{"id":"https://openalex.org/W2006812487","doi":"https://doi.org/10.1073/pnas.1313662110","title":"Necking and failure of constrained 3D microtissues induced by cellular tension","display_name":"Necking and failure of constrained 3D microtissues induced by cellular tension","publication_year":2013,"publication_date":"2013-12-09","ids":{"openalex":"https://openalex.org/W2006812487","doi":"https://doi.org/10.1073/pnas.1313662110","mag":"2006812487","pmid":"https://pubmed.ncbi.nlm.nih.gov/24324149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876233"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1313662110","doi":"https://doi.org/10.1073/pnas.1313662110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1313662110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100367763","display_name":"Hailong Wang","orcid":"https://orcid.org/0000-0002-5999-1182","observed_orcids":["https://orcid.org/0000-0002-5999-1182"]},"institutions":[{"id":"https://openalex.org/I4210129794","display_name":"Division of Materials Science and Engineering","ror":"https://ror.org/03rs0fg31","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210129794","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Hailong Wang","raw_affiliation_strings":["Department of Materials Science and Engineering and","Department of Materials Science and Engineering and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering and","institution_ids":["https://openalex.org/I4210129794"]},{"raw_affiliation_string":"Department of Materials Science and Engineering and Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061596858","display_name":"Alexander A. Svoronos","orcid":"https://orcid.org/0000-0002-3288-7350","observed_orcids":["https://orcid.org/0000-0002-3288-7350"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Svoronos","raw_affiliation_strings":["Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912; and","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061219770","display_name":"Thomas Boudou","orcid":"https://orcid.org/0000-0002-6821-2937","observed_orcids":["https://orcid.org/0000-0002-6821-2937"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Boudou","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;","cDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"cDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008447841","display_name":"Mahmut Selman Sakar","orcid":"https://orcid.org/0000-0002-7226-3382","observed_orcids":["https://orcid.org/0000-0002-7226-3382"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405256907","display_name":"Institute of Robotics and Intelligent Systems","ror":"https://ror.org/04neydj61","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405256907"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mahmut Selman Sakar","raw_affiliation_strings":["Institute of Robotics and Intelligent Systems, Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich, CH 8092 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Robotics and Intelligent Systems, Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich, CH 8092 Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405256907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000487742","display_name":"Jacquelyn Y. Schell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacquelyn Youssef Schell","raw_affiliation_strings":["Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912; and","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054959711","display_name":"Jeffrey R. Morgan","orcid":"https://orcid.org/0000-0002-7546-3443","observed_orcids":["https://orcid.org/0000-0002-7546-3443"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Morgan","raw_affiliation_strings":["Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology, Physiology, and Biotechnology, Center for Biomedical Engineering, Brown University, Providence, RI 02912; and","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609547","display_name":"Christopher S. Chen","orcid":"https://orcid.org/0000-0003-2445-8449","observed_orcids":["https://orcid.org/0000-0003-2445-8449"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Chen","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;","cDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"cDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011906405","display_name":"Vivek B. Shenoy","orcid":"https://orcid.org/0000-0002-2645-1016","observed_orcids":["https://orcid.org/0000-0002-2645-1016"]},"institutions":[{"id":"https://openalex.org/I4210129794","display_name":"Division of Materials Science and Engineering","ror":"https://ror.org/03rs0fg31","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210129794","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vivek B. Shenoy","raw_affiliation_strings":["Department of Materials Science and Engineering and","aDepartment of Materials Science and Engineering and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering and","institution_ids":["https://openalex.org/I4210129794"]},{"raw_affiliation_string":"aDepartment of Materials Science and Engineering and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3046,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.86410402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"110","issue":"52","first_page":"20923","last_page":"20928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-failure","display_name":"tissue failure","score":0.9470000267028809},{"id":"https://openalex.org/keywords/3d-microtissues","display_name":"3D microtissues","score":0.8849999904632568},{"id":"https://openalex.org/keywords/actomyosin-contraction","display_name":"actomyosin contraction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/morphological-instability","display_name":"morphological instability","score":0.9459999799728394},{"id":"https://openalex.org/keywords/extracellular-matrix-stiffness","display_name":"extracellular matrix stiffness","score":0.8360000252723694},{"id":"https://openalex.org/keywords/phase-diagram","display_name":"phase diagram","score":0.503000020980835},{"id":"https://openalex.org/keywords/cardiac-microtissues","display_name":"cardiac microtissues","score":0.9710000157356262},{"id":"https://openalex.org/keywords/microcantilever","display_name":"microcantilever","score":0.8379999995231628},{"id":"https://openalex.org/keywords/active-stress","display_name":"active stress","score":0.4740000069141388},{"id":"https://openalex.org/keywords/tissue-morphology","display_name":"tissue morphology","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6745933294296265},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5872185826301575},{"id":"https://openalex.org/C119001679","wikidata":"https://www.wikidata.org/wiki/Q381645","display_name":"Necking","level":2,"score":0.5584290623664856},{"id":"https://openalex.org/C186068551","wikidata":"https://www.wikidata.org/wiki/Q13255585","display_name":"Tension (geology)","level":3,"score":0.5385753512382507},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5349686741828918},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4587135910987854},{"id":"https://openalex.org/C160343418","wikidata":"https://www.wikidata.org/wiki/Q185256","display_name":"Rigidity (electromagnetism)","level":2,"score":0.42643705010414124},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3839814364910126},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3763209283351898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34420186281204224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28931230306625366},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.09982544183731079},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07769182324409485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0722605288028717},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.1313662110","doi":"https://doi.org/10.1073/pnas.1313662110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1313662110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3876233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:24324149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24324149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.724.6034","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.724.6034","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://sites.bu.edu/chenlab/files/2014/01/148_Hailong_PNAS_2013.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-01545191v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01545191","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (52), pp.20923 - 20928. ⟨10.1073/pnas.1313662110⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:216003","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/216003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:216003","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/216003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3876233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W161364762","https://openalex.org/W1669238509","https://openalex.org/W1964195356","https://openalex.org/W1966403992","https://openalex.org/W1966545054","https://openalex.org/W1967326153","https://openalex.org/W1969189085","https://openalex.org/W1974469532","https://openalex.org/W1975781184","https://openalex.org/W1981052551","https://openalex.org/W1983805504","https://openalex.org/W1983991540","https://openalex.org/W1993313340","https://openalex.org/W1994694826","https://openalex.org/W2007903825","https://openalex.org/W2010020475","https://openalex.org/W2014276510","https://openalex.org/W2023392069","https://openalex.org/W2025003977","https://openalex.org/W2027472036","https://openalex.org/W2027901151","https://openalex.org/W2029663660","https://openalex.org/W2030884803","https://openalex.org/W2040843328","https://openalex.org/W2043376331","https://openalex.org/W2050612706","https://openalex.org/W2053121568","https://openalex.org/W2054635074","https://openalex.org/W2059950344","https://openalex.org/W2078415101","https://openalex.org/W2081492632","https://openalex.org/W2084332178","https://openalex.org/W2085320707","https://openalex.org/W2086061329","https://openalex.org/W2093395964","https://openalex.org/W2096020531","https://openalex.org/W2097998348","https://openalex.org/W2111550900","https://openalex.org/W2126531317","https://openalex.org/W2130103532","https://openalex.org/W2131960777","https://openalex.org/W2134909621","https://openalex.org/W2139234903","https://openalex.org/W2145411235","https://openalex.org/W2155418737","https://openalex.org/W2162198931","https://openalex.org/W2166245930","https://openalex.org/W2167956058"],"related_works":["https://openalex.org/W1971467221","https://openalex.org/W2047723100","https://openalex.org/W3096232574","https://openalex.org/W2966694646","https://openalex.org/W6961205905","https://openalex.org/W6987363638","https://openalex.org/W2085320707","https://openalex.org/W2111550900","https://openalex.org/W2073096715","https://openalex.org/W3000425833"],"abstract_inverted_index":{"In":[0],"this":[1],"paper":[2],"we":[3,35,178,203],"report":[4],"a":[5,30,128,156,207],"fundamental":[6],"morphological":[7],"instability":[8,72],"of":[9,42,53,60,70,81,87,94,108,124,130,138,149,171,174,190],"constrained":[10,154,163,176],"3D":[11,31,125,220],"microtissues":[12,162],"induced":[13],"by":[14,63,78,143],"positive":[15],"chemomechanical":[16,183],"feedback":[17],"between":[18,164],"actomyosin-driven":[19],"contraction":[20],"and":[21,65,91,105,121,147,160,200,225],"the":[22,27,40,58,61,71,79,85,88,92,95,102,106,109,113,145,168,172,175,182,188,198],"mechanical":[23],"stresses":[24,192],"arising":[25],"from":[26],"constraints.":[28],"Using":[29],"model":[32,140],"for":[33],"mechanotransduction":[34],"find":[36],"that":[37,55,97,111,118,186],"perturbations":[38],"in":[39,46,99,155,193,218],"shape":[41],"contractile":[43,83],"tissues":[44,126,177],"grow":[45],"an":[47],"unstable":[48,122],"manner":[49],"leading":[50],"to":[51,57,75,210],"formation":[52],"\"necks\"":[54],"lead":[56],"failure":[59,148],"tissue":[62,96,153,216],"narrowing":[64],"subsequent":[66],"elongation.":[67],"The":[68,136],"magnitude":[69],"is":[73,134],"shown":[74],"be":[76],"determined":[77,181],"level":[80],"active":[82,103,191],"strain,":[84],"stiffness":[86,107],"extracellular":[89],"matrix,":[90],"components":[93],"act":[98],"parallel":[100],"with":[101],"component":[104],"boundaries":[110],"constrain":[112],"tissue.":[114],"A":[115],"phase":[116],"diagram":[117],"demarcates":[119],"stable":[120],"behavior":[123],"as":[127,223],"function":[129],"these":[131,194],"material":[132],"parameters":[133,185],"derived.":[135],"predictions":[137],"our":[139],"are":[141],"verified":[142],"analyzing":[144,167],"necking":[146],"normal":[150],"human":[151],"fibroblast":[152],"loop-ended":[157],"dog-bone":[158],"geometry":[159],"cardiac":[161],"microcantilevers.":[165],"By":[166],"time":[169],"evolution":[170],"morphology":[173,217],"have":[179,204],"quantitatively":[180],"coupling":[184],"characterize":[187],"generation":[189],"tissues.":[195],"More":[196],"generally,":[197],"analytical":[199],"numerical":[201],"methods":[202],"developed":[205],"provide":[206],"quantitative":[208],"framework":[209],"study":[211],"how":[212],"contractility":[213],"can":[214],"influence":[215],"complex":[219],"environments":[221],"such":[222],"morphogenesis":[224],"organogenesis.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}