{"id":"https://openalex.org/W2006940700","doi":"https://doi.org/10.1016/0896-6273(95)90066-7","title":"Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation","display_name":"Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W2006940700","doi":"https://doi.org/10.1016/0896-6273(95)90066-7","mag":"2006940700","pmid":"https://pubmed.ncbi.nlm.nih.gov/7619532"},"language":"en","primary_location":{"id":"doi:10.1016/0896-6273(95)90066-7","doi":"https://doi.org/10.1016/0896-6273(95)90066-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0896-6273(95)90066-7","pdf_url":"https://doi.org/10.1016/0896-6273(95)90066-7","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/0896-6273(95)90066-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045615097","display_name":"Rachel M. Kindt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel M. Kindt","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA","Department of Biology, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030125759","display_name":"Arthur D. Lander","orcid":"https://orcid.org/0000-0002-4380-5525","observed_orcids":["https://orcid.org/0000-0002-4380-5525"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur D. Lander","raw_affiliation_strings":["Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":2.1906,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88176368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"1","first_page":"79","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurite-guidance","display_name":"neurite guidance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/growth-cones","display_name":"growth cones","score":0.6949999928474426},{"id":"https://openalex.org/keywords/g-protein-inactivation","display_name":"G protein inactivation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/n-glycans","display_name":"N-glycans","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-surface-carbohydrates","display_name":"cell surface carbohydrates","score":0.9259999990463257},{"id":"https://openalex.org/keywords/repulsive-guidance-cues","display_name":"repulsive guidance cues","score":0.9340000152587891},{"id":"https://openalex.org/keywords/growth-cone-collapse","display_name":"growth cone collapse","score":0.8169999718666077},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.9229848384857178},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.8795032501220703},{"id":"https://openalex.org/C135903288","wikidata":"https://www.wikidata.org/wiki/Q559423","display_name":"Growth cone","level":3,"score":0.7423662543296814},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.6596053838729858},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6304625272750854},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.5948445796966553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4450171887874603},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37509891390800476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33616143465042114},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.2990638017654419},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28546279668807983},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2229156494140625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19091767072677612},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.1606048047542572},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000246","descriptor_name":"Adenosine Diphosphate Ribose","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/0896-6273(95)90066-7","doi":"https://doi.org/10.1016/0896-6273(95)90066-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0896-6273(95)90066-7","pdf_url":"https://doi.org/10.1016/0896-6273(95)90066-7","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},{"id":"pmid:7619532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7619532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9j26w3s2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/9j26w3s2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuron, vol 15, iss 1","raw_type":"article"},{"id":"pmh:qt9j26w3s2","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/9j26w3s2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kindt, RM; & Lander, AD. (1995). Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation.. Neuron, 15(1), 79 - 88. doi: 10.1016/0896-6273(95)90066-7. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9j26w3s2","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/0896-6273(95)90066-7","doi":"https://doi.org/10.1016/0896-6273(95)90066-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0896-6273(95)90066-7","pdf_url":"https://doi.org/10.1016/0896-6273(95)90066-7","source":{"id":"https://openalex.org/S45757444","display_name":"Neuron","issn_l":"0896-6273","issn":["0896-6273","1097-4199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuron","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306079","display_name":"David and Lucile Packard Foundation","ror":"https://ror.org/032atxq54"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006940700.pdf"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1484827186","https://openalex.org/W1489932031","https://openalex.org/W1536457191","https://openalex.org/W1573941076","https://openalex.org/W1602962366","https://openalex.org/W1840940138","https://openalex.org/W1901367531","https://openalex.org/W1916984064","https://openalex.org/W1928800192","https://openalex.org/W1930859186","https://openalex.org/W1955200347","https://openalex.org/W1966108425","https://openalex.org/W1973524445","https://openalex.org/W1984884782","https://openalex.org/W1991392504","https://openalex.org/W1996439275","https://openalex.org/W1998225973","https://openalex.org/W1999623969","https://openalex.org/W2001700083","https://openalex.org/W2002471001","https://openalex.org/W2011645131","https://openalex.org/W2014425904","https://openalex.org/W2015648732","https://openalex.org/W2021947797","https://openalex.org/W2024259606","https://openalex.org/W2028132309","https://openalex.org/W2041700814","https://openalex.org/W2056239892","https://openalex.org/W2059287299","https://openalex.org/W2060015752","https://openalex.org/W2061322846","https://openalex.org/W2066375551","https://openalex.org/W2071877947","https://openalex.org/W2073569988","https://openalex.org/W2075409024","https://openalex.org/W2081216682","https://openalex.org/W2086238489","https://openalex.org/W2091645973","https://openalex.org/W2092485469","https://openalex.org/W2102215341","https://openalex.org/W2116607514","https://openalex.org/W2116792521","https://openalex.org/W2124642745","https://openalex.org/W2138894342","https://openalex.org/W2140277678","https://openalex.org/W2141692538","https://openalex.org/W2155222159","https://openalex.org/W2156679476","https://openalex.org/W2161753433","https://openalex.org/W2162567095","https://openalex.org/W2260855040","https://openalex.org/W2411444621","https://openalex.org/W4234670759","https://openalex.org/W4300043430"],"related_works":["https://openalex.org/W7099958441","https://openalex.org/W2735584932","https://openalex.org/W174048642","https://openalex.org/W2044806829","https://openalex.org/W7111976505","https://openalex.org/W4236367398","https://openalex.org/W6986225411","https://openalex.org/W1227781688","https://openalex.org/W2073258118","https://openalex.org/W1930859186"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}