differences in drug response","score":0.6570000052452087},{"id":"https://openalex.org/keywords/idiosyncratic-adverse-drug-reactions","display_name":"idiosyncratic drug reactions","score":0.7649999856948853},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7980435490608215},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.7302130460739136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6434975266456604},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6157315969467163},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5662764310836792},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.5050175786018372},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.4965859055519104},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4474220871925354},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4408608675003052},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.43041107058525085},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00415-004-0619-5","doi":"https://doi.org/10.1007/s00415-004-0619-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00415-004-0619-5","pdf_url":null,"source":{"id":"https://openalex.org/S175814247","display_name":"Journal of Neurology","issn_l":"0012-1037","issn":["0012-1037","0340-5354","1432-1459"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology","raw_type":"journal-article"},{"id":"pmid:15592724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15592724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W38847137","https://openalex.org/W151589041","https://openalex.org/W155155760","https://openalex.org/W217090552","https://openalex.org/W1552049428","https://openalex.org/W1967754942","https://openalex.org/W1969152369","https://openalex.org/W1975096256","https://openalex.org/W1977977481","https://openalex.org/W1984063837","https://openalex.org/W1984441096","https://openalex.org/W1987343877","https://openalex.org/W1987489990","https://openalex.org/W1987790752","https://openalex.org/W1997850414","https://openalex.org/W2003219845","https://openalex.org/W2008369480","https://openalex.org/W2009989557","https://openalex.org/W2017100876","https://openalex.org/W2017936518","https://openalex.org/W2017974487","https://openalex.org/W2022714644","https://openalex.org/W2023799934","https://openalex.org/W2033390324","https://openalex.org/W2034432056","https://openalex.org/W2042186321","https://openalex.org/W2042395109","https://openalex.org/W2046560907","https://openalex.org/W2053942511","https://openalex.org/W2060611222","https://openalex.org/W2063731257","https://openalex.org/W2074528669","https://openalex.org/W2083712891","https://openalex.org/W2091146135","https://openalex.org/W2092276202","https://openalex.org/W2093532348","https://openalex.org/W2097659800","https://openalex.org/W2108163359","https://openalex.org/W2118966296","https://openalex.org/W2139367012","https://openalex.org/W2148835653","https://openalex.org/W2158318581","https://openalex.org/W2165239524","https://openalex.org/W2166459925","https://openalex.org/W2169098250","https://openalex.org/W2313164875","https://openalex.org/W2321700180","https://openalex.org/W2332230275","https://openalex.org/W2340533542","https://openalex.org/W2399569131","https://openalex.org/W2409981812","https://openalex.org/W2465783138","https://openalex.org/W3021092633","https://openalex.org/W3151658272","https://openalex.org/W4210548604"],"related_works":["https://openalex.org/W2008369480","https://openalex.org/W2136964907","https://openalex.org/W2161151145","https://openalex.org/W2063236934","https://openalex.org/W2092276202","https://openalex.org/W2002339381","https://openalex.org/W1847765940","https://openalex.org/W1972876345","https://openalex.org/W2790590756","https://openalex.org/W1975863178"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
