{"id":"https://openalex.org/W2006607638","doi":"https://doi.org/10.3109/08820130009062289","title":"Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology","display_name":"Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2006607638","doi":"https://doi.org/10.3109/08820130009062289","mag":"2006607638","pmid":"https://pubmed.ncbi.nlm.nih.gov/10854174"},"language":"en","primary_location":{"id":"doi:10.3109/08820130009062289","doi":"https://doi.org/10.3109/08820130009062289","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08820130009062289","pdf_url":null,"source":{"id":"https://openalex.org/S44471553","display_name":"Immunological Investigations","issn_l":"0882-0139","issn":["0882-0139","1532-4311"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Investigations","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058183468","display_name":"Domenico Tortorella","orcid":"https://orcid.org/0000-0003-0961-3535","observed_orcids":["https://orcid.org/0000-0003-0961-3535"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domenico Tortorella","raw_affiliation_strings":["Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA","Harvard Medical School Department of Pathology, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Department of Pathology, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074992735","display_name":"Benjamin E. Gewurz","orcid":"https://orcid.org/0000-0002-3965-3418","observed_orcids":["https://orcid.org/0000-0002-3965-3418"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Gewurz","raw_affiliation_strings":["Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042143593","display_name":"Danny Joseph Schust","orcid":"https://orcid.org/0000-0003-4561-7808","observed_orcids":["https://orcid.org/0000-0003-4561-7808"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny Schust","raw_affiliation_strings":["Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028871989","display_name":"Margo H. Furman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margo Furman","raw_affiliation_strings":["Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081514135","display_name":"Hidde L. Ploegh","orcid":"https://orcid.org/0000-0002-1090-6071","observed_orcids":["https://orcid.org/0000-0002-1090-6071"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidde Ploegh","raw_affiliation_strings":["Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Pathology, Boston, Massachusetts, 02115","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":1.582,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.81941056,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"2","first_page":"97","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.6474999785423279,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.6474999785423279,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.18619999289512634,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-class-i-antigen-presentation","display_name":"MHC class I antigen presentation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mhc-class-i-downregulation","display_name":"MHC class I downregulation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ctl-escape","display_name":"CTL escape","score":0.578000009059906},{"id":"https://openalex.org/keywords/peptide-loading","display_name":"peptide loading","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tapasin","display_name":"tapasin","score":0.6890000104904175},{"id":"https://openalex.org/keywords/calnexin","display_name":"calnexin","score":0.7419999837875366},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/erp57","display_name":"ERp57","score":0.9359999895095825},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7168841361999512},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.5990872979164124},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.5807254910469055},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5689970850944519},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5416184067726135},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5049806237220764},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.4431610107421875},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.43828338384628296},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.4363909959793091},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4133462607860565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3981248736381531},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3723723888397217},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.17291131615638733},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1400565505027771},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08820130009062289","doi":"https://doi.org/10.3109/08820130009062289","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08820130009062289","pdf_url":null,"source":{"id":"https://openalex.org/S44471553","display_name":"Immunological Investigations","issn_l":"0882-0139","issn":["0882-0139","1532-4311"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Investigations","raw_type":"journal-article"},{"id":"pmid:10854174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10854174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological investigations","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1971936988","https://openalex.org/W1976601347","https://openalex.org/W1990806106","https://openalex.org/W2001563221","https://openalex.org/W2016359645","https://openalex.org/W2020229204","https://openalex.org/W2039863802","https://openalex.org/W2040668078","https://openalex.org/W2085279345","https://openalex.org/W2102510758","https://openalex.org/W2107617257","https://openalex.org/W2112326894","https://openalex.org/W2117313136","https://openalex.org/W2120580958","https://openalex.org/W2150632173","https://openalex.org/W2169053959"],"related_works":["https://openalex.org/W1545961894","https://openalex.org/W7135793447","https://openalex.org/W2142614224","https://openalex.org/W2139994202","https://openalex.org/W4251318601","https://openalex.org/W2407073439","https://openalex.org/W2948022345","https://openalex.org/W2407270361","https://openalex.org/W2124097265","https://openalex.org/W2151862967"],"abstract_inverted_index":{"MHC":[0,181],"class":[1,50,79,116,138,161,182,220,233,250,266,276],"I":[2,51,61,80,117,139,162,183,221,234,251,267,277],"antigen":[3,268],"presentation":[4,269],"is":[5,54,87,128,253,279],"a":[6,57,67],"tightly":[7],"regulated":[8],"process":[9],"that":[10,53,108],"begins":[11],"in":[12,281],"the":[13,17,23,31,34,40,49,78,85,101,124,136,146,150,153,173,180,197,204,216,224],"cell":[14,154,174,199],"cytoplasm":[15],"with":[16,90,110,114,131,185,265],"generation":[18,134],"of":[19,56,77,135,145,179,219,232],"peptide":[20],"ligands":[21],"by":[22,246],"proteasome":[24],"(1,":[25],"2).":[26],"Peptides":[27],"are":[28,46],"translocated":[29],"from":[30,92,167],"cytosol":[32],"into":[33,274],"endoplasmic":[35],"reticulum":[36],"(ER)":[37],"lumen":[38],"through":[39,149],"MHC-encoded":[41],"TAP":[42],"complex.":[43],"These":[44],"peptides":[45,165],"loaded":[47,130],"onto":[48],"heterodimer":[52],"comprised":[55],"43":[58],"kDa":[59,69],"type":[60],"membrane":[62],"glycoprotein":[63],"heavy":[64,81],"chain":[65,72,82],"and":[66,83,100,120,148,169,195,211,226,270],"12":[68],"soluble":[70],"light":[71],"(p2m).":[73],"Shortly":[74],"after":[75],"synthesis":[76],"&m,":[84],"complex":[86,119,140,159],"properly":[88],"folded":[89],"assistance":[91],"ER":[93,147],"resident":[94],"chaperones":[95],"such":[96],"as":[97,284],"calnexin,":[98],"calreticulin":[99],"thiol-reductase,":[102],"ERp57(3).":[103],"Tapasin,":[104],"an":[105,192],"ER-resident":[106],"protein":[107],"associates":[109],"TAP,":[111,125],"can":[112,190,214],"interact":[113],"peptide-free":[115],"heterodimerkhaperone":[118],"guide":[121],"it":[122,127],"to":[123,152,240],"where":[126],"subsequently":[129],"peptide.":[132],"The":[133,156,177,230,244],"trimeric":[137],"allows":[141,237],"its":[142],"exit":[143],"out":[144],"Golgi":[151],"surface.":[155],"major":[157],"histocompatibility":[158],"(MHC)":[160],"molecules":[163,184,252],"present":[164],"derived":[166],"microbial":[168],"cellular":[170],"proteins":[171,259],"on":[172],"surface":[175,217,235],"(4).":[176],"interaction":[178],"cytotoxic":[186],"CD8'T":[187],"lymphocytes":[188],"(CTL)":[189],"activate":[191],"immune":[193],"response":[194],"target":[196],"host":[198],"for":[200],"lysis,":[201],"thereby":[202],"eliminating":[203],"infected":[205],"or":[206],"abnormal":[207],"cell.":[208],"Several":[209],"viruses":[210],"tumor":[212,282],"cells":[213,239,283],"down-regulate":[215,249],"expression":[218,236],"molecuies":[222],"at":[223],"transcriptional":[225],"post-translational":[227],"levels(5,":[228],"6).":[229],"prevention":[231],"these":[238],"escape":[241],"CTL":[242],"detection.":[243],"mechanism":[245],"which":[247,263],"tumors":[248],"not":[254],"clearly":[255],"understood.":[256],"However,":[257],"viral":[258],"have":[260],"been":[261],"identified":[262],"interfere":[264],"may":[271],"provide":[272],"insight":[273],"how":[275],"down-regulation":[278],"achieved":[280],"well.":[285]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}