{"id":"https://openalex.org/W2006762292","doi":"https://doi.org/10.1083/jcb.119.5.1193","title":"Differential localization of Acanthamoeba myosin I isoforms.","display_name":"Differential localization of Acanthamoeba myosin I isoforms.","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W2006762292","doi":"https://doi.org/10.1083/jcb.119.5.1193","mag":"2006762292","pmid":"https://pubmed.ncbi.nlm.nih.gov/1447297","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2289716"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.119.5.1193","doi":"https://doi.org/10.1083/jcb.119.5.1193","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.119.5.1193","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2289716","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045645633","display_name":"Ivan Baines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I C Baines","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051791334","display_name":"Hanna Brzeska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Brzeska","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056320284","display_name":"Edward D. Korn","orcid":"https://orcid.org/0000-0003-3867-6295","observed_orcids":["https://orcid.org/0000-0003-3867-6295"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E D Korn","raw_affiliation_strings":["Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8764,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.962,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"119","issue":"5","first_page":"1193","last_page":"1203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.19920000433921814,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.19920000433921814,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.1386999934911728,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13362","display_name":"Slime Mold and Myxomycetes Research","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acanthamoeba","display_name":"Acanthamoeba","score":0.9390000104904175},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8040000200271606},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/contractile-vacuole","display_name":"contractile vacuole","score":0.8579999804496765},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cortical-contraction","display_name":"cortical contraction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/pseudopod-extension","display_name":"pseudopod extension","score":0.9570000171661377},{"id":"https://openalex.org/keywords/membrane-targeting","display_name":"membrane targeting","score":0.6600000262260437},{"id":"https://openalex.org/keywords/phospholipid-binding","display_name":"phospholipid binding","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.9479719400405884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7589036226272583},{"id":"https://openalex.org/C110506794","wikidata":"https://www.wikidata.org/wiki/Q900261","display_name":"Contractile vacuole","level":4,"score":0.6885436773300171},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5952701568603516},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.5715543031692505},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.5699989795684814},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5156780481338501},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5047415494918823},{"id":"https://openalex.org/C2993140218","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Immunoelectron microscopy","level":3,"score":0.49076399207115173},{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.4166529178619385},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4151241183280945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3998008966445923},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.05233946442604065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D000048","descriptor_name":"Acanthamoeba","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.119.5.1193","doi":"https://doi.org/10.1083/jcb.119.5.1193","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.119.5.1193","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2289716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2289716","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:1447297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1447297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.1449","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.1449","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b8/e4/J_Cell_Biol_1992_Dec_1_119(5)_1193-1203.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2289716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2289716","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W957367289","https://openalex.org/W1013212960","https://openalex.org/W1482201556","https://openalex.org/W1510627613","https://openalex.org/W1515321682","https://openalex.org/W1523812006","https://openalex.org/W1579490087","https://openalex.org/W1594700207","https://openalex.org/W1606723080","https://openalex.org/W1651271817","https://openalex.org/W1826456176","https://openalex.org/W1964200801","https://openalex.org/W1999873712","https://openalex.org/W2011756605","https://openalex.org/W2018227928","https://openalex.org/W2018289835","https://openalex.org/W2020867437","https://openalex.org/W2023375965","https://openalex.org/W2024782877","https://openalex.org/W2025882607","https://openalex.org/W2060788310","https://openalex.org/W2062405903","https://openalex.org/W2070500970","https://openalex.org/W2074582190","https://openalex.org/W2083243989","https://openalex.org/W2100837269","https://openalex.org/W2101024664","https://openalex.org/W2101108802","https://openalex.org/W2130837666","https://openalex.org/W2134843408","https://openalex.org/W2135577583","https://openalex.org/W2265438201","https://openalex.org/W4235326831","https://openalex.org/W4245343011"],"related_works":["https://openalex.org/W1977878435","https://openalex.org/W2020867437","https://openalex.org/W2134843408","https://openalex.org/W1915591814","https://openalex.org/W7097866933","https://openalex.org/W1188624728","https://openalex.org/W7099181367","https://openalex.org/W2004416463","https://openalex.org/W7097912963","https://openalex.org/W2334904515"],"abstract_inverted_index":{"Acanthamoeba":[0],"myosins":[1,23,188,231],"IA":[2,56,156,189],"and":[3,9,14,17,26,47,80,101,104,134,138,163,173,175,185,190],"IB":[4,88,169,191],"were":[5,28,41],"localized":[6],"by":[7,30],"immunofluorescence":[8],"immunoelectron":[10],"microscopy":[11],"in":[12,60,74,81,114,159,170,178],"vegetative":[13],"phagocytosing":[15],"cells":[16],"the":[18,36,48,61,70,75,90,95,110,115,125,131,140,147,197,209,227,230],"total":[19,71,111,126],"cell":[20],"contents":[21],"of":[22,35,52,69,109,124,200,203,229],"IA,":[24],"IB,":[25],"IC":[27,118,177],"quantified":[29],"immunoprecipitation.":[31],"The":[32],"quantitative":[33],"distributions":[34],"three":[37],"myosin":[38,53,72,112,127,142,155,164,168,176,211],"I":[39,113,128,143,212],"isoforms":[40,213],"then":[42],"calculated":[43],"from":[44],"these":[45],"data":[46,152],"previously":[49],"determined":[50],"localization":[51],"IC.":[54],"Myosin":[55,87,117],"occurs":[57],"almost":[58,107],"exclusively":[59],"cytoplasm,":[62],"where":[63],"it":[64],"accounts":[65,105,119],"for":[66,106,120,232],"approximately":[67],"50%":[68],"I,":[73],"cortex":[76],"beneath":[77],"phagocytic":[78,102],"cups":[79],"association":[82],"with":[83,94,130,146,196],"small":[84],"cytoplasmic":[85,160,198],"vesicles.":[86],"is":[89,139],"predominant":[91],"isoform":[92,144],"associated":[93,129,145,195],"plasma":[96,132,205],"membrane,":[97],"large":[98,135],"vacuole":[99,136,149,180],"membranes":[100,103,137,206],"half":[108],"cytoplasm.":[116],"a":[121,221],"significant":[122],"fraction":[123],"membrane":[133,218],"only":[141],"contractile":[148,179],"membrane.":[150],"These":[151],"suggest":[153],"that":[154,208,223],"may":[157],"function":[158],"vesicle":[161],"transport":[162],"I-mediated":[165],"cortical":[166],"contraction,":[167],"pseudopod":[171],"extension":[172],"phagocytosis,":[174],"function.":[181],"In":[182],"addition,":[183],"endogenous":[184],"exogenously":[186],"added":[187],"appeared":[192],"to":[193,216],"be":[194],"surface":[199],"different":[201,210],"subpopulations":[202],"purified":[204],"implying":[207],"are":[214],"targeted":[215],"specific":[217],"domains":[219],"through":[220],"mechanism":[222],"involves":[224],"more":[225],"than":[226],"affinity":[228],"anionic":[233],"phospholipids.":[234]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}