{"id":"https://openalex.org/W2006771589","doi":"https://doi.org/10.1021/ac103301r","title":"Highly Sensitive Detection of HER2 Extracellular Domain in the Serum of Breast Cancer Patients by Piezoelectric Microcantilevers","display_name":"Highly Sensitive Detection of HER2 Extracellular Domain in the Serum of Breast Cancer Patients by Piezoelectric Microcantilevers","publication_year":2011,"publication_date":"2011-03-30","ids":{"openalex":"https://openalex.org/W2006771589","doi":"https://doi.org/10.1021/ac103301r","mag":"2006771589","pmid":"https://pubmed.ncbi.nlm.nih.gov/21449604","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084889"},"language":"en","primary_location":{"id":"doi:10.1021/ac103301r","doi":"https://doi.org/10.1021/ac103301r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac103301r","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069141513","display_name":"LiNa Loo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LiNa Loo","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003356399","display_name":"Joseph A. Capobianco","orcid":"https://orcid.org/0000-0003-3651-4284","observed_orcids":["https://orcid.org/0000-0003-3651-4284"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Capobianco","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083981644","display_name":"Wei Wu","orcid":"https://orcid.org/0000-0001-5164-2765","observed_orcids":["https://orcid.org/0000-0001-5164-2765"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wu","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103040157","display_name":"Xiaotong Gao","orcid":"https://orcid.org/0000-0002-4219-4275","observed_orcids":["https://orcid.org/0000-0002-4219-4275"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaotong Gao","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113589221","display_name":"Wan Y. Shih","orcid":"https://orcid.org/0000-0002-7113-4503","observed_orcids":["https://orcid.org/0000-0002-7113-4503","https://orcid.org/0000-0001-8443-4727"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wan Y. Shih","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031144833","display_name":"Wei\u2010Heng Shih","orcid":"https://orcid.org/0000-0001-8443-4727","observed_orcids":["https://orcid.org/0000-0001-8443-4727","https://orcid.org/0000-0002-7113-4503"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Heng Shih","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009294693","display_name":"Kambiz Pourrezaei","orcid":"https://orcid.org/0000-0002-6031-2669","observed_orcids":["https://orcid.org/0000-0002-6031-2669"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kambiz Pourrezaei","raw_affiliation_strings":["\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2021 Department of Materials Science and Engineering and \u00a7 School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, United States","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102720068","display_name":"Matthew K. Robinson","orcid":"https://orcid.org/0000-0003-4525-0065","observed_orcids":["https://orcid.org/0000-0003-4525-0065"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Robinson","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050269562","display_name":"Gregory Paul Adams","orcid":"https://orcid.org/0000-0003-4207-2881","observed_orcids":["https://orcid.org/0000-0003-4207-2881"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory P. Adams","raw_affiliation_strings":["Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, Pennsylvania 19111, United States","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050269562"],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.971,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.93537213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"83","issue":"9","first_page":"3392","last_page":"3397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11160","display_name":"Acoustic Wave Resonator Technologies","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11160","display_name":"Acoustic Wave Resonator Technologies","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10369","display_name":"Advanced MEMS and NEMS Technologies","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-extracellular-domain","display_name":"HER2 extracellular domain","score":0.9269999861717224},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8059999942779541},{"id":"https://openalex.org/keywords/serum-biomarker-detection","display_name":"serum biomarker detection","score":0.6100000143051147},{"id":"https://openalex.org/keywords/anti-her2-antibody","display_name":"anti-HER2 antibody","score":0.8740000128746033},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/disease-progression-monitoring","display_name":"disease progression monitoring","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8405417203903198},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7704534530639648},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7054626941680908},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6159150004386902},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5734630823135376},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5191337466239929},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4059380292892456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.209812730550766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13572514057159424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10771012306213379},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07079184055328369}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004560","descriptor_name":"Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ac103301r","doi":"https://doi.org/10.1021/ac103301r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac103301r","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:21449604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21449604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3084889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3084889","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3084889","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5186046641","display_name":"Defining the Role of Affinity in Antibody-Based Tumor Targeting and Penetration","funder_award_id":"R01CA118159","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1729812787","https://openalex.org/W1823540830","https://openalex.org/W1875933026","https://openalex.org/W1973521380","https://openalex.org/W1986720319","https://openalex.org/W1987380783","https://openalex.org/W1997334984","https://openalex.org/W2006019019","https://openalex.org/W2008480689","https://openalex.org/W2016552610","https://openalex.org/W2032902318","https://openalex.org/W2047747331","https://openalex.org/W2065168125","https://openalex.org/W2069334003","https://openalex.org/W2080652348","https://openalex.org/W2083902817","https://openalex.org/W2085640403","https://openalex.org/W2088623150","https://openalex.org/W2091718799","https://openalex.org/W2105702970","https://openalex.org/W2105764874","https://openalex.org/W2106949434","https://openalex.org/W2129530019","https://openalex.org/W2130074283","https://openalex.org/W2130686586","https://openalex.org/W2132226869","https://openalex.org/W2137399990","https://openalex.org/W2137777210","https://openalex.org/W2151241561","https://openalex.org/W2169782526","https://openalex.org/W2397597031","https://openalex.org/W2402116735","https://openalex.org/W2436070688","https://openalex.org/W3101080616","https://openalex.org/W4232643594"],"related_works":["https://openalex.org/W4206220126","https://openalex.org/W2100463160","https://openalex.org/W2339332279","https://openalex.org/W4323569428","https://openalex.org/W4321487339","https://openalex.org/W4399332994","https://openalex.org/W3158854644","https://openalex.org/W1986720319","https://openalex.org/W2144851798","https://openalex.org/W2008480689"],"abstract_inverted_index":{"Rapid":[0],"and":[1,77,125],"sensitive":[2,18],"detection":[3],"of":[4,48,71,79,104],"serum":[5,39,103],"tumor":[6],"biomarkers":[7],"are":[8],"needed":[9],"to":[10,42,59,96,120],"monitor":[11],"cancer":[12,73,106],"patients":[13,107],"for":[14,27,145],"disease":[15],"progression.":[16],"Highly":[17],"piezoelectric":[19],"microcantilever":[20],"sensors":[21],"(PEMS)":[22],"offer":[23],"an":[24],"attractive":[25],"tool":[26,144],"biomarker":[28,62,146],"detection;":[29],"however,":[30],"their":[31],"utility":[32],"in":[33,38,68,101],"the":[34,69,102,115],"complex":[35],"environment":[36],"encountered":[37],"has":[40],"yet":[41],"be":[43],"determined.":[44,110],"As":[45],"a":[46,61,141],"proof":[47],"concept,":[49],"we":[50],"have":[51,112],"functionalized":[52],"PEMS":[53,82,117],"with":[54],"antibodies":[55],"that":[56,64,114,137],"specifically":[57],"bind":[58],"HER2,":[60],"(antigen)":[63],"is":[65],"commonly":[66],"overexpressed":[67],"blood":[70],"breast":[72,105],"patients.":[74],"The":[75],"function":[76],"sensitivity":[78],"these":[80],"anti-HER2":[81,116],"biosensors":[83,139],"was":[84,108],"initially":[85],"assessed":[86],"using":[87],"recombinant":[88,124],"HER2":[89,99,128],"spiked":[90],"into":[91],"human":[92],"serum.":[93],"Their":[94],"ability":[95],"detect":[97,122],"native":[98],"present":[100],"then":[109],"We":[111],"found":[113],"were":[118],"able":[119],"accurately":[121],"both":[123],"naturally":[126],"occurring":[127],"at":[129],"clinically":[130],"relevant":[131],"levels":[132],"(>2":[133],"ng/mL).":[134],"This":[135],"indicates":[136],"PEMS-based":[138],"provide":[140],"potentially":[142],"effective":[143],"detection.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}