{"id":"https://openalex.org/W2006654545","doi":"https://doi.org/10.3103/s089141681404003x","title":"Hemagglutinin codon optimization: a promising tool for enhancing the immunogenicity of influenza virus vaccines","display_name":"Hemagglutinin codon optimization: a promising tool for enhancing the immunogenicity of influenza virus vaccines","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2006654545","doi":"https://doi.org/10.3103/s089141681404003x","mag":"2006654545","pmid":"https://pubmed.ncbi.nlm.nih.gov/25845134"},"language":"ru","primary_location":{"id":"doi:10.3103/s089141681404003x","doi":"https://doi.org/10.3103/s089141681404003x","is_oa":false,"landing_page_url":"https://doi.org/10.3103/s089141681404003x","pdf_url":null,"source":{"id":"https://openalex.org/S200760274","display_name":"Molecular Genetics Microbiology and Virology","issn_l":"0891-4168","issn":["0891-4168","1934-841X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics, Microbiology and Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112531675","display_name":"\u0415. \u0410. \u0424\u0435\u0434\u043e\u0440\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"E. A. Fedorova","raw_affiliation_strings":["Institute of Experimental Medicine, Northwestern Branch, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376, Russia","Russian Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Medicine, Northwestern Branch, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376, Russia","institution_ids":["https://openalex.org/I4210126033"]},{"raw_affiliation_string":"Russian Academy of Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041407488","display_name":"Irina Kiseleva","orcid":"https://orcid.org/0000-0002-3892-9873","observed_orcids":["https://orcid.org/0000-0002-3892-9873"]},"institutions":[{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. V. Kiseleva","raw_affiliation_strings":["Institute of Experimental Medicine, Northwestern Branch, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376, Russia","Russian Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Medicine, Northwestern Branch, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376, Russia","institution_ids":["https://openalex.org/I4210126033"]},{"raw_affiliation_string":"Russian Academy of Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009987979","display_name":"Prasert Auewarakul","orcid":"https://orcid.org/0000-0002-4745-4291","observed_orcids":["https://orcid.org/0000-0002-4745-4291"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"P. Auewarakul","raw_affiliation_strings":["Mahidol University, 272 Rama VI Rd., Ratchathewi, Bangkok, 10400, Thailand","Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahidol University, 272 Rama VI Rd., Ratchathewi, Bangkok, 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]},{"raw_affiliation_string":"Mahidol University","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069692819","display_name":"Ornpreya Suptawiwat","orcid":"https://orcid.org/0000-0003-0832-0079","observed_orcids":["https://orcid.org/0000-0003-0832-0079"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"O. Suptawiwat","raw_affiliation_strings":["Mahidol University, 272 Rama VI Rd., Ratchathewi, Bangkok, 10400, Thailand","Mahidol University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahidol University, 272 Rama VI Rd., Ratchathewi, Bangkok, 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]},{"raw_affiliation_string":"Mahidol University","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074265719","display_name":"\u0420\u0443\u0434\u0435\u043d\u043a\u043e \u041b\u0430\u0440\u0438\u0441\u0430 \u0413\u0435\u043e\u0440\u0433\u0438\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-0107-9959","observed_orcids":["https://orcid.org/0000-0002-0107-9959"]},"institutions":[{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. G. Rudenko","raw_affiliation_strings":["Institute of Experimental Medicine, Northwestern Branch, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376, Russia","Russian Academy of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Medicine, Northwestern Branch, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376, Russia","institution_ids":["https://openalex.org/I4210126033"]},{"raw_affiliation_string":"Russian Academy of Medical Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112531675"],"corresponding_institution_ids":["https://openalex.org/I4210126033"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12179523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"29","issue":"4","first_page":"159","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/codon-optimization","display_name":"codon optimization","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/influenza-virus-vaccine","display_name":"influenza virus vaccine","score":0.8339999914169312},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7910000085830688},{"id":"https://openalex.org/keywords/codon-usage-bias","display_name":"codon usage bias","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8854806423187256},{"id":"https://openalex.org/C87253356","wikidata":"https://www.wikidata.org/wiki/Q1106472","display_name":"Codon usage bias","level":4,"score":0.8084182739257812},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.716271698474884},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5570677518844604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5015718936920166},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4932941794395447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47579631209373474},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4463382363319397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35732242465019226},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.18187358975410461},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13436639308929443}],"mesh":[{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3103/s089141681404003x","doi":"https://doi.org/10.3103/s089141681404003x","is_oa":false,"landing_page_url":"https://doi.org/10.3103/s089141681404003x","pdf_url":null,"source":{"id":"https://openalex.org/S200760274","display_name":"Molecular Genetics Microbiology and Virology","issn_l":"0891-4168","issn":["0891-4168","1934-841X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics, Microbiology and Virology","raw_type":"journal-article"},{"id":"pmid:25845134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25845134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molekuliarnaia genetika, mikrobiologiia i virusologiia","raw_type":"English Abstract"},{"id":"mag:2280282658","doi":null,"is_oa":false,"landing_page_url":"https://cyberleninka.ru/article/n/optimizatsiya-kodonnogo-sostava-gemagglyutinina-kak-perspektivnyy-sposob-povysheniya-immunogennosti-grippoznyh-vaktsin","pdf_url":null,"source":{"id":"https://openalex.org/S4306539626","display_name":"\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0430, \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0432\u0438\u0440\u0443\u0441\u043e\u043b\u043e\u0433\u0438\u044f","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0430, \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0432\u0438\u0440\u0443\u0441\u043e\u043b\u043e\u0433\u0438\u044f","raw_type":null},{"id":"mag:2412386287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25845134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1492110990","https://openalex.org/W1502090161","https://openalex.org/W1528398343","https://openalex.org/W1963781218","https://openalex.org/W1970301913","https://openalex.org/W1974358592","https://openalex.org/W1981078760","https://openalex.org/W1983438661","https://openalex.org/W1984744713","https://openalex.org/W1988462066","https://openalex.org/W1993985216","https://openalex.org/W1994871739","https://openalex.org/W1998691187","https://openalex.org/W1999308392","https://openalex.org/W2001674944","https://openalex.org/W2016981893","https://openalex.org/W2020829318","https://openalex.org/W2032265205","https://openalex.org/W2036379239","https://openalex.org/W2038367446","https://openalex.org/W2039854683","https://openalex.org/W2040488285","https://openalex.org/W2046391048","https://openalex.org/W2046561902","https://openalex.org/W2051908280","https://openalex.org/W2053736049","https://openalex.org/W2055149416","https://openalex.org/W2057700014","https://openalex.org/W2057814775","https://openalex.org/W2063508859","https://openalex.org/W2069795235","https://openalex.org/W2082317854","https://openalex.org/W2088627568","https://openalex.org/W2092283636","https://openalex.org/W2092847011","https://openalex.org/W2099127292","https://openalex.org/W2101551832","https://openalex.org/W2115835708","https://openalex.org/W2120253101","https://openalex.org/W2121646171","https://openalex.org/W2136890185","https://openalex.org/W2151373788","https://openalex.org/W2157613837","https://openalex.org/W2162770595","https://openalex.org/W2168036974","https://openalex.org/W2398528261","https://openalex.org/W2466088802"],"related_works":["https://openalex.org/W1998691187","https://openalex.org/W1945582139","https://openalex.org/W6920981494","https://openalex.org/W2350077285","https://openalex.org/W2509958117","https://openalex.org/W3138522454","https://openalex.org/W3208414328","https://openalex.org/W1982054904","https://openalex.org/W3100939371","https://openalex.org/W2955098089"],"abstract_inverted_index":{"Modification":[0],"of":[1,5,11,19,37,46,59,62],"the":[2,12,20,30,44,47,60,63],"codon":[3,21,33,53,64],"bias":[4,34],"sequences":[6],"is":[7,23,56],"a":[8],"promising":[9],"tool":[10],"gene":[13,32],"expression":[14],"control.":[15],"The":[16],"theoretical":[17],"basis":[18],"optimization":[22,54,65],"reviewed,":[24],"data":[25],"on":[26],"experiments":[27],"in":[28],"changing":[29],"viral":[31],"for":[35,67],"purposes":[36],"vaccine":[38,49,69],"development":[39,70],"are":[40,71],"discussed.":[41],"Research":[42],"into":[43],"field":[45],"influenza":[48,68],"immunogenicity":[50],"improvement":[51],"with":[52],"method":[55],"reviewed.":[57],"Prospects":[58],"use":[61],"technique":[66],"considered.":[72]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}