{"id":"https://openalex.org/W2006808201","doi":"https://doi.org/10.1016/s0968-0896(03)00274-8","title":"Novel tetrahydropyran-based peptidomimetics from a bioisosteric transformation of a tripeptide. Evidence of their activity at melanocortin receptors","display_name":"Novel tetrahydropyran-based peptidomimetics from a bioisosteric transformation of a tripeptide. Evidence of their activity at melanocortin receptors","publication_year":2003,"publication_date":"2003-06-02","ids":{"openalex":"https://openalex.org/W2006808201","doi":"https://doi.org/10.1016/s0968-0896(03)00274-8","mag":"2006808201","pmid":"https://pubmed.ncbi.nlm.nih.gov/12818667"},"language":"en","primary_location":{"id":"doi:10.1016/s0968-0896(03)00274-8","doi":"https://doi.org/10.1016/s0968-0896(03)00274-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(03)00274-8","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Adam W Mazur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam W Mazur","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. amazur@cinci.rr.com","Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. amazur@cinci.rr.com","institution_ids":["https://openalex.org/I74680897"]},{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106629889","display_name":"Anna Kulesza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Kulesza","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035299142","display_name":"Rajesh Mishra","orcid":"https://orcid.org/0000-0001-8505-4443","observed_orcids":["https://orcid.org/0000-0001-8505-4443"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh K Mishra","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043454995","display_name":"Doreen Cross\u2010Doersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doreen Cross-Doersen","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039026744","display_name":"Anne F. Russell","orcid":"https://orcid.org/0000-0001-9673-6941","observed_orcids":["https://orcid.org/0000-0001-9673-6941"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne F Russell","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070859925","display_name":"Frank H. Ebetino","orcid":"https://orcid.org/0000-0002-9133-1360","observed_orcids":["https://orcid.org/0000-0002-9133-1360"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank H Ebetino","raw_affiliation_strings":["Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74680897"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":1.0343,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.72567755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"14","first_page":"3053","last_page":"3063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydropyran","display_name":"tetrahydropyran","score":0.9100000262260437},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tripeptides","display_name":"tripeptides","score":0.7350000143051147},{"id":"https://openalex.org/keywords/melanocortin-receptors","display_name":"melanocortin receptors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mc1r","display_name":"MC1R","score":1.0},{"id":"https://openalex.org/keywords/regioselective-cyclization","display_name":"regioselective cyclization","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.950301468372345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8389549255371094},{"id":"https://openalex.org/C2777728192","wikidata":"https://www.wikidata.org/wiki/Q412815","display_name":"Tetrahydropyran","level":3,"score":0.8073013424873352},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.7564963698387146},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.6736790537834167},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.6554465293884277},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6113502383232117},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.48388513922691345},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.33683913946151733},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3179333806037903},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16030389070510864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1483491063117981},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.09704744815826416}],"mesh":[{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D044101","descriptor_name":"Receptors, Melanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0968-0896(03)00274-8","doi":"https://doi.org/10.1016/s0968-0896(03)00274-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(03)00274-8","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:12818667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12818667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1990871455","https://openalex.org/W2017482591","https://openalex.org/W2018085228","https://openalex.org/W2023593011","https://openalex.org/W2030953755","https://openalex.org/W2032447576","https://openalex.org/W2033486542","https://openalex.org/W2037229865","https://openalex.org/W2043698477","https://openalex.org/W2045317565","https://openalex.org/W2045992813","https://openalex.org/W2083116048","https://openalex.org/W2083318160","https://openalex.org/W2105470099","https://openalex.org/W2108918515","https://openalex.org/W2125817211","https://openalex.org/W2133805778","https://openalex.org/W2135175432","https://openalex.org/W2150924354","https://openalex.org/W2156740257","https://openalex.org/W2178642191","https://openalex.org/W2343434599","https://openalex.org/W2949059937","https://openalex.org/W2951099152","https://openalex.org/W4231711043","https://openalex.org/W4235464535","https://openalex.org/W4237264691","https://openalex.org/W4242399426"],"related_works":["https://openalex.org/W2076378628","https://openalex.org/W2317336491","https://openalex.org/W2084374539","https://openalex.org/W2103204604","https://openalex.org/W2040222483","https://openalex.org/W2061894658","https://openalex.org/W2020521702","https://openalex.org/W1975531787","https://openalex.org/W1997078439","https://openalex.org/W2002028250"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
