{"id":"https://openalex.org/W2006593248","doi":"https://doi.org/10.1371/journal.pone.0062562","title":"Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder","display_name":"Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder","publication_year":2013,"publication_date":"2013-05-03","ids":{"openalex":"https://openalex.org/W2006593248","doi":"https://doi.org/10.1371/journal.pone.0062562","mag":"2006593248","pmid":"https://pubmed.ncbi.nlm.nih.gov/23658744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3643938"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0062562","doi":"https://doi.org/10.1371/journal.pone.0062562","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0062562","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062562&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062562&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068641535","display_name":"James J. Vald\u00e9s","orcid":"https://orcid.org/0000-0002-0237-8061","observed_orcids":["https://orcid.org/0000-0002-0237-8061"]},"institutions":[{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"James J. Vald\u00e9s","raw_affiliation_strings":["Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic. valdjj@gmail.com","Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic,\u010cesk\u00e9 Bud\u011bjovice,Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic. valdjj@gmail.com","institution_ids":["https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"raw_affiliation_string":"Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic,\u010cesk\u00e9 Bud\u011bjovice,Czech Republic","institution_ids":["https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111651071","display_name":"Alexandra Schwarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Alexandra Schwarz","raw_affiliation_strings":["Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic","institution_ids":["https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029965580","display_name":"Israel Cabeza de Vaca","orcid":"https://orcid.org/0000-0002-6208-1091","observed_orcids":["https://orcid.org/0000-0002-6208-1091"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I2799803557","display_name":"Barcelona Supercomputing Center","ror":"https://ror.org/05sd8tv96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2799803557","https://openalex.org/I9617848"]},{"id":"https://openalex.org/I4210122345","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/01z1gye03","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122345","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Israel Cabeza de Vaca","raw_affiliation_strings":["Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain","Joint Barcelona Supercomputing Center-Institute for Research in Biomedicine (BSC-IRB) Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Joint Barcelona Supercomputing Center-Institute for Research in Biomedicine (BSC-IRB) Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain","institution_ids":["https://openalex.org/I2799803557","https://openalex.org/I4210122345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019239675","display_name":"Eric Calvo","orcid":"https://orcid.org/0000-0001-7880-2730","observed_orcids":["https://orcid.org/0000-0001-7880-2730"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Calvo","raw_affiliation_strings":["Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011934705","display_name":"Joao H. F. Pedra","orcid":"https://orcid.org/0000-0001-8740-2667","observed_orcids":["https://orcid.org/0000-0001-8740-2667"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joao H. F. Pedra","raw_affiliation_strings":["Center for Disease Vector Research and Department of Entomology, University of California Riverside, Riverside, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Disease Vector Research and Department of Entomology, University of California Riverside, Riverside, California, United States of America","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060698638","display_name":"V\u0131\u0301ctor Guallar","orcid":"https://orcid.org/0000-0002-4580-1114","observed_orcids":["https://orcid.org/0000-0002-4580-1114"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I2799803557","display_name":"Barcelona Supercomputing Center","ror":"https://ror.org/05sd8tv96","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2799803557","https://openalex.org/I9617848"]},{"id":"https://openalex.org/I4210122345","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/01z1gye03","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122345","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Victor Guallar","raw_affiliation_strings":["Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain","Joint Barcelona Supercomputing Center-Institute for Research in Biomedicine (BSC-IRB) Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Joint Barcelona Supercomputing Center-Institute for Research in Biomedicine (BSC-IRB) Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain","institution_ids":["https://openalex.org/I2799803557","https://openalex.org/I4210122345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000889591","display_name":"Michail Kotsyfakis","orcid":"https://orcid.org/0000-0002-7526-1876","observed_orcids":["https://orcid.org/0000-0002-7526-1876"]},"institutions":[{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michalis Kotsyfakis","raw_affiliation_strings":["Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic","institution_ids":["https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5068641535"],"corresponding_institution_ids":["https://openalex.org/I4210161358","https://openalex.org/I4210164740"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.1553,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.93915501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"e62562","last_page":"e62562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ixodes-scapularis","display_name":"Ixodes scapularis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tick-salivary-proteins","display_name":"tick salivary proteins","score":0.9279999732971191},{"id":"https://openalex.org/keywords/beta-tryptase","display_name":"beta-tryptase","score":0.7390000224113464},{"id":"https://openalex.org/keywords/intrinsic-disorder","display_name":"intrinsic disorder","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cysteine-motifs","display_name":"cysteine motifs","score":0.7839999794960022},{"id":"https://openalex.org/keywords/rhipicephalus-appendiculatus","display_name":"Rhipicephalus appendiculatus","score":0.9229999780654907},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tick-host-interactions","display_name":"tick-host interactions","score":0.5320000052452087},{"id":"https://openalex.org/keywords/salivary-proteome","display_name":"salivary proteome","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2781453105","wikidata":"https://www.wikidata.org/wiki/Q1497962","display_name":"Ixodes scapularis","level":4,"score":0.819861888885498},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.7950704097747803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6191014051437378},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6044089794158936},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5539481043815613},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5311620831489563},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5217110514640808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49624377489089966},{"id":"https://openalex.org/C2776397665","wikidata":"https://www.wikidata.org/wiki/Q1951212","display_name":"Ixodes","level":3,"score":0.4643123149871826},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.4588383734226227},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4169352650642395},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.3140838146209717},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1945568025112152},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15670612454414368},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.13081249594688416},{"id":"https://openalex.org/C2776127032","wikidata":"https://www.wikidata.org/wiki/Q1429304","display_name":"Ixodidae","level":3,"score":0.11180296540260315},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012471","descriptor_name":"Salivary Proteins and Peptides","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012471","descriptor_name":"Salivary Proteins and Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012471","descriptor_name":"Salivary Proteins and Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012471","descriptor_name":"Salivary Proteins and Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018884","descriptor_name":"Ixodes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018884","descriptor_name":"Ixodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018884","descriptor_name":"Ixodes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048494","descriptor_name":"Rhipicephalus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048494","descriptor_name":"Rhipicephalus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048494","descriptor_name":"Rhipicephalus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0062562","doi":"https://doi.org/10.1371/journal.pone.0062562","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0062562","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062562&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2646397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3643938","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3643938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3643938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23658744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23658744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.5240","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.5240","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/6b/pone.0062562.PMC3643938.pdf","raw_type":"text"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0397485","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0225141","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0919d6a2abf94b288ac6b9a86ad94cb3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0919d6a2abf94b288ac6b9a86ad94cb3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 5, p e62562 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/697090","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Tryptogalinin_Is_a_Tick_Kunitz_Serine_Protease_Inhibitor_with_a_Unique_Intrinsic_Disorder_/697090","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0062562","doi":"https://doi.org/10.1371/journal.pone.0062562","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0062562","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062562&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1736281816","display_name":null,"funder_award_id":"CZ. 1.07/2.3.00/30.0032","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G2112627551","display_name":null,"funder_award_id":"25027","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2397731120","display_name":null,"funder_award_id":"CZ.1.07/2.3.00/30.0032","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G2499686605","display_name":"Exploring the salivary transcriptome of Ixodes ricinus, the Lyme disease vector in Europe, and the potential role of its cystatins in pathogen transmission","funder_award_id":"268177","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3303585017","display_name":null,"funder_award_id":"Z60220518","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G5621785900","display_name":"Next-generation sequencing of salivary gland gene transcripts of Triatoma infestans for the discovery of triatomine exposure markers","funder_award_id":"LH12002","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G5883217300","display_name":null,"funder_award_id":"Z60220518","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G6311649877","display_name":null,"funder_award_id":"Z60220518","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G6461011143","display_name":null,"funder_award_id":"CZ.1.07","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G6466030038","display_name":"Development of recombinant salivary antigens of Triatoma infestans for the detection of low-level infestation of triatomines","funder_award_id":"GPP302/11/P798","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G6584597142","display_name":null,"funder_award_id":"CZ.1.07/2.3.00/30.0032","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"},{"id":"https://openalex.org/G6648466122","display_name":"Rickettsial Immunity During Tick Transmission","funder_award_id":"R01AI093653","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G968853706","display_name":"Investigating the role of tick salivary protease inhibitors at the interface between ticks, pathogens and the vertebrate host","funder_award_id":"GAP502/12/2409","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321005","display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","ror":"https://ror.org/037n8p820"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"},{"id":"https://openalex.org/F4320323868","display_name":"Barcelona Supercomputing Center","ror":"https://ror.org/05sd8tv96"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006593248.pdf","grobid_xml":"https://content.openalex.org/works/W2006593248.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1528328138","https://openalex.org/W1535820401","https://openalex.org/W1547785538","https://openalex.org/W1896254721","https://openalex.org/W1930283217","https://openalex.org/W1963916236","https://openalex.org/W1965435949","https://openalex.org/W1972723499","https://openalex.org/W1973277508","https://openalex.org/W1975050432","https://openalex.org/W1981309444","https://openalex.org/W1986876979","https://openalex.org/W1988952550","https://openalex.org/W1996367770","https://openalex.org/W2001913929","https://openalex.org/W2002011866","https://openalex.org/W2005912584","https://openalex.org/W2016030444","https://openalex.org/W2018999493","https://openalex.org/W2030437369","https://openalex.org/W2031935242","https://openalex.org/W2041668538","https://openalex.org/W2043568569","https://openalex.org/W2043676276","https://openalex.org/W2047081204","https://openalex.org/W2051023574","https://openalex.org/W2059654627","https://openalex.org/W2060259273","https://openalex.org/W2062018285","https://openalex.org/W2062523228","https://openalex.org/W2063377311","https://openalex.org/W2064092874","https://openalex.org/W2065283382","https://openalex.org/W2073745520","https://openalex.org/W2073989193","https://openalex.org/W2074631079","https://openalex.org/W2078701521","https://openalex.org/W2079487514","https://openalex.org/W2084146420","https://openalex.org/W2093654784","https://openalex.org/W2094201044","https://openalex.org/W2094272156","https://openalex.org/W2096495474","https://openalex.org/W2098787526","https://openalex.org/W2102312699","https://openalex.org/W2103933130","https://openalex.org/W2105638686","https://openalex.org/W2112743424","https://openalex.org/W2119362018","https://openalex.org/W2121197587","https://openalex.org/W2121934903","https://openalex.org/W2124630903","https://openalex.org/W2130479394","https://openalex.org/W2138274020","https://openalex.org/W2140422547","https://openalex.org/W2141584209","https://openalex.org/W2144634347","https://openalex.org/W2144654387","https://openalex.org/W2145171186","https://openalex.org/W2148180707","https://openalex.org/W2151460035","https://openalex.org/W2153731681","https://openalex.org/W2154320306","https://openalex.org/W2154501851","https://openalex.org/W2155201844","https://openalex.org/W2156686805","https://openalex.org/W2158982711","https://openalex.org/W2160868144","https://openalex.org/W2162347651","https://openalex.org/W2163659831","https://openalex.org/W2165792098","https://openalex.org/W2167208380","https://openalex.org/W2168597484","https://openalex.org/W2168696662","https://openalex.org/W2170421654","https://openalex.org/W2171249995","https://openalex.org/W2172239530","https://openalex.org/W2320979717","https://openalex.org/W2883755802"],"related_works":["https://openalex.org/W2165792098","https://openalex.org/W2047081204","https://openalex.org/W4315798080","https://openalex.org/W1892659823","https://openalex.org/W2094040493","https://openalex.org/W2032616813","https://openalex.org/W2617076055","https://openalex.org/W6909879143","https://openalex.org/W2022826820","https://openalex.org/W2953699504"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"salivary":[2,19,27],"proteome-transcriptome":[3],"project":[4],"on":[5],"the":[6,16,95,136,144,150,153,186,202,209],"hard":[7],"tick":[8],"Ixodes":[9,193],"scapularis":[10],"revealed":[11],"that":[12,100],"Kunitz":[13,23,43,66,107,190],"peptides":[14,24,93],"are":[15],"most":[17],"abundant":[18],"proteins.":[20],"Ticks":[21],"use":[22],"(among":[25],"other":[26,90,125],"proteins)":[28],"to":[29,35,82,105,114,132,199],"combat":[30],"host":[31],"defense":[32],"mechanisms":[33],"and":[34,77,134,155,178],"obtain":[36],"a":[37,65,106,116,189],"blood":[38],"meal.":[39],"Most":[40],"of":[41,139,143,152,188,205],"these":[42],"peptides,":[44],"however,":[45],"remain":[46],"functionally":[47,91],"uncharacterized,":[48],"thus":[49],"limiting":[50],"our":[51,181],"knowledge":[52],"about":[53,201],"their":[54],"biochemical":[55],"interactions.":[56],"RESULTS:":[57],"We":[58],"discovered":[59],"an":[60,160],"unusual":[61],"cysteine":[62],"motif":[63],"in":[64],"peptide.":[67],"This":[68],"peptide":[69,108,154,191],"inhibits":[70],"several":[71],"serine":[72,172],"proteases":[73],"with":[74,89,167],"high":[75,84,117,165],"affinity":[76,85,118,166],"was":[78],"named":[79],"tryptogalinin":[80,101,146],"due":[81],"its":[83,164,168],"for":[86,119,163],"\u03b2-tryptase.":[87,120],"Compared":[88],"described":[92],"from":[94,109,149,192],"Acari":[96],"subclass,":[97],"we":[98,129],"showed":[99],"is":[102,147],"phylogenetically":[103],"related":[104],"Rhipicephalus":[110],"appendiculatus,":[111],"also":[112,196],"reported":[113],"have":[115],"Using":[121],"homology-based":[122],"modeling":[123],"(and":[124],"protein":[126],"prediction":[127],"programs)":[128],"were":[130],"able":[131],"model":[133],"explain":[135],"multifaceted":[137],"function":[138,187,207],"tryptogalinin.":[140],"The":[141],"N-terminus":[142],"modeled":[145],"detached":[148],"rest":[151],"exhibits":[156],"intrinsic":[157],"disorder":[158],"allowing":[159],"increased":[161],"flexibility":[162],"inhibiting":[169],"partners":[170],"(i.e.,":[171],"proteases).":[173],"CONCLUSIONS:":[174],"By":[175],"incorporating":[176],"experimental":[177],"computational":[179],"methods":[180],"data":[182],"not":[183],"only":[184],"describes":[185],"scapularis,":[194],"but":[195],"allows":[197],"us":[198],"hypothesize":[200],"molecular":[203],"basis":[204],"this":[206],"at":[208],"atomic":[210],"level.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}