{"id":"https://openalex.org/W2006447258","doi":"https://doi.org/10.1016/j.orthres.2004.12.016","title":"Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype","display_name":"Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype","publication_year":2005,"publication_date":"2005-06-05","ids":{"openalex":"https://openalex.org/W2006447258","doi":"https://doi.org/10.1016/j.orthres.2004.12.016","mag":"2006447258","pmid":"https://pubmed.ncbi.nlm.nih.gov/15936918"},"language":"en","primary_location":{"id":"doi:10.1016/j.orthres.2004.12.016","doi":"https://doi.org/10.1016/j.orthres.2004.12.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.orthres.2004.12.016","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.12.016","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.12.016","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113650041","display_name":"Rieko Yagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rieko Yagi","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA","Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA","institution_ids":["https://openalex.org/I95240055"]},{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111728384","display_name":"Denise L. McBurney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise McBurney","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006820847","display_name":"David C. Laverty","orcid":"https://orcid.org/0000-0003-0009-5508","observed_orcids":["https://orcid.org/0000-0003-0009-5508"]},"institutions":[{"id":"https://openalex.org/I1294639003","display_name":"Summa Health System","ror":"https://ror.org/03p6fpw74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294639003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Laverty","raw_affiliation_strings":["Department of Orthopaedics, Summa Health System, Akron, OH 44309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Summa Health System, Akron, OH 44309, USA","institution_ids":["https://openalex.org/I1294639003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022445308","display_name":"Scott D. Weiner","orcid":"https://orcid.org/0000-0002-3786-3315","observed_orcids":["https://orcid.org/0000-0002-3786-3315","https://orcid.org/0000-0003-3858-2854"]},"institutions":[{"id":"https://openalex.org/I1294639003","display_name":"Summa Health System","ror":"https://ror.org/03p6fpw74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294639003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Weiner","raw_affiliation_strings":["Department of Orthopaedics, Summa Health System, Akron, OH 44309, USA","Summa Health System **"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Summa Health System, Akron, OH 44309, USA","institution_ids":["https://openalex.org/I1294639003"]},{"raw_affiliation_string":"Summa Health System **","institution_ids":["https://openalex.org/I1294639003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010132216","display_name":"Walter E. Horton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walter E. Horton","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010132216"],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":5.4817,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.95901244,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"5","first_page":"1128","last_page":"1138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.7450000047683716},{"id":"https://openalex.org/keywords/chondrocyte-phenotype","display_name":"chondrocyte phenotype","score":0.9179999828338623},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8500000238418579},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":1.0},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":1.0},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.8579999804496765},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.878000020980835},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.8970000147819519},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/link-protein","display_name":"link protein","score":0.7870000004768372},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.8420000076293945},{"id":"https://openalex.org/keywords/proteoglycan-depletion","display_name":"proteoglycan depletion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cartilage-fibrillation","display_name":"cartilage fibrillation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/femoral-condyle","display_name":"femoral condyle","score":0.6499999761581421},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.8928852081298828},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8191492557525635},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8077559471130371},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6892908811569214},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.6168763041496277},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.5844801068305969},{"id":"https://openalex.org/C2781013607","wikidata":"https://www.wikidata.org/wiki/Q14877666","display_name":"Type II collagen","level":3,"score":0.5541462898254395},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.5442209243774414},{"id":"https://openalex.org/C2778486617","wikidata":"https://www.wikidata.org/wiki/Q18031654","display_name":"SOX9","level":4,"score":0.5150763392448425},{"id":"https://openalex.org/C2779457992","wikidata":"https://www.wikidata.org/wiki/Q18028707","display_name":"Lumican","level":5,"score":0.4575490355491638},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44681480526924133},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40313446521759033},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34190237522125244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34080052375793457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31099265813827515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2937409281730652},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2872561812400818},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.2870309352874756},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20706075429916382},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.17075398564338684},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.1150948703289032},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10814458131790161},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055758","descriptor_name":"SOX9 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.orthres.2004.12.016","doi":"https://doi.org/10.1016/j.orthres.2004.12.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.orthres.2004.12.016","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.12.016","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:15936918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15936918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/j.orthres.2004.12.016","doi":"https://doi.org/10.1016/j.orthres.2004.12.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.orthres.2004.12.016","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.orthres.2004.12.016","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2434819059","display_name":null,"funder_award_id":"AR-046459","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8298432324","display_name":"THE ROLE OF BCL2 PROTEINS IN CHONDROCYTE BIOLOGY","funder_award_id":"5r01ar046459-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306237","display_name":"Arthritis Foundation","ror":"https://ror.org/04zk9fe75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006447258.pdf","grobid_xml":"https://content.openalex.org/works/W2006447258.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W4996342","https://openalex.org/W206711978","https://openalex.org/W650762618","https://openalex.org/W1551310212","https://openalex.org/W1950911242","https://openalex.org/W1972218085","https://openalex.org/W1974384763","https://openalex.org/W1984038876","https://openalex.org/W1988036581","https://openalex.org/W1990513491","https://openalex.org/W1990844960","https://openalex.org/W1996467022","https://openalex.org/W2004488501","https://openalex.org/W2015996457","https://openalex.org/W2016251547","https://openalex.org/W2017385039","https://openalex.org/W2017604635","https://openalex.org/W2019983212","https://openalex.org/W2023070796","https://openalex.org/W2023156173","https://openalex.org/W2027458529","https://openalex.org/W2030780288","https://openalex.org/W2032691826","https://openalex.org/W2032896509","https://openalex.org/W2041865050","https://openalex.org/W2043479687","https://openalex.org/W2047433270","https://openalex.org/W2047636197","https://openalex.org/W2050730387","https://openalex.org/W2055316800","https://openalex.org/W2056710407","https://openalex.org/W2062522737","https://openalex.org/W2063051429","https://openalex.org/W2064454940","https://openalex.org/W2065151410","https://openalex.org/W2068183722","https://openalex.org/W2071915571","https://openalex.org/W2072874559","https://openalex.org/W2076532493","https://openalex.org/W2081563776","https://openalex.org/W2089539789","https://openalex.org/W2089860867","https://openalex.org/W2089874268","https://openalex.org/W2094193282","https://openalex.org/W2099669252","https://openalex.org/W2101787021","https://openalex.org/W2106439638","https://openalex.org/W2112882256","https://openalex.org/W2130415027","https://openalex.org/W2138847465","https://openalex.org/W2152217106","https://openalex.org/W2162584273","https://openalex.org/W2170335058","https://openalex.org/W2320063753","https://openalex.org/W2436627941","https://openalex.org/W4251725734","https://openalex.org/W4292542165"],"related_works":["https://openalex.org/W2160964180","https://openalex.org/W2508816894","https://openalex.org/W2006666256","https://openalex.org/W2122165039","https://openalex.org/W2434889057","https://openalex.org/W2056776698","https://openalex.org/W1974384763","https://openalex.org/W336702611","https://openalex.org/W1965245788","https://openalex.org/W2173165013"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2],"a":[3,13,24,181,230,289],"degenerative":[4],"cartilage":[5,34,82,92,166,216,263],"disease":[6,107],"with":[7,64,97],"varying":[8],"degrees":[9],"of":[10,18,44,60,87,120,195,220,232,258,295],"severity":[11,108],"within":[12,85],"given":[14],"joint.":[15],"The":[16,117,145,163,254],"purpose":[17],"this":[19],"study":[20,54],"was":[21,55,83,93,115,138,238],"to":[22,40,187,214],"define":[23],"sampling":[25],"procedure":[26],"for":[27,106,147,198],"comparing":[28],"human":[29],"minimal":[30,91,160,174,188,215,259],"and":[31,39,66,90,109,112,133,136,151,159,204,243,247,250,260,268,271],"advanced":[32,80,158,164,185,212,261],"OA":[33,81,161,165,175,189,262,281],"in":[35,47,70,76,184,211,217,266,273,280,291,299,304],"the":[36,57,173,193,218,221,293],"same":[37],"patient":[38,255],"determine":[41],"basic":[42],"patterns":[43],"gene":[45,274],"expression":[46,58,69,118,179,228,275,294],"these":[48],"regions.":[49],"A":[50,234],"specific":[51,122],"hypothesis":[52],"under":[53],"that":[56,276],"level":[59,119,194],"Bcl-2":[61,242,249,285],"would":[62],"correlate":[63],"Sox9":[65,203,244,298],"aggrecan":[67,251,296],"mRNA":[68,178,196,227,245,252],"vivo":[71,300],"as":[72,301,303],"has":[73],"been":[74],"demonstrated":[75],"vitro.":[77,305],"Femoral":[78],"condylar":[79],"located":[84],"1cm":[86],"overt":[88],"lesions,":[89],"taken":[94],"from":[95],"areas":[96],"no":[98],"obvious":[99],"surface":[100],"defects.":[101],"Histological":[102],"sections":[103],"were":[104,154,208],"scored":[105],"chondroitin":[110,170],"sulfate":[111,171],"hydroxyproline":[113],"content":[114],"determined.":[116],"nine":[121],"genes":[123],"(aggrecan,":[124],"collagen":[125],"type":[126,225],"II,":[127],"Bcl-2,":[128,202],"Sox9,":[129],"Link":[130],"protein,":[131,201],"osteopontin,":[132],"MMP-13,":[134],"-3,":[135],"-9)":[137],"determined":[139],"by":[140],"quantitative":[141],"real":[142],"time":[143],"PCR.":[144],"scores":[146],"fibrillation,":[148],"chondrocyte":[149],"cloning,":[150],"proteoglycan":[152],"depletion":[153],"significantly":[155,168],"different":[156],"between":[157,241,248],"cartilage.":[162,176,190],"had":[167],"less":[169],"than":[172],"Osteopontin":[177],"showed":[180],"3.6-fold":[182],"increase":[183],"compared":[186,213],"In":[191,283],"contrast,":[192],"coding":[197],"aggrecan,":[199],"link":[200],"MMP-3,":[205],"-9,":[206],"-13":[207],"all":[209],"decreased":[210],"majority":[219],"patients":[222],"studied.":[223],"Collagen":[224],"II":[226],"displayed":[229],"wide-range":[231],"variation.":[233],"statistically":[235],"significant":[236],"correlation":[237],"observed":[239],"both":[240],"level,":[246],"expression.":[253],"matched":[256],"comparison":[257],"revealed":[264],"differences":[265],"cellular":[267],"tissue":[269],"characteristics,":[270],"changes":[272],"may":[277,286],"be":[278],"involved":[279],"progression.":[282],"addition,":[284],"also":[287],"play":[288],"role":[290],"regulating":[292],"through":[297],"well":[302]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}