{"id":"https://openalex.org/W2006926947","doi":"https://doi.org/10.1021/jp405904g","title":"Engineering Folding Dynamics from Two-State to Downhill: Application to \u03bb-Repressor","display_name":"Engineering Folding Dynamics from Two-State to Downhill: Application to \u03bb-Repressor","publication_year":2013,"publication_date":"2013-09-30","ids":{"openalex":"https://openalex.org/W2006926947","doi":"https://doi.org/10.1021/jp405904g","mag":"2006926947","pmid":"https://pubmed.ncbi.nlm.nih.gov/24079652","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3840902"},"language":"en","primary_location":{"id":"doi:10.1021/jp405904g","doi":"https://doi.org/10.1021/jp405904g","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jp405904g","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/jp405904g","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076485026","display_name":"James W. Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James W. Carter","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (United Kingdom)","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101907495","display_name":"Christopher M. Baker","orcid":"https://orcid.org/0000-0002-9834-5351","observed_orcids":["https://orcid.org/0000-0002-9834-5351"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher M. Baker","raw_affiliation_strings":["Department\rof Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059620610","display_name":"Robert B. Best","orcid":"https://orcid.org/0000-0002-7893-3543","observed_orcids":["https://orcid.org/0000-0002-7893-3543"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Best","raw_affiliation_strings":["Laboratory\rof Chemical Physics, National Institute of Diabetes and Digestive\rand Kidney Diseases, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892-0520, United States","Laboratory#R#of Chemical Physics, National Institute of Diabetes and Digestive#R#and Kidney Diseases, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892-0520, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory\rof Chemical Physics, National Institute of Diabetes and Digestive\rand Kidney Diseases, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892-0520, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Laboratory#R#of Chemical Physics, National Institute of Diabetes and Digestive#R#and Kidney Diseases, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892-0520, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054817549","display_name":"David De Sancho","orcid":"https://orcid.org/0000-0002-8985-2685","observed_orcids":["https://orcid.org/0000-0002-8985-2685"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David De Sancho","raw_affiliation_strings":["Department\rof Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department\rof Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054817549"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":0.597,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6690242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"117","issue":"43","first_page":"13435","last_page":"13443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12044","display_name":"Advanced Physical and Chemical Molecular Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/downhill-folding","display_name":"downhill folding","score":0.906000018119812},{"id":"https://openalex.org/keywords/protein-folding-kinetics","display_name":"protein folding kinetics","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lambda-repressor","display_name":"lambda repressor","score":0.7749999761581421},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.46700000762939453},{"id":"https://openalex.org/keywords/energy-landscape","display_name":"energy landscape","score":0.6399999856948853},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.8600000143051147},{"id":"https://openalex.org/keywords/markov-state-models","display_name":"Markov state models","score":0.8870000243186951},{"id":"https://openalex.org/keywords/coarse-grained-simulation","display_name":"coarse-grained simulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/two-state-folding","display_name":"two-state folding","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.7745116353034973},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6292588114738464},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.5368554592132568},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.5324901938438416},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.500119686126709},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.49592646956443787},{"id":"https://openalex.org/C46449900","wikidata":"https://www.wikidata.org/wiki/Q5303170","display_name":"Downhill folding","level":4,"score":0.44889289140701294},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.40218183398246765},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3587397634983063},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3563038408756256},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.35297006368637085},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.35077381134033203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3302028775215149},{"id":"https://openalex.org/C162203774","wikidata":"https://www.wikidata.org/wiki/Q7181581","display_name":"Phi value analysis","level":3,"score":0.3138420581817627},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18154558539390564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1780986785888672},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.14120033383369446},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11144837737083435},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.08694922924041748},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/jp405904g","doi":"https://doi.org/10.1021/jp405904g","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jp405904g","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2824913","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3840902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3840902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3840902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Phys Chem B","raw_type":"Text"},{"id":"pmid:24079652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24079652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.815.7236","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.815.7236","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f6/be/jp405904g.PMC3840902.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1021/jp405904g","doi":"https://doi.org/10.1021/jp405904g","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jp405904g","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3413763552","display_name":"Development of a microscopic gas diffusion-reaction model for a H2 producing biocatalyst","funder_award_id":"EP/J016764/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5012189741","display_name":null,"funder_award_id":"EP/J016764/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320313684","display_name":"Federation of European Biochemical Societies","ror":"https://ror.org/0100zbm77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1964556356","https://openalex.org/W1966078827","https://openalex.org/W1966111577","https://openalex.org/W1966712500","https://openalex.org/W1967480194","https://openalex.org/W1969903391","https://openalex.org/W1972675000","https://openalex.org/W1980073965","https://openalex.org/W1985006546","https://openalex.org/W1987654889","https://openalex.org/W1988606236","https://openalex.org/W1989297730","https://openalex.org/W1990771740","https://openalex.org/W1999796021","https://openalex.org/W2002513517","https://openalex.org/W2020563037","https://openalex.org/W2025611730","https://openalex.org/W2025899185","https://openalex.org/W2029871341","https://openalex.org/W2029948741","https://openalex.org/W2039592270","https://openalex.org/W2045142209","https://openalex.org/W2046912614","https://openalex.org/W2062759724","https://openalex.org/W2065835934","https://openalex.org/W2066952483","https://openalex.org/W2067015232","https://openalex.org/W2067236515","https://openalex.org/W2083939457","https://openalex.org/W2084638727","https://openalex.org/W2085213650","https://openalex.org/W2088647884","https://openalex.org/W2090393756","https://openalex.org/W2091707670","https://openalex.org/W2091983181","https://openalex.org/W2092000257","https://openalex.org/W2092387745","https://openalex.org/W2095407452","https://openalex.org/W2097992482","https://openalex.org/W2102074396","https://openalex.org/W2105632084","https://openalex.org/W2112154906","https://openalex.org/W2115005877","https://openalex.org/W2117897510","https://openalex.org/W2128572087","https://openalex.org/W2132540199","https://openalex.org/W2135707652","https://openalex.org/W2145326890","https://openalex.org/W2149064382","https://openalex.org/W2150559353","https://openalex.org/W2150614072","https://openalex.org/W2151373045","https://openalex.org/W2152949473","https://openalex.org/W2165222310","https://openalex.org/W2171546617","https://openalex.org/W2171755502","https://openalex.org/W2172034373","https://openalex.org/W2313002107","https://openalex.org/W2318146698","https://openalex.org/W2324064269","https://openalex.org/W2342204193"],"related_works":["https://openalex.org/W2045142209","https://openalex.org/W2022548331","https://openalex.org/W2289358163","https://openalex.org/W2039592270","https://openalex.org/W2062759724","https://openalex.org/W1983488742","https://openalex.org/W2804811125","https://openalex.org/W2046082363","https://openalex.org/W2067015232","https://openalex.org/W2340273771"],"abstract_inverted_index":{"One":[0],"strategy":[1],"for":[2,10,38,58,93,139],"reaching":[3,165],"the":[4,11,39,72,76,81,94,102,110,118,121,131,159,166],"downhill":[5,167],"folding":[6,107,168],"regime,":[7],"primarily":[8],"exploited":[9],"\u03bb(6-85)":[12],"protein":[13,59,78],"fragment,":[14],"consists":[15],"of":[16,41,75,83,109,145,155],"cumulatively":[17],"introducing":[18],"mutations":[19,85],"that":[20,56,69],"speed":[21],"up":[22],"folding.":[23,105],"This":[24],"is":[25,133,149],"an":[26,48,152],"experimentally":[27],"demanding":[28],"process":[29],"where":[30],"chemical":[31],"intuition":[32],"usually":[33],"serves":[34],"as":[35],"a":[36,90,126,140],"guide":[37],"choice":[40],"amino":[42],"acid":[43],"residues":[44,99],"to":[45,101,161],"mutate.":[46],"Such":[47],"approach":[49],"can":[50],"be":[51],"aided":[52],"by":[53],"computational":[54],"methods":[55],"screen":[57],"engineering":[60],"hot":[61],"spots.":[62],"Here":[63],"we":[64,96,136],"present":[65,137],"one":[66],"such":[67],"method":[68,132],"involves":[70],"sampling":[71],"energy":[73],"landscape":[74],"pseudo-wild-type":[77],"and":[79,117],"investigating":[80],"effect":[82],"point":[84],"on":[86],"this":[87],"landscape.":[88],"Using":[89],"novel":[91],"metric":[92],"cooperativity,":[95],"identify":[97],"those":[98],"leading":[100],"least":[103],"cooperative":[104],"The":[106],"dynamics":[108],"selected":[111],"mutants":[112],"are":[113,123],"then":[114],"directly":[115],"characterized":[116],"differences":[119],"in":[120],"kinetics":[122],"analyzed":[124],"within":[125],"Markov-state":[127],"model":[128,144],"framework.":[129],"Although":[130],"general,":[134],"here":[135],"results":[138],"coarse-grained":[141],"topology-based":[142],"simulation":[143],"\u03bb-repressor,":[146],"whose":[147],"barrier":[148],"reduced":[150],"from":[151],"initial":[153],"value":[154],"\u223c4":[156],"k(B)T":[157],"at":[158],"midpoint":[160],"\u223c1":[162],"k(B)T,":[163],"thereby":[164],"regime.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
