{"id":"https://openalex.org/W2007092547","doi":"https://doi.org/10.1200/jco.2008.16.0705","title":"Immunoembolization of Malignant Liver Tumors, Including Uveal Melanoma, Using Granulocyte-Macrophage Colony-Stimulating Factor","display_name":"Immunoembolization of Malignant Liver Tumors, Including Uveal Melanoma, Using Granulocyte-Macrophage Colony-Stimulating Factor","publication_year":2008,"publication_date":"2008-10-07","ids":{"openalex":"https://openalex.org/W2007092547","doi":"https://doi.org/10.1200/jco.2008.16.0705","mag":"2007092547","pmid":"https://pubmed.ncbi.nlm.nih.gov/18838710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6815970"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.16.0705","doi":"https://doi.org/10.1200/jco.2008.16.0705","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2008.16.0705","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.16.0705?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.16.0705?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053828591","display_name":"Takami Sato","orcid":"https://orcid.org/0000-0003-2221-0415","observed_orcids":["https://orcid.org/0000-0003-2221-0415"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takami Sato","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041226344","display_name":"David J. Eschelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Eschelman","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005966612","display_name":"Carin F. Gonsalves","orcid":"https://orcid.org/0000-0003-4417-3045","observed_orcids":["https://orcid.org/0000-0003-4417-3045"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carin F. Gonsalves","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036217332","display_name":"Mizue Terai","orcid":"https://orcid.org/0000-0003-2672-9468","observed_orcids":["https://orcid.org/0000-0003-2672-9468"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mizue Terai","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022471130","display_name":"Inna Chervoneva","orcid":"https://orcid.org/0000-0002-9104-4505","observed_orcids":["https://orcid.org/0000-0002-9104-4505"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inna Chervoneva","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012659487","display_name":"Peter A. McCue","orcid":"https://orcid.org/0000-0001-9806-0594","observed_orcids":["https://orcid.org/0000-0001-9806-0594"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. McCue","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110175602","display_name":"Jerry A. Shields","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry A. Shields","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001760520","display_name":"Carol L. Shields","orcid":"https://orcid.org/0000-0002-3288-3632","observed_orcids":["https://orcid.org/0000-0002-3288-3632"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol L. Shields","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002085584","display_name":"Akira Yamamoto","orcid":"https://orcid.org/0000-0002-4567-9745","observed_orcids":["https://orcid.org/0000-0002-4567-9745"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akira Yamamoto","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045802455","display_name":"David Berd","orcid":"https://orcid.org/0000-0003-2974-9085","observed_orcids":["https://orcid.org/0000-0003-2974-9085"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Berd","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110153353","display_name":"Michael J. Mastrangelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Mastrangelo","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113454221","display_name":"Kevin L. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin L. Sullivan","raw_affiliation_strings":["From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology; Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics; Division of Surgical Pathology, Department of Pathology; and Division of Ocular Oncology, Wills Eye Institute; Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Medical Oncology, Thomas Jefferson University, 1025 Walnut St, Suite 1024, Philadelphia, PA 19107;","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Division of Biostatistics, Department of Pharmacology and Experimental Thera-peutics; Division of Surgical Pathology,","institution_ids":[]},{"raw_affiliation_string":"From the Department of Medical Oncology; Division of Interventional Radiology, Department of Radiology;","institution_ids":[]},{"raw_affiliation_string":"Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":null,"apc_paid":null,"fwci":3.8353,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.92024014,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"26","issue":"33","first_page":"5436","last_page":"5442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sargramostim","display_name":"sargramostim","score":0.9710000157356262},{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.875},{"id":"https://openalex.org/keywords/liver-tumors","display_name":"liver tumors","score":0.5839999914169312},{"id":"https://openalex.org/keywords/hepatic-artery-embolization","display_name":"hepatic artery embolization","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9480000138282776},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9380338191986084},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8205492496490479},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5686099529266357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5168057680130005},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4852614104747772},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4794013500213623},{"id":"https://openalex.org/C2910410966","wikidata":"https://www.wikidata.org/wiki/Q356372","display_name":"Ocular Melanoma","level":3,"score":0.44907432794570923},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44398343563079834},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.430254191160202},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4162985682487488},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.4124011993408203},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3817828297615051},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.12148293852806091}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006499","descriptor_name":"Hepatic Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1200/jco.2008.16.0705","doi":"https://doi.org/10.1200/jco.2008.16.0705","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2008.16.0705","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.16.0705?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6815970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6815970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmid:18838710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18838710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase I"}],"best_oa_location":{"id":"doi:10.1200/jco.2008.16.0705","doi":"https://doi.org/10.1200/jco.2008.16.0705","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2008.16.0705","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2008.16.0705?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320320303","display_name":"Bayer HealthCare","ror":"https://ror.org/04hmn8g73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007092547.pdf","grobid_xml":"https://content.openalex.org/works/W2007092547.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1573356710","https://openalex.org/W1923481401","https://openalex.org/W1970569984","https://openalex.org/W1985024930","https://openalex.org/W1990404563","https://openalex.org/W1991148746","https://openalex.org/W1991933930","https://openalex.org/W2004382582","https://openalex.org/W2011832231","https://openalex.org/W2013944616","https://openalex.org/W2048119106","https://openalex.org/W2063495860","https://openalex.org/W2065626916","https://openalex.org/W2081392142","https://openalex.org/W2102626808","https://openalex.org/W2110920908","https://openalex.org/W2112897941","https://openalex.org/W2124262559","https://openalex.org/W2124757685","https://openalex.org/W2125763116","https://openalex.org/W2139248078","https://openalex.org/W2139771875","https://openalex.org/W2150988923","https://openalex.org/W2166771927","https://openalex.org/W2407879537","https://openalex.org/W2416818602","https://openalex.org/W2472149399","https://openalex.org/W4244591305","https://openalex.org/W4244614680"],"related_works":["https://openalex.org/W2591476419","https://openalex.org/W2140312356","https://openalex.org/W2247044559","https://openalex.org/W2329707226","https://openalex.org/W4410816792","https://openalex.org/W2160515375","https://openalex.org/W3101468227","https://openalex.org/W4388069196","https://openalex.org/W4392791597","https://openalex.org/W4379339253"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"conducted":[2],"a":[3],"phase":[4],"I":[5],"study":[6,229],"to":[7,64,108,185],"investigate":[8],"the":[9,109],"feasibility":[10],"and":[11,77,115,134,174,180,209,223],"safety":[12,224],"of":[13,60,87,97,112,137,148,167,176,192],"immunoembolization":[14],"with":[15,30,39,48,124,196,205,213],"granulocyte-macrophage":[16],"colony-stimulating":[17],"factor":[18],"(GM-CSF;":[19],"sargramostim)":[20],"for":[21,91],"malignant":[22,42],"liver":[23,43],"tumors,":[24,44],"predominantly":[25],"hepatic":[26,92,142,177,214],"metastases":[27,178],"from":[28,216],"patients":[29,38,47,98,123,150,212],"primary":[31,49,217],"uveal":[32,50,125,154,218,232],"melanoma.":[33,219,233],"PATIENTS":[34],"AND":[35],"METHODS:":[36],"Thirty-nine":[37],"surgically":[40],"unresectable":[41],"including":[45],"34":[46],"melanoma,":[51],"were":[52,89,99,117,183,194],"enrolled.":[53],"Hepatic":[54],"artery":[55],"embolization":[56],"accompanied":[57],"an":[58],"infusion":[59],"dose-escalated":[61],"GM-CSF":[62,168,193,206],"(25":[63],"2,000":[65,113],"microg)":[66],"given":[67],"every":[68],"4":[69],"weeks.":[70],"Primary":[71],"end":[72],"points":[73],"included":[74],"dose-limiting":[75],"toxicity":[76],"maximum":[78],"tolerated":[79],"dose":[80,110],"(MTD).":[81],"Patients":[82],"who":[83,151],"completed":[84],"two":[85,128],"cycles":[86],"treatments":[88],"monitored":[90],"antitumor":[93],"response.":[94],"Survival":[95],"rates":[96],"also":[100],"monitored.":[101],"RESULTS:":[102],"MTD":[103],"was":[104,156],"not":[105],"reached":[106],"up":[107],"level":[111],"microg,":[114],"there":[116],"no":[118],"treatment-related":[119],"deaths.":[120],"Thirty-one":[121],"assessable":[122],"melanoma":[126,155],"demonstrated":[127],"complete":[129],"responses,":[130,133],"eight":[131],"partial":[132,181],"10":[135],"occurrences":[136],"stable":[138],"disease":[139],"in":[140,200,211,230],"their":[141],"metastases.":[143],"The":[144],"median":[145],"overall":[146,187],"survival":[147,199],"intent-to-treat":[149],"had":[152],"metastatic":[153,231],"14.4":[157],"months.":[158],"Multivariate":[159],"analyses":[160],"indicated":[161],"that":[162],"female":[163],"sex,":[164],"high":[165,190],"doses":[166,191],"(>":[169],"or":[170],"=":[171],"1,500":[172],"microg),":[173],"regression":[175],"(complete":[179],"responses)":[182],"correlated":[184],"longer":[186],"survival.":[188],"Moreover,":[189],"associated":[195],"prolonged":[197],"progression-free":[198],"extrahepatic":[201],"sites.":[202],"CONCLUSION:":[203],"Immunoembolization":[204],"is":[207],"safe":[208],"feasible":[210],"metastasis":[215],"Encouraging":[220],"preliminary":[221],"efficacy":[222],"results":[225],"warrant":[226],"additional":[227],"clinical":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}