{"id":"https://openalex.org/W2007057774","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05717.x","title":"The Effects of Renal Function on the Disposition of Isradipine","display_name":"The Effects of Renal Function on the Disposition of Isradipine","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W2007057774","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05717.x","mag":"2007057774","pmid":"https://pubmed.ncbi.nlm.nih.gov/2977394"},"language":"en","primary_location":{"id":"doi:10.1002/j.1552-4604.1988.tb05717.x","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05717.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1988.tb05717.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111746291","display_name":"Mary H.H. Chandler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary H. H. Chandler","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington","Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","institution_ids":[]},{"raw_affiliation_string":"Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055718195","display_name":"HORST F. SCHRAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horst F. Schran","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","institution_ids":[]},{"raw_affiliation_string":"Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108794770","display_name":"Ralph E. Cutler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph E. Cutler","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","institution_ids":[]},{"raw_affiliation_string":"Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103507408","display_name":"Albert J. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert J. Smith","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","institution_ids":[]},{"raw_affiliation_string":"Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058685547","display_name":"Leonard M. Gonasun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard M. Gonasun","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","institution_ids":[]},{"raw_affiliation_string":"Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110537749","display_name":"Robert A. Blouin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A. Blouin","raw_affiliation_strings":["Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Product Evaluation Unit, University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Drug Safety and Metabolism and Medical Research Divisions, Sandoz Research Institute, East Hanover, New Jersey","institution_ids":[]},{"raw_affiliation_string":"Jerry L. Pettis Memorial V.A. Hospital, Loma Linda, California","institution_ids":["https://openalex.org/I4210116750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110537749"],"corresponding_institution_ids":["https://openalex.org/I143302722","https://openalex.org/I4210116750"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.7668,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82303695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"28","issue":"12","first_page":"1076","last_page":"1080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.06210000067949295,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isradipine","display_name":"isradipine","score":1.0},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oral-clearance","display_name":"oral clearance","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.6129999756813049},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6850000023841858},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.6850000023841858},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7987282276153564},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7842108011245728},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7591001987457275},{"id":"https://openalex.org/C2776066529","wikidata":"https://www.wikidata.org/wiki/Q414873","display_name":"Isradipine","level":4,"score":0.7418508529663086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6074314117431641},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.537087619304657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5355244874954224},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42203933000564575},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.401073694229126},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3398969769477844},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.21571078896522522},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017275","descriptor_name":"Isradipine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/j.1552-4604.1988.tb05717.x","doi":"https://doi.org/10.1002/j.1552-4604.1988.tb05717.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1988.tb05717.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:2977394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2977394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W143941869","https://openalex.org/W1986211909","https://openalex.org/W1990652405","https://openalex.org/W2000765389","https://openalex.org/W2046988336","https://openalex.org/W2071092830","https://openalex.org/W2079736596","https://openalex.org/W2088054863","https://openalex.org/W2091529897","https://openalex.org/W2102319124","https://openalex.org/W2122686506","https://openalex.org/W2321169636","https://openalex.org/W2328867190"],"related_works":["https://openalex.org/W2043823503","https://openalex.org/W2161595437","https://openalex.org/W358114491","https://openalex.org/W2001913285","https://openalex.org/W2088054863","https://openalex.org/W2073310817","https://openalex.org/W2061742189","https://openalex.org/W1995472890","https://openalex.org/W1490884660","https://openalex.org/W2099930447"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,13,77,176],"renal":[3,23,100,121,131,195],"function":[4,122,132],"on":[5,189],"isradipine":[6,28,47,171],"kinetics":[7],"was":[8,81],"examined":[9],"in":[10,170,179,194],"four":[11],"groups":[12,102,126],"subjects":[14],"(N":[15],"=":[16,138,146],"55)":[17],"who":[18],"had":[19],"normal":[20],"or":[21,129],"impaired":[22],"function.":[24],"Each":[25],"subject":[26],"received":[27],"orally":[29],"as":[30],"a":[31],"10-mg":[32],"capsule.":[33],"Serial":[34],"blood":[35],"samples":[36],"were":[37,72,91,103,109,153],"obtained":[38],"from":[39],"0":[40],"to":[41,69],"48":[42],"hours":[43],"postdose":[44],"and":[45,64,96,144,159,161,164,173],"the":[46,78,117,167,174],"plasma":[48],"concentrations":[49],"determined":[50],"by":[51],"radioimmunoassay.":[52],"Kinetic":[53],"parameters,":[54],"Cmax,":[55],"lambda":[56],"3,":[57],"t":[58],"1/2,":[59],"AUC,":[60,94],"CL'o":[61],"(oral":[62,66],"clearance),":[63],"CLo":[65,160,180],"clearance":[67,157],"standardized":[68],"body":[70],"weight)":[71],"determined.":[73],"Marked":[74],"intersubject":[75],"variability":[76,169],"pharmacokinetic":[79],"parameters":[80,98],"observed.":[82],"No":[83,134],"statistically":[84],"significant":[85,135,177],"differences":[86,178],"(P":[87,111],"greater":[88,141,149],"than":[89,113,124,142,150],".05)":[90],"found":[92,154],"for":[93,116,125],"Cl'o,":[95],"Clo":[97],"when":[99],"impairment":[101,123],"compared":[104],"with":[105,119,127],"controls.":[106],"AUC":[107],"values":[108],"lower":[110],"less":[112],".05),":[114],"however,":[115],"group":[118],"severe":[120],"mild":[128],"moderate":[130],"impairment.":[133,196],"correlations":[136],"(r":[137],"-.23,":[139],"P":[140,148],".05;":[143],"r":[145],".13,":[147],".05,":[151],"respectively)":[152],"between":[155,162,181],"creatinine":[156],"(CLCR)":[158],"age":[163],"CLo.":[165],"Considering":[166],"interpatient":[168],"disposition":[172],"lack":[175],"groups,":[182],"no":[183],"clear-cut":[184],"dosing":[185],"regimen":[186],"alterations,":[187],"based":[188],"single-dose":[190],"data,":[191],"are":[192],"warranted":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}