{"id":"https://openalex.org/W2007023401","doi":"https://doi.org/10.1158/1538-7445.am2014-5384","title":"Abstract 5384: Systematic high-throughput drug sensitivity and resistance testing (DSRT) of ovarian cancer cell lines indicates novel therapeutic possibilities with existing and emerging drugs","display_name":"Abstract 5384: Systematic high-throughput drug sensitivity and resistance testing (DSRT) of ovarian cancer cell lines indicates novel therapeutic possibilities with existing and emerging drugs","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2007023401","doi":"https://doi.org/10.1158/1538-7445.am2014-5384","mag":"2007023401"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-5384","doi":"https://doi.org/10.1158/1538-7445.am2014-5384","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5384","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079668567","display_name":"Akira Hirasawa","orcid":"https://orcid.org/0000-0003-4124-5488","observed_orcids":["https://orcid.org/0000-0003-4124-5488"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Akira Hirasawa","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033369123","display_name":"Astrid Murum\u00e4gi","orcid":"https://orcid.org/0000-0002-7797-188X","observed_orcids":["https://orcid.org/0000-0002-7797-188X"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Astrid Murum\u00e4gi","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003065165","display_name":"Mariliina Arjama","orcid":"https://orcid.org/0000-0003-1627-9571","observed_orcids":["https://orcid.org/0000-0003-1627-9571"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mariliina Arjama","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079229880","display_name":"Bhagwan Yadav","orcid":"https://orcid.org/0000-0002-3502-9335","observed_orcids":["https://orcid.org/0000-0002-3502-9335"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Bhagwan Yadav","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110451534","display_name":"John Patrick Mpindi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"John Patrick Mpindi","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067760174","display_name":"Krister Wennerberg","orcid":"https://orcid.org/0000-0002-1352-4220","observed_orcids":["https://orcid.org/0000-0002-1352-4220"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Krister Wennerberg","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero A. Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769","observed_orcids":["https://orcid.org/0000-0002-0886-9769"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013258133","display_name":"Daisuke Aoki","orcid":"https://orcid.org/0000-0002-9596-8326","observed_orcids":["https://orcid.org/0000-0002-9596-8326"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Aoki","raw_affiliation_strings":["2School of Medicine, Keio University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2School of Medicine, Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050670008","display_name":"Olli Kallioniemi","orcid":"https://orcid.org/0000-0002-3231-0332","observed_orcids":["https://orcid.org/0000-0002-3231-0332"]},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli Kallioniemi","raw_affiliation_strings":["1Institute for Molecular Medicine Finland, Helsinki, Finland;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Institute for Molecular Medicine Finland, Helsinki, Finland;","institution_ids":["https://openalex.org/I4210133586"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"5384","last_page":"5384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.878000020980835},{"id":"https://openalex.org/keywords/ovarian-cancer-cell-lines","display_name":"ovarian cancer cell lines","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/mucinous-ovarian-carcinoma","display_name":"mucinous ovarian carcinoma","score":1.0},{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"serous ovarian cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dose-response-curves","display_name":"dose-response curves","score":0.6679999828338623},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.7519999742507935},{"id":"https://openalex.org/keywords/entinostat","display_name":"entinostat","score":0.9660000205039978},{"id":"https://openalex.org/keywords/belinostat","display_name":"belinostat","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.6359999775886536},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.5789999961853027},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6252917647361755},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6104525327682495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6056954264640808},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5455086827278137},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5125722885131836},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.438549667596817},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4383618235588074},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.4107521176338196},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.39341554045677185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35104095935821533},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34759530425071716},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33295249938964844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27743133902549744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10037344694137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-5384","doi":"https://doi.org/10.1158/1538-7445.am2014-5384","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5384","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2333795265","https://openalex.org/W2003877259","https://openalex.org/W2886091803","https://openalex.org/W4231844868","https://openalex.org/W2567273070","https://openalex.org/W4401158753","https://openalex.org/W2742046051","https://openalex.org/W2885184363","https://openalex.org/W4412523369","https://openalex.org/W2401176598"],"abstract_inverted_index":{"Abstract":[0],"There":[1],"is":[2,355],"an":[3],"urgent":[4],"need":[5],"to":[6,28,31,40,48,52,78,145,168,197,330],"develop":[7],"better":[8],"understanding":[9],"of":[10,83,176,222,248,259,292,340,343,345,351,396,413,418],"the":[11,20,32,160,165,170,177,191,219,223,228,238,242,252,260,352,414,419],"drug":[12,152,171,178,210,319,332,390],"responsivenes":[13],"in":[14,19,86,130,143,153,186,275,290,321,334],"ovarian":[15,100,397],"cancer":[16,101,398],"(OC),":[17],"particularly":[18],"clear":[21,95],"cell":[22,90,96,102,155,183,200,225,245,294,323,353,399],"and":[23,43,60,67,97,116,123,256,271,309,325,357,362,392,407],"mucinous":[24,99],"subtypes,":[25],"which":[26],"tend":[27],"be":[29],"resistant":[30],"commonly":[33],"used":[34],"platinum-based":[35],"regimens.":[36],"This":[37],"would":[38],"help":[39,329],"improve":[41],"survival":[42],"facilitate":[44],"precision":[45],"medicine":[46],"approaches":[47],"therapy.":[49],"In":[50],"order":[51,144],"discover":[53],"previously":[54],"unsuspected":[55],"anti-cancer":[56],"effects":[57,82],"with":[58,348,405],"approved":[59,108],"emerging":[61,408],"drugs,":[62,261,303],"we":[63,280],"applied":[64],"Drug":[65],"Sensitivity":[66],"Resistance":[68],"Testing":[69],"(DSRT)":[70,395],"technology":[71,312],"(Pemovska":[72],"et":[73],"al.,":[74],"Cancer":[75,423,434],"Discovery,":[76],"2013)":[77],"determine":[79],"detailed":[80,147],"dose-response":[81,148,166],"300":[84],"drugs":[85,109,127,230,287],"25":[87,243],"established":[88],"OC":[89,182,199,224,244,293,322],"lines":[91,184,201,354,400],"(10":[92],"serous,":[93],"10":[94],"5":[98,131],"lines).":[103],"The":[104,157],"panel":[105],"covered":[106],"160":[107],"as":[110,112,121,263,299,301,305],"well":[111,300],"162":[113],"emerging,":[114,284],"investigational":[115],"pre-clinical":[117],"oncology":[118],"compounds":[119],"such":[120,262,304],"kinase":[122,298],"non-kinase":[124,302],"inhibitors.":[125],"All":[126],"were":[128,231,288],"tested":[129],"different":[132],"concentrations":[133],"covering":[134],"a":[135,314],"10,000-fold":[136],"concentration":[137],"range":[138],"using":[139],"Labcyte":[140],"nano-dispensing":[141],"technology,":[142],"generate":[146],"curves":[149],"for":[150,317,365,422],"each":[151,154,273],"line.":[156],"area":[158],"under":[159],"curve":[161,167],"was":[162],"estimated":[163],"from":[164,181],"obtain":[169],"sensitivity":[172,391],"score.":[173],"Bioinformatic":[174],"processing":[175],"response":[179,239,320],"data":[180,193,240,347,350],"resulted":[185],"several":[187],"key":[188],"observations.":[189],"First,":[190],"DSRT":[192,311,346],"made":[194],"it":[195,326],"possible":[196],"classify":[198],"into":[202,233],"four":[203],"functional":[204,234],"taxonomic":[205],"subtypes":[206],"based":[207,236],"on":[208,218,237],"comprehensive":[209],"responses.":[211],"Interestingly,":[212],"these":[213],"clusters":[214],"did":[215],"not":[216],"depend":[217],"histological":[220],"origin":[221],"lines.":[226,246],"Second,":[227],"322":[229],"clustered":[232],"subsets":[235],"across":[241],"Most":[247],"this":[249],"clustering":[250,274],"followed":[251],"expected":[253],"chemical":[254],"similarity":[255],"target":[257],"space":[258],"topoisomerase":[264],"II":[265],"inhibitors,":[266,268],"MEK":[267],"mTOR":[269],"inhibitors":[270,307],"Taxanes":[272],"their":[276],"own":[277],"subgroups.":[278],"Third,":[279],"found":[281],"that":[282],"many":[283],"currently":[285],"not-yet-approved":[286],"active":[289],"subgroups":[291],"lines,":[295],"including":[296],"both":[297],"HDAC":[306],"Entinostat":[308],"Belinostat.":[310],"provides":[313],"powerful":[315],"strategy":[316],"assessing":[318],"models,":[324],"could":[327],"also":[328],"asses":[331],"responses":[333],"patient-derived":[335],"ex":[336],"vivo":[337],"model":[338],"systems":[339],"OC.":[341,366],"Analysis":[342],"correlations":[344],"genomic":[349],"underway":[356],"will":[358],"yield":[359],"new":[360],"translational":[361],"pharmacogenomic":[363],"opportunities":[364],"Citation":[367],"Format:":[368],"Akira":[369],"Hirasawa,":[370],"Astrid":[371],"Murum\u00e4gi,":[372],"Mariliina":[373],"Arjama,":[374],"Bhagwan":[375],"Yadav,":[376],"John":[377],"Patrick":[378],"Mpindi,":[379],"Krister":[380],"Wennerberg,":[381],"Tero":[382],"Aittokallio,":[383],"Daisuke":[384],"Aoki,":[385],"Olli":[386],"Kallioniemi.":[387],"Systematic":[388],"high-throughput":[389],"resistance":[393],"testing":[394],"indicates":[401],"novel":[402],"therapeutic":[403],"possibilities":[404],"existing":[406],"drugs.":[409],"[abstract].":[410],"In:":[411],"Proceedings":[412],"105th":[415],"Annual":[416],"Meeting":[417],"American":[420],"Association":[421],"Research;":[424],"2014":[425],"Apr":[426],"5-9;":[427],"San":[428],"Diego,":[429],"CA.":[430],"Philadelphia":[431],"(PA):":[432],"AACR;":[433],"Res":[435],"2014;74(19":[436],"Suppl):Abstract":[437],"nr":[438],"5384.":[439],"doi:10.1158/1538-7445.AM2014-5384":[440]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
