{"id":"https://openalex.org/W2006954677","doi":"https://doi.org/10.1055/s-0034-1368507","title":"Anti-inflammatory and Antinociceptive Activities of Azadirachtin in Mice","display_name":"Anti-inflammatory and Antinociceptive Activities of Azadirachtin in Mice","publication_year":2014,"publication_date":"2014-05-28","ids":{"openalex":"https://openalex.org/W2006954677","doi":"https://doi.org/10.1055/s-0034-1368507","mag":"2006954677","pmid":"https://pubmed.ncbi.nlm.nih.gov/24871207"},"language":"en","primary_location":{"id":"doi:10.1055/s-0034-1368507","doi":"https://doi.org/10.1055/s-0034-1368507","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1368507","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087452683","display_name":"Darly Gomes Soares Delfino","orcid":"https://orcid.org/0000-0002-3544-4969","observed_orcids":["https://orcid.org/0000-0002-3544-4969"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Darly Soares","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063877883","display_name":"Adriana M. Godin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Godin","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026207248","display_name":"Raquel R. Menezes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raquel Menezes","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102096002","display_name":"Rafaela Francisca Nogueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafaela Nogueira","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Brito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Brito","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084788196","display_name":"Ivo S.F. Melo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ivo Melo","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073802473","display_name":"Giovanna M.E. Coura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giovanna Coura","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030746099","display_name":"Danielle G. Souza","orcid":"https://orcid.org/0000-0002-7478-5934","observed_orcids":["https://orcid.org/0000-0002-7478-5934"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Danielle Souza","raw_affiliation_strings":["Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Microbiologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058648013","display_name":"Fl\u00e1vio A. Amaral","orcid":"https://orcid.org/0000-0002-1695-0612","observed_orcids":["https://orcid.org/0000-0002-1695-0612"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1vio Amaral","raw_affiliation_strings":["Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076265805","display_name":"Tony P. Paulino","orcid":"https://orcid.org/0000-0001-8856-4684","observed_orcids":["https://orcid.org/0000-0001-8856-4684"]},"institutions":[{"id":"https://openalex.org/I4210106570","display_name":"Universidade Federal do Tri\u00e2ngulo Mineiro","ror":"https://ror.org/01av3m334","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210106570"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Tony Paulino","raw_affiliation_strings":["Centro de Forma\u00e7\u00e3o Especial em Sa\u00fade, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Forma\u00e7\u00e3o Especial em Sa\u00fade, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210106570"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M\u00e1rcio Coelho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcio Coelho","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056383710","display_name":"Renes R. Machado","orcid":"https://orcid.org/0000-0002-1284-1195","observed_orcids":["https://orcid.org/0000-0002-1284-1195"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renes Machado","raw_affiliation_strings":["Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.308,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.75467234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"80","issue":"08/09","first_page":"630","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azadirachtin","display_name":"azadirachtin","score":1.0},{"id":"https://openalex.org/keywords/neem","display_name":"Azadirachta indica","score":0.9520000219345093},{"id":"https://openalex.org/keywords/limonoids","display_name":"limonoids","score":0.8339999914169312},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antinociceptive-activity","display_name":"antinociceptive activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cotton-pellet-granuloma","display_name":"cotton pellet granuloma","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.847000002861023},{"id":"https://openalex.org/keywords/opioidergic-pathway","display_name":"opioidergic pathway","score":0.48500001430511475},{"id":"https://openalex.org/keywords/serotonergic-pathways","display_name":"serotonergic pathways","score":0.8019999861717224},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cyproheptadine","display_name":"cyproheptadine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nociceptive-pain","display_name":"nociceptive pain","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.7287875413894653},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7251246571540833},{"id":"https://openalex.org/C2779955036","wikidata":"https://www.wikidata.org/wiki/Q793471","display_name":"Azadirachtin","level":3,"score":0.7171124815940857},{"id":"https://openalex.org/C2781227287","wikidata":"https://www.wikidata.org/wiki/Q421991","display_name":"Carrageenan","level":2,"score":0.6316426992416382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5341177582740784},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.4643452763557434},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.460310697555542},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4338165521621704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34999364614486694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16700506210327148},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15726950764656067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14236319065093994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13064372539520264},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0925264060497284},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002351","descriptor_name":"Carrageenan","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031601","descriptor_name":"Azadirachta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D036701","descriptor_name":"Limonins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D036701","descriptor_name":"Limonins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D036701","descriptor_name":"Limonins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0034-1368507","doi":"https://doi.org/10.1055/s-0034-1368507","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1368507","pdf_url":null,"source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:24871207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24871207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992228522","https://openalex.org/W1971462225","https://openalex.org/W2954122897","https://openalex.org/W4242008691","https://openalex.org/W7162577648","https://openalex.org/W2596705401","https://openalex.org/W2904058034","https://openalex.org/W3143209257","https://openalex.org/W4387544457","https://openalex.org/W2417762701"],"abstract_inverted_index":{"Azadirachta":[0],"indica":[1],"(Meliaceae)":[2],"extracts":[3],"have":[4,29],"been":[5,30],"reported":[6],"to":[7,71,88,164],"exhibit":[8],"anti-inflammatory":[9,74],"and":[10,20,52,59,82,110,116,176,211,264,267,273,288,303],"antinociceptive":[11,91],"properties.":[12],"However,":[13,140],"the":[14,21,27,37,42,73,90,99,111,133,141,145,166,180,184,190,202,225,255,280,283],"activities":[15,297],"of":[16,50,76,97,101,127,144,148,183,193,207,220,227,257,262,271,282,285,290,301],"azadirachtin,":[17],"a":[18,233,245],"limonoid":[19],"major":[22],"bioactive":[23],"compound":[24],"found":[25],"in":[26,33,47,54,78,105,205,224,259,269,298],"extracts,":[28],"poorly":[31],"investigated":[32,41],"animal":[34],"models.":[35],"In":[36,162,250],"present":[38],"study,":[39],"we":[40],"effects":[43],"induced":[44,63,113,137,152,170,214],"by":[45,64,114,138,153,160,171,189,215,232,244],"azadirachtin":[46,77,128,173,221,258,296],"experimental":[48,260,299],"models":[49,206,261,270,300],"pain":[51,229],"inflammation":[53,302],"mice.":[55,79],"Carrageenan-induced":[56],"paw":[57,135,146,168],"edema":[58,136,169],"fibrovascular":[60,194],"tissue":[61,107,195],"growth":[62],"subcutaneous":[65],"cotton":[66],"pellet":[67],"implantation":[68],"were":[69,86],"used":[70],"investigate":[72],"activity":[75,219,256],"Zymosan-induced":[80],"writhing":[81],"hot":[83],"plate":[84],"tests":[85],"employed":[87],"evaluate":[89],"activity.":[92],"To":[93],"explore":[94],"putative":[95],"mechanisms":[96],"action,":[98],"level":[100],"tumor":[102,149],"necrosis":[103,150],"factor-\u03b1":[104,151],"inflammatory":[106,155,185,212,265,286],"was":[108,119,157,230],"measured":[109],"effect":[112],"opioidergic":[115],"serotonergic":[117,247],"antagonists":[118],"evaluated.":[120],"Previous":[121],"per":[122],"os":[123],"(p.":[124],"o.)":[125],"administration":[126],"(120":[129,198,222],"mg/kg)":[130,178,199,223],"significantly":[131],"reduced":[132,159,191],"acute":[134,167,272],"carrageenan.":[139],"concomitant":[142],"increase":[143],"concentration":[147],"this":[154,252],"stimulus":[156],"not":[158,243],"azadirachtin.":[161],"addition":[163],"inhibiting":[165],"carrageenan,":[172],"(6,":[174],"60,":[175],"120":[177],"inhibited":[179,201],"proliferative":[181],"phase":[182],"response,":[186],"as":[187],"demonstrated":[188],"formation":[192],"growth.":[196],"Azadirachtin":[197],"also":[200,268],"nociceptive":[203,208,228,263],"response":[204],"(hot":[209],"plate)":[210],"(writhing":[213],"zymosan)":[216],"pain.":[217,304],"The":[218],"model":[226],"attenuated":[231],"nonselective":[234,246],"opioid":[235,292],"antagonist,":[236,248],"naltrexone":[237],"(10":[238],"mg/kg,":[239],"i.":[240],"p.),":[241],"but":[242],"cyproheptadine.":[249],"conclusion,":[251],"study":[253],"demonstrates":[254],"pain,":[266],"chronic":[274],"inflammation.":[275],"Finally,":[276],"multiple":[277],"mechanisms,":[278],"including":[279],"inhibition":[281],"production":[284],"mediators":[287],"activation":[289],"endogenous":[291],"pathways,":[293],"may":[294],"mediate":[295]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}