{"id":"https://openalex.org/W2006866450","doi":"https://doi.org/10.1097/aci.0b013e328357b4b9","title":"Ocular graft-versus-host disease","display_name":"Ocular graft-versus-host disease","publication_year":2012,"publication_date":"2012-08-14","ids":{"openalex":"https://openalex.org/W2006866450","doi":"https://doi.org/10.1097/aci.0b013e328357b4b9","mag":"2006866450","pmid":"https://pubmed.ncbi.nlm.nih.gov/22892710"},"language":"en","primary_location":{"id":"doi:10.1097/aci.0b013e328357b4b9","doi":"https://doi.org/10.1097/aci.0b013e328357b4b9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0b013e328357b4b9","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy &amp; Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076518330","display_name":"Michelle Hessen","orcid":"https://orcid.org/0000-0002-7394-5852","observed_orcids":["https://orcid.org/0000-0002-7394-5852"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Hessen","raw_affiliation_strings":["Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066770174","display_name":"Esen K. Akpek","orcid":"https://orcid.org/0000-0001-7700-207X","observed_orcids":["https://orcid.org/0000-0001-7700-207X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Esen K. Akpek","raw_affiliation_strings":["Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA","to Esen K. Akpek, MD, 600 N Wolfe Street, Maumenee Building, Suite #317, Baltimore, MD 21287, USA. Tel: +1 410 955 5214; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","to Esen K. Akpek, MD, 600 N Wolfe Street, Maumenee Building, Suite #317, Baltimore, MD 21287, USA. Tel: +1 410 955 5214"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"to Esen K. Akpek, MD, 600 N Wolfe Street, Maumenee Building, Suite #317, Baltimore, MD 21287, USA. Tel: +1 410 955 5214; e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Esen K. Akpek, MD, 600 N Wolfe Street, Maumenee Building, Suite #317, Baltimore, MD 21287, USA. Tel: +1 410 955 5214","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066770174"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":1.1842,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.73408769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"5","first_page":"540","last_page":"547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocular-graft-versus-host-disease","display_name":"ocular graft-versus-host disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.734000027179718},{"id":"https://openalex.org/keywords/ocular-surface-disease","display_name":"ocular surface disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/posterior-segment-complications","display_name":"posterior segment complications","score":0.8429999947547913},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.949999988079071},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.871999979019165},{"id":"https://openalex.org/keywords/tranilast","display_name":"tranilast","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antifibrotic-agents","display_name":"antifibrotic agents","score":0.7490000128746033},{"id":"https://openalex.org/keywords/corneal-involvement","display_name":"corneal involvement","score":0.8949999809265137},{"id":"https://openalex.org/keywords/blindness-prevention","display_name":"blindness prevention","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9523720741271973},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.7479075193405151},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.7005422115325928},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.6891628503799438},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5982725620269775},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5589825510978699},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4327646493911743},{"id":"https://openalex.org/C2780686511","wikidata":"https://www.wikidata.org/wiki/Q579361","display_name":"Corneal transplantation","level":3,"score":0.42653128504753113},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4223913252353668},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36775022745132446},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33097678422927856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32346004247665405},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32201045751571655}],"mesh":[{"descriptor_ui":"D005128","descriptor_name":"Eye Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005128","descriptor_name":"Eye Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/aci.0b013e328357b4b9","doi":"https://doi.org/10.1097/aci.0b013e328357b4b9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0b013e328357b4b9","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy &amp; Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:22892710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22892710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in allergy and clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W81509564","https://openalex.org/W128114675","https://openalex.org/W1523354060","https://openalex.org/W1571382825","https://openalex.org/W1608695296","https://openalex.org/W1795844187","https://openalex.org/W1964927140","https://openalex.org/W1965030247","https://openalex.org/W1966216288","https://openalex.org/W1973055702","https://openalex.org/W1973180551","https://openalex.org/W1975960012","https://openalex.org/W1976290674","https://openalex.org/W1980498795","https://openalex.org/W1988614811","https://openalex.org/W1988865180","https://openalex.org/W1993174539","https://openalex.org/W1999491958","https://openalex.org/W2001457611","https://openalex.org/W2001968948","https://openalex.org/W2002430796","https://openalex.org/W2012582550","https://openalex.org/W2014309753","https://openalex.org/W2014480837","https://openalex.org/W2015184686","https://openalex.org/W2023705804","https://openalex.org/W2027735186","https://openalex.org/W2030598848","https://openalex.org/W2031418444","https://openalex.org/W2032024169","https://openalex.org/W2033599899","https://openalex.org/W2035003126","https://openalex.org/W2041508848","https://openalex.org/W2051019964","https://openalex.org/W2052605694","https://openalex.org/W2054007885","https://openalex.org/W2056145311","https://openalex.org/W2067494913","https://openalex.org/W2071077542","https://openalex.org/W2072021875","https://openalex.org/W2073605492","https://openalex.org/W2075627451","https://openalex.org/W2077245952","https://openalex.org/W2087023384","https://openalex.org/W2088344821","https://openalex.org/W2091821425","https://openalex.org/W2093934346","https://openalex.org/W2094292853","https://openalex.org/W2099672692","https://openalex.org/W2099738114","https://openalex.org/W2125347389","https://openalex.org/W2130582270","https://openalex.org/W2138946470","https://openalex.org/W2140677655","https://openalex.org/W2145708130","https://openalex.org/W2145736817","https://openalex.org/W2157979692","https://openalex.org/W2197550445","https://openalex.org/W2287087682","https://openalex.org/W2415776198","https://openalex.org/W2418902046","https://openalex.org/W2618073389","https://openalex.org/W2782175582","https://openalex.org/W4313347678"],"related_works":["https://openalex.org/W2023705804","https://openalex.org/W2930975712","https://openalex.org/W2607147061","https://openalex.org/W269491337","https://openalex.org/W4404470833","https://openalex.org/W2060490589","https://openalex.org/W4407012958","https://openalex.org/W7018011115","https://openalex.org/W4308368856","https://openalex.org/W2980839094"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3],"review":[4],"was":[5],"carried":[6],"out":[7],"to":[8,70,94,128],"study":[9],"the":[10,19,34,58,64,157],"frequency,":[11],"and":[12,27,32,108,133,167],"severity":[13],"of":[14,21,37,49,67,82,152,159],"ocular":[15,153],"surface":[16,154],"involvement":[17,43],"at":[18],"setting":[20],"allogeneic":[22],"hematopoietic":[23],"stem":[24],"cell":[25],"transplantation":[26],"subsequent":[28],"graft-versus-host":[29],"disease":[30],"(GVHD)":[31],"evaluate":[33],"clinical":[35],"outcomes":[36],"newer":[38],"treatments.":[39],"RECENT":[40],"FINDINGS:":[41],"Ocular":[42],"has":[44],"been":[45,140],"reported":[46],"in":[47,63,80,99],"60-90%":[48],"patients":[50,68,83],"with":[51,142,156],"chronic":[52],"GVHD.":[53,101],"Although":[54],"dry":[55],"eye":[56],"is":[57,147],"most":[59],"frequent":[60,150],"finding":[61],"occurring":[62],"great":[65],"majority":[66],"(up":[69],"90%),":[71],"posterior":[72],"segment":[73],"complications":[74],"are":[75,118],"also":[76],"not":[77],"infrequent,":[78],"seen":[79],"12.8%":[81],"after":[84],"bone":[85],"marrow":[86],"transplantation.":[87],"Anti-inflammatory":[88],"treatments":[89],"particularly":[90],"T-cell":[91],"suppressants":[92],"seem":[93],"have":[95,139],"a":[96,130],"beneficial":[97],"effect":[98],"managing":[100],"Corticoteroids,":[102],"calcineurin":[103],"inhibitors,":[104],"such":[105,115],"as":[106,110,112,116,170,172],"cyclosporine":[107],"tacrolimus,":[109],"well":[111,131,171],"antifibrotic":[113],"agents":[114],"tranilast":[117],"available":[119],"options":[120],"for":[121],"topical":[122],"application.":[123],"Cyclosporine":[124],"ophthalmic":[125],"drop":[126],"seems":[127],"be":[129,176],"tolerated":[132],"effective":[134],"treatment":[135,174],"modality;":[136],"favorable":[137],"results":[138],"demonstrated":[141],"increased":[143],"dosage.":[144],"SUMMARY:":[145],"GVHD":[146],"an":[148],"increasingly":[149],"cause":[151],"morbidity":[155],"potential":[158],"visual":[160],"loss":[161],"from":[162],"corneal":[163],"involvement.":[164],"Early":[165],"diagnosis":[166],"aggressive":[168],"local":[169],"systemic":[173],"can":[175],"vision":[177],"saving.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
