{"id":"https://openalex.org/W2006864909","doi":"https://doi.org/10.1016/0006-2952(86)90502-2","title":"Leukotrienes as mediators of ischemia and shock","display_name":"Leukotrienes as mediators of ischemia and shock","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2006864909","doi":"https://doi.org/10.1016/0006-2952(86)90502-2","mag":"2006864909","pmid":"https://pubmed.ncbi.nlm.nih.gov/3002383"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(86)90502-2","doi":"https://doi.org/10.1016/0006-2952(86)90502-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(86)90502-2","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":["Department of Physiology, Ischemia-Shock Research Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Ischemia-Shock Research Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, U.S.A","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110287816"],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":12.0022,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.9970809,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"2","first_page":"123","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":1.0},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.6370000243186951},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/leukotriene-synthesis-inhibitors","display_name":"leukotriene synthesis inhibitors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/leukotriene-receptor-antagonists","display_name":"leukotriene receptor antagonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9490000009536743},{"id":"https://openalex.org/keywords/slow-reacting-substance-of-anaphylaxis","display_name":"slow reacting substance of anaphylaxis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.7979999780654907},{"id":"https://openalex.org/keywords/leukotriene-d4","display_name":"leukotriene D4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leukotriene-e4","display_name":"leukotriene E4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-mediators","display_name":"vascular mediators","score":0.847000002861023},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.906000018119812},{"id":"https://openalex.org/keywords/thromboxane","display_name":"thromboxane","score":0.9430000185966492},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7275729775428772},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.5211946368217468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4838930070400238},{"id":"https://openalex.org/C115955781","wikidata":"https://www.wikidata.org/wiki/Q6063798","display_name":"Ionotropic effect","level":4,"score":0.4798285961151123},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.47893840074539185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43765050172805786},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4220772385597229},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.41507017612457275},{"id":"https://openalex.org/C26702167","wikidata":"https://www.wikidata.org/wiki/Q901988","display_name":"Metabotropic receptor","level":4,"score":0.4110254645347595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38315117359161377},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3446928858757019},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.32064345479011536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27487683296203613}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018077","descriptor_name":"Receptors, Leukotriene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018102","descriptor_name":"Receptors, Leukotriene B4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(86)90502-2","doi":"https://doi.org/10.1016/0006-2952(86)90502-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(86)90502-2","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:3002383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3002383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3226002114","display_name":"THROMBOXANNE &PAF ANALOGS IN ISCHEMIA-SHOCK","funder_award_id":"R01HL025575","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W609393515","https://openalex.org/W1607010538","https://openalex.org/W1890393137","https://openalex.org/W1982203813","https://openalex.org/W1987146416","https://openalex.org/W1987425357","https://openalex.org/W1991857378","https://openalex.org/W1995835626","https://openalex.org/W1999057730","https://openalex.org/W1999425237","https://openalex.org/W2000758473","https://openalex.org/W2004351423","https://openalex.org/W2004384775","https://openalex.org/W2013299494","https://openalex.org/W2036106967","https://openalex.org/W2046996305","https://openalex.org/W2050155711","https://openalex.org/W2051558704","https://openalex.org/W2067901510","https://openalex.org/W2077383756","https://openalex.org/W2127987311","https://openalex.org/W2233334410","https://openalex.org/W2404814291","https://openalex.org/W2413659846","https://openalex.org/W2466364808","https://openalex.org/W3033251716","https://openalex.org/W4244271951"],"related_works":["https://openalex.org/W2427531519","https://openalex.org/W2414950180","https://openalex.org/W2410555839","https://openalex.org/W2463756959","https://openalex.org/W2251345545","https://openalex.org/W2404265982","https://openalex.org/W2078317672","https://openalex.org/W422492373","https://openalex.org/W2397941314","https://openalex.org/W48038541"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}