{"id":"https://openalex.org/W2006982410","doi":"https://doi.org/10.1038/sj.onc.1203276","title":"MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways","display_name":"MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways","publication_year":2000,"publication_date":"2000-02-21","ids":{"openalex":"https://openalex.org/W2006982410","doi":"https://doi.org/10.1038/sj.onc.1203276","mag":"2006982410","pmid":"https://pubmed.ncbi.nlm.nih.gov/10713682"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1203276","doi":"https://doi.org/10.1038/sj.onc.1203276","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203276","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111490657","display_name":"Robert Callahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Callahan","raw_affiliation_strings":["Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA","Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082987275","display_name":"Gilbert H. Smith","orcid":"https://orcid.org/0000-0002-1908-5425","observed_orcids":["https://orcid.org/0000-0002-1908-5425"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilbert H Smith","raw_affiliation_strings":["Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":0.9326,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.66787004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"8","first_page":"992","last_page":"1001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4447999894618988,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4447999894618988,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.23100000619888306,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-mammary-tumor-virus","display_name":"mouse mammary tumor virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/mammary-epithelium","display_name":"mammary epithelium","score":0.9100000262260437},{"id":"https://openalex.org/keywords/somatic-mutagenesis","display_name":"somatic mutagenesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/proviral-integration","display_name":"proviral integration","score":0.597000002861023},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7129999995231628},{"id":"https://openalex.org/keywords/mammary-stem-cells","display_name":"mammary stem cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/acquired-mutations","display_name":"acquired mutations","score":0.7770000100135803},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8796021938323975},{"id":"https://openalex.org/C2779777497","wikidata":"https://www.wikidata.org/wiki/Q1775519","display_name":"Mouse mammary tumor virus","level":3,"score":0.7432233095169067},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6681134700775146},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5895421504974365},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.5660494565963745},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5106161236763},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4984610080718994},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49317997694015503},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.44949716329574585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4096441864967346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.402762770652771},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3798675835132599},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.27636468410491943},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074562","descriptor_name":"Receptor, Notch4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008324","descriptor_name":"Mammary Tumor Virus, Mouse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008324","descriptor_name":"Mammary Tumor Virus, Mouse","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010448","descriptor_name":"Peptide Initiation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039621","descriptor_name":"Eukaryotic Initiation Factor-3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051524","descriptor_name":"Fibroblast Growth Factor 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1203276","doi":"https://doi.org/10.1038/sj.onc.1203276","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1203276","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:10713682","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10713682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W350354450","https://openalex.org/W380957372","https://openalex.org/W1486906704","https://openalex.org/W1495121347","https://openalex.org/W1503253060","https://openalex.org/W1506600482","https://openalex.org/W1518003863","https://openalex.org/W1518709728","https://openalex.org/W1529620938","https://openalex.org/W1535954305","https://openalex.org/W1572032955","https://openalex.org/W1598742335","https://openalex.org/W1686683669","https://openalex.org/W1738481395","https://openalex.org/W1751787271","https://openalex.org/W1814546794","https://openalex.org/W1831282506","https://openalex.org/W1854803455","https://openalex.org/W1922661470","https://openalex.org/W1965783123","https://openalex.org/W1966082762","https://openalex.org/W1966686416","https://openalex.org/W1969425389","https://openalex.org/W1969614962","https://openalex.org/W1973516848","https://openalex.org/W1975771868","https://openalex.org/W1976481318","https://openalex.org/W1979041271","https://openalex.org/W1981106680","https://openalex.org/W1983633709","https://openalex.org/W1983809085","https://openalex.org/W1984704490","https://openalex.org/W1988365075","https://openalex.org/W1992682395","https://openalex.org/W1993013570","https://openalex.org/W1996294835","https://openalex.org/W1996628643","https://openalex.org/W1998131878","https://openalex.org/W1999473730","https://openalex.org/W2001532707","https://openalex.org/W2005121248","https://openalex.org/W2008922304","https://openalex.org/W2009882028","https://openalex.org/W2011403484","https://openalex.org/W2012083927","https://openalex.org/W2014033142","https://openalex.org/W2016709569","https://openalex.org/W2017131203","https://openalex.org/W2017724386","https://openalex.org/W2017757823","https://openalex.org/W2020854296","https://openalex.org/W2021267003","https://openalex.org/W2023552341","https://openalex.org/W2025047211","https://openalex.org/W2025203479","https://openalex.org/W2027128159","https://openalex.org/W2029033124","https://openalex.org/W2029646324","https://openalex.org/W2030241223","https://openalex.org/W2031511195","https://openalex.org/W2033618020","https://openalex.org/W2036050422","https://openalex.org/W2041988832","https://openalex.org/W2050342016","https://openalex.org/W2051570103","https://openalex.org/W2054328852","https://openalex.org/W2054587682","https://openalex.org/W2059257969","https://openalex.org/W2062691081","https://openalex.org/W2066403228","https://openalex.org/W2068425472","https://openalex.org/W2074376751","https://openalex.org/W2075587654","https://openalex.org/W2077532475","https://openalex.org/W2079932863","https://openalex.org/W2081377043","https://openalex.org/W2082630050","https://openalex.org/W2083979717","https://openalex.org/W2084220146","https://openalex.org/W2086028819","https://openalex.org/W2086124000","https://openalex.org/W2090628094","https://openalex.org/W2104495363","https://openalex.org/W2109848609","https://openalex.org/W2111387596","https://openalex.org/W2111909938","https://openalex.org/W2115774187","https://openalex.org/W2117928953","https://openalex.org/W2118166455","https://openalex.org/W2129172191","https://openalex.org/W2129219824","https://openalex.org/W2135264572","https://openalex.org/W2136003241","https://openalex.org/W2138269860","https://openalex.org/W2139936955","https://openalex.org/W2146660065","https://openalex.org/W2147001975","https://openalex.org/W2153838631","https://openalex.org/W2158228414","https://openalex.org/W2158773962","https://openalex.org/W2160399392","https://openalex.org/W2160455157","https://openalex.org/W2165781463","https://openalex.org/W2169270915","https://openalex.org/W2290176401","https://openalex.org/W2336312348","https://openalex.org/W2396846050","https://openalex.org/W4206161920","https://openalex.org/W4210958860","https://openalex.org/W4211089574","https://openalex.org/W4242097343"],"related_works":["https://openalex.org/W2081377043","https://openalex.org/W1999549536","https://openalex.org/W166535930","https://openalex.org/W2076399053","https://openalex.org/W3025304685","https://openalex.org/W239324590","https://openalex.org/W2295033088","https://openalex.org/W2321894035","https://openalex.org/W2039697834","https://openalex.org/W70086597"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}