{"id":"https://openalex.org/W2007104705","doi":"https://doi.org/10.1055/s-2007-988501","title":"HBV-spezifische HLA-DR1 Tetramere zur Analyse der antiviralen Immunantwort w\u00e4hrend der akuten und chronischen Hepatitis B","display_name":"HBV-spezifische HLA-DR1 Tetramere zur Analyse der antiviralen Immunantwort w\u00e4hrend der akuten und chronischen Hepatitis B","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W2007104705","doi":"https://doi.org/10.1055/s-2007-988501","mag":"2007104705"},"language":"de","primary_location":{"id":"doi:10.1055/s-2007-988501","doi":"https://doi.org/10.1055/s-2007-988501","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-988501","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111602657","display_name":"Malte H. J. Heeg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"MHJ Heeg","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110162453","display_name":"Axel Ulsenheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Ulsenheimer","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077884562","display_name":"N.H. Gr\u00fcner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N Gr\u00fcner","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113539739","display_name":"Helmut Michael Diepolder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"HM Diepolder","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089706933","display_name":"Bijan Raziorrouh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Raziorrouh","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109459184","display_name":"W. Schraut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259207","display_name":"Institut f\u00fcr Immunologie","ror":"https://ror.org/01x8c0495","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405259207","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Schraut","raw_affiliation_strings":["Institut f\u00fcr Immunologie, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Immunologie, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405259207","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030380569","display_name":"Martin W\u00e4chtler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091445","display_name":"M\u00fcnchen Klinik Schwabing","ror":"https://ror.org/002bjfj29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210091445","https://openalex.org/I4210121101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M W\u00e4chtler","raw_affiliation_strings":["Krankenhaus M\u00fcnchen-Schwabing, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krankenhaus M\u00fcnchen-Schwabing, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4210091445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055386960","display_name":"R Zachoval","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Zachoval","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103749420","display_name":"MC Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"MC Jung","raw_affiliation_strings":["Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik II, Klinikum Gro\u00dfhadern, LMU M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14559387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"08","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.8159999847412109},{"id":"https://openalex.org/keywords/antiviral-t-cell-responses","display_name":"antiviral T cell responses","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/acute-hepatitis-b","display_name":"acute hepatitis B","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":1.0},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.7229999899864197},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6729999780654907},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48544031381607056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4120885729789734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3205462396144867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17056936025619507}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-988501","doi":"https://doi.org/10.1055/s-2007-988501","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-988501","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2621611530","https://openalex.org/W2047865205","https://openalex.org/W6921511823","https://openalex.org/W2074530690","https://openalex.org/W2105681098","https://openalex.org/W2133831952","https://openalex.org/W2326044211","https://openalex.org/W2048242184","https://openalex.org/W7155551189","https://openalex.org/W2244455563"],"abstract_inverted_index":{"Die":[0,38,131,267],"bisherigen":[1],"Untersuchungsergebnisse":[2],"zur":[3],"HBV-Infektion":[4],"zeigen,":[5],"dass":[6],"die":[7,27,47,54],"akute":[8],"selbstlimierte":[9],"Viruselimination":[10],"ist":[11,240],"durch":[12],"eine":[13,30,109],"starke,":[14],"gegen":[15],"verschiedene":[16],"Virusproteine":[17],"gerichtet":[18],"CD4+":[19,140,189,237,264],"und":[20,42,92,149,201,249,260],"CD8+":[21],"T-Zellantwort":[22],"gekennzeichnet":[23],"ist,":[24],"w\u00e4hrend":[25,177],"f\u00fcr":[26,106],"chronische":[28],"Infektion":[29,213,283],"schwache":[31],"oder":[32,217],"nicht":[33],"nachweisbare":[34],"T-Zellreaktion":[35],"typisch":[36],"ist.":[37],"Ursache":[39],"hierf\u00fcr":[40],"unklar":[41],"schwierig":[43],"zu":[44,78,247],"untersuchen,":[45],"da":[46],"Charakterisierung":[48],"der":[49,56,70,178,193,204,225,235,262,278],"CD4+-T-Zellantwort":[50],"bisher":[51],"ausschlie\u00dflich":[52],"\u00fcber":[53],"Untersuchung":[55],"Effektorfunktionen":[57],"m\u00f6glich":[58],"war.":[59],"Mithilfe":[60],"von":[61,69,82,117,185],"HLA-Klasse-II-Tetrameren":[62],"k\u00f6nnen":[63],"nun":[64],"erstmals":[65],"viruspezifische":[66],"Zellen":[67,162,181,195],"unabh\u00e4ngig":[68],"Funktion":[71],"identifiziert":[72],"werden.":[73,143,164],"Um":[74],"relevante":[75,101],"HBV-core":[76,89,102,245],"Epitope":[77,103],"identifizieren,":[79],"wurden":[80,99],"PBMC":[81],"Patienten":[83,152,173,209,253],"mit":[84,87,153,174,197,210,254],"akuter":[85,154,175,255],"HBV":[86,155,176,212,227,256,282],"\u00fcberlappenden":[88],"Peptiden":[90],"stimuliert":[91],"ihre":[93],"Aktivierung":[94],"mittels":[95],"H3-Proliferationsassays":[96],"erfasst.":[97],"Hierdurch":[98],"drei":[100,170,251],"identifiziert,":[104,123],"wobei":[105],"ein":[107,126,244],"Epitop":[108],"HLA-DR1-Restriktion":[110],"nachgewiesen":[111,163],"werden":[112],"konnte.":[113],"Durch":[114],"den":[115],"Einsatz":[116],"trunkierten":[118],"Peptidvarianten":[119],"wurde":[120],"das":[121],"Minimalepitop":[122],"anhand":[124,136],"welchem":[125],"HLA-DRB*0101":[127],"Tetramer":[128],"synthetisiert":[129],"wurde.":[130],"Spezifit\u00e4t":[132],"dieses":[133,269],"Tetramers":[134],"konnte":[135],"eines":[137],"korrespondierenden":[138],"spezifischen":[139],"T-Zellklons":[141],"gezeigt":[142],"In":[144,208],"f\u00fcnf":[145,151],"HLA-DR1+":[146,172,252],"gesunden":[147],"Kontrollpersonen":[148],"in":[150,168,182,277],"ohne":[156],"HLA-DR1":[157],"Hintergrund":[158],"konnten":[159],"keine":[160,216],"Tet+":[161,180,194,221,236,263],"Dagegen":[165],"fanden":[166],"sich":[167,215,229],"allen":[169],"untersuchten":[171],"Peakphase":[179],"einem":[183],"Frequenzbereich":[184],"900":[186],"bis":[187],"1680/106":[188],"T-Zellen.":[190,238],"Der":[191],"Frequenzgipfel":[192],"war":[196],"dem":[198,202],"GPT":[199],"Gipfel":[200,203],"IFN-\u03b3":[205],"Sekretion":[206],"assoziiert.":[207],"chronischer":[211],"zeigten":[214,228],"nur":[218],"sehr":[219],"niedrige":[220],"Zellfrequenzen.":[222],"Im":[223],"Verlauf":[224],"akuten":[226],"deutliche":[230],"Ver\u00e4nderungen":[231],"bez\u00fcglich":[232,258],"des":[233],"Ph\u00e4notyps":[234],"Zusammenfassend":[239],"es":[241],"uns":[242],"gelungen":[243],"HLA-Klasse-II-Tetramer":[246],"etablieren":[248],"an":[250],"Verlaufsuntersuchungen":[257],"Frequenz":[259],"Ph\u00e4notyp":[261],"T-Zellen":[265],"durchzuf\u00fchren.":[266],"Anwendung":[268],"neuen":[270],"Untersuchungswerkzeugs":[271],"kann":[272],"helfen,":[273],"neue":[274],"immunpathogenetische":[275],"Mechanismen":[276],"Entstehung":[279],"einer":[280],"chronischen":[281],"aufzudecken.":[284]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
