{"id":"https://openalex.org/W2006431667","doi":"https://doi.org/10.1021/bi900670d","title":"Structure-Dependent Charge Density as a Determinant of Antimicrobial Activity of Peptide Analogues of Defensin","display_name":"Structure-Dependent Charge Density as a Determinant of Antimicrobial Activity of Peptide Analogues of Defensin","publication_year":2009,"publication_date":"2009-07-06","ids":{"openalex":"https://openalex.org/W2006431667","doi":"https://doi.org/10.1021/bi900670d","mag":"2006431667","pmid":"https://pubmed.ncbi.nlm.nih.gov/19580334"},"language":"en","primary_location":{"id":"doi:10.1021/bi900670d","doi":"https://doi.org/10.1021/bi900670d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi900670d","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111633855","display_name":"Yang Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yang Bai","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048275793","display_name":"Shouping Liu","orcid":"https://orcid.org/0000-0003-2415-076X","observed_orcids":["https://orcid.org/0000-0003-2415-076X"]},"institutions":[{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shouping Liu","raw_affiliation_strings":["Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ping Jiang","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674991","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0001-5893-6002","observed_orcids":["https://orcid.org/0000-0001-5893-6002","https://orcid.org/0000-0001-8251-3974","https://orcid.org/0009-0007-9394-309X"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336759","display_name":"Jing Li","orcid":"https://orcid.org/0000-0001-5860-0605","observed_orcids":["https://orcid.org/0000-0001-5860-0605"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110338979","display_name":"Charles Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Charles Tang","raw_affiliation_strings":["Department of Pathology, Pharmaceutical Microbiology Laboratory, Singapore General Hospital, Singapore 168751"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Pharmaceutical Microbiology Laboratory, Singapore General Hospital, Singapore 168751","institution_ids":["https://openalex.org/I2251586001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045760818","display_name":"Chandra Shekhar Verma","orcid":"https://orcid.org/0000-0003-0733-9798","observed_orcids":["https://orcid.org/0000-0003-0733-9798","https://orcid.org/0000-0003-2319-9510"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chandra Verma","raw_affiliation_strings":["Bioinformatics Institute (A-STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (A-STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071286986","display_name":"Yuguang Mu","orcid":"https://orcid.org/0000-0002-2499-026X","observed_orcids":["https://orcid.org/0000-0002-2499-026X"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Yuguang Mu","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007551999","display_name":"Roger Wilmer Beuerman","orcid":"https://orcid.org/0000-0002-0725-9336","observed_orcids":["https://orcid.org/0000-0002-0725-9336"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I4210116917","display_name":"Singapore Eye Research Institute","ror":"https://ror.org/02crz6e12","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4210116917"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Roger W. Beuerman","raw_affiliation_strings":["Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074","School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459","Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459","institution_ids":["https://openalex.org/I172675005"]},{"raw_affiliation_string":"Singapore Eye Research Institute, 11 Third Hospital Avenue, #06-00, Singapore 168751","institution_ids":["https://openalex.org/I4210116917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111700424","display_name":"Konstantin V. Pervushin","orcid":"https://orcid.org/0000-0002-6393-4340","observed_orcids":["https://orcid.org/0000-0002-6393-4340","https://orcid.org/0000-0003-1654-8583"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Konstantin Pervushin","raw_affiliation_strings":["School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007551999","https://openalex.org/A5071286986","https://openalex.org/A5111700424"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I172675005","https://openalex.org/I4210116917"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.3482,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.95819257,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"48","issue":"30","first_page":"7229","last_page":"7239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/defensins","display_name":"defensins","score":0.8180000185966492},{"id":"https://openalex.org/keywords/human-beta-defensin-3","display_name":"human beta-defensin 3","score":0.9729999899864197},{"id":"https://openalex.org/keywords/peptide-analogs","display_name":"peptide analogues","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8930000066757202},{"id":"https://openalex.org/keywords/charge-density","display_name":"charge density","score":0.800000011920929},{"id":"https://openalex.org/keywords/peptide-structure","display_name":"peptide structure","score":0.5929999947547913},{"id":"https://openalex.org/keywords/lipid-bilayer-binding","display_name":"lipid bilayer binding","score":0.5149999856948853},{"id":"https://openalex.org/keywords/lipid-bicelles","display_name":"lipid bicelles","score":0.7039999961853027},{"id":"https://openalex.org/keywords/dodecylphosphocholine","display_name":"dodecylphosphocholine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lipid-peptide-interactions","display_name":"peptide-lipid interactions","score":0.7149999737739563},{"id":"https://openalex.org/keywords/peptide-dimerization","display_name":"peptide dimerization","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cationic-peptides","display_name":"cationic peptides","score":0.6340000033378601},{"id":"https://openalex.org/keywords/host-innate-immunity","display_name":"host innate immunity","score":0.6800000071525574},{"id":"https://openalex.org/keywords/antimicrobial-peptide-design","display_name":"antimicrobial peptide design","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7304202318191528},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7299388647079468},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.7109229564666748},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.587407648563385},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.538740336894989},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5375774502754211},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.5140591859817505},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5041948556900024},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.48849332332611084},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.48060986399650574},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4780728816986084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4461899995803833},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4440813660621643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19069916009902954},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11521050333976746},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08260142803192139}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi900670d","doi":"https://doi.org/10.1021/bi900670d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi900670d","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:19580334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19580334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W55627219","https://openalex.org/W1505446510","https://openalex.org/W1580859983","https://openalex.org/W1895129045","https://openalex.org/W1964611156","https://openalex.org/W1964763038","https://openalex.org/W1968376152","https://openalex.org/W1975580333","https://openalex.org/W1979367016","https://openalex.org/W1983521156","https://openalex.org/W1989422057","https://openalex.org/W1990519548","https://openalex.org/W1998721601","https://openalex.org/W1998825758","https://openalex.org/W2000563070","https://openalex.org/W2002195659","https://openalex.org/W2003361945","https://openalex.org/W2007744639","https://openalex.org/W2009939017","https://openalex.org/W2019513270","https://openalex.org/W2025829142","https://openalex.org/W2026885029","https://openalex.org/W2029880915","https://openalex.org/W2030739599","https://openalex.org/W2046704370","https://openalex.org/W2054205048","https://openalex.org/W2056039068","https://openalex.org/W2063116767","https://openalex.org/W2068717425","https://openalex.org/W2070847413","https://openalex.org/W2072705503","https://openalex.org/W2074731052","https://openalex.org/W2075873057","https://openalex.org/W2077814131","https://openalex.org/W2079611746","https://openalex.org/W2083183071","https://openalex.org/W2084175456","https://openalex.org/W2090459158","https://openalex.org/W2099107614","https://openalex.org/W2101724872","https://openalex.org/W2108792803","https://openalex.org/W2110733672","https://openalex.org/W2124347634","https://openalex.org/W2129997556","https://openalex.org/W2130974803","https://openalex.org/W2140922100","https://openalex.org/W2155324715","https://openalex.org/W2159359219","https://openalex.org/W2161964027","https://openalex.org/W2164270482","https://openalex.org/W2164371312","https://openalex.org/W2170921880","https://openalex.org/W2171268876","https://openalex.org/W4211190410"],"related_works":["https://openalex.org/W1939969132","https://openalex.org/W2083845392","https://openalex.org/W1982218254","https://openalex.org/W860561067","https://openalex.org/W2078793544","https://openalex.org/W3216410266","https://openalex.org/W2912100491","https://openalex.org/W2988803200","https://openalex.org/W2108792803","https://openalex.org/W2030739599"],"abstract_inverted_index":{"Defensins":[0],"are":[1,31,45],"small":[2,40],"(3-5":[3],"kDa)":[4],"cysteine-rich":[5],"cationic":[6],"proteins":[7],"found":[8,160],"in":[9,95],"both":[10],"vertebrates":[11],"and":[12,26,75,101,111,121,127,132],"invertebrates":[13],"constituting":[14],"the":[15,88,105,118,124,128,165,177],"front":[16],"line":[17],"of":[18,29,61,66,81,109,144,179],"host":[19,55],"innate":[20],"immunity.":[21],"Despite":[22],"intensive":[23],"research,":[24],"bactericidal":[25,49],"cytotoxic":[27],"mechanisms":[28],"defensins":[30,44],"still":[32],"largely":[33],"unknown.":[34],"Moreover,":[35],"we":[36],"recently":[37],"demonstrated":[38],"that":[39,83,117],"peptides":[41,85],"derived":[42],"from":[43],"even":[46],"more":[47],"potent":[48],"agents":[50],"with":[51,138,164],"less":[52],"toxicity":[53],"toward":[54],"cells.":[56,113],"In":[57],"this":[58],"paper,":[59],"structures":[60,135],"three":[62],"C-terminal":[63],"(R36-K45)":[64],"analogues":[65],"human":[67],"beta-defensin-3":[68],"were":[69,93],"studied":[70],"by":[71,155],"1H":[72],"NMR":[73],"spectroscopy":[74],"extensive":[76],"molecular":[77],"dynamics":[78],"simulations.":[79],"Because":[80],"indications":[82],"these":[84],"might":[86],"target":[87],"inner":[89],"bacterial":[90,112],"membrane,":[91],"they":[92],"reconstituted":[94],"dodecylphosphocholine":[96],"or":[97],"dodecylphosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]":[98],"mixed":[99],"micelles,":[100],"lipid":[102,125,139],"bicelles":[103],"mimicking":[104],"phospholipid-constituted":[106],"bilayer":[107],"membrane":[108],"mammalian":[110],"The":[114,150],"results":[115],"show":[116],"binding":[119],"affinity":[120],"partitioning":[122],"into":[123],"phase":[126],"ability":[129],"to":[130,142,161],"dimerize":[131],"accrete":[133],"well-defined":[134],"upon":[136],"interactions":[137],"membranes":[140],"contribute":[141],"compactization":[143],"positive":[145],"charges":[146],"within":[147],"peptide":[148,151],"oligomers.":[149],"charge":[152],"density,":[153],"mediated":[154],"corresponding":[156],"three-dimensional":[157],"structures,":[158],"was":[159],"directly":[162],"correlate":[163],"antimicrobial":[166,181],"activity.":[167],"These":[168],"novel":[169],"observations":[170],"may":[171],"provide":[172],"a":[173],"new":[174],"rationale":[175],"for":[176],"design":[178],"improved":[180],"agents.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
