{"id":"https://openalex.org/W2006578029","doi":"https://doi.org/10.1248/bpb.35.131","title":"\u03b2-Amyloid42 Induces Desensitization of CXC Chemokine Receptor-4 via Formyl Peptide Receptor in Neural Stem/Progenitor Cells","display_name":"\u03b2-Amyloid42 Induces Desensitization of CXC Chemokine Receptor-4 via Formyl Peptide Receptor in Neural Stem/Progenitor Cells","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2006578029","doi":"https://doi.org/10.1248/bpb.35.131","mag":"2006578029","pmid":"https://pubmed.ncbi.nlm.nih.gov/22293341"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.35.131","doi":"https://doi.org/10.1248/bpb.35.131","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.35.131","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/35/2/35_2_131/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/35/2/35_2_131/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100440836","display_name":"Can Martin Zhang","orcid":"https://orcid.org/0000-0002-4340-5118","observed_orcids":["https://orcid.org/0000-0002-4340-5118"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Can Zhang","raw_affiliation_strings":["School of Pharmacy, Shanghai Jiaotong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiaotong University","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878596","display_name":"Zejian Wang","orcid":"https://orcid.org/0000-0002-9024-509X","observed_orcids":["https://orcid.org/0000-0002-9024-509X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze-Jian Wang","raw_affiliation_strings":["School of Pharmacy, Shanghai Jiaotong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiaotong University","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037834017","display_name":"Kenghoe Lok","orcid":"https://orcid.org/0009-0007-2960-4990","observed_orcids":["https://orcid.org/0009-0007-2960-4990"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keng-Hoe Lok","raw_affiliation_strings":["School of Pharmacy, Shanghai Jiaotong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiaotong University","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041497480","display_name":"Ming Yin","orcid":"https://orcid.org/0000-0001-6095-1973","observed_orcids":["https://orcid.org/0000-0001-6095-1973"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Yin","raw_affiliation_strings":["School of Pharmacy, Shanghai Jiaotong University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai Jiaotong University","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":null,"apc_paid":null,"fwci":1.2871,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.78973738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"2","first_page":"131","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neural-stem-progenitor-cells","display_name":"neural stem/progenitor cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/formyl-peptide-receptor","display_name":"formyl peptide receptor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.8920000195503235},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9020000100135803},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-kinase-2","display_name":"G protein-coupled receptor kinase 2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cyclosporin-h","display_name":"cyclosporin H","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6942686438560486},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6051461100578308},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5609242916107178},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5462992191314697},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5439330339431763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4511297941207886},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.44349098205566406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.404929518699646},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.36739861965179443},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3284143805503845},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.2841798961162567},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25082406401634216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23561227321624756}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054769","descriptor_name":"G-Protein-Coupled Receptor Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1248/bpb.35.131","doi":"https://doi.org/10.1248/bpb.35.131","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.35.131","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/35/2/35_2_131/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:22293341","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22293341","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/bpb.35.131","doi":"https://doi.org/10.1248/bpb.35.131","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.35.131","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/35/2/35_2_131/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological &amp; Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006578029.pdf","grobid_xml":"https://content.openalex.org/works/W2006578029.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W79768257","https://openalex.org/W1537787027","https://openalex.org/W1538369257","https://openalex.org/W1540711779","https://openalex.org/W1577244262","https://openalex.org/W1589552381","https://openalex.org/W1608128587","https://openalex.org/W1611957532","https://openalex.org/W1733936020","https://openalex.org/W1862266358","https://openalex.org/W1967135718","https://openalex.org/W1983326277","https://openalex.org/W1984485329","https://openalex.org/W1988227656","https://openalex.org/W1991494867","https://openalex.org/W2010092829","https://openalex.org/W2015370039","https://openalex.org/W2016815862","https://openalex.org/W2035250926","https://openalex.org/W2046968637","https://openalex.org/W2048228486","https://openalex.org/W2058566746","https://openalex.org/W2060015752","https://openalex.org/W2060133530","https://openalex.org/W2083628520","https://openalex.org/W2084235708","https://openalex.org/W2094677401","https://openalex.org/W2099183368","https://openalex.org/W2101832470","https://openalex.org/W2104799415","https://openalex.org/W2117066100","https://openalex.org/W2135970284","https://openalex.org/W2146032033","https://openalex.org/W2152228047","https://openalex.org/W2158768490","https://openalex.org/W2160862072","https://openalex.org/W2162289930","https://openalex.org/W2214378700","https://openalex.org/W2399457421"],"related_works":["https://openalex.org/W2898830764","https://openalex.org/W1980729492","https://openalex.org/W2015991982","https://openalex.org/W2375274081","https://openalex.org/W2047573089","https://openalex.org/W1589552381","https://openalex.org/W3176101485","https://openalex.org/W2018496107","https://openalex.org/W2236888552","https://openalex.org/W2140332898"],"abstract_inverted_index":{"The":[0,65,103,120],"deposition":[1],"of":[2,9,15,20,31,38,50,59,67,97,105,122,134,146],"\u03b2-amyloid":[3],"(A\u03b2)":[4],"plaques":[5],"and":[6,81,110,156],"progressive":[7],"loss":[8],"neurons":[10],"are":[11],"two":[12],"main":[13],"characteristics":[14],"Alzheimer's":[16],"disease":[17],"(AD).":[18],"Supplement":[19],"neural":[21],"stem/progenitor":[22],"cells":[23],"(NSPCs)":[24],"is":[25,41],"a":[26,62,79],"promising":[27],"strategy":[28],"for":[29,43,91,163],"repair":[30],"the":[32,44,48,57,94,132,143,164],"neurodegenerative":[33,39],"diseases.":[34],"However,":[35],"hostile":[36],"microenvironment":[37],"brain":[40],"harmful":[42],"neuroregeneration.":[45],"A\u03b2(42)":[46,53,70,90,141],"promoted":[47,56],"proliferation":[49],"NSPCs.":[51,119],"Moreover,":[52],"(10-1000":[54],"nM)":[55],"migration":[58,95],"NSPCs":[60,68,98,135,147,159],"in":[61,118,158],"dose-dependent":[63],"manner.":[64],"attraction":[66],"toward":[69],"was":[71,99,129],"significantly":[72,100,116],"offset":[73],"by":[74,148],"10":[75],"\u03bcM":[76],"cyclosporin":[77],"H,":[78],"potent":[80],"selective":[82],"formyl":[83,106],"peptide":[84,107],"receptor":[85,108,125],"antagonist.":[86],"After":[87],"incubation":[88],"with":[89],"9":[92],"d,":[93],"ability":[96],"decreased":[101,117],"(p<0.05).":[102],"expression":[104,121],"(FPR)":[109],"CXC":[111],"chemokine":[112],"receptor-4":[113],"(CXCR4)":[114],"were":[115],"G":[123],"protein-coupled":[124],"kinase":[126],"2":[127],"(GRK2)":[128],"up-regulated":[130],"on":[131],"membrane":[133],"correspondingly.":[136],"Our":[137],"results":[138],"suggested":[139],"that":[140],"decreases":[142],"migratory":[144,166],"capacity":[145],"FPR":[149],"heterologous":[150],"desensitization":[151],"after":[152],"long":[153],"time":[154],"incubation,":[155],"GRK2":[157],"may":[160],"be":[161],"responsible":[162],"damaged":[165],"capacity.":[167]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}