{"id":"https://openalex.org/W2006387906","doi":"https://doi.org/10.1210/endo.130.3.1537299","title":"Paradoxical responses of hypothalamic corticotropin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial proopiomelanocortin mRNA during chronic inflammatory stress","display_name":"Paradoxical responses of hypothalamic corticotropin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial proopiomelanocortin mRNA during chronic inflammatory stress","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2006387906","doi":"https://doi.org/10.1210/endo.130.3.1537299","mag":"2006387906","pmid":"https://pubmed.ncbi.nlm.nih.gov/1537299"},"language":"en","primary_location":{"id":"doi:10.1210/endo.130.3.1537299","doi":"https://doi.org/10.1210/endo.130.3.1537299","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.130.3.1537299","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109920610","display_name":"Michael S. Harbuz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S Harbuz","raw_affiliation_strings":["Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028489654","display_name":"Richard G. Rees","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R G Rees","raw_affiliation_strings":["Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112224086","display_name":"D.J.A. Eckland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Eckland","raw_affiliation_strings":["Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109814596","display_name":"D. S. Jessop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D S Jessop","raw_affiliation_strings":["Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113636771","display_name":"D. A. Brewerton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Brewerton","raw_affiliation_strings":["Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017571758","display_name":"Stafford Louis Lightman","orcid":"https://orcid.org/0000-0002-8546-9646","observed_orcids":["https://orcid.org/0000-0002-8546-9646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Lightman","raw_affiliation_strings":["Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroendocrinology Unit, Charing Cross and Westminster Medical School, London, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":9.0239,"has_fulltext":false,"cited_by_count":206,"citation_normalized_percentile":{"value":0.98897464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"130","issue":"3","first_page":"1394","last_page":"1400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypothalamic-paraventricular-nucleus","display_name":"hypothalamic paraventricular nucleus","score":0.8349999785423279},{"id":"https://openalex.org/keywords/adjuvant-induced-arthritis","display_name":"adjuvant-induced arthritis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mycobacterial-adjuvant","display_name":"mycobacterial adjuvant","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.843999981880188},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.7789999842643738},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9190000295639038},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.6240000128746033},{"id":"https://openalex.org/keywords/pvg-rats","display_name":"PVG rats","score":0.6190000176429749},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.9597291946411133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8893028497695923},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8883757591247559},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.6839006543159485},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6501848697662354},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6295969486236572},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.6045286655426025},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5532248020172119},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.5119119882583618},{"id":"https://openalex.org/C2778458438","wikidata":"https://www.wikidata.org/wiki/Q386664","display_name":"Corticotropin-releasing hormone","level":3,"score":0.48330095410346985},{"id":"https://openalex.org/C2780090379","wikidata":"https://www.wikidata.org/wiki/Q419119","display_name":"Prohormone","level":3,"score":0.4805184304714203},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.44643792510032654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38412582874298096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2858850955963135},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21306374669075012},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.20176514983177185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05647358298301697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001170","descriptor_name":"Arthritis, Infectious","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001170","descriptor_name":"Arthritis, Infectious","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003346","descriptor_name":"Corticotropin-Releasing Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003959","descriptor_name":"Diamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007271","descriptor_name":"Injections, Intradermal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007369","descriptor_name":"Interferon Inducers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009164","descriptor_name":"Mycobacterium Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011333","descriptor_name":"Pro-Opiomelanocortin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/endo.130.3.1537299","doi":"https://doi.org/10.1210/endo.130.3.1537299","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.130.3.1537299","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.130.3.1394","doi":"https://doi.org/10.1210/en.130.3.1394","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.130.3.1394","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:1537299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1537299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1970523903","https://openalex.org/W1995525962","https://openalex.org/W1998405496","https://openalex.org/W2001512814","https://openalex.org/W2020713540","https://openalex.org/W2024285133","https://openalex.org/W2025243321","https://openalex.org/W2027498069","https://openalex.org/W2050815672","https://openalex.org/W2072568231","https://openalex.org/W2084736187","https://openalex.org/W2087381547","https://openalex.org/W2089560571"],"related_works":["https://openalex.org/W2050517674","https://openalex.org/W2297764895","https://openalex.org/W7098688671","https://openalex.org/W2054650955","https://openalex.org/W2096305168","https://openalex.org/W2002339478","https://openalex.org/W2024402521","https://openalex.org/W4255483509","https://openalex.org/W2056185263","https://openalex.org/W1975498688"],"abstract_inverted_index":{"We":[0],"have":[1],"determined":[2],"the":[3,7,15,28,40,54,75,86,99,107,135,144,156,164,167,178,195,203,225,256],"time":[4,29],"course":[5],"of":[6,10,17,30,32,43,101,106,166,202,208,227,238,259],"neuroendocrine":[8],"response":[9],"Piebald-Viral-Glaxo":[11],"(PVG)":[12],"rats":[13,160],"during":[14],"development":[16,100],"mycobacterially":[18,33],"induced":[19,34],"adjuvant":[20,120,185],"arthritis.":[21,168],"Anterior":[22],"pituitary":[23,197],"POMC":[24,132,192,244],"mRNA":[25,52,133,142,193,245,251],"increased":[26,114,249],"at":[27],"onset":[31],"arthritis,":[35,102],"but,":[36],"paradoxically,":[37],"coincident":[38],"with":[39,59,98,248],"first":[41],"signs":[42],"arthritis":[44],"there":[45,65,210,219],"was":[46,66,88,91,111,173,211],"a":[47,67,138,149,188,235,239],"consistent":[48],"fall":[49,61],"in":[50,53,62,70,94,131,134,140,143,151,158,187,191,194,215,224,229,242,270],"CRF":[51,63,141,216,230,250,261],"hypothalamic":[55,145],"paraventricular":[56,146],"nucleus.":[57],"Coincident":[58],"this":[60,206,271],"message,":[64],"corresponding":[68,213],"decrease":[69,139,150],"CRF-41":[71,152],"peptide":[72,153,253],"release":[73,84,154],"into":[74,85,155],"hypophysial":[76],"portal":[77],"blood":[78],"(HPB).":[79],"In":[80,181,205,255],"contrast,":[81],"however,":[82],"vasopressin":[83,171],"HPB":[87,157],"increased.":[89],"There":[90],"an":[92,129],"increase":[93,130,190,241],"adrenal":[95],"weight":[96],"associated":[97,247],"reflecting":[103],"chronic":[104],"activation":[105],"HPA":[108],"axis,":[109],"which":[110,122],"reflected":[112],"by":[113],"circulating":[115],"corticosterone":[116],"concentrations.":[117],"The":[118,169,267],"synthetic":[119],"CP20961,":[121],"has":[123],"different":[124,176],"antigenic":[125],"determinants,":[126],"also":[127],"caused":[128],"anterior":[136,196],"pituitary,":[137],"nucleus,":[147],"and":[148],"PVG":[159,257],"28":[161,198],"days":[162,199],"after":[163,200],"induction":[165],"arginine":[170],"level":[172],"not":[174,246],"significantly":[175],"from":[177],"control":[179],"value.":[180],"Sprague-Dawley":[182],"rats,":[183],"mycobacterial":[184],"resulted":[186],"similar":[189],"injection":[201],"adjuvant.":[204],"strain":[207,222,258],"rat":[209],"no":[212],"change":[214,228],"mRNA.":[217],"While":[218],"are":[220,273],"some":[221],"differences":[223],"degree":[226],"mRNA,":[231],"both":[232],"strains":[233],"showed":[234],"common":[236],"paradox":[237],"marked":[240],"adenohypophyseal":[243],"or":[252],"release.":[254],"rat,":[260],"actually":[262],"appears":[263],"to":[264],"be":[265],"inhibited.":[266],"mechanisms":[268],"involved":[269],"disparity":[272],"unclear.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
