{"id":"https://openalex.org/W2006477103","doi":"https://doi.org/10.1096/fj.00-0102rev","title":"Control of the eukaryotic cell cycle by MAP kinase signaling pathways","display_name":"Control of the eukaryotic cell cycle by MAP kinase signaling pathways","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2006477103","doi":"https://doi.org/10.1096/fj.00-0102rev","mag":"2006477103","pmid":"https://pubmed.ncbi.nlm.nih.gov/11053235"},"language":"en","primary_location":{"id":"doi:10.1096/fj.00-0102rev","doi":"https://doi.org/10.1096/fj.00-0102rev","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.00-0102rev","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114252751","display_name":"Marc G. Wilkinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc G. Wilkinson","raw_affiliation_strings":["New Frontiers Science Park Harlow Essex CM19 5AW U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Frontiers Science Park Harlow Essex CM19 5AW U.K","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079482952","display_name":"Jonathan B. A. Millar","orcid":"https://orcid.org/0000-0002-9930-3989","observed_orcids":["https://orcid.org/0000-0002-9930-3989"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan B. A. Millar","raw_affiliation_strings":["National Institute for Medical Research The Ridgeway, Mill Hill London NW7 1AA U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Medical Research The Ridgeway, Mill Hill London NW7 1AA U.K","institution_ids":["https://openalex.org/I4405285715"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.4808,"has_fulltext":false,"cited_by_count":281,"citation_normalized_percentile":{"value":0.82045455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"14","first_page":"2147","last_page":"2157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0272000003606081,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.699999988079071},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.765999972820282},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase-cascade","display_name":"mitogen-activated protein kinase cascade","score":0.8740000128746033},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9739999771118164},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.7459999918937683},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6230000257492065},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.7129999995231628},{"id":"https://openalex.org/keywords/stress-signals","display_name":"stress signals","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7521976232528687},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7183933854103088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6246486902236938},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5562089085578918},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5283578038215637},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5093949437141418},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4758020341396332},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.44095632433891296},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4401150941848755},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41614794731140137},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4135645925998688},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3630519509315491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20779168605804443}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1096/fj.00-0102rev","doi":"https://doi.org/10.1096/fj.00-0102rev","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.00-0102rev","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:11053235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11053235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W11746033","https://openalex.org/W1530284699","https://openalex.org/W1537459781","https://openalex.org/W1562863690","https://openalex.org/W1619161113","https://openalex.org/W1774418672","https://openalex.org/W1797931385","https://openalex.org/W1845790496","https://openalex.org/W1860728469","https://openalex.org/W1888823860","https://openalex.org/W1963995727","https://openalex.org/W1968606500","https://openalex.org/W1968870061","https://openalex.org/W1969759973","https://openalex.org/W1970424369","https://openalex.org/W1971657539","https://openalex.org/W1971869045","https://openalex.org/W1973588973","https://openalex.org/W1973766879","https://openalex.org/W1975646272","https://openalex.org/W1976462601","https://openalex.org/W1976655304","https://openalex.org/W1980095812","https://openalex.org/W1980855212","https://openalex.org/W1982499214","https://openalex.org/W1983481482","https://openalex.org/W1984903682","https://openalex.org/W1990861922","https://openalex.org/W1991738330","https://openalex.org/W1992772703","https://openalex.org/W1994523623","https://openalex.org/W1994651714","https://openalex.org/W1999824658","https://openalex.org/W2001399809","https://openalex.org/W2007255413","https://openalex.org/W2010968880","https://openalex.org/W2013650960","https://openalex.org/W2014598325","https://openalex.org/W2018876412","https://openalex.org/W2019142280","https://openalex.org/W2021669986","https://openalex.org/W2026951979","https://openalex.org/W2032241710","https://openalex.org/W2032666422","https://openalex.org/W2032731042","https://openalex.org/W2033060201","https://openalex.org/W2034419242","https://openalex.org/W2035641694","https://openalex.org/W2037792829","https://openalex.org/W2038087154","https://openalex.org/W2043590465","https://openalex.org/W2044312503","https://openalex.org/W2048875557","https://openalex.org/W2050413324","https://openalex.org/W2054566768","https://openalex.org/W2054779757","https://openalex.org/W2058184498","https://openalex.org/W2063960509","https://openalex.org/W2065797900","https://openalex.org/W2068689381","https://openalex.org/W2072720547","https://openalex.org/W2075104267","https://openalex.org/W2077309295","https://openalex.org/W2079494240","https://openalex.org/W2082421715","https://openalex.org/W2087404852","https://openalex.org/W2091403769","https://openalex.org/W2091877548","https://openalex.org/W2093728614","https://openalex.org/W2095147188","https://openalex.org/W2095152292","https://openalex.org/W2096657295","https://openalex.org/W2098573045","https://openalex.org/W2100254469","https://openalex.org/W2101892850","https://openalex.org/W2106157965","https://openalex.org/W2108958930","https://openalex.org/W2109838780","https://openalex.org/W2112013596","https://openalex.org/W2112294647","https://openalex.org/W2112533411","https://openalex.org/W2115692032","https://openalex.org/W2116500217","https://openalex.org/W2121619780","https://openalex.org/W2121724121","https://openalex.org/W2121812359","https://openalex.org/W2123600940","https://openalex.org/W2125547572","https://openalex.org/W2126553652","https://openalex.org/W2127150495","https://openalex.org/W2130026994","https://openalex.org/W2132188426","https://openalex.org/W2133203551","https://openalex.org/W2134468110","https://openalex.org/W2135448828","https://openalex.org/W2136222819","https://openalex.org/W2138103542","https://openalex.org/W2146035452","https://openalex.org/W2147114673","https://openalex.org/W2149419925","https://openalex.org/W2154169742","https://openalex.org/W2160822037","https://openalex.org/W2164767056","https://openalex.org/W2165712565","https://openalex.org/W2166731355","https://openalex.org/W4237306139","https://openalex.org/W7014262633"],"related_works":["https://openalex.org/W4319333327","https://openalex.org/W2381506031","https://openalex.org/W1996405087","https://openalex.org/W2735763362","https://openalex.org/W2019896687","https://openalex.org/W4292820908","https://openalex.org/W2786258633","https://openalex.org/W1899552864","https://openalex.org/W2066548490","https://openalex.org/W2284676147"],"abstract_inverted_index":{"In":[0],"an":[1],"often":[2,60],"rapidly":[3],"changing":[4],"environment,":[5],"cells":[6],"must":[7],"adapt":[8],"by":[9,18,46,177],"monitoring":[10],"and":[11,21,38,43,53,77,109,134,137,157,172,187],"reacting":[12],"quickly":[13],"to":[14,73,139,151],"extracellular":[15],"stimuli":[16,108],"detected":[17],"membrane-bound":[19],"receptors":[20],"proteins.":[22],"Reversible":[23],"phosphorylation":[24],"of":[25,40,50,92,106,130,154,161],"intracellular":[26],"regulatory":[27],"proteins":[28],"has":[29],"emerged":[30],"as":[31,90],"a":[32,104],"crucial":[33],"mechanism":[34],"effecting":[35],"the":[36,47,56,82,93,115,121,128,145,152,168,174],"transmission":[37],"modulation":[39],"such":[41,142],"signals":[42,143],"is":[44,101,124],"determined":[45],"relative":[48],"activities":[49],"protein":[51,86],"kinases":[52],"phosphatases":[54],"within":[55],"cell.":[57],"These":[58],"are":[59],"arranged":[61],"into":[62,144],"complex":[63],"signaling":[64,182],"networks":[65],"that":[66],"may":[67],"function":[68],"independently":[69],"or":[70],"be":[71],"subject":[72],"cross-regulation.":[74],"Recently,":[75],"genetic":[76,155],"biochemical":[78],"analyses":[79],"have":[80],"identified":[81],"universally":[83],"conserved":[84],"mitogen-activated":[85],"(MAP)":[87],"kinase":[88,170],"cascade":[89,171],"one":[91],"most":[94],"ubiquitous":[95],"signal":[96],"transduction":[97],"systems.":[98],"This":[99],"pathway":[100],"activated":[102],"after":[103],"variety":[105],"cellular":[107],"regulates":[110],"numerous":[111],"physiological":[112],"processes,":[113],"particularly":[114],"cell":[116,122,146,185],"division":[117],"cycle.":[118],"Progression":[119],"through":[120],"cycle":[123,147],"critically":[125],"dependent":[126],"on":[127,167],"presence":[129],"environmental":[131],"growth":[132,186],"factors":[133],"stress":[135],"stimuli,":[136],"failure":[138],"correctly":[140],"integrate":[141],"machinery":[148],"can":[149],"lead":[150],"accumulation":[153],"damage":[156],"genomic":[158],"instability":[159],"characteristic":[160],"cancer":[162],"cells.":[163],"Here":[164],"we":[165],"focus":[166],"MAP":[169],"discuss":[173],"molecular":[175],"mechanisms":[176],"which":[178],"these":[179],"extensively":[180],"studied":[181],"pathways":[183],"influence":[184],"proliferation.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
