{"id":"https://openalex.org/W2007069030","doi":"https://doi.org/10.5402/2011/476158","title":"Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons","display_name":"Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons","publication_year":2011,"publication_date":"2011-04-17","ids":{"openalex":"https://openalex.org/W2007069030","doi":"https://doi.org/10.5402/2011/476158","mag":"2007069030","pmid":"https://pubmed.ncbi.nlm.nih.gov/22389821","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3263561"},"language":"en","primary_location":{"id":"doi:10.5402/2011/476158","doi":"https://doi.org/10.5402/2011/476158","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2011/476158","pdf_url":"https://downloads.hindawi.com/archive/2011/476158.pdf","source":{"id":"https://openalex.org/S4210188070","display_name":"ISRN Neurology","issn_l":"2090-5505","issn":["2090-5505","2090-5513"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://downloads.hindawi.com/archive/2011/476158.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A. Machado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"A. Machado","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085387252","display_name":"Antonio J. Herrera","orcid":"https://orcid.org/0000-0002-3379-9598","observed_orcids":["https://orcid.org/0000-0002-3379-9598"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. J. Herrera","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088461518","display_name":"Jose Luis Venero","orcid":"https://orcid.org/0000-0003-1137-8706","observed_orcids":["https://orcid.org/0000-0003-1137-8706"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. L. Venero","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081079449","display_name":"Marti Santiago","orcid":"https://orcid.org/0000-0003-2128-4981","observed_orcids":["https://orcid.org/0000-0003-2128-4981"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Santiago","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044465596","display_name":"Roc\u00edo M. de Pablos","orcid":"https://orcid.org/0000-0002-8683-9805","observed_orcids":["https://orcid.org/0000-0002-8683-9805"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. M. de Pablos","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014196966","display_name":"Ruth F. Villar\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. F. Villar\u00e1n","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073839439","display_name":"Ana M. Espinosa\u2010Oliva","orcid":"https://orcid.org/0000-0002-2442-767X","observed_orcids":["https://orcid.org/0000-0002-2442-767X"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. M. Espinosa-Oliva","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081908980","display_name":"Sandro Arg\u00fcelles","orcid":"https://orcid.org/0000-0001-8450-3227","observed_orcids":["https://orcid.org/0000-0001-8450-3227"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Arg\u00fcelles","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Sarmiento","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Sarmiento","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010126637","display_name":"Mar\u00eda Jos\u00e9 Delgado\u2010Cort\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. J. Delgado-Cort\u00e9s","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069200510","display_name":"Raquel Mauri\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Mauri\u00f1o","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032384763","display_name":"J. Cano","orcid":"https://orcid.org/0000-0003-4495-4394","observed_orcids":["https://orcid.org/0000-0003-4495-4394"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Cano","raw_affiliation_strings":["Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]},{"raw_affiliation_string":"Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo/CSIC, Universidad de Sevilla, 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I79238269"],"apc_list":null,"apc_paid":null,"fwci":1.5526,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.81469237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2011","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.3765000104904175,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9700000286102295},{"id":"https://openalex.org/keywords/intranigral-injection","display_name":"intranigral injection","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nigrostriatal-dopaminergic-neurons","display_name":"nigrostriatal dopaminergic neurons","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.7480000257492065},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9760000109672546},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6110000014305115},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.901208758354187},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.8787484169006348},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7782833576202393},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7296834588050842},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6921209096908569},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6338176131248474},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6297178864479065},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6289049983024597},{"id":"https://openalex.org/C2776355744","wikidata":"https://www.wikidata.org/wiki/Q4318555","display_name":"Nigrostriatal pathway","level":5,"score":0.5805178880691528},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.526029646396637},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.45261651277542114},{"id":"https://openalex.org/C2776286997","wikidata":"https://www.wikidata.org/wiki/Q2880966","display_name":"Dopaminergic pathways","level":4,"score":0.4521810710430145},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.44299957156181335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3737668991088867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25360965728759766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1870470941066742},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18175199627876282},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1497265100479126}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.5402/2011/476158","doi":"https://doi.org/10.5402/2011/476158","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2011/476158","pdf_url":"https://downloads.hindawi.com/archive/2011/476158.pdf","source":{"id":"https://openalex.org/S4210188070","display_name":"ISRN Neurology","issn_l":"2090-5505","issn":["2090-5505","2090-5513"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Neurology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2302130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3263561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3263561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3263561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Neurol","raw_type":"Text"},{"id":"pmid:22389821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22389821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN neurology","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:idus________::65287565af402178bbc736ea71985589","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle/11441/41537","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.3793","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.3793","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f0/e7/ISRN_Neurol_2011_Apr_17_2011_476158.tar.gz","raw_type":"text"},{"id":"pmh:oai:idus.us.es:11441/41537","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11441/41537","pdf_url":null,"source":{"id":"https://openalex.org/S4306401665","display_name":"Deposito de Investigacion Universidad de Sevilla (University of Seville)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.5402/2011/476158","doi":"https://doi.org/10.5402/2011/476158","is_oa":true,"landing_page_url":"https://doi.org/10.5402/2011/476158","pdf_url":"https://downloads.hindawi.com/archive/2011/476158.pdf","source":{"id":"https://openalex.org/S4210188070","display_name":"ISRN Neurology","issn_l":"2090-5505","issn":["2090-5505","2090-5513"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISRN Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8249692241","display_name":null,"funder_award_id":"SAF2008-04366","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"}],"funders":[{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007069030.pdf","grobid_xml":"https://content.openalex.org/works/W2007069030.grobid-xml"},"referenced_works_count":193,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W168949879","https://openalex.org/W1485896673","https://openalex.org/W1487655984","https://openalex.org/W1512972301","https://openalex.org/W1535600179","https://openalex.org/W1559486481","https://openalex.org/W1576211545","https://openalex.org/W1579269952","https://openalex.org/W1579589376","https://openalex.org/W1584876723","https://openalex.org/W1676358823","https://openalex.org/W1753183749","https://openalex.org/W1774746154","https://openalex.org/W1820305336","https://openalex.org/W1855226200","https://openalex.org/W1862122604","https://openalex.org/W1862349412","https://openalex.org/W1875597365","https://openalex.org/W1900066504","https://openalex.org/W1964428139","https://openalex.org/W1964922357","https://openalex.org/W1966437242","https://openalex.org/W1966905916","https://openalex.org/W1967579194","https://openalex.org/W1967640115","https://openalex.org/W1969185518","https://openalex.org/W1970356687","https://openalex.org/W1973512436","https://openalex.org/W1974924674","https://openalex.org/W1976032493","https://openalex.org/W1976266656","https://openalex.org/W1978658991","https://openalex.org/W1979454766","https://openalex.org/W1980060390","https://openalex.org/W1980541855","https://openalex.org/W1980637734","https://openalex.org/W1981834071","https://openalex.org/W1983447138","https://openalex.org/W1983876762","https://openalex.org/W1984445417","https://openalex.org/W1984801123","https://openalex.org/W1984816842","https://openalex.org/W1985407614","https://openalex.org/W1988569037","https://openalex.org/W1989775509","https://openalex.org/W1990203556","https://openalex.org/W1991757174","https://openalex.org/W1991805788","https://openalex.org/W1993262247","https://openalex.org/W1996932429","https://openalex.org/W1997007231","https://openalex.org/W1997282323","https://openalex.org/W1997464282","https://openalex.org/W1999066258","https://openalex.org/W1999506939","https://openalex.org/W1999922500","https://openalex.org/W2002715956","https://openalex.org/W2002851005","https://openalex.org/W2003890592","https://openalex.org/W2005249439","https://openalex.org/W2005754114","https://openalex.org/W2010186735","https://openalex.org/W2010297897","https://openalex.org/W2011305790","https://openalex.org/W2012766958","https://openalex.org/W2014254254","https://openalex.org/W2017289418","https://openalex.org/W2017364016","https://openalex.org/W2017472087","https://openalex.org/W2020363132","https://openalex.org/W2021815999","https://openalex.org/W2023164204","https://openalex.org/W2023419933","https://openalex.org/W2023765759","https://openalex.org/W2026688102","https://openalex.org/W2027911070","https://openalex.org/W2031387417","https://openalex.org/W2032532472","https://openalex.org/W2034901173","https://openalex.org/W2035682659","https://openalex.org/W2036600670","https://openalex.org/W2036697045","https://openalex.org/W2036717742","https://openalex.org/W2036960054","https://openalex.org/W2037312593","https://openalex.org/W2037958123","https://openalex.org/W2038030879","https://openalex.org/W2038882987","https://openalex.org/W2039177462","https://openalex.org/W2039222951","https://openalex.org/W2039430422","https://openalex.org/W2040088974","https://openalex.org/W2041495185","https://openalex.org/W2044439800","https://openalex.org/W2044946346","https://openalex.org/W2045566752","https://openalex.org/W2046050946","https://openalex.org/W2048897966","https://openalex.org/W2050232551","https://openalex.org/W2051441972","https://openalex.org/W2054817857","https://openalex.org/W2056266675","https://openalex.org/W2059482443","https://openalex.org/W2064016659","https://openalex.org/W2065700794","https://openalex.org/W2065840171","https://openalex.org/W2067032924","https://openalex.org/W2067368984","https://openalex.org/W2067518064","https://openalex.org/W2067931227","https://openalex.org/W2068210940","https://openalex.org/W2068287578","https://openalex.org/W2068312274","https://openalex.org/W2068934107","https://openalex.org/W2069438549","https://openalex.org/W2069554650","https://openalex.org/W2071793324","https://openalex.org/W2073845471","https://openalex.org/W2074022605","https://openalex.org/W2074455856","https://openalex.org/W2076719196","https://openalex.org/W2078700489","https://openalex.org/W2078928773","https://openalex.org/W2079235930","https://openalex.org/W2081753893","https://openalex.org/W2082922682","https://openalex.org/W2085429548","https://openalex.org/W2085842958","https://openalex.org/W2086129363","https://openalex.org/W2086148521","https://openalex.org/W2089313647","https://openalex.org/W2089518139","https://openalex.org/W2089915293","https://openalex.org/W2090451764","https://openalex.org/W2090956088","https://openalex.org/W2093192158","https://openalex.org/W2094960332","https://openalex.org/W2095378987","https://openalex.org/W2096911568","https://openalex.org/W2097281218","https://openalex.org/W2097996208","https://openalex.org/W2098946775","https://openalex.org/W2099599536","https://openalex.org/W2101934488","https://openalex.org/W2103738800","https://openalex.org/W2104938127","https://openalex.org/W2110060230","https://openalex.org/W2112743489","https://openalex.org/W2114808045","https://openalex.org/W2116605894","https://openalex.org/W2116672660","https://openalex.org/W2120412340","https://openalex.org/W2120812632","https://openalex.org/W2122032354","https://openalex.org/W2122113931","https://openalex.org/W2123139763","https://openalex.org/W2125284469","https://openalex.org/W2131130040","https://openalex.org/W2132343030","https://openalex.org/W2133045741","https://openalex.org/W2136348600","https://openalex.org/W2143959688","https://openalex.org/W2145653235","https://openalex.org/W2146008698","https://openalex.org/W2148726772","https://openalex.org/W2152526087","https://openalex.org/W2154349779","https://openalex.org/W2155790751","https://openalex.org/W2156168338","https://openalex.org/W2157966921","https://openalex.org/W2162565534","https://openalex.org/W2162974200","https://openalex.org/W2166170833","https://openalex.org/W2171671459","https://openalex.org/W2172547375","https://openalex.org/W2253953550","https://openalex.org/W2272437577","https://openalex.org/W2292308933","https://openalex.org/W2318796889","https://openalex.org/W2319445361","https://openalex.org/W2339380718","https://openalex.org/W2410956377","https://openalex.org/W2414360673","https://openalex.org/W2417691959","https://openalex.org/W2423196442","https://openalex.org/W2431264911","https://openalex.org/W2460144057","https://openalex.org/W2471955324","https://openalex.org/W2584646003","https://openalex.org/W2797732082","https://openalex.org/W4285719527","https://openalex.org/W4406989315"],"related_works":["https://openalex.org/W7100542871","https://openalex.org/W2080258249","https://openalex.org/W1999922500","https://openalex.org/W2991106024","https://openalex.org/W2146008698","https://openalex.org/W2057913943","https://openalex.org/W2033632185","https://openalex.org/W2063285691","https://openalex.org/W2746380062","https://openalex.org/W4322629569"],"abstract_inverted_index":{"We":[0,68],"have":[1,155],"developed":[2],"an":[3,166],"animal":[4],"model":[5,161],"of":[6,8,23,36,44,59,72,82,110,129,169,172,193],"degeneration":[7,171,195],"the":[9,13,34,40,57,60,73,83,89,108,137,170,173,191],"nigrostriatal":[10,174],"dopaminergic":[11,95,112,130,139,175,194],"neurons,":[12],"neuronal":[14],"system":[15],"involved":[16,55],"in":[17,31,39,56,79,179,196],"Parkinson's":[18],"disease":[19,27,61],"(PD).":[20],"The":[21,126],"implication":[22],"neuroinflammation":[24],"on":[25],"this":[26,105,197],"was":[28,46],"originally":[29],"established":[30],"1988,":[32],"when":[33],"presence":[35],"activated":[37],"microglia":[38,151],"substantia":[41],"nigra":[42],"(SN)":[43],"parkinsonians":[45],"reported":[47],"by":[48,117,123,145],"McGeer":[49],"et":[50],"al.":[51],"Neuroinflammation":[52],"could":[53,183],"be":[54,134,184],"progression":[58],"or":[62,152,188],"even":[63],"has":[64],"more":[65],"direct":[66],"implications.":[67],"injected":[69],"2":[70],"\u03bcg":[71],"potent":[74],"proinflammatory":[75],"compound":[76],"lipopolysaccharide":[77],"(LPS)":[78],"different":[80],"areas":[81],"CNS,":[84],"finding":[85],"that":[86,94,149,163],"SN":[87],"displayed":[88],"highest":[90],"inflammatory":[91],"response":[92],"and":[93,101],"(body)":[96],"neurons":[97,131],"showed":[98],"a":[99],"special":[100,127],"specific":[102],"sensitivity":[103,128],"to":[104,133,136,158,186],"process":[106],"with":[107],"induction":[109],"selective":[111],"degeneration.":[113],"Neurodegeneration":[114],"is":[115,121,143,165],"induced":[116],"inflammation":[118,154,164],"since":[119,141],"it":[120,142],"prevented":[122],"anti-inflammatory":[124],"compounds.":[125],"seems":[132],"related":[135],"endogenous":[138],"content,":[140],"overcome":[144],"dopamine":[146],"depletion.":[147],"Compounds":[148],"activate":[150],"induce":[153],"similar":[156],"effects":[157],"LPS.":[159],"This":[160],"suggest":[162],"important":[167],"component":[168],"system,":[176],"probably":[177],"also":[178],"PD.":[180],"Anti-inflammatory":[181],"treatments":[182],"useful":[185],"prevent":[187],"slow":[189],"down":[190],"rate":[192],"disease.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
