{"id":"https://openalex.org/W2006462255","doi":"https://doi.org/10.1115/sbc2012-80307","title":"Investigating the Sieving and Structural Property of the Osteocyte Pericellular Matrix: Experiments and Modeling","display_name":"Investigating the Sieving and Structural Property of the Osteocyte Pericellular Matrix: Experiments and Modeling","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W2006462255","doi":"https://doi.org/10.1115/sbc2012-80307","mag":"2006462255"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2012-80307","doi":"https://doi.org/10.1115/sbc2012-80307","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80307","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaozhou Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaozhou Zhou","raw_affiliation_strings":["University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053103595","display_name":"Bin Wang","orcid":"https://orcid.org/0000-0003-0225-9393","observed_orcids":["https://orcid.org/0000-0003-0225-9393"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bin Wang","raw_affiliation_strings":["Chongqing University, Chongqing, China","University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029261960","display_name":"Christopher Price","orcid":"https://orcid.org/0000-0001-6573-6551","observed_orcids":["https://orcid.org/0000-0001-6573-6551"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Price","raw_affiliation_strings":["University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Li","raw_affiliation_strings":["University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100774962","display_name":"Jun Ping Pan","orcid":"https://orcid.org/0000-0002-5091-982X","observed_orcids":["https://orcid.org/0000-0002-5091-982X"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Pan","raw_affiliation_strings":["Chongqing University, Chongqing, China","ChongQing University, ChongQing, China#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"ChongQing University, ChongQing, China#TAB#","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107930462","display_name":"Liyun Wang","orcid":"https://orcid.org/0000-0002-6050-5911","observed_orcids":["https://orcid.org/0000-0002-6050-5911"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyun Wang","raw_affiliation_strings":["University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0984375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"541","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/bone-mechanosensing","display_name":"bone mechanosensing","score":0.6510000228881836},{"id":"https://openalex.org/keywords/lacunar-canalicular-system","display_name":"lacunar-canalicular system","score":0.7559999823570251},{"id":"https://openalex.org/keywords/proteoglycan-matrix","display_name":"proteoglycan matrix","score":0.7670000195503235},{"id":"https://openalex.org/keywords/outside-in-signaling","display_name":"outside-in signaling","score":0.5659999847412109},{"id":"https://openalex.org/keywords/bone-adaptation","display_name":"bone adaptation","score":0.47999998927116394},{"id":"https://openalex.org/keywords/molecular-sieves","display_name":"molecular sieves","score":0.3409999907016754},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.36399999260902405},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.7753386497497559},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.7037741541862488},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.628718912601471},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5370228886604309},{"id":"https://openalex.org/C72921944","wikidata":"https://www.wikidata.org/wiki/Q206621","display_name":"Drag","level":2,"score":0.5368168354034424},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5170108079910278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5143531560897827},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.41604089736938477},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.37979546189308167},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3710814416408539},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3635692298412323},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.25968390703201294},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.17621099948883057},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14367017149925232},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11548611521720886},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2012-80307","doi":"https://doi.org/10.1115/sbc2012-80307","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80307","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1581938358","https://openalex.org/W2275432660","https://openalex.org/W3120729155","https://openalex.org/W2145937652","https://openalex.org/W2945919722","https://openalex.org/W4224287259","https://openalex.org/W2155736277","https://openalex.org/W2163416267","https://openalex.org/W4200403446","https://openalex.org/W4410707602"],"abstract_inverted_index":{"Growing":[0],"evidence":[1],"shows":[2],"that":[3,16,64,96,185,201],"osteocytes,":[4],"the":[5,12,23,45,65,70,74,78,87,103,109,114,120,146,155,168,171,175,186,190,196,209,218,221,238,243,258,269,279,297,301,306,310,331,335],"most":[6],"abundant":[7],"bone":[8,24,125,340],"cells,":[9],"serve":[10],"as":[11,249,260],"primary":[13],"sensory":[14],"cells":[15],"detect":[17],"external":[18],"mechanical":[19],"forces":[20,200],"[1],":[21],"enabling":[22],"to":[25,31,37,102,111,133,223,296,329,347],"adapt":[26],"its":[27,33,39,314],"mass":[28],"and":[29,36,47,60,77,141,170,192,226,230,255,264,271,281,292,305,317,346],"structure":[30,316],"meet":[32],"environmental":[34],"requirements":[35],"fulfill":[38],"weight":[40],"bearing":[41],"functions":[42],"[2].":[43],"Although":[44],"cellular":[46],"molecular":[48,246,262],"mechanisms":[49],"of":[50,119,174,198,245,273,284,300,325,334],"such":[51,248],"adaptation":[52],"phenomena":[53],"are":[54,286],"not":[55],"fully":[56],"understood,":[57],"recent":[58],"experiments":[59],"theoretical":[61],"models":[62,179],"suggest":[63],"pericellular":[66],"matrix":[67,80,130],"(PCM)":[68],"filling":[69,129],"tiny":[71,147],"gap":[72],"between":[73,189],"cell":[75,156],"membrane":[76],"canalicular":[79],"wall":[81],"plays":[82],"a":[83,97,128,261],"critical":[84],"role":[85],"in":[86,124,145,151,288,308,312,337],"osteocytes\u2019":[88],"outside-in":[89],"signaling":[90],"process":[91],"[1].":[92],"Weinbaum":[93],"first":[94],"hypothesized":[95],"proteoglycan-like":[98],"fiber":[99],"matrix,":[100],"similar":[101],"endothelial":[104],"glycocalyx,":[105],"must":[106],"exist":[107],"within":[108],"PCM":[110,176,182,191,219,285,302,311,336,351],"account":[112],"for":[113,232],"surprisingly":[115],"long":[116],"relaxation":[117,140],"times":[118],"strain-generated":[121],"potentials":[122],"measured":[123],"[3].":[126],"Such":[127],"was":[131,328],"predicted":[132],"impose":[134],"hydraulic":[135],"resistance,":[136],"impede":[137],"fluid":[138,143,193],"pressure":[139],"reduce":[142],"flow":[144],"lacunar-canalicular":[148],"pore":[149],"system":[150],"bone,":[152],"thus":[153],"protecting":[154],"membranes":[157],"from":[158],"being":[159],"ruptured":[160],"under":[161],"shear.":[162],"Later":[163],"electronic":[164],"microscopic":[165],"studies":[166],"confirmed":[167],"existence":[169],"proteoglycan":[172],"nature":[173],"[4].":[177,322],"Previous":[178],"using":[180,353],"idealized":[181],"ultrastructure":[183],"suggested":[184],"hydrodynamic":[187],"interactions":[188],"could":[194],"determine":[195],"magnitude":[197],"drag":[199],"deform":[202],"cytoskeleton":[203],"via":[204],"tethered":[205],"transmembrane":[206],"components":[207],"or":[208],"focal":[210],"contacts":[211],"containing":[212],"integrins":[213],"[5,6].":[214],"In":[215,235],"both":[216],"scenarios,":[217],"is":[220],"key":[222],"force":[224],"transmission":[225],"strain":[227],"signal":[228],"amplification,":[229],"responsible":[231],"downstream":[233],"mechanotransduction.":[234],"addition,":[236],"once":[237],"mechanically":[239,338],"excited":[240],"osteocytes":[241],"affect":[242],"release":[244],"signals":[247],"ATP,":[250],"NO,":[251],"PGE2,":[252],"OPG,":[253],"RANKL,":[254],"sclerostin":[256],"[2],":[257],"PCM,":[259],"sieve":[263],"temporary":[265],"storage,":[266],"may":[267],"influence":[268],"transport":[270],"availability":[272],"these":[274],"bioactive":[275],"molecules":[276],"[7].":[277],"Therefore,":[278],"structural":[280],"sieving":[282,332],"properties":[283,318],"important":[287],"regulating":[289],"bone\u2019s":[290],"mechanotransduction":[291],"adaptation.":[293],"However,":[294],"due":[295],"small":[298],"dimensions":[299],"(\u223c100nm":[303],"thick)":[304],"difficulty":[307],"preserving":[309],"situ,":[313],"detailed":[315],"have":[319],"remained":[320],"elusive":[321],"The":[323],"objective":[324],"this":[326],"study":[327],"elucidate":[330],"property":[333],"loaded":[339],"with":[341],"an":[342],"innovative":[343],"imaging":[344],"approach":[345],"further":[348],"deduce":[349],"plausible":[350],"structures":[352],"mathematical":[354],"modeling.":[355]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}