{"id":"https://openalex.org/W2006504845","doi":"https://doi.org/10.1097/00004424-199701000-00005","title":"Perfluorocarbon Compound Aerosols for Delivery to the Lung as Potential 19F Magnetic Resonance Reporters of Regional Pulmonary pO2","display_name":"Perfluorocarbon Compound Aerosols for Delivery to the Lung as Potential 19F Magnetic Resonance Reporters of Regional Pulmonary pO2","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2006504845","doi":"https://doi.org/10.1097/00004424-199701000-00005","mag":"2006504845","pmid":"https://pubmed.ncbi.nlm.nih.gov/9007645"},"language":"en","primary_location":{"id":"doi:10.1097/00004424-199701000-00005","doi":"https://doi.org/10.1097/00004424-199701000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004424-199701000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S136338150","display_name":"Investigative Radiology","issn_l":"0020-9996","issn":["0020-9996","1536-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INVESTIGATIVE RADIOLOGY","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"STEPHEN R. THOMAS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"STEPHEN R. THOMAS","raw_affiliation_strings":["Department of Radiology, University of Cincinnati, Ohio 45267-0579, USA. steve.thomas@uc.edu","Department of Radiology, University of Cincinnati, Ohio 45267-0579, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Cincinnati, Ohio 45267-0579, USA. steve.thomas@uc.edu","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Radiology, University of Cincinnati, Ohio 45267-0579, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078735377","display_name":"Leon Grado\u0144","orcid":"https://orcid.org/0000-0002-2391-3529","observed_orcids":["https://orcid.org/0000-0002-2391-3529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LEON GRADON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063774939","display_name":"Sotiris E. Pratsinis","orcid":"https://orcid.org/0000-0003-2042-249X","observed_orcids":["https://orcid.org/0000-0003-2042-249X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SOTIRIS E. PRATSINIS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074308000","display_name":"Ronald G. Pratt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RONALD G. PRATT","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085465166","display_name":"George P. Fotou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GEORGE P. FOTOU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072922405","display_name":"Anthony J. McGoron","orcid":"https://orcid.org/0000-0003-3714-4676","observed_orcids":["https://orcid.org/0000-0003-3714-4676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ANTHONY J. McGORON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770792","display_name":"A. Podg\u00f3rski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ALBERT L. PODGORSKI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114152467","display_name":"Ronald Wesley Millard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RONALD W. MILLARD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7347,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.72554687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"32","issue":"1","first_page":"29","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11993","display_name":"Atomic and Subatomic Physics Research","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perfluorotributylamine","display_name":"perfluorotributylamine","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fc-43","display_name":"FC-43","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pulmonary-oxygenation","display_name":"pulmonary oxygenation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/aerosol-deposition","display_name":"aerosol deposition","score":0.6269999742507935},{"id":"https://openalex.org/keywords/tracheotomy","display_name":"tracheotomy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2779345167","wikidata":"https://www.wikidata.org/wiki/Q104541","display_name":"Aerosol","level":2,"score":0.8106905221939087},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.6399942636489868},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6108996868133545},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5827271342277527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5042461156845093},{"id":"https://openalex.org/C2778551211","wikidata":"https://www.wikidata.org/wiki/Q324921","display_name":"Tracheotomy","level":2,"score":0.47009798884391785},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.4541345536708832},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.4530869722366333},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.44247299432754517},{"id":"https://openalex.org/C2780352487","wikidata":"https://www.wikidata.org/wiki/Q2281580","display_name":"Nebulizer","level":2,"score":0.41673779487609863},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38913071155548096},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3399444818496704},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.24442607164382935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18076160550117493},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1416589915752411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09076359868049622},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.07319843769073486},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005466","descriptor_name":"Fluorocarbons","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004424-199701000-00005","doi":"https://doi.org/10.1097/00004424-199701000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004424-199701000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S136338150","display_name":"Investigative Radiology","issn_l":"0020-9996","issn":["0020-9996","1536-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"INVESTIGATIVE RADIOLOGY","raw_type":"journal-article"},{"id":"pmid:9007645","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9007645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1974857513","https://openalex.org/W1984369877","https://openalex.org/W1986079450","https://openalex.org/W1986536556","https://openalex.org/W1986848713","https://openalex.org/W1990201295","https://openalex.org/W2006394417","https://openalex.org/W2009486214","https://openalex.org/W2010356988","https://openalex.org/W2019496453","https://openalex.org/W2021758700","https://openalex.org/W2023034693","https://openalex.org/W2032675214","https://openalex.org/W2044433232","https://openalex.org/W2046149011","https://openalex.org/W2053690920","https://openalex.org/W2061234238","https://openalex.org/W2075568345","https://openalex.org/W2082330074","https://openalex.org/W2084056529","https://openalex.org/W2091104814","https://openalex.org/W2091210055","https://openalex.org/W2320734453","https://openalex.org/W2326318277","https://openalex.org/W2345732794"],"related_works":["https://openalex.org/W2059400233","https://openalex.org/W2906746769","https://openalex.org/W7057890137","https://openalex.org/W2002187439","https://openalex.org/W2082330074","https://openalex.org/W2037110469","https://openalex.org/W2025010824","https://openalex.org/W2563729576","https://openalex.org/W2067783738","https://openalex.org/W2914968760"],"abstract_inverted_index":{"RATIONALE":[0],"AND":[1],"OBJECTIVES:":[2],"Perfluorocarbon":[3,95,235],"(PFC)":[4],"aerosols":[5,43,236],"present":[6],"the":[7,39,51,59,100,126,165,189,196,201,210,222,253,272],"opportunity":[8],"for":[9,28,47,61,99,146,250,266],"simultaneous":[10],"analysis":[11],"of":[12,34,64,76,113,173,177,195,200,237,277,282,289],"lung":[13,52,128,211],"structure":[14],"and":[15,37,111,227,257,275],"pulmonary":[16,65,255,273,290],"oxygenation":[17],"patterns.":[18],"The":[19,121,156,263],"authors":[20],"investigated":[21],"techniques":[22],"to":[23,50,86,117,252],"nebulize":[24],"neat":[25,89],"liquid":[26,90],"PFCs":[27],"inhalation":[29,96],"as":[30,286],"a":[31,88,114,160,287],"new":[32],"method":[33],"PFC":[35,42,91,122,147,161],"administration":[36],"tested":[38],"hypothesis":[40],"that":[41],"may":[44],"be":[45,242],"developed":[46],"efficient":[48,197],"delivery":[49,124],"in":[53,135,214,267,271],"an":[54,108],"experimental":[55,153,279],"rat":[56,101,127],"model":[57,102,144],"allowing":[58],"potential":[60,264],"sequential":[62],"monitoring":[63],"status":[66],"via":[67],"quantitative":[68],"fluorine-19":[69],"(19F)":[70],"magnetic":[71],"resonance":[72],"(MR)":[73],"partial":[74],"pressure":[75],"oxygen":[77,284],"(pO2)":[78],"imaging.":[79,262],"METHODS:":[80],"Pneumatic":[81],"aerosol":[82,109,123,162,187,207],"generators":[83,249],"were":[84,150,212,225],"configured":[85],"produce":[87],"perfluorotributylamine":[92],"(FC-43)":[93],"aerosol.":[94],"breathing":[97,106,193],"protocols":[98],"included:":[103],"spontaneous":[104,192],"direct":[105],"from":[107],"chamber,":[110],"use":[112],"tracheotomy":[115],"tube":[116],"bypass":[118],"nasal":[119,203],"breathing.":[120],"into":[125],"was":[129,232],"documented":[130],"through":[131],"19F":[132,230,260],"MR":[133,141,261],"imaging":[134,231,270],"correlation":[136],"with":[137,152,218,247],"high-resolution":[138],"anatomic":[139],"proton":[140],"images.":[142],"Theoretical":[143],"calculations":[145],"mass":[148,215],"deposition":[149],"compared":[151],"results.":[154],"RESULTS:":[155],"pneumatic":[157,248],"generator":[158],"produced":[159,243],"droplet":[163],"within":[164,209],"theoretically":[166],"targeted":[167],"range":[168],"(geometric":[169],"mean":[170],"particle":[171],"diameter":[172],"1.2":[174],"microns;":[175],"concentration":[176,246],"approximately":[178],"4":[179],"x":[180],"10(7)":[181],"droplets":[182],"per":[183],"cm3).":[184],"No":[185],"measurable":[186],"reached":[188],"lungs":[190],"during":[191],"because":[194],"filtering":[198],"capabilities":[199],"turbinated":[202],"passages.":[204],"With":[205],"tracheotomy,":[206],"depositions":[208],"achieved":[213],"quantities":[216],"consistent":[217],"theoretical":[219],"expectations;":[220],"however,":[221],"distribution":[223,240,251],"patterns":[224],"nonuniform":[226],"unpredictable.":[228],"Oxygen-enhanced":[229],"demonstrated.":[233],"CONCLUSIONS:":[234],"controlled":[238],"size":[239],"can":[241],"at":[244],"sufficient":[245],"terminal":[254],"architecture":[256],"visualization":[258],"using":[259],"exists":[265],"vivo":[268],"oxygen-sensitive":[269],"system":[274],"development":[276],"sophisticated":[278],"animal":[280],"models":[281],"systemic":[283],"transport":[285],"function":[288],"status.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
