{"id":"https://openalex.org/W2007125032","doi":"https://doi.org/10.1159/000334722","title":"Natalizumab May Improve Cognition and Mood in Multiple Sclerosis","display_name":"Natalizumab May Improve Cognition and Mood in Multiple Sclerosis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2007125032","doi":"https://doi.org/10.1159/000334722","mag":"2007125032","pmid":"https://pubmed.ncbi.nlm.nih.gov/22269396"},"language":"en","primary_location":{"id":"doi:10.1159/000334722","doi":"https://doi.org/10.1159/000334722","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000334722","pdf_url":null,"source":{"id":"https://openalex.org/S162735375","display_name":"European Neurology","issn_l":"0014-3022","issn":["0014-3022","1421-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-46755","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C. Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Lang","raw_affiliation_strings":["Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. christoph.lang@uk-erlangen.de","Department of Neurology, University of Erlangen-Nuremberg, Erlangen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. christoph.lang@uk-erlangen.de","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Department of Neurology, University of Erlangen-Nuremberg, Erlangen, and","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001173219","display_name":"Christine Reiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Reiss","raw_affiliation_strings":["Department of Neurology, University of Erlangen-Nuremberg, Erlangen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Erlangen-Nuremberg, Erlangen, and","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102939720","display_name":"M. M\u00e4urer","orcid":"https://orcid.org/0009-0009-7696-3931","observed_orcids":["https://orcid.org/0009-0009-7696-3931"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210140440","display_name":"Caritas-Krankenhaus Bad Mergentheim","ror":"https://ror.org/04gh6x779","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210140440"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. M\u00e4urer","raw_affiliation_strings":["Caritas Krankenhaus GmbH, Bad Mergentheim, Germany","Department of Neurology, University of Erlangen-Nuremberg, Erlangen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Caritas Krankenhaus GmbH, Bad Mergentheim, Germany","institution_ids":["https://openalex.org/I4210140440"]},{"raw_affiliation_string":"Department of Neurology, University of Erlangen-Nuremberg, Erlangen, and","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3023,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87117776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"67","issue":"3","first_page":"162","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natalizumab","display_name":"natalizumab","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mood","display_name":"mood","score":0.9959999918937683},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.6809999942779541},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":1.0},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chronic-disease","display_name":"chronic disease","score":0.5400000214576721},{"id":"https://openalex.org/keywords/edss-disability","display_name":"EDSS disability","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2781004633","wikidata":"https://www.wikidata.org/wiki/Q386119","display_name":"Natalizumab","level":3,"score":0.9629361629486084},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8499428629875183},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.809032678604126},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.7191846966743469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4675995707511902},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4652918577194214},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43258509039878845},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.4137857258319855},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.40778034925460815},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.05567169189453125}],"mesh":[{"descriptor_ui":"D000069442","descriptor_name":"Natalizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000339","descriptor_name":"Affect","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1159/000334722","doi":"https://doi.org/10.1159/000334722","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000334722","pdf_url":null,"source":{"id":"https://openalex.org/S162735375","display_name":"European Neurology","issn_l":"0014-3022","issn":["0014-3022","1421-9913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Neurology","raw_type":"journal-article"},{"id":"pmid:22269396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22269396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European neurology","raw_type":"Journal Article"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-026057763","doi":null,"is_oa":false,"landing_page_url":"https://open.fau.de/handle/openfau/3395","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},{"id":"pmh:oai:ub.uni-erlangen.de-opus:3395","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-46755","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:ub.uni-erlangen.de-opus:3395","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-46755","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1978392406","https://openalex.org/W2007784985","https://openalex.org/W2055670101","https://openalex.org/W2070076482","https://openalex.org/W2075646622","https://openalex.org/W2105053272","https://openalex.org/W2108442841","https://openalex.org/W2130632081","https://openalex.org/W2151846232","https://openalex.org/W2158820471","https://openalex.org/W2167502715","https://openalex.org/W2327627377"],"related_works":["https://openalex.org/W1971404108","https://openalex.org/W2466340424","https://openalex.org/W2151846232","https://openalex.org/W2514912494","https://openalex.org/W4403522637","https://openalex.org/W1581162662","https://openalex.org/W2162803038","https://openalex.org/W2008706841","https://openalex.org/W2888164912","https://openalex.org/W1488617601"],"abstract_inverted_index":{"Immunomodulating":[0],"therapies":[1],"may":[2],"prevent":[3],"relapses":[4],"in":[5,44,58,103],"multiple":[6,105],"sclerosis":[7],"and":[8,42,65,81,100],"stabilize":[9,96],"neurological":[10],"status.":[11],"However,":[12],"little":[13],"is":[14,36,89,93],"known":[15],"about":[16],"the":[17],"influence":[18],"particularly":[19],"of":[20,61,86],"newer":[21],"drugs":[22],"on":[23],"cognitive":[24,40],"functions.":[25],"We":[26,55],"conducted":[27],"an":[28,83],"open-label":[29],"prospective":[30],"study":[31],"to":[32,38,95],"demonstrate":[33],"whether":[34],"natalizumab":[35,92],"apt":[37],"improve":[39,98],"functions":[41],"mood":[43,101],"29":[45],"patients":[46,71],"tested":[47],"psychometrically":[48],"while":[49],"under":[50],"treatment":[51],"for":[52,76],"6":[53],"months.":[54],"found":[56],"improvements":[57],"some":[59],"measures":[60],"attention,":[62],"memory,":[63],"mood,":[64],"well-being,":[66],"but":[67],"no":[68],"deterioration,":[69],"although":[70],"suffered":[72],"from":[73],"their":[74],"diseases":[75],"more":[77],"than":[78],"10":[79],"years":[80],"had":[82],"EDSS":[84],"score":[85],"3.5.":[87],"It":[88],"concluded":[90],"that":[91],"able":[94],"or":[97],"cognition":[99],"even":[102],"longer-lasting":[104],"sclerosis.":[106]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
