{"id":"https://openalex.org/W2006713610","doi":"https://doi.org/10.1165/ajrcmb.13.2.7626286","title":"The Role of Tumor Necrosis Factor in Increased Airspace Epithelial Permeability in Acute Lung Inflammation","display_name":"The Role of Tumor Necrosis Factor in Increased Airspace Epithelial Permeability in Acute Lung Inflammation","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2006713610","doi":"https://doi.org/10.1165/ajrcmb.13.2.7626286","mag":"2006713610","pmid":"https://pubmed.ncbi.nlm.nih.gov/7626286"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb.13.2.7626286","doi":"https://doi.org/10.1165/ajrcmb.13.2.7626286","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.13.2.7626286","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086647749","display_name":"X Y Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"X Y Li","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034736085","display_name":"Ken Donaldson","orcid":"https://orcid.org/0000-0002-2093-1852","observed_orcids":["https://orcid.org/0000-0002-2093-1852"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K Donaldson","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107842900","display_name":"David M. Brown","orcid":"https://orcid.org/0000-0002-6013-2713","observed_orcids":["https://orcid.org/0000-0002-6013-2713"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D Brown","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W MacNee","raw_affiliation_strings":["Department of Medicine, University of Edinburgh, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Edinburgh, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":null,"apc_paid":null,"fwci":9.4936,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.98252885,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"2","first_page":"185","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/alveolar-epithelial-permeability","display_name":"alveolar epithelial permeability","score":0.8870000243186951},{"id":"https://openalex.org/keywords/acute-lung-inflammation","display_name":"acute lung inflammation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/corynebacterium-parvum","display_name":"Corynebacterium parvum","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neutrophil-influx","display_name":"neutrophil influx","score":0.6039999723434448},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/alveolitis","display_name":"alveolitis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8700000047683716},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.6887180805206299},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5819609761238098},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5633859634399414},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5340437293052673},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.5037092566490173},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.46198755502700806},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45768773555755615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42292213439941406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37565481662750244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2831878662109375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17789551615715027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07268223166465759},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011425","descriptor_name":"Propionibacterium acnes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1165/ajrcmb.13.2.7626286","doi":"https://doi.org/10.1165/ajrcmb.13.2.7626286","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.13.2.7626286","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:7626286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7626286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W22038449","https://openalex.org/W62348831","https://openalex.org/W122568697","https://openalex.org/W146890548","https://openalex.org/W191913208","https://openalex.org/W280067737","https://openalex.org/W304964940","https://openalex.org/W1507082667","https://openalex.org/W1563886262","https://openalex.org/W1566391720","https://openalex.org/W1856713444","https://openalex.org/W1864783363","https://openalex.org/W1985247684","https://openalex.org/W1997579271","https://openalex.org/W2005598261","https://openalex.org/W2009712277","https://openalex.org/W2010028028","https://openalex.org/W2011582754","https://openalex.org/W2016144032","https://openalex.org/W2020497098","https://openalex.org/W2030596990","https://openalex.org/W2036143502","https://openalex.org/W2041910281","https://openalex.org/W2043553674","https://openalex.org/W2049941827","https://openalex.org/W2062879085","https://openalex.org/W2072196714","https://openalex.org/W2080902714","https://openalex.org/W2090700732","https://openalex.org/W2092923216","https://openalex.org/W2098950295","https://openalex.org/W2112492230","https://openalex.org/W2120940234","https://openalex.org/W2158951531","https://openalex.org/W2175849901","https://openalex.org/W2415134785"],"related_works":["https://openalex.org/W2052260418","https://openalex.org/W1890955362","https://openalex.org/W2037937847","https://openalex.org/W2058809062","https://openalex.org/W2165258471","https://openalex.org/W2160419207","https://openalex.org/W7097982548","https://openalex.org/W2020497098","https://openalex.org/W2131550766","https://openalex.org/W1998876760"],"abstract_inverted_index":{"Increased":[0],"airspace":[1],"epithelial":[2,28,59,89,95,145,172,199,239,245,255,272],"permeability":[3,29,43,60,90,96,146,173,240,256,273],"is":[4,265],"an":[5,117],"early":[6],"event":[7],"in":[8,53,58,88,128,171,212,216,222,244,247,269],"lung":[9,40],"inflammation":[10],"and":[11,130,249],"injury.":[12],"In":[13],"this":[14],"study,":[15],"we":[16],"have":[17],"developed":[18],"a":[19,70,168,219,266],"rat":[20,179],"model":[21],"to":[22,30,104,147,218],"study":[23],"the":[24,27,47,54,76,85,134,144,183,197,229,237,250,261,270],"mechanisms":[25],"of":[26,49,65,73,110,120,140,182,203,207,231,252],"125iodine-labeled":[31],"bovine":[32],"serum":[33],"albumin":[34],"(125I-BSA),":[35],"instilled":[36,50],"intratracheally":[37,176],"during":[38,276],"acute":[39,279],"inflammation.":[41],"Epithelial":[42],"was":[44,114],"measured":[45],"as":[46],"percentage":[48],"125I-BSA":[51],"appearing":[52],"blood.":[55],"The":[56,93,124,201],"increase":[57,87,170,221],"induced":[61,97,241],"by":[62,98,116,242,257],"intratracheal":[63],"instillation":[64,139],"heat-killed":[66],"Corynebacterium":[67],"parvum":[68,100,142,166],"produced":[69],"peak":[71,86],"influx":[72,132],"neutrophils":[74,113,192],"into":[75,133,177],"bronchoalveolar":[77],"space":[78],"at":[79],"16":[80,160,224],"h,":[81,157,161],"which":[82],"occurred":[83],"after":[84,138,162,226],"(8":[91],"h).":[92],"increased":[94,198,205,238,271],"C.":[99,141,165,227,253,277],"did":[101],"not":[102,159],"appear":[103],"be":[105],"protease-":[106],"or":[107],"oxidant-mediated.":[108],"Depletion":[109],"peripheral":[111],"blood":[112],"achieved":[115],"intravenous":[118],"injection":[119],"anti-neutrophil":[121],"polyclonal":[122],"antibody.":[123],"consequent":[125],"profound":[126],"reduction":[127],"neutrophil":[129],"macrophage":[131],"airspaces":[135],"8":[136,156,214,234],"h":[137,215,225,235],"reduced":[143],"control":[148,178],"values.":[149],"Bronchoalveolar":[150],"lavage":[151],"(BAL)":[152],"leukocytes":[153,184],"from":[154,233],"rats":[155],"but":[158],"treatment":[163],"with":[164],"caused":[167],"modest":[169],"when":[174],"re-instilled":[175],"lungs.":[180],"Separation":[181],"before":[185],"re-instillation":[186],"indicated":[187],"that":[188,263,274],"macrophages":[189],"rather":[190],"than":[191],"were":[193],"predominantly":[194],"responsible":[195],"for":[196],"permeability.":[200],"presence":[202],"dramatically":[204],"levels":[206],"tumor":[208],"necrosis":[209],"factor":[210],"(TNF)":[211],"BAL":[213,223],"contrast":[217],"slight":[220],"parvum,":[228],"release":[230],"TNF":[232,243,258,264],"macrophages,":[236],"monolayers":[246],"vitro,":[248],"inhibition":[251],"parvum-induced":[254,278],"antibody":[259],"support":[260],"premise":[262],"major":[267],"player":[268],"occurs":[275],"alveolitis.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}