{"id":"https://openalex.org/W2006379986","doi":"https://doi.org/10.1016/0006-291x(78)91369-4","title":"Denaturation of cytochrome P-450 by cyclophosphamide metabolites","display_name":"Denaturation of cytochrome P-450 by cyclophosphamide metabolites","publication_year":1978,"publication_date":"1978-08-01","ids":{"openalex":"https://openalex.org/W2006379986","doi":"https://doi.org/10.1016/0006-291x(78)91369-4","mag":"2006379986","pmid":"https://pubmed.ncbi.nlm.nih.gov/697865"},"language":"en","primary_location":{"id":"doi:10.1016/0006-291x(78)91369-4","doi":"https://doi.org/10.1016/0006-291x(78)91369-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-291x(78)91369-4","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031507553","display_name":"Anthony J. Marinello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.J. Marinello","raw_affiliation_strings":["Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","Southern Research Institute (RFS) Birmingham, Alabama 35205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Southern Research Institute (RFS) Birmingham, Alabama 35205 USA","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112415769","display_name":"Hira L. Gurtoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H.L. Gurtoo","raw_affiliation_strings":["Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","Southern Research Institute (RFS) Birmingham, Alabama 35205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Southern Research Institute (RFS) Birmingham, Alabama 35205 USA","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061417895","display_name":"Robert F. Struck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.F. Struck","raw_affiliation_strings":["Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","Southern Research Institute (RFS) Birmingham, Alabama 35205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Southern Research Institute (RFS) Birmingham, Alabama 35205 USA","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108948091","display_name":"B. Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Paul","raw_affiliation_strings":["Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","Southern Research Institute (RFS) Birmingham, Alabama 35205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Grace Cancer Drug Center (AJM, HLG AND BP) Roswell Park Memorial Institute Buffalo, New York 14263 USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Southern Research Institute (RFS) Birmingham, Alabama 35205 USA","institution_ids":["https://openalex.org/I108109523"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112415769"],"corresponding_institution_ids":["https://openalex.org/I108109523","https://openalex.org/I1292894508"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":3.5725,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.91577106,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"83","issue":"4","first_page":"1347","last_page":"1353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophosphamide-metabolites","display_name":"cyclophosphamide metabolites","score":0.890999972820282},{"id":"https://openalex.org/keywords/acrolein","display_name":"acrolein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/phosphoramide-mustard","display_name":"phosphoramide mustard","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ifosfamide","display_name":"ifosfamide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.8600000143051147},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.7820000052452087},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8245434761047363},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.7892922163009644},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7821199893951416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7657463550567627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5500891208648682},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5035895705223083},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.48761358857154846},{"id":"https://openalex.org/C2780422782","wikidata":"https://www.wikidata.org/wiki/Q342790","display_name":"Acrolein","level":3,"score":0.4583650529384613},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33081674575805664},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2846272587776184},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2347847819328308},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000171","descriptor_name":"Acrolein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010752","descriptor_name":"Phosphoramide Mustards","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-291x(78)91369-4","doi":"https://doi.org/10.1016/0006-291x(78)91369-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-291x(78)91369-4","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:697865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/697865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1503334168","https://openalex.org/W1635142128","https://openalex.org/W1775749144","https://openalex.org/W1986026417","https://openalex.org/W2002409888","https://openalex.org/W2021169562","https://openalex.org/W2043154857","https://openalex.org/W2061326217","https://openalex.org/W2064457286","https://openalex.org/W2076404680","https://openalex.org/W2141440856","https://openalex.org/W2437901053","https://openalex.org/W4234017622","https://openalex.org/W4290174497"],"related_works":["https://openalex.org/W1544197713","https://openalex.org/W2015438178","https://openalex.org/W2142896220","https://openalex.org/W2031784658","https://openalex.org/W2000864542","https://openalex.org/W2316700862","https://openalex.org/W1992170407","https://openalex.org/W1984457522","https://openalex.org/W2056110311","https://openalex.org/W1998348867"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
