{"id":"https://openalex.org/W2006866629","doi":"https://doi.org/10.1016/s0022-2836(83)80032-1","title":"A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA","display_name":"A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W2006866629","doi":"https://doi.org/10.1016/s0022-2836(83)80032-1","mag":"2006866629","pmid":"https://pubmed.ncbi.nlm.nih.gov/6306253"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2836(83)80032-1","doi":"https://doi.org/10.1016/s0022-2836(83)80032-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(83)80032-1","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052446148","display_name":"Jeffrey N. Masters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey N. Masters","raw_affiliation_strings":["Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084576845","display_name":"Jiyoung K. Yang","orcid":"https://orcid.org/0000-0002-4598-6542","observed_orcids":["https://orcid.org/0000-0002-4598-6542"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyoung K. Yang","raw_affiliation_strings":["Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054122806","display_name":"Alessandra Cellini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandra Cellini","raw_affiliation_strings":["Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061536209","display_name":"Giuseppe M. Attardi","orcid":"https://orcid.org/0000-0003-3875-6404","observed_orcids":["https://orcid.org/0000-0003-3875-6404"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Attardi","raw_affiliation_strings":["Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, California Institute of Technology Pasadena, Calif. 91125, U.S.A","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":3.3836,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.93559139,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"167","issue":"1","first_page":"23","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6913999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.996999979019165},{"id":"https://openalex.org/keywords/pseudogenes","display_name":"pseudogenes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/3-noncoding-region","display_name":"3' non-coding region","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mrna-processing","display_name":"mRNA processing","score":0.4309999942779541},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.4490000009536743},{"id":"https://openalex.org/keywords/methotrexate-resistance","display_name":"methotrexate resistance","score":0.949999988079071},{"id":"https://openalex.org/keywords/gene-conversion","display_name":"gene conversion","score":0.40400001406669617},{"id":"https://openalex.org/keywords/intron-loss","display_name":"intron loss","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C34957205","wikidata":"https://www.wikidata.org/wiki/Q277338","display_name":"Pseudogene","level":4,"score":0.7492787837982178},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.747878909111023},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.7033250331878662},{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.596843957901001},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5816512107849121},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.5777099132537842},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5733979940414429},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5354685187339783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5288551449775696},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.46215468645095825},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4551134705543518},{"id":"https://openalex.org/C35101798","wikidata":"https://www.wikidata.org/wiki/Q414491","display_name":"Cosmid","level":3,"score":0.4329180121421814},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43130674958229065},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42639321088790894},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.4231944978237152},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.4189216196537018},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1612180471420288},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003854","descriptor_name":"Deoxyribonucleotides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-2836(83)80032-1","doi":"https://doi.org/10.1016/s0022-2836(83)80032-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(83)80032-1","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:6306253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6306253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:authors.library.caltech.edu:95159","doi":null,"is_oa":false,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20190501-163158550","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G260839292","display_name":"PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRY","funder_award_id":"T32GM007616","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1512553642","https://openalex.org/W1526101099","https://openalex.org/W1534119891","https://openalex.org/W1558516755","https://openalex.org/W1605142281","https://openalex.org/W1608179452","https://openalex.org/W1797668920","https://openalex.org/W1970581401","https://openalex.org/W1978483415","https://openalex.org/W1980299957","https://openalex.org/W1996879160","https://openalex.org/W2000475723","https://openalex.org/W2001208543","https://openalex.org/W2002311567","https://openalex.org/W2005511335","https://openalex.org/W2006848191","https://openalex.org/W2010934303","https://openalex.org/W2012887097","https://openalex.org/W2016240281","https://openalex.org/W2019410656","https://openalex.org/W2021359963","https://openalex.org/W2039690518","https://openalex.org/W2042846149","https://openalex.org/W2044648543","https://openalex.org/W2071688043","https://openalex.org/W2074889449","https://openalex.org/W2075816835","https://openalex.org/W2078039023","https://openalex.org/W2078803127","https://openalex.org/W2080721346","https://openalex.org/W2084043863","https://openalex.org/W2085875002","https://openalex.org/W2102071252","https://openalex.org/W2126356716","https://openalex.org/W2137583334","https://openalex.org/W2142617031","https://openalex.org/W2161076846","https://openalex.org/W2161524167"],"related_works":["https://openalex.org/W2923664177","https://openalex.org/W2067478447","https://openalex.org/W1980291279","https://openalex.org/W1994082769","https://openalex.org/W2075816835","https://openalex.org/W2133127117","https://openalex.org/W2121888311","https://openalex.org/W1503386326","https://openalex.org/W1995755848","https://openalex.org/W2090480028"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}