{"id":"https://openalex.org/W2007011272","doi":"https://doi.org/10.1089/ars.2012.5057","title":"HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization","display_name":"HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization","publication_year":2013,"publication_date":"2013-08-06","ids":{"openalex":"https://openalex.org/W2007011272","doi":"https://doi.org/10.1089/ars.2012.5057","mag":"2007011272","pmid":"https://pubmed.ncbi.nlm.nih.gov/23919584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785857"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2012.5057","doi":"https://doi.org/10.1089/ars.2012.5057","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2012.5057","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785857","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010691390","display_name":"Vidhya Sivakumaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidhya Sivakumaran","raw_affiliation_strings":["Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia","Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103684457","display_name":"Brian A. Stanley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Stanley","raw_affiliation_strings":["Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061316252","display_name":"Carlo Gabriele Tocchetti","orcid":"https://orcid.org/0000-0001-5983-688X","observed_orcids":["https://orcid.org/0000-0001-5983-688X"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlo G. Tocchetti","raw_affiliation_strings":["Clinica Montevergine, Mercogliano, Italy","Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Montevergine, Mercogliano, Italy","institution_ids":[]},{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016550404","display_name":"Jeff D. Ballin","orcid":"https://orcid.org/0000-0002-2712-130X","observed_orcids":["https://orcid.org/0000-0002-2712-130X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210098833","display_name":"Excet (United States)","ror":"https://ror.org/00yx8y731","country_code":"US","type":"company","lineage":["https://openalex.org/I4210098833"]},{"id":"https://openalex.org/I4387153805","display_name":"U.S. Army Combat Capabilities Development Command Chemical Biological Center","ror":"https://ror.org/022j0mn33","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802705668","https://openalex.org/I4210154437","https://openalex.org/I4387153805"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff D. Ballin","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, Maryland","Excet, Inc., Springfield, Virginia","US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Aberdeen, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Excet, Inc., Springfield, Virginia","institution_ids":["https://openalex.org/I4210098833"]},{"raw_affiliation_string":"US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Aberdeen, Maryland","institution_ids":["https://openalex.org/I4387153805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013872886","display_name":"Viviane Caceres","orcid":"https://orcid.org/0000-0002-6052-0273","observed_orcids":["https://orcid.org/0000-0002-6052-0273"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Viviane Caceres","raw_affiliation_strings":["Departamento de Farmacologia, Universidade Federal de Sao Paulo (UNIFESP/EPM), Sao Paolo, Brazil","Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacologia, Universidade Federal de Sao Paulo (UNIFESP/EPM), Sao Paolo, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022429262","display_name":"Lufang Zhou","orcid":"https://orcid.org/0000-0002-1321-8442","observed_orcids":["https://orcid.org/0000-0002-1321-8442"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lufang Zhou","raw_affiliation_strings":["Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058924500","display_name":"Gizem Keceli","orcid":"https://orcid.org/0000-0002-9562-7994","observed_orcids":["https://orcid.org/0000-0002-9562-7994"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gizem Keceli","raw_affiliation_strings":["Department of Chemistry, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031315514","display_name":"Peter P. Rainer","orcid":"https://orcid.org/0000-0002-2840-6454","observed_orcids":["https://orcid.org/0000-0002-2840-6454"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Peter P. Rainer","raw_affiliation_strings":["Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","Division of Cardiology, Medical University of Graz, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Division of Cardiology, Medical University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006312779","display_name":"Dong I. Lee","orcid":"https://orcid.org/0000-0002-5475-5922","observed_orcids":["https://orcid.org/0000-0002-5475-5922"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong I. Lee","raw_affiliation_strings":["Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015146106","display_name":"Sabine Huke","orcid":"https://orcid.org/0000-0003-1734-7871","observed_orcids":["https://orcid.org/0000-0003-1734-7871"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabine Huke","raw_affiliation_strings":["Department of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040074839","display_name":"Mark T. Ziolo","orcid":"https://orcid.org/0000-0002-8810-2284","observed_orcids":["https://orcid.org/0000-0002-8810-2284"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark T. Ziolo","raw_affiliation_strings":["Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelia G. Kranias","raw_affiliation_strings":["Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, Ohio","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047937683","display_name":"John P. Toscano","orcid":"https://orcid.org/0000-0002-4277-3533","observed_orcids":["https://orcid.org/0000-0002-4277-3533"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Toscano","raw_affiliation_strings":["Department of Chemistry, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006990099","display_name":"Gerald M. Wilson","orcid":"https://orcid.org/0000-0002-1273-7507","observed_orcids":["https://orcid.org/0000-0002-1273-7507"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald M. Wilson","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080198568","display_name":"Brian P O'Rourke","orcid":"https://orcid.org/0000-0002-5548-4853","observed_orcids":["https://orcid.org/0000-0002-5548-4853"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian O'Rourke","raw_affiliation_strings":["Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081031540","display_name":"David A. Kass","orcid":"https://orcid.org/0000-0003-1596-2299","observed_orcids":["https://orcid.org/0000-0003-1596-2299"]},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Kass","raw_affiliation_strings":["Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112032907","display_name":"James E. Mahaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]},{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James E. Mahaney","raw_affiliation_strings":["Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia","Edward Via College of Osteopathic Medicine, Blacksburg, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Edward Via College of Osteopathic Medicine, Blacksburg, Virginia","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010660115","display_name":"Nazareno Paolocci","orcid":"https://orcid.org/0000-0001-7011-997X","observed_orcids":["https://orcid.org/0000-0001-7011-997X"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["IT","US"],"is_corresponding":true,"raw_author_name":"Nazareno Paolocci","raw_affiliation_strings":["Department of Clinical Medicine, University of Perugia, Perugia, Italy","Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5010660115","https://openalex.org/A5112032907"],"corresponding_institution_ids":["https://openalex.org/I27483092","https://openalex.org/I2799853436","https://openalex.org/I4210150714","https://openalex.org/I859038795","https://openalex.org/I896114043"],"apc_list":null,"apc_paid":null,"fwci":5.893,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.96776783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"19","issue":"11","first_page":"1185","last_page":"1197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroxyl","display_name":"nitroxyl","score":0.996999979019165},{"id":"https://openalex.org/keywords/phospholamban","display_name":"phospholamban","score":0.8140000104904175},{"id":"https://openalex.org/keywords/serca2a","display_name":"SERCA2a","score":1.0},{"id":"https://openalex.org/keywords/cardiomyocyte-function","display_name":"cardiomyocyte function","score":0.6819999814033508},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.7039999961853027},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.8270000219345093},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8830000162124634},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/inotropic-effect","display_name":"inotropic effect","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lusitropy","display_name":"lusitropy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8420000076293945},{"id":"https://openalex.org/keywords/beta-adrenergic-responsiveness","display_name":"beta-adrenergic responsiveness","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.9399447441101074},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.6346647143363953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5501726269721985},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5329073071479797},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.49197742342948914},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4603521525859833},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42408937215805054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3137893080711365},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.29111289978027344},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099211","descriptor_name":"Phospholamban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009589","descriptor_name":"Nitrogen Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1089/ars.2012.5057","doi":"https://doi.org/10.1089/ars.2012.5057","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2012.5057","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3160878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785857","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3785857","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785857","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxid Redox Signal","raw_type":"Text"},{"id":"pmid:23919584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23919584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/36875","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/36875","pdf_url":null,"source":{"id":"https://openalex.org/S4377196380","display_name":"UNIFESP Institutional Repository (Universidade Federal de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88273585","host_organization_name":"Universidade Federal de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I88273585"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artigo"},{"id":"pmh:oai:www.research.unipd.it:11577/3323963","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/3323963","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3160878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3785857","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G13299949","display_name":"Mechanisms directing oncoprotein and cytokine mRNA decay","funder_award_id":"R01CA102428","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2138760503","display_name":"Pathobiology of Cardiac Dyssynchrony & Resynchronization","funder_award_id":"P01HL077180","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2365392527","display_name":"Nitric oxide signaling in healthy and diseased cardiac myocytes","funder_award_id":"K02HL094692","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2377336609","display_name":"Investigate the effect of mitochondrial energy state on Ca2+ sparks and handling","funder_award_id":"K99HL095648","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3667157341","display_name":"Calcium Handling in Cardiac Pathophysiology","funder_award_id":"R01HL026057","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4537166063","display_name":"Nitroxyl cardiac effects are mediated by cAMP/PKA signal","funder_award_id":"R01HL075265","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5005330114","display_name":null,"funder_award_id":"1 R15HL091410","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5693544556","display_name":"Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic Heart","funder_award_id":"R01HL091923","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5961016736","display_name":"MItochondrial Dysfunction in Cardiac Hypertrophy and Failure","funder_award_id":"R01HL101235","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6399022356","display_name":"Redox Modification of the Arrhythmic Substrate in Heart Failure","funder_award_id":"R01HL105216","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G733343312","display_name":"NOS1/NOS3 Functional Effects on Cardiac Myocyte Function","funder_award_id":"R01HL079283","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G752937828","display_name":"Calcium Pump Nitration and Inhibition of Calcium Transport in the Aging Heart","funder_award_id":"1r15hl091410-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8376805483","display_name":"Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins","funder_award_id":"R01HL064018","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1430858901","https://openalex.org/W1486949053","https://openalex.org/W1506043065","https://openalex.org/W1538762668","https://openalex.org/W1980664012","https://openalex.org/W1980898855","https://openalex.org/W1997874930","https://openalex.org/W2006591185","https://openalex.org/W2009059892","https://openalex.org/W2010344791","https://openalex.org/W2010576268","https://openalex.org/W2015009081","https://openalex.org/W2015769784","https://openalex.org/W2023097830","https://openalex.org/W2024212213","https://openalex.org/W2024918253","https://openalex.org/W2028664000","https://openalex.org/W2032948757","https://openalex.org/W2033427134","https://openalex.org/W2034592170","https://openalex.org/W2042960561","https://openalex.org/W2051541317","https://openalex.org/W2055117340","https://openalex.org/W2062351178","https://openalex.org/W2064363834","https://openalex.org/W2064471243","https://openalex.org/W2065281025","https://openalex.org/W2065536134","https://openalex.org/W2071328595","https://openalex.org/W2088836080","https://openalex.org/W2107590406","https://openalex.org/W2112808920","https://openalex.org/W2115638751","https://openalex.org/W2121998234","https://openalex.org/W2122991452","https://openalex.org/W2133203435","https://openalex.org/W2134033040","https://openalex.org/W2134592435","https://openalex.org/W2138783312","https://openalex.org/W2147410890","https://openalex.org/W2150335297","https://openalex.org/W2153382667","https://openalex.org/W2154554241","https://openalex.org/W2156995088","https://openalex.org/W2157581901","https://openalex.org/W2158714558","https://openalex.org/W2161895190","https://openalex.org/W2792980560","https://openalex.org/W2913008332"],"related_works":["https://openalex.org/W200158926","https://openalex.org/W2019102104","https://openalex.org/W7024387526","https://openalex.org/W2018814121","https://openalex.org/W2769765431","https://openalex.org/W2078060006","https://openalex.org/W2034676010","https://openalex.org/W4389008162","https://openalex.org/W2085740910","https://openalex.org/W2420159586"],"abstract_inverted_index":{"AIMS:":[0],"Nitroxyl":[1],"(HNO)":[2],"interacts":[3],"with":[4,226],"thiols":[5],"to":[6,32,90,214,246],"act":[7],"as":[8],"a":[9,60,204],"redox-sensitive":[10],"modulator":[11],"of":[12,35,182,199,210,238],"protein":[13],"function.":[14],"It":[15],"enhances":[16],"sarcoplasmic":[17,55,71],"reticular":[18],"Ca(2+)":[19,23,64,100,111,134,248],"uptake":[20,135],"and":[21,53,75,102,110,116,220],"myofilament":[22],"sensitivity,":[24],"improving":[25,63],"cardiac":[26],"contractility.":[27],"This":[28],"activity":[29],"has":[30],"led":[31],"clinical":[33],"testing":[34],"HNO":[36,45,106,131,152,166],"donors":[37],"for":[38],"heart":[39],"failure.":[40],"Here":[41],"we":[42],"tested":[43],"whether":[44],"alters":[46],"the":[47,54,180,239],"inhibitory":[48,184],"interaction":[49],"between":[50],"phospholamban":[51],"(PLN)":[52],"reticulum":[56,72],"Ca(2+)-ATPase":[57],"(SERCA2a)":[58],"in":[59,66,113,120,128,136,144,173,192,207,217,235,250],"redox-dependent":[61],"manner,":[62],"handling":[65,249],"isolated":[67,79],"myocytes/hearts.":[68],"RESULTS:":[69],"Ventriculocytes,":[70],"(SR)":[73],"vesicles,":[74],"whole":[76],"hearts":[77],"were":[78,125],"from":[80],"control":[81],"(wildtype":[82],"[WT])":[83],"or":[84],"PLN":[85,161,172,186,194,197,202,222,231],"knockout":[86],"(pln(-/-))":[87],"mice.":[88],"Compared":[89],"WT,":[91],"pln(-/-)":[92,129,140],"myocytes":[93,219],"displayed":[94],"enhanced":[95,132],"resting":[96],"sarcomere":[97],"shortening,":[98,108],"peak":[99],"transient,":[101],"blunted":[103,127],"\u03b2-adrenergic":[104],"responsiveness.":[105],"stimulated":[107],"relaxation,":[109],"transient":[112],"WT":[114,137],"cardiomyocytes,":[115,165],"evoked":[117],"positive":[118],"inotropy/lusitropy":[119,216],"intact":[121,218],"hearts.":[122,221,252],"These":[123,241],"changes":[124,191],"markedly":[126],"cells/hearts.":[130],"SR":[133],"but":[138,158],"not":[139],"SR-vesicles.":[141],"Spectroscopic":[142],"studies":[143],"insect":[145],"cell":[146],"microsomes":[147],"expressing":[148],"SERCA2a\u00b1PLN":[149],"showed":[150],"that":[151],"increased":[153,215],"Ca(2+)-dependent":[154],"SERCA2a":[155,211],"conformational":[156],"flexibility":[157],"only":[159],"when":[160],"was":[162],"present.":[163],"In":[164],"achieved":[167],"this":[168],"effect":[169],"by":[170],"stabilizing":[171],"an":[174],"oligomeric":[175],"disulfide":[176],"bond-dependent":[177],"configuration,":[178],"decreasing":[179],"amount":[181],"free":[183],"monomeric":[185,230],"available.":[187],"INNOVATION:":[188],"HNO-dependent":[189],"redox":[190],"myocyte":[193],"oligomerization":[195],"relieve":[196],"inhibition":[198,237],"SERCA2a.":[200],"CONCLUSIONS:":[201],"plays":[203],"central":[205],"role":[206],"HNO-induced":[208],"enhancement":[209],"activity,":[212],"leading":[213],"remains":[223],"physically":[224],"associated":[225],"SERCA2a;":[227],"however,":[228],"less":[229],"is":[232],"available":[233],"resulting":[234],"decreased":[236],"enzyme.":[240],"findings":[242],"offer":[243],"new":[244],"avenues":[245],"improve":[247],"failing":[251]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}