{"id":"https://openalex.org/W2006429969","doi":"https://doi.org/10.1002/cncr.10832","title":"Characteristics and outcome of patients with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia","display_name":"Characteristics and outcome of patients with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia","publication_year":2002,"publication_date":"2002-10-03","ids":{"openalex":"https://openalex.org/W2006429969","doi":"https://doi.org/10.1002/cncr.10832","mag":"2006429969","pmid":"https://pubmed.ncbi.nlm.nih.gov/12365015"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.10832","doi":"https://doi.org/10.1002/cncr.10832","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.10832","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10832","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10832","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060552661","display_name":"Francesco Onida","orcid":"https://orcid.org/0000-0002-2991-3474","observed_orcids":["https://orcid.org/0000-0002-2991-3474"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesco Onida","raw_affiliation_strings":["Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001705395","display_name":"Greg Ball","orcid":"https://orcid.org/0000-0001-5626-904X","observed_orcids":["https://orcid.org/0000-0001-5626-904X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Ball","raw_affiliation_strings":["Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M. Kantarjian","raw_affiliation_strings":["Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112029632","display_name":"Terry L. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry L. Smith","raw_affiliation_strings":["Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110518576","display_name":"Armand B. Glassman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armand Glassman","raw_affiliation_strings":["Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027800341","display_name":"Maher X. Albitar","orcid":"https://orcid.org/0000-0002-0050-2030","observed_orcids":["https://orcid.org/0000-0002-0050-2030","https://orcid.org/0000-0001-7661-9537"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maher Albitar","raw_affiliation_strings":["Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030706737","display_name":"Barbara Scappini","orcid":"https://orcid.org/0000-0002-4162-0009","observed_orcids":["https://orcid.org/0000-0002-4162-0009"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Scappini","raw_affiliation_strings":["Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109262636","display_name":"Mary Beth Rios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Beth Rios","raw_affiliation_strings":["Department of Leukemia , Box 428 , The University of Texas M. D. Anderson Cancer Center , 1515 Holcombe Boulevard , Houston , TX 77030 ;","Department of Leukemia,The University of Texas M.D. Anderson Cancer Center,Houston,Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia , Box 428 , The University of Texas M. D. Anderson Cancer Center , 1515 Holcombe Boulevard , Houston , TX 77030 ;","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Leukemia,The University of Texas M.D. Anderson Cancer Center,Houston,Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027575595","display_name":"Michael J. Keating","orcid":"https://orcid.org/0000-0002-9121-6450","observed_orcids":["https://orcid.org/0000-0002-9121-6450","https://orcid.org/0000-0002-4008-9893"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Keating","raw_affiliation_strings":["Department of Leukemia , Box 428 , The University of Texas M. D. Anderson Cancer Center , 1515 Holcombe Boulevard , Houston , TX 77030 ;","Department of Leukemia,The University of Texas M.D. Anderson Cancer Center,Houston,Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia , Box 428 , The University of Texas M. D. Anderson Cancer Center , 1515 Holcombe Boulevard , Houston , TX 77030 ;","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Leukemia,The University of Texas M.D. Anderson Cancer Center,Houston,Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014102823","display_name":"Miloslav Beran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Miloslav Beran","raw_affiliation_strings":["","Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014102823"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.6475,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.6763044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"95","issue":"8","first_page":"1673","last_page":"1684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6899999976158142},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8059999942779541},{"id":"https://openalex.org/keywords/blastic-transformation","display_name":"blastic transformation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/trisomy-8","display_name":"trisomy 8","score":0.9440000057220459},{"id":"https://openalex.org/keywords/complex-chromosomal-abnormalities","display_name":"complex chromosomal abnormalities","score":0.7689999938011169},{"id":"https://openalex.org/keywords/monosomy-7","display_name":"monosomy 7","score":0.871999979019165},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.8410000205039978},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.5460000038146973},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7672510743141174},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.7565354108810425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6645105481147766},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.6403956413269043},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5403035879135132},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5254101753234863},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.5190597176551819},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5034779906272888},{"id":"https://openalex.org/C2780365373","wikidata":"https://www.wikidata.org/wiki/Q2454191","display_name":"Trisomy 8","level":5,"score":0.48950421810150146},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4708808362483978},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44529467821121216},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42404651641845703},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.3899228572845459},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33626848459243774},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2899436950683594},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.26382365822792053},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.11983305215835571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08886748552322388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08835256099700928},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016313","descriptor_name":"Genes, abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054438","descriptor_name":"Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054438","descriptor_name":"Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.10832","doi":"https://doi.org/10.1002/cncr.10832","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.10832","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10832","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:12365015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12365015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cncr.10832","doi":"https://doi.org/10.1002/cncr.10832","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.10832","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.10832","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006429969.pdf","grobid_xml":"https://content.openalex.org/works/W2006429969.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W39467412","https://openalex.org/W53178620","https://openalex.org/W54286179","https://openalex.org/W110944710","https://openalex.org/W131463769","https://openalex.org/W143424147","https://openalex.org/W170068962","https://openalex.org/W585439232","https://openalex.org/W994031148","https://openalex.org/W1487237305","https://openalex.org/W1515452591","https://openalex.org/W1527623537","https://openalex.org/W1548477840","https://openalex.org/W1582301735","https://openalex.org/W1603236395","https://openalex.org/W1679570532","https://openalex.org/W1691946357","https://openalex.org/W1799579309","https://openalex.org/W1829333924","https://openalex.org/W1979300931","https://openalex.org/W1981696481","https://openalex.org/W1983392832","https://openalex.org/W1984988545","https://openalex.org/W1986086620","https://openalex.org/W1991534121","https://openalex.org/W1995647148","https://openalex.org/W1996550140","https://openalex.org/W1997091454","https://openalex.org/W1998593414","https://openalex.org/W2002613149","https://openalex.org/W2010207364","https://openalex.org/W2010699843","https://openalex.org/W2016164162","https://openalex.org/W2018312242","https://openalex.org/W2019130358","https://openalex.org/W2020252485","https://openalex.org/W2031495167","https://openalex.org/W2034646423","https://openalex.org/W2036180570","https://openalex.org/W2038952853","https://openalex.org/W2040280296","https://openalex.org/W2047197470","https://openalex.org/W2056454565","https://openalex.org/W2064523439","https://openalex.org/W2068179361","https://openalex.org/W2072583409","https://openalex.org/W2074645148","https://openalex.org/W2074908271","https://openalex.org/W2085077030","https://openalex.org/W2089483984","https://openalex.org/W2090727662","https://openalex.org/W2093102589","https://openalex.org/W2094674244","https://openalex.org/W2104485296","https://openalex.org/W2107436056","https://openalex.org/W2110007614","https://openalex.org/W2116453632","https://openalex.org/W2126524003","https://openalex.org/W2146580621","https://openalex.org/W2148775668","https://openalex.org/W2156568059","https://openalex.org/W2272476958","https://openalex.org/W2276472705","https://openalex.org/W2303212700","https://openalex.org/W2314938037","https://openalex.org/W2325556817","https://openalex.org/W2339359539","https://openalex.org/W2339475636","https://openalex.org/W2396079853","https://openalex.org/W2407465084","https://openalex.org/W2408172393","https://openalex.org/W2409390161","https://openalex.org/W2412509587","https://openalex.org/W2465846258","https://openalex.org/W2472561355","https://openalex.org/W2596224382","https://openalex.org/W3041047318","https://openalex.org/W3117567585","https://openalex.org/W3147894994","https://openalex.org/W4230607497","https://openalex.org/W4234688365","https://openalex.org/W4253476700","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2074645148","https://openalex.org/W2085077030","https://openalex.org/W1995647148","https://openalex.org/W2188890062","https://openalex.org/W1603236395","https://openalex.org/W2090727662","https://openalex.org/W2412509587","https://openalex.org/W2068179361","https://openalex.org/W1582301735","https://openalex.org/W2044496404"],"abstract_inverted_index":{"BACKGROUND:":[0],"Up":[1],"to":[2],"5%":[3],"of":[4,28,64,85,104,128,148,169,249],"patients":[5,40,66,106,152,235],"with":[6,41,67,82,94,107,173,223,246,266],"chronic":[7],"myelogenous":[8],"leukemia":[9],"(CML)":[10],"do":[11],"not":[12,54,113,189,193],"have":[13,47],"the":[14,25,83,116,129,133,138,146,149,170,176],"Philadelphia":[15],"(Ph)":[16],"translocation":[17],"t(9;22)(q34;q11)":[18],"or":[19,75],"a":[20,48,237,242,261,276],"bcr/abl":[21,44,68,117,134],"molecular":[22],"rearrangement.":[23],"Although":[24],"diagnostic":[26],"criteria":[27],"this":[29],"entity":[30,264],"are":[31,273],"still":[32],"under":[33],"debate,":[34],"there":[35],"is":[36,53,260],"general":[37],"agreement":[38],"that":[39,52],"Ph":[42,108],"negative,":[43],"negative":[45,69,109,135,258],"CML":[46,70,110,259],"severe":[49,212],"clinical":[50,87,263],"course":[51],"affected":[55,194],"significantly":[56,195],"by":[57,96,196],"current":[58],"treatment":[59],"options.":[60],"METHODS:":[61],"A":[62,102,230],"population":[63],"76":[65,171],"who":[71,111],"had":[72,154],"received":[73],"minimal":[74],"no":[76],"previous":[77],"therapy":[78],"was":[79,121,142,188,192],"characterized":[80],"carefully":[81],"intent":[84],"investigating":[86],"and":[88,91,99,124,156,185,211,241,252,285],"hematologic":[89],"variables":[90,222],"their":[92],"association":[93],"survival":[95,141],"univariate,":[97],"correlation,":[98],"multivariate":[100],"analyses.":[101],"group":[103,239,244],"73":[105],"were":[112,165,183],"tested":[114],"for":[115,126,227],"rearrangement":[118],"(bcr/abl":[119],"unknown)":[120],"analyzed":[122],"separately":[123],"used":[125],"extension":[127],"analysis.":[130],"RESULTS:":[131],"In":[132],"patient":[136],"population,":[137],"median":[139,247],"overall":[140],"24":[143],"months.":[144],"At":[145],"time":[147],"analysis,":[150],"38":[151,250],"(50%)":[153],"died,":[155],"blastic":[157],"transformation":[158],"preceded":[159],"death":[160],"in":[161,167],"31%.":[162],"Chromosomal":[163],"abnormalities":[164,182],"found":[166],"30%":[168],"patients,":[172],"trisomy":[174],"8":[175],"most":[177],"common":[178],"abnormality.":[179],"Complex":[180],"chromosomal":[181],"rare,":[184],"monosomy":[186],"7":[187],"observed.":[190],"Survival":[191],"treatment.":[197],"Multivariate":[198],"analysis":[199],"identified":[200],"older":[201],"age":[202],"(>":[203],"65":[204],"years),":[205],"anemia":[206],"(hemoglobin":[207],"<":[208],"10":[209],"g/dL),":[210],"leukocytosis":[213],"(white":[214],"blood":[215],"cells":[216],">":[217],"50":[218],"x":[219],"10(9)/L)":[220],"as":[221],"independent":[224],"prognostic":[225,231],"significance":[226],"poor":[228,268],"survival.":[229],"scoring":[232,278],"system":[233,279],"stratified":[234],"into":[236],"low-risk":[238],"(53%)":[240],"high-risk":[243],"(47%),":[245],"survivals":[248],"months":[251],"9":[253],"months,":[254],"respectively.":[255],"CONCLUSIONS:":[256],"Bcr/abl":[257],"distinct":[262],"associated":[265],"very":[267],"prognosis.":[269],"Two":[270],"risk":[271],"categories":[272],"identifiable":[274],"using":[275],"simple":[277],"based":[280],"on":[281],"age,":[282],"hemoglobin":[283],"level,":[284],"leukocyte":[286],"number.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}