{"id":"https://openalex.org/W2006690845","doi":"https://doi.org/10.1073/pnas.77.2.780","title":"Coated vesicles transport newly synthesized membrane glycoproteins from endoplasmic reticulum to plasma membrane in two successive stages.","display_name":"Coated vesicles transport newly synthesized membrane glycoproteins from endoplasmic reticulum to plasma membrane in two successive stages.","publication_year":1980,"publication_date":"1980-02-01","ids":{"openalex":"https://openalex.org/W2006690845","doi":"https://doi.org/10.1073/pnas.77.2.780","mag":"2006690845","pmid":"https://pubmed.ncbi.nlm.nih.gov/6244586","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/348364"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.77.2.780","doi":"https://doi.org/10.1073/pnas.77.2.780","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.77.2.780","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC348364","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107942278","display_name":"James Edward Rothman","orcid":"https://orcid.org/0000-0003-4822-4161","observed_orcids":["https://orcid.org/0000-0003-4822-4161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Rothman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109879394","display_name":"Richard E. Fine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Fine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.3364,"has_fulltext":false,"cited_by_count":225,"citation_normalized_percentile":{"value":0.99536178,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"77","issue":"2","first_page":"780","last_page":"784"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus-g-protein","display_name":"vesicular stomatitis virus G protein","score":0.9129999876022339},{"id":"https://openalex.org/keywords/clathrin-coated-vesicles","display_name":"clathrin-coated vesicles","score":0.949999988079071},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8610000014305115},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.996999979019165},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oligosaccharide-processing","display_name":"oligosaccharide processing","score":0.8709999918937683},{"id":"https://openalex.org/keywords/high-mannose-oligosaccharides","display_name":"high-mannose oligosaccharides","score":0.949999988079071},{"id":"https://openalex.org/keywords/endoglycosidase-h","display_name":"endoglycosidase H","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pulse-chase","display_name":"pulse-chase","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.5899999737739563},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.871583878993988},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.8383175134658813},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.7406798601150513},{"id":"https://openalex.org/C2779571893","wikidata":"https://www.wikidata.org/wiki/Q24775767","display_name":"Endoglycosidase H","level":4,"score":0.6858841180801392},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.6756805777549744},{"id":"https://openalex.org/C2780654058","wikidata":"https://www.wikidata.org/wiki/Q5376339","display_name":"Endoglycosidase","level":3,"score":0.6334166526794434},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.5847461819648743},{"id":"https://openalex.org/C206912223","wikidata":"https://www.wikidata.org/wiki/Q21111963","display_name":"COPI","level":5,"score":0.5634236931800842},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4942047894001007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4765251874923706},{"id":"https://openalex.org/C167019083","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular transport protein","level":4,"score":0.47651922702789307},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45677393674850464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42305922508239746},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.4137875735759735},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.41154107451438904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36570531129837036},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2989540994167328},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.13177675008773804},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0789436399936676},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002966","descriptor_name":"Clathrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.77.2.780","doi":"https://doi.org/10.1073/pnas.77.2.780","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.77.2.780","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:61168","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC348364","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:348364","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/348364","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6244586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6244586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:61168","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC348364","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1516872187","https://openalex.org/W1600904956","https://openalex.org/W1643746483","https://openalex.org/W1684801917","https://openalex.org/W1986167530","https://openalex.org/W1993084626","https://openalex.org/W2003022694","https://openalex.org/W2016417523","https://openalex.org/W2018289835","https://openalex.org/W2024996459","https://openalex.org/W2054606275","https://openalex.org/W2086271423","https://openalex.org/W2100837269","https://openalex.org/W2131706430","https://openalex.org/W2172095199"],"related_works":["https://openalex.org/W1979295999","https://openalex.org/W7100265724","https://openalex.org/W7099402099","https://openalex.org/W7098374642","https://openalex.org/W2005014403","https://openalex.org/W7095169355","https://openalex.org/W2024463272","https://openalex.org/W1480298386","https://openalex.org/W1527093201","https://openalex.org/W2096168820"],"abstract_inverted_index":{"The":[0,87,126],"G":[1,49,63,73,137],"protein":[2,50,64,91,115,138],"of":[3,17,84,89,98,113,136],"vesicular":[4,42],"stomatitis":[5,43],"virus":[6,44],"is":[7,12,65,74,129,160],"a":[8,66],"transmembrane":[9],"glycoprotein":[10],"that":[11,61,72],"transported":[13,75],"from":[14,37,142,168],"its":[15],"site":[16],"synthesis":[18],"in":[19,51,80,93,116,139],"the":[20,25,29,77,94,99,107,111,117,143,147,151,162,169,173],"rough":[21],"endoplasmic":[22,144],"reticulum":[23,145],"to":[24,47,76,123,132,134,146,157,172],"plasma":[26,174],"membrane":[27],"via":[28],"Golgi":[30,148,170],"apparatus.":[31],"Clathrin-coated":[32],"vesicles":[33,141],"have":[34,59,70],"been":[35],"purified":[36],"CHO":[38],"cells":[39],"infected":[40],"with":[41,55],"and":[45,69,155],"shown":[46],"contain":[48],"amounts":[52],"nearly":[53],"stoichiometric":[54],"clathrin.":[56],"Pulse-chase":[57],"experiments":[58],"demonstrated":[60],"this":[62],"transit":[67],"form":[68],"revealed":[71],"cell":[78],"surface":[79],"two":[81],"successive":[82],"waves":[83],"coated":[85,140],"vesicles.":[86],"oligosaccharides":[88,112,152],"G1":[90],"carried":[92],"early":[95,127],"wave":[96,120,128,164],"are":[97,121,153],"\"high-mannose\"":[100],"variety":[101],"which":[102],"can":[103],"be":[104],"cleaved":[105],"by":[106],"enzyme":[108],"endoglycosidase":[109,124,158],"H;":[110],"G2":[114],"second,":[118],"later":[119],"resistant":[122],"H.":[125],"therefore":[130],"proposed":[131],"correspond":[133],"transport":[135,167],"apparatus,":[149],"where":[150],"processed":[154],"resistance":[156],"H":[159],"conferred;":[161],"succeeding":[163],"would":[165],"represent":[166],"apparatus":[171],"membrane.":[175]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}