{"id":"https://openalex.org/W2006566770","doi":"https://doi.org/10.1021/la8026804","title":"How Focal Adhesion Size Depends on Integrin Affinity","display_name":"How Focal Adhesion Size Depends on Integrin Affinity","publication_year":2009,"publication_date":"2009-01-08","ids":{"openalex":"https://openalex.org/W2006566770","doi":"https://doi.org/10.1021/la8026804","mag":"2006566770","pmid":"https://pubmed.ncbi.nlm.nih.gov/19132823"},"language":"en","primary_location":{"id":"doi:10.1021/la8026804","doi":"https://doi.org/10.1021/la8026804","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la8026804","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005458755","display_name":"Tong Zhao","orcid":"https://orcid.org/0000-0002-2169-6268","observed_orcids":["https://orcid.org/0000-0002-2169-6268","https://orcid.org/0000-0002-1521-3522"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Zhao","raw_affiliation_strings":["Department of Chemistry, Department of Physics, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Department of Physics, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Department of Chemistry, Department of Physics, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Department of Physics, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075498364","display_name":"Aaron R. Dinner","orcid":"https://orcid.org/0000-0001-8328-6427","observed_orcids":["https://orcid.org/0000-0001-8328-6427","https://orcid.org/0000-0002-2871-7244"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron R. Dinner","raw_affiliation_strings":["Department of Chemistry, Department of Physics, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Department of Physics, James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075498364"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0178,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84780689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"1540","last_page":"1546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-affinity","display_name":"integrin affinity","score":0.972000002861023},{"id":"https://openalex.org/keywords/integrin-clustering","display_name":"integrin clustering","score":0.8610000014305115},{"id":"https://openalex.org/keywords/receptor-ligand-binding-kinetics","display_name":"receptor-ligand binding kinetics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/kinetic-monte-carlo","display_name":"kinetic Monte Carlo","score":0.7829999923706055},{"id":"https://openalex.org/keywords/lattice-model","display_name":"lattice model","score":0.6549999713897705},{"id":"https://openalex.org/keywords/membrane-fluctuations","display_name":"membrane fluctuations","score":0.9860000014305115},{"id":"https://openalex.org/keywords/receptor-heterogeneity","display_name":"receptor heterogeneity","score":0.6000000238418579},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.8277980089187622},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8233113288879395},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.607831597328186},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.5713058114051819},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5354549884796143},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5279839634895325},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.4946691691875458},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4879142940044403},{"id":"https://openalex.org/C45786274","wikidata":"https://www.wikidata.org/wiki/Q3333611","display_name":"Kinetic Monte Carlo","level":3,"score":0.47499528527259827},{"id":"https://openalex.org/C152900378","wikidata":"https://www.wikidata.org/wiki/Q7302366","display_name":"Receptor\u2013ligand kinetics","level":3,"score":0.4197548031806946},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39985010027885437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3594653606414795},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.32319653034210205},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.320448637008667},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2721174955368042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19716835021972656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1563589870929718},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12750312685966492},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.11529907584190369},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10873278975486755},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D022001","descriptor_name":"Focal Adhesions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/la8026804","doi":"https://doi.org/10.1021/la8026804","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la8026804","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},{"id":"pmid:19132823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19132823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir : the ACS journal of surfaces and colloids","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W133332340","https://openalex.org/W1576773659","https://openalex.org/W1590619267","https://openalex.org/W1938388466","https://openalex.org/W1964350332","https://openalex.org/W1967265143","https://openalex.org/W1973757009","https://openalex.org/W1977764445","https://openalex.org/W1984872320","https://openalex.org/W1987851811","https://openalex.org/W1991386525","https://openalex.org/W1994653877","https://openalex.org/W1996880045","https://openalex.org/W2007115361","https://openalex.org/W2012678565","https://openalex.org/W2020472510","https://openalex.org/W2027810531","https://openalex.org/W2029231027","https://openalex.org/W2030181238","https://openalex.org/W2040369209","https://openalex.org/W2040379229","https://openalex.org/W2053001031","https://openalex.org/W2063220206","https://openalex.org/W2066367871","https://openalex.org/W2067836657","https://openalex.org/W2076468533","https://openalex.org/W2088992013","https://openalex.org/W2094389040","https://openalex.org/W2094585694","https://openalex.org/W2100996687","https://openalex.org/W2111811045","https://openalex.org/W2123029770","https://openalex.org/W2125644189","https://openalex.org/W2136443584","https://openalex.org/W2136949471","https://openalex.org/W2141075109","https://openalex.org/W2142501126","https://openalex.org/W2148377692","https://openalex.org/W2152002380","https://openalex.org/W2156530903","https://openalex.org/W2160912589","https://openalex.org/W2167956058","https://openalex.org/W4213141530","https://openalex.org/W4240278375"],"related_works":["https://openalex.org/W1973757009","https://openalex.org/W2016841866","https://openalex.org/W2048213038","https://openalex.org/W4205297311","https://openalex.org/W7128140753","https://openalex.org/W2501294695","https://openalex.org/W7164426721","https://openalex.org/W2127449358","https://openalex.org/W2007115361","https://openalex.org/W1545004047"],"abstract_inverted_index":{"Understanding":[0],"how":[1],"the":[2,13,22,102,124,136],"thermodynamics":[3],"and":[4,10,28,89,110],"kinetics":[5],"of":[6,15,46,112],"integrin":[7],"receptor":[8],"binding":[9],"clustering":[11],"impact":[12],"formation":[14],"focal":[16,47],"adhesions":[17,48],"is":[18,115],"important":[19],"for":[20,72,120],"understanding":[21],"mechanisms":[23],"cells":[24],"use":[25],"to":[26,30,43],"sense":[27],"respond":[29],"physical":[31],"cues":[32],"in":[33,79,122,129],"their":[34,90],"environment.":[35],"Cells":[36],"on":[37,86,105],"chemically":[38],"well-defined":[39],"surfaces":[40],"were":[41],"observed":[42],"have":[44],"distributions":[45],"shifted":[49],"toward":[50],"smaller":[51],"sizes":[52],"when":[53],"presented":[54,126],"with":[55,75,95],"higher":[56],"affinity":[57],"ligands":[58,125],"(Kato,":[59],"M.;":[60],"Mrksich,":[61],"M.":[62],"Biochemistry":[63],"2004,":[64],"43,":[65],"2699).":[66],"In":[67],"this":[68,73],"paper,":[69],"we":[70],"account":[71],"trend":[74,103],"a":[76,87,96],"simple":[77],"model":[78,137],"which":[80,123],"integrins":[81],"are":[82,93,118],"treated":[83],"as":[84],"particles":[85],"lattice,":[88],"stochastic":[91],"dynamics":[92],"simulated":[94],"kinetic":[97],"Monte":[98],"Carlo":[99],"algorithm.":[100],"How":[101],"depends":[104],"force-coupled":[106],"growth,":[107],"membrane":[108],"fluctuations,":[109],"heterogeneity":[111],"receptor-ligand":[113],"interactions":[114],"analyzed.":[116],"Predictions":[117],"made":[119],"substrates":[121],"can":[127,138],"vary":[128],"either":[130],"space":[131],"or":[132],"time,":[133],"so":[134],"that":[135],"be":[139],"validated":[140],"experimentally.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}