{"id":"https://openalex.org/W2006467537","doi":"https://doi.org/10.1097/00001756-200012180-00012","title":"Modulated expression of secreted Frizzledrelated proteins in human retinal degeneration","display_name":"Modulated expression of secreted Frizzledrelated proteins in human retinal degeneration","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2006467537","doi":"https://doi.org/10.1097/00001756-200012180-00012","mag":"2006467537","pmid":"https://pubmed.ncbi.nlm.nih.gov/11192610"},"language":"en","primary_location":{"id":"doi:10.1097/00001756-200012180-00012","doi":"https://doi.org/10.1097/00001756-200012180-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-200012180-00012","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen E. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen E. Jones","raw_affiliation_strings":["Division of Pharmacology and Therapeutics, The Rayne Institute, GKT, St Thomas' Hospital, London, UK","Retinitis Pigmentosa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacology and Therapeutics, The Rayne Institute, GKT, St Thomas' Hospital, London, UK","institution_ids":["https://openalex.org/I1324925910"]},{"raw_affiliation_string":"Retinitis Pigmentosa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072548410","display_name":"Catherine Jomary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Jomary","raw_affiliation_strings":["Retinitis Pigmentosa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Retinitis Pigmentosa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070467212","display_name":"John Grist","orcid":"https://orcid.org/0000-0001-8939-2626","observed_orcids":["https://orcid.org/0000-0001-8939-2626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Grist","raw_affiliation_strings":["Retinitis Pigmentosa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Retinitis Pigmentosa","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hannah J. Stewart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah J. Stewart","raw_affiliation_strings":["Retinitis Pigmentosa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Retinitis Pigmentosa","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103489968","display_name":"Michael J. Neal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Neal","raw_affiliation_strings":["Retinitis Pigmentosa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Retinitis Pigmentosa","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.835,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.8353505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"18","first_page":"3963","last_page":"3967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.8610000014305115},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8370000123977661},{"id":"https://openalex.org/keywords/secreted-frizzled-related-proteins","display_name":"secreted frizzled-related proteins","score":0.9200000166893005},{"id":"https://openalex.org/keywords/sfrp2","display_name":"SFRP2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sfrp1","display_name":"SFRP1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/secreted-frizzled-related-protein-3","display_name":"SFRP3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sfrp5","display_name":"SFRP5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/photoreceptor-apoptosis","display_name":"photoreceptor apoptosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/internal-limiting-membrane","display_name":"internal limiting membrane","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5090000033378601},{"id":"https://openalex.org/keywords/retinal-neurodegeneration","display_name":"retinal neurodegeneration","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.8309327960014343},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.7745920419692993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7366350889205933},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.7069644927978516},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6853535771369934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6426436305046082},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6330507397651672},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.585963249206543},{"id":"https://openalex.org/C131667965","wikidata":"https://www.wikidata.org/wiki/Q445081","display_name":"Visual phototransduction","level":3,"score":0.45293503999710083},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.44715356826782227},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3971147835254669},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33118754625320435},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19196265935897827},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12240901589393616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12039506435394287},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000094742","descriptor_name":"Secreted Frizzled-Related Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099274","descriptor_name":"Frizzled-Related Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/00001756-200012180-00012","doi":"https://doi.org/10.1097/00001756-200012180-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-200012180-00012","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},{"id":"pmid:11192610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11192610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.6749","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.6749","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/41/6/1297.full.pdf","raw_type":"text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/7a2d4535-01da-4119-ac0d-bc4e1e4ab4ae","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/7a2d4535-01da-4119-ac0d-bc4e1e4ab4ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jones, S E, Jomary, C, Grist, J, Stewart, H J & Neal, M J 2000, 'Modulated expression of secreted frizzled-related proteins in human retinal degeneration', Neuroreport, vol. 11, no. 18, pp. 3963 - 3967.","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W98762308","https://openalex.org/W1971604303","https://openalex.org/W2015963628","https://openalex.org/W2068789738","https://openalex.org/W2074584047","https://openalex.org/W2183318287"],"related_works":["https://openalex.org/W1566775178","https://openalex.org/W2168002381","https://openalex.org/W3012184400","https://openalex.org/W2111852904","https://openalex.org/W1180241171","https://openalex.org/W23369194","https://openalex.org/W7096231589","https://openalex.org/W1982775497","https://openalex.org/W1427048924","https://openalex.org/W2052567517"],"abstract_inverted_index":{"Inherited":[0],"retinal":[1,118],"degenerations":[2],"such":[3],"as":[4],"retinitis":[5],"pigmentosa":[6],"(RP)":[7],"are":[8,55,88,116],"characterized":[9],"by":[10,16],"progressive":[11],"loss":[12],"of":[13,22,39,49,112],"photoreceptors,":[14],"apparently":[15],"apoptosis,":[17],"and":[18,52,86],"our":[19],"recent":[20],"report":[21],"increased":[23,97],"secreted":[24],"Frizzled-related":[25],"protein-2":[26],"(SFRP2)":[27],"in":[28,58,81,101],"RP":[29],"retinas":[30],"suggests":[31],"altered":[32],"Wnt":[33,113],"signalling":[34,115],"may":[35],"be":[36],"a":[37,82],"component":[38],"the":[40,70,76,92,108],"degenerative":[41,68],"process.":[42],"The":[43],"present":[44],"study":[45],"shows":[46],"that":[47,110],"levels":[48],"SFRPI,":[50],"SFRP3":[51],"SFRP5":[53,87],"mRNAs":[54],"also":[56],"abnormal":[57],"RP,":[59],"giving":[60],"rise":[61],"to":[62,75,91],"idiosyncratic":[63],"expression":[64,100],"patterns.":[65],"In":[66],"highly":[67],"retinas,":[69],"SFRP":[71],"proteins":[72],"localize":[73],"mainly":[74],"inner":[77],"limiting":[78],"membrane,":[79],"but":[80],"well-preserved":[83],"retina":[84],"SFRPI":[85],"notably":[89],"localized":[90],"surviving":[93],"photoreceptors.":[94],"Together":[95],"with":[96],"c-jun":[98],"mRNA":[99],"all":[102],"cases":[103],"examined,":[104],"these":[105],"results":[106],"support":[107],"notion":[109],"disruptions":[111],"network":[114],"involved":[117],"neurodegeneration.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
