{"id":"https://openalex.org/W2006567237","doi":"https://doi.org/10.1185/03007995.2011.580341","title":"Effects of alendronate plus alfacalcidol in osteoporosis patients with a high risk of fracture: the Japanese Osteoporosis Intervention Trial (JOINT) \u2013 02","display_name":"Effects of alendronate plus alfacalcidol in osteoporosis patients with a high risk of fracture: the Japanese Osteoporosis Intervention Trial (JOINT) \u2013 02","publication_year":2011,"publication_date":"2011-05-10","ids":{"openalex":"https://openalex.org/W2006567237","doi":"https://doi.org/10.1185/03007995.2011.580341","mag":"2006567237","pmid":"https://pubmed.ncbi.nlm.nih.gov/21554143"},"language":"en","primary_location":{"id":"doi:10.1185/03007995.2011.580341","doi":"https://doi.org/10.1185/03007995.2011.580341","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007995.2011.580341","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108539297","display_name":"Hajime Orimo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Orimo","raw_affiliation_strings":["Health Science University,\rYamanashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Science University,\rYamanashi, Japan","institution_ids":["https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780481","display_name":"Toshitaka Nakamura","orcid":"https://orcid.org/0000-0002-4917-5843","observed_orcids":["https://orcid.org/0000-0002-4917-5843"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshitaka Nakamura","raw_affiliation_strings":["Department of Orthopedic Surgery, University of Occupational and Environmental Health School of Medicine,\rFukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, University of Occupational and Environmental Health School of Medicine,\rFukuoka, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101609688","display_name":"Masao Fukunaga","orcid":"https://orcid.org/0000-0002-8700-4009","observed_orcids":["https://orcid.org/0000-0002-8700-4009"]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Fukunaga","raw_affiliation_strings":["Department of Nuclear Medicine, Kawasaki Medical School,\rOkayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Kawasaki Medical School,\rOkayama, Japan","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971912","display_name":"Hiroaki Ohta","orcid":"https://orcid.org/0000-0003-2490-3442","observed_orcids":["https://orcid.org/0000-0003-2490-3442"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Ohta","raw_affiliation_strings":["Department of Obstetric and Gynecology, Tokyo Women\u2019s Medical University,\rTokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetric and Gynecology, Tokyo Women\u2019s Medical University,\rTokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113611097","display_name":"Takayuki Hosoi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Hosoi","raw_affiliation_strings":["Department of Clinical Research and Development, National Center for Geriatrics and Gerontology,\rAichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research and Development, National Center for Geriatrics and Gerontology,\rAichi, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007957984","display_name":"Yukari Uemura","orcid":"https://orcid.org/0000-0002-3013-7775","observed_orcids":["https://orcid.org/0000-0002-3013-7775"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukari Uemura","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, The University of Tokyo,\rTokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, The University of Tokyo,\rTokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007369236","display_name":"Tatsuhiko Kuroda","orcid":"https://orcid.org/0000-0002-2261-309X","observed_orcids":["https://orcid.org/0000-0002-2261-309X"]},"institutions":[{"id":"https://openalex.org/I4405257087","display_name":"Public Health Research Foundation","ror":"https://ror.org/04w7eg945","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405257087"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiko Kuroda","raw_affiliation_strings":["Public Health Research Foundation,\rTokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Foundation,\rTokyo, Japan","institution_ids":["https://openalex.org/I4405257087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052273989","display_name":"Nobuaki Miyakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257087","display_name":"Public Health Research Foundation","ror":"https://ror.org/04w7eg945","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4405257087"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuaki Miyakawa","raw_affiliation_strings":["Public Health Research Foundation,\rTokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Public Health Research Foundation,\rTokyo, Japan","institution_ids":["https://openalex.org/I4405257087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090955736","display_name":"Yasuo Ohashi","orcid":"https://orcid.org/0000-0003-3177-4474","observed_orcids":["https://orcid.org/0000-0003-3177-4474"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuo Ohashi","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, The University of Tokyo,\rTokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, The University of Tokyo,\rTokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049082567","display_name":"Masataka Shiraki","orcid":"https://orcid.org/0000-0001-6599-6185","observed_orcids":["https://orcid.org/0000-0001-6599-6185"]},"institutions":[{"id":"https://openalex.org/I4405283332","display_name":"Research Institute and Practice for Involutional Diseases","ror":"https://ror.org/01eq7me35","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283332"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masataka Shiraki","raw_affiliation_strings":["Department of Internal Medicine, Research Institute and Practice for Involutional Diseases,\rNagano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Research Institute and Practice for Involutional Diseases,\rNagano, Japan","institution_ids":["https://openalex.org/I4405283332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5049082567"],"corresponding_institution_ids":["https://openalex.org/I4405283332"],"apc_list":null,"apc_paid":null,"fwci":6.6873,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.96584361,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"6","first_page":"1273","last_page":"1284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alfacalcidol","display_name":"alfacalcidol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/fracture-prevention","display_name":"fracture prevention","score":0.8379999995231628},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.8429999947547913},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8730000257492065},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.6460000276565552},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.871999979019165},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.718999981880188},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9821167588233948},{"id":"https://openalex.org/C2779126354","wikidata":"https://www.wikidata.org/wiki/Q155883","display_name":"Alfacalcidol","level":4,"score":0.9470116496086121},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7336853742599487},{"id":"https://openalex.org/C2779809032","wikidata":"https://www.wikidata.org/wiki/Q420057","display_name":"Alendronic acid","level":4,"score":0.5426886081695557},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5417161583900452},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5298081636428833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.526395320892334},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4677106738090515},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4649829566478729},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4484812319278717},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.2750639319419861},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006887","descriptor_name":"Hydroxycholecalciferols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006887","descriptor_name":"Hydroxycholecalciferols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006887","descriptor_name":"Hydroxycholecalciferols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019386","descriptor_name":"Alendronate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019386","descriptor_name":"Alendronate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019386","descriptor_name":"Alendronate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1185/03007995.2011.580341","doi":"https://doi.org/10.1185/03007995.2011.580341","is_oa":false,"landing_page_url":"https://doi.org/10.1185/03007995.2011.580341","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:21554143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21554143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321627","display_name":"Dainippon Sumitomo Pharma","ror":"https://ror.org/04sapgw72"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1493312300","https://openalex.org/W1995989871","https://openalex.org/W2023360726","https://openalex.org/W2026518081","https://openalex.org/W2037040844","https://openalex.org/W2044178924","https://openalex.org/W2046127352","https://openalex.org/W2049831726","https://openalex.org/W2089340794","https://openalex.org/W2090820041","https://openalex.org/W2093082282","https://openalex.org/W2095430655","https://openalex.org/W2098782984","https://openalex.org/W2101285723","https://openalex.org/W2106975935","https://openalex.org/W2107490395","https://openalex.org/W2108501167","https://openalex.org/W2112629831","https://openalex.org/W2124527463","https://openalex.org/W2128498016","https://openalex.org/W2142065728","https://openalex.org/W2144456338","https://openalex.org/W2147247664","https://openalex.org/W2149949422","https://openalex.org/W2153009489","https://openalex.org/W2161837912","https://openalex.org/W2161933674","https://openalex.org/W2166683880","https://openalex.org/W2396798113","https://openalex.org/W2917781841","https://openalex.org/W3035625241","https://openalex.org/W4240851819","https://openalex.org/W4252543199","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2094185090","https://openalex.org/W58890505","https://openalex.org/W2027848017","https://openalex.org/W2026518081","https://openalex.org/W2336242322","https://openalex.org/W2032511277","https://openalex.org/W2172623693","https://openalex.org/W3029444428","https://openalex.org/W3217340772","https://openalex.org/W2167376621"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,52,159,254],"authors":[2],"conducted":[3],"a":[4,22,114,193],"randomized":[5,81],"controlled":[6],"trial":[7],"to":[8,68,82,238,249],"clarify":[9],"the":[10,61,69,93,97,103,109,122,131,138,170,176,180,210,227],"efficacy":[11,63],"and":[12,44,60,150,218,248,289],"safety":[13],"of":[14,57,77,99,118,140,142,146,153,161,196,226,246],"alendronate":[15,19,83,89,204],"plus":[16,84],"alfacalcidol":[17,85],"versus":[18],"alone":[20,90],"in":[21,66,96,137,169,175,230,279],"clinical":[23],"setting.":[24],"RESEARCH":[25],"DESIGN":[26],"AND":[27],"METHODS:":[28],"Eligible":[29],"patients":[30,79,240,280],"were":[31,38,80,222],"postmenopausal":[32],"women":[33],"with":[34,192,241,281],"severe":[35,282],"osteoporosis":[36,251],"who":[37],"aged":[39],"70":[40],"years":[41,245],"or":[42,88],"older":[43],"had":[45,113,213],"several":[46],"risk":[47,117],"factors":[48],"for":[49,261,276,290],"incident":[50,58],"fractures.":[51],"primary":[53],"endpoint":[54],"was":[55,64,106,135,166,190,257,273],"prevention":[56,278],"fractures,":[59,288],"anti-fracture":[62],"evaluated":[65],"relation":[67],"baseline":[70,187],"serum":[71],"25(OH)D":[72,188],"level.":[73],"RESULTS:":[74],"A":[75,185],"total":[76],"2164":[78],"(combination":[86],"therapy)":[87],"(monotherapy).":[91],"Although":[92,206],"overall":[94,262],"difference":[95],"incidence":[98,195],"vertebral":[100,119,144,155,263,283,287],"fracture":[101,264,277,294],"between":[102],"two":[104],"groups":[105],"not":[107,223,236],"significant,":[108],"combination":[110,132,171,211,255],"therapy":[111,133,172,212,256],"group":[112,134,173,178],"significantly":[115,167],"reduced":[116],"fractures":[120,145,156,165,200],"after":[121],"first":[123],"6":[124],"months":[125],"(HR,":[126,148,157,183,201],"0.53).":[127],"In":[128],"subgroup":[129,267],"analyses,":[130],"superior":[136],"strata":[139],"number":[141],"prevalent":[143,154,286],"\u22652":[147],"0.51)":[149],"grade":[151],"3":[152],"0.55).":[158],"rate":[160],"non-vertebral":[162,197,291],"weight-bearing":[163,198,292],"bone":[164,199,293],"lower":[168,186],"than":[174,243],"monotherapy":[177],"during":[179],"follow-up":[181],"period":[182],"0.31).":[184],"level":[189],"associated":[191],"higher":[194],"3.42)":[202],"despite":[203],"use.":[205],"one":[207],"patient":[208],"given":[209],"mild":[214],"hypercalcemia,":[215],"serious":[216],"hypercalcemia":[217],"unknown":[219],"adverse":[220],"events":[221],"encountered.":[224],"Because":[225],"limitations":[228],"presented":[229],"this":[231],"study,":[232],"these":[233],"results":[234],"may":[235],"apply":[237],"female":[239],"longer":[242],"2":[244],"treatments,":[247],"male":[250],"patients.":[252],"CONCLUSIONS:":[253],"no":[258],"more":[259,274],"effective":[260,275],"prevention.":[265,295],"However,":[266],"analysis":[268],"has":[269],"shown":[270],"that":[271],"it":[272],"deformity,":[284],"multiple":[285]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}