{"id":"https://openalex.org/W2006704307","doi":"https://doi.org/10.1097/00041433-200410000-00012","title":"The accumulation of specific types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture","display_name":"The accumulation of specific types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture","publication_year":2004,"publication_date":"2004-09-09","ids":{"openalex":"https://openalex.org/W2006704307","doi":"https://doi.org/10.1097/00041433-200410000-00012","mag":"2006704307","pmid":"https://pubmed.ncbi.nlm.nih.gov/15361794"},"language":"en","primary_location":{"id":"doi:10.1097/00041433-200410000-00012","doi":"https://doi.org/10.1097/00041433-200410000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041433-200410000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068524141","display_name":"Frank D. Kolodgie","orcid":"https://orcid.org/0000-0002-6007-2044","observed_orcids":["https://orcid.org/0000-0002-6007-2044"]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank D Kolodgie","raw_affiliation_strings":["Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA","Abbreviation","SMC: smooth muscle cell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA","institution_ids":["https://openalex.org/I4210151970"]},{"raw_affiliation_string":"Abbreviation","institution_ids":[]},{"raw_affiliation_string":"SMC: smooth muscle cell","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055643217","display_name":"ALLEN P. BURKE","orcid":"https://orcid.org/0000-0001-5300-5903","observed_orcids":["https://orcid.org/0000-0001-5300-5903"]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen P Burke","raw_affiliation_strings":["Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC and","Abbreviation","SMC: smooth muscle cell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC and","institution_ids":["https://openalex.org/I4210151970"]},{"raw_affiliation_string":"Abbreviation","institution_ids":[]},{"raw_affiliation_string":"SMC: smooth muscle cell","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035268339","display_name":"Thomas N. Wight","orcid":"https://orcid.org/0000-0002-2794-4197","observed_orcids":["https://orcid.org/0000-0002-2794-4197"]},"institutions":[{"id":"https://openalex.org/I4210147149","display_name":"Hope Heart Institute","ror":"https://ror.org/03shyvb83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210147149"]},{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas N Wight","raw_affiliation_strings":["Department of Vascular Biology, The Hope Heart Program, Benaroya Research Institute, Seattle, Washington, USA","Abbreviation","SMC: smooth muscle cell"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Biology, The Hope Heart Program, Benaroya Research Institute, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210147149","https://openalex.org/I4391012615"]},{"raw_affiliation_string":"Abbreviation","institution_ids":[]},{"raw_affiliation_string":"SMC: smooth muscle cell","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071287538","display_name":"Renu Virmani","orcid":"https://orcid.org/0000-0003-1879-0015","observed_orcids":["https://orcid.org/0000-0003-1879-0015"]},"institutions":[{"id":"https://openalex.org/I4210151970","display_name":"Armed Forces Institute of Pathology","ror":"https://ror.org/04se3fj97","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210151970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Renu Virmani","raw_affiliation_strings":["Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC and","to Renu Virmani MD, Chairperson, Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Building 54, Room 2005, 6825 16th Street, NW, Washington, DC 20306-6000, USA Tel: +1 202 782 2844; fax: +1 202 782 9021; e-mail: [email\u00a0protected]","Abbreviation","SMC: smooth muscle cell","e-mail: [email\u00a0protected]","fax: +1 202 782 9021","to Renu Virmani MD, Chairperson, Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Building 54, Room 2005, 6825 16th Street, NW, Washington, DC 20306-6000, USA Tel: +1 202 782 2844"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC and","institution_ids":["https://openalex.org/I4210151970"]},{"raw_affiliation_string":"to Renu Virmani MD, Chairperson, Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Building 54, Room 2005, 6825 16th Street, NW, Washington, DC 20306-6000, USA Tel: +1 202 782 2844; fax: +1 202 782 9021; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I4210151970"]},{"raw_affiliation_string":"Abbreviation","institution_ids":[]},{"raw_affiliation_string":"SMC: smooth muscle cell","institution_ids":[]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 202 782 9021","institution_ids":[]},{"raw_affiliation_string":"to Renu Virmani MD, Chairperson, Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Building 54, Room 2005, 6825 16th Street, NW, Washington, DC 20306-6000, USA Tel: +1 202 782 2844","institution_ids":["https://openalex.org/I4210151970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071287538"],"corresponding_institution_ids":["https://openalex.org/I4210151970"],"apc_list":null,"apc_paid":null,"fwci":0.1923,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.13836478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"5","first_page":"575","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-erosion","display_name":"plaque erosion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/coronary-thrombosis","display_name":"coronary thrombosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9210000038146973},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9679999947547913},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.8450000286102295},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.6320000290870667},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.6671114563941956},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.6488536596298218},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6420143842697144},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.5918448567390442},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.559666097164154},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5569227933883667},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5039069056510925},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4972851574420929},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.49716857075691223},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4893326163291931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4660414755344391},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4542047679424286},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41654908657073975},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35704654455184937},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33984625339508057},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.3252890110015869},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2178819477558136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15202340483665466},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15177631378173828}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003029","descriptor_name":"Coagulants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003328","descriptor_name":"Coronary Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003328","descriptor_name":"Coronary Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00041433-200410000-00012","doi":"https://doi.org/10.1097/00041433-200410000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00041433-200410000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S203964698","display_name":"Current Opinion in Lipidology","issn_l":"0957-9672","issn":["0957-9672","1473-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Lipidology","raw_type":"journal-article"},{"id":"pmid:15361794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15361794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in lipidology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2863889944","display_name":null,"funder_award_id":"R01 HL61799-02","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3074115277","display_name":null,"funder_award_id":"R01 HL18645","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4515361101","display_name":"CHOLESTEROL &PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION","funder_award_id":"R01HL061799","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7727674750","display_name":"Plaque Progression, Apoptosis and Inflammation","funder_award_id":"R01HL071148","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G995962012","display_name":null,"funder_award_id":"R01 HL 71148-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W17992636","https://openalex.org/W109329984","https://openalex.org/W124719744","https://openalex.org/W158322050","https://openalex.org/W307590521","https://openalex.org/W1543809841","https://openalex.org/W1964457547","https://openalex.org/W1969327353","https://openalex.org/W1977894710","https://openalex.org/W1978203083","https://openalex.org/W1978573346","https://openalex.org/W1989706049","https://openalex.org/W2009412597","https://openalex.org/W2026475481","https://openalex.org/W2028908277","https://openalex.org/W2047334981","https://openalex.org/W2061886045","https://openalex.org/W2065049096","https://openalex.org/W2069649792","https://openalex.org/W2073751205","https://openalex.org/W2081527966","https://openalex.org/W2093664978","https://openalex.org/W2105936580","https://openalex.org/W2119761763","https://openalex.org/W2121020822","https://openalex.org/W2138063219","https://openalex.org/W2155760431","https://openalex.org/W2155766474","https://openalex.org/W2161682643","https://openalex.org/W2163431279","https://openalex.org/W2327467387"],"related_works":["https://openalex.org/W2119761763","https://openalex.org/W4414091350","https://openalex.org/W2907012814","https://openalex.org/W4390813077","https://openalex.org/W2061886045","https://openalex.org/W2390343257","https://openalex.org/W2147409024","https://openalex.org/W4322696921","https://openalex.org/W2146788236","https://openalex.org/W4385246528"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Although":[3],"fibrous":[4],"cap":[5],"rupture":[6],"is":[7,16],"the":[8,27,38,42,48,59,98,121,132,135,186,189,201,237,243],"primary":[9],"cause":[10],"of":[11,20,26,37,51,61,82,94,111,123,134,171,177,191,203,209,213,228,239,245],"coronary":[12,63,240],"thrombosis,":[13],"plaque":[14,178,224],"erosion":[15,74,101,179],"responsible":[17,222],"for":[18,223],"30%-40%":[19],"acute":[21,62],"thrombotic":[22,136],"events.":[23],"The":[24,70,92,109,207,226],"interface":[25,72],"eroded":[28],"surface":[29,78,192],"involves":[30],"a":[31,76,214],"denuded":[32],"endothelium":[33,193,210],"allowing":[34],"direct":[35],"contact":[36],"platelet/fibrin":[39],"thrombus":[40],"with":[41,66,87,149,195],"underlying":[43],"lesion.":[44],"This":[45],"review":[46],"discusses":[47],"putative":[49],"role":[50,119],"extracellular":[52],"matrix":[53,115,218],"molecules,":[54],"in":[55,58,73,120,158,164,242],"particular":[56],"proteoglycans/hyaluronan,":[57],"development":[60,122,202,227],"thrombosis":[64,241],"associated":[65],"erosion.":[67,225],"RECENT":[68],"FINDINGS:":[69],"plaque/thrombus":[71],"presents":[75],"unique":[77],"since":[79],"it":[80],"consists":[81],"predominantly":[83],"SMCs":[84],"and":[85,113,147,163,211],"proteoglycans":[86],"minimal":[88],"or":[89,138],"no":[90],"inflammation.":[91],"lack":[93],"significant":[95],"inflammation":[96],"raises":[97],"possibility":[99],"that":[100,188],"represents":[102],"chronic":[103],"wounding":[104],"rather":[105],"than":[106],"true":[107],"atherogenesis.":[108],"abundance":[110],"proteoglycan":[112],"hyaluronan":[114],"suggests":[116],"their":[117],"potential":[118],"thrombosis.":[124],"Matrix":[125],"changes":[126],"may":[127,199,219],"contribute":[128],"to":[129,151],"endothelial":[130],"loss,":[131],"magnitude":[133],"event,":[137],"both.":[139],"Versican":[140],"facilitates":[141],"platelet":[142,153],"adhesion":[143],"at":[144],"low":[145],"shear":[146],"cooperates":[148],"collagen":[150],"promote":[152],"aggregation.":[154],"Further,":[155],"versican":[156],"may,":[157],"part,":[159],"regulate":[160],"water":[161],"content":[162],"turn":[165],"support":[166],"coagulation":[167],"because":[168],"water-dependent":[169],"functionality":[170],"anticoagulation":[172],"molecules.":[173],"Finally,":[174],"experimental":[175],"models":[176,231],"are":[180],"currently":[181],"being":[182],"developed":[183],"guided":[184],"by":[185],"premise":[187],"loss":[190,208],"together":[194],"other":[196],"procoagulant":[197,216],"factors":[198],"underlie":[200],"platelet-rich":[204],"thrombi.":[205],"SUMMARY:":[206],"exposure":[212],"potentially":[215],"versican-hyaluronan":[217],"be":[220],"largely":[221],"relevant":[229],"animal":[230],"should":[232],"allow":[233],"further":[234],"insight":[235],"into":[236],"pathophysiology":[238],"absence":[244],"rupture.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}