{"id":"https://openalex.org/W2007131729","doi":"https://doi.org/10.1073/pnas.78.12.7769","title":"Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome.","display_name":"Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome.","publication_year":1981,"publication_date":"1981-12-01","ids":{"openalex":"https://openalex.org/W2007131729","doi":"https://doi.org/10.1073/pnas.78.12.7769","mag":"2007131729","pmid":"https://pubmed.ncbi.nlm.nih.gov/6950417","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/349352"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.78.12.7769","doi":"https://doi.org/10.1073/pnas.78.12.7769","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.78.12.7769","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/349352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048258883","display_name":"Marvin Scott Medow","orcid":"https://orcid.org/0000-0001-6535-7316","observed_orcids":["https://orcid.org/0000-0001-6535-7316"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Medow","raw_affiliation_strings":["Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; and tDepartment of Clinical Studies, School of Veterinary Medicine,","University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; and tDepartment of Clinical Studies, School of Veterinary Medicine,","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110240641","display_name":"Robert A. Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Reynolds","raw_affiliation_strings":["Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; and tDepartment of Clinical Studies, School of Veterinary Medicine,","University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; and tDepartment of Clinical Studies, School of Veterinary Medicine,","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113654227","display_name":"Kenneth C. Bov\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K C Bovee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113556670","display_name":"Stanton Segal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Segal","raw_affiliation_strings":["Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; and tDepartment of Clinical Studies, School of Veterinary Medicine,","University of Pennsylvania, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, and the Departments of Pediatrics and Medicine, Medical School of the University of Pennsylvania, Philadelphia, Pennsylvania 19104; and tDepartment of Clinical Studies, School of Veterinary Medicine,","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1764,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.41903371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"78","issue":"12","first_page":"7769","last_page":"7772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.510699987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.42969998717308044,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fanconi-syndrome","display_name":"Fanconi syndrome","score":0.8880000114440918},{"id":"https://openalex.org/keywords/proline-transport","display_name":"proline transport","score":0.9769999980926514},{"id":"https://openalex.org/keywords/glucose-transport","display_name":"glucose transport","score":1.0},{"id":"https://openalex.org/keywords/renal-brush-border-membrane","display_name":"renal brush border membrane","score":0.8130000233650208},{"id":"https://openalex.org/keywords/basenji-dogs","display_name":"Basenji dogs","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sodium-dependent-transport","display_name":"sodium-dependent transport","score":0.6880000233650208},{"id":"https://openalex.org/keywords/tubular-reabsorption","display_name":"tubular reabsorption","score":0.7760000228881836},{"id":"https://openalex.org/keywords/transport-kinetics","display_name":"transport kinetics","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.8641107082366943},{"id":"https://openalex.org/C2779026464","wikidata":"https://www.wikidata.org/wiki/Q1179460","display_name":"Fanconi syndrome","level":3,"score":0.8228588700294495},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6259180903434753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4923959970474243},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.49054497480392456},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.47421717643737793},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47113579511642456},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.4622371792793274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45699000358581543},{"id":"https://openalex.org/C5426402","wikidata":"https://www.wikidata.org/wiki/Q2462753","display_name":"Brush border","level":4,"score":0.45024773478507996},{"id":"https://openalex.org/C90466245","wikidata":"https://www.wikidata.org/wiki/Q7312490","display_name":"Renal glucose reabsorption","level":4,"score":0.4384014904499054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4206704795360565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3978545665740967},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.38463401794433594},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.23087945580482483},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1795191764831543},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15143728256225586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14456266164779663},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10463035106658936},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005198","descriptor_name":"Fanconi Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008871","descriptor_name":"Microvilli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.78.12.7769","doi":"https://doi.org/10.1073/pnas.78.12.7769","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.78.12.7769","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1294852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/349352","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:349352","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/349352","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6950417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6950417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1294852","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/349352","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W43906695","https://openalex.org/W1544647282","https://openalex.org/W1775749144","https://openalex.org/W1804060812","https://openalex.org/W2006855724","https://openalex.org/W2016762192","https://openalex.org/W2022066806","https://openalex.org/W2042704099","https://openalex.org/W2048884077","https://openalex.org/W2065310582","https://openalex.org/W2076936325","https://openalex.org/W2090059307","https://openalex.org/W2118654939","https://openalex.org/W2134807830","https://openalex.org/W2329140117","https://openalex.org/W2413321248","https://openalex.org/W2415586691","https://openalex.org/W2417960834","https://openalex.org/W2436961375","https://openalex.org/W2470317365","https://openalex.org/W2588617971","https://openalex.org/W2885035991","https://openalex.org/W4409138353"],"related_works":["https://openalex.org/W2092576195","https://openalex.org/W80948715","https://openalex.org/W2076936325","https://openalex.org/W1982393061","https://openalex.org/W1966757725","https://openalex.org/W2024569590","https://openalex.org/W1987485874","https://openalex.org/W2042704099","https://openalex.org/W2420776709","https://openalex.org/W2145378324"],"abstract_inverted_index":{"The":[0,23,85],"uptake":[1,29,50],"of":[2,25,30,92,99,108],"proline":[3,31,64,77,100],"and":[4,34,55,65,72,78,101],"glucose":[5,35,79,102],"by":[6,38],"renal":[7,97],"brush":[8],"border":[9],"membrane":[10],"vesicles":[11,39,52],"isolated":[12],"from":[13,40,53],"Basenji":[14],"dogs":[15,57],"exhibiting":[16],"a":[17,59],"spontaneous":[18],"Fanconi":[19,93],"syndrome":[20],"was":[21,44],"examined.":[22],"magnitude":[24],"the":[26,82,95],"1-min,":[27],"Na+-gradient":[28],"(0.02":[32],"mM)":[33,37],"(1.0":[36],"affected":[41,56,83],"dog":[42],"kidney":[43],"lower":[45],"than":[46],"normal.":[47],"Concentration-dependent":[48],"15-sec":[49],"in":[51,81,89],"normal":[54],"reveals":[58],"two-component":[60],"transport":[61,80,110],"system":[62],"for":[63,75],"glucose.":[66],"Kinetic":[67],"analysis":[68],"shows":[69],"altered":[70],"Km":[71],"Vmax":[73],"values":[74],"both":[76],"dogs.":[84],"data":[86],"suggest":[87],"that,":[88],"this":[90],"model":[91],"syndrome,":[94],"defective":[96],"reabsorption":[98],"is":[103],"associated":[104],"with":[105],"an":[106],"alteration":[107],"luminal":[109],"system.":[111]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}