{"id":"https://openalex.org/W2006669293","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-150","title":"Abstract LB-150: Local maturation and inhibition of antitumor CD8 T-cell responses in a model of immunoevasive breast cancer","display_name":"Abstract LB-150: Local maturation and inhibition of antitumor CD8 T-cell responses in a model of immunoevasive breast cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2006669293","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-150","mag":"2006669293"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-lb-150","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-150","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-lb-150","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017436409","display_name":"Bijan A. Boldajipour","orcid":"https://orcid.org/0000-0003-2065-555X","observed_orcids":["https://orcid.org/0000-0003-2065-555X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bijan A. Boldajipour","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA","University of California, San Francisco, San Francisco, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA#TAB#","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018179968","display_name":"Matthew F. Krummel","orcid":"https://orcid.org/0000-0001-7915-3533","observed_orcids":["https://orcid.org/0000-0001-7915-3533"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew F. Krummel","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA","University of California, San Francisco, San Francisco, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA#TAB#","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"LB","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.13289999961853027,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7070000171661377},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.7630000114440918},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.7480000257492065},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/t-cell-motility","display_name":"T cell motility","score":0.6959999799728394},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/intravital-imaging","display_name":"intravital imaging","score":0.7279999852180481},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6585684418678284},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6050159931182861},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5697294473648071},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5055432319641113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49220195412635803},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4598664939403534},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.44516676664352417},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.43225085735321045},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4121400713920593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40136903524398804},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37041664123535156},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3494037389755249},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1672339141368866},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-lb-150","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-150","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-lb-150","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2101846531","https://openalex.org/W7221813005","https://openalex.org/W3183359162","https://openalex.org/W4282962817","https://openalex.org/W2258107434","https://openalex.org/W1031103114","https://openalex.org/W2068519535","https://openalex.org/W2047564123","https://openalex.org/W4393088969","https://openalex.org/W3041532296"],"abstract_inverted_index":{"Abstract":[0],"The":[1,232],"purpose":[2],"of":[3,29,39,92,111,142,234,248,339,366,374,381,386],"this":[4,71,129,172],"study":[5],"is":[6],"to":[7,32,107,151,205,239,277,303,316,350],"investigate":[8,108],"the":[9,34,109,145,152,182,246,301,344,382,387],"cell":[10,19,94,122,194,250,257,270,313,331],"interactions":[11,160,191],"and":[12,36,79,89,100,115,125,164,168,180,196,221,227,321,364],"mechanisms":[13],"that":[14,133,292,337,341],"limit":[15],"anti-tumor":[16,37,120],"CD8":[17,40,236,368],"T":[18,41,49,65,93,121,137,155,175,209,237,269,286,312],"responses":[20,38,370],"in":[21,99,124,158,224,252,296,371],"tumor":[22,56,60,73,97,146,153,183,201,235,249,263,289,305],"microenvironments.":[23],"We":[24],"used":[25],"cutting-edge":[26],"multiphoton":[27],"imaging":[28,91],"immunoevasive":[30,375],"tumors":[31,261],"determine":[33],"behavior":[35],"cells.":[42,202],"This":[43,334],"was":[44],"achieved":[45,324],"by":[46,325],"adoptively":[47],"transferring":[48],"cells":[50,74,98,114,138,156,163,176,210,238,287,307],"into":[51],"a":[52,82,318,329,372],"modified":[53],"MMTV-PyMT":[54],"breast":[55,68,376],"model":[57,373],"(mouse":[58],"mammary":[59],"virus":[61],"promoter-driven,":[62],"polyoma":[63],"middle":[64],"antigen-induced":[66],"luminal":[67],"cancer).":[69],"In":[70,128,203],"model,":[72],"expresses":[75],"ovalbumin":[76],"as":[77,81,275],"tumor-antigen":[78],"mCherry":[80],"fluorescent":[83],"markers,":[84],"thus":[85],"allowing":[86],"immunologic":[87],"assessment":[88],"intravital":[90],"activity":[95,123],"against":[96],"ex":[101,126,228,242],"vivo.":[102,127,253],"Furthermore,":[103],"we":[104,131],"were":[105],"able":[106],"effect":[110],"antigen-presenting":[112,162,306],"immune":[113,256],"immunomodulatory":[116],"treatment":[117],"regimens":[118],"on":[119,300],"work":[130],"found":[132],"newly":[134],"arriving":[135,150],"tumor-specific":[136],"undergo":[139],"defined":[140],"phases":[141],"maturation":[143,346,363],"within":[144],"microenvironment.":[147],"First,":[148],"after":[149],"site,":[154],"engage":[157,200],"close":[159],"with":[161,192,217,245],"exhibit":[165,222,268],"reduced":[166],"motility":[167,179],"rounded":[169],"morphology.":[170],"After":[171],"initial":[173],"phase,":[174],"dramatically":[177],"increase":[178],"survey":[181],"microenvironment,":[184],"however":[185],"they":[186],"do":[187,198,211,266],"not":[188,199,212,267],"form":[189],"stable":[190],"other":[193,206],"types":[195],"further":[197],"contrary":[204],"publications,":[207],"swarming":[208],"express":[213],"surface":[214],"markers":[215],"associated":[216],"exhaustion":[218],"or":[219,262,328],"anergy,":[220],"extensive":[223],"situ":[225],"proliferation":[226],"vivo":[229,243],"CTL":[230],"activity.":[231],"capability":[233,272],"kill":[240],"targets":[241],"conflicts":[244],"absence":[247],"death":[251],"Additionally,":[254],"individual":[255],"populations":[258],"isolated":[259],"from":[260],"culture":[264],"supernatants":[265],"suppressive":[271],"when":[273],"added":[274],"supplements":[276],"killing":[278],"assays.":[279],"Our":[280],"results":[281],"define":[282],"sequential":[283],"fates":[284],"for":[285,390],"entering":[288],"microenvironments,":[290],"suggesting":[291],"tumor-infiltrating":[293],"lymphocytes":[294],"exist":[295],"distinct":[297],"\u2018states\u2019":[298],"depending":[299],"extent":[302],"which":[304],"have":[308],"matured":[309],"them.":[310],"Further,":[311],"suppression":[314],"appears":[315],"be":[317,323],"local":[319],"phenomenon":[320],"cannot":[322],"soluble":[326],"factors":[327],"specific":[330],"type":[332],"alone.":[333],"may":[335],"suggest":[336],"combinations":[338],"therapies":[340],"individually":[342],"target":[343],"different":[345],"states":[347],"are":[348],"required":[349],"achieve":[351],"therapeutic":[352],"effects.":[353],"Citation":[354],"Format:":[355],"Bijan":[356],"A.":[357],"Boldajipour,":[358],"Matthew":[359],"F.":[360],"Krummel.":[361],"Local":[362],"inhibition":[365],"antitumor":[367],"T-cell":[369],"cancer.":[377],"[abstract].":[378],"In:":[379],"Proceedings":[380],"105th":[383],"Annual":[384],"Meeting":[385],"American":[388],"Association":[389],"Cancer":[391,402],"Research;":[392],"2014":[393],"Apr":[394],"5-9;":[395],"San":[396],"Diego,":[397],"CA.":[398],"Philadelphia":[399],"(PA):":[400],"AACR;":[401],"Res":[403],"2014;74(19":[404],"Suppl):Abstract":[405],"nr":[406],"LB-150.":[407],"doi:10.1158/1538-7445.AM2014-LB-150":[408]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}