{"id":"https://openalex.org/W2006366129","doi":"https://doi.org/10.1371/journal.pone.0098354","title":"Should Expectations about the Rate of New Antiretroviral Drug Development Impact the Timing of HIV Treatment Initiation and Expectations about Treatment Benefits?","display_name":"Should Expectations about the Rate of New Antiretroviral Drug Development Impact the Timing of HIV Treatment Initiation and Expectations about Treatment Benefits?","publication_year":2014,"publication_date":"2014-06-25","ids":{"openalex":"https://openalex.org/W2006366129","doi":"https://doi.org/10.1371/journal.pone.0098354","mag":"2006366129","pmid":"https://pubmed.ncbi.nlm.nih.gov/24963883"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0098354","doi":"https://doi.org/10.1371/journal.pone.0098354","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0098354","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0098354&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0098354&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022344291","display_name":"Amin Khademi","orcid":"https://orcid.org/0000-0002-5281-8715","observed_orcids":["https://orcid.org/0000-0002-5281-8715"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amin Khademi","raw_affiliation_strings":["Department of Industrial Engineering, Clemson University, Clemson, South Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, Clemson University, Clemson, South Carolina, United States of America","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042602382","display_name":"Ronald Scott Braithwaite","orcid":"https://orcid.org/0000-0001-7067-3655","observed_orcids":["https://orcid.org/0000-0001-7067-3655"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Scott Braithwaite","raw_affiliation_strings":["Department of Medicine, New York University, New York City, New York, United States of America; Division of Comparative Effectiveness and Decision Sciences, Department of Population Health, NYU School of Medicine, New York City, New York, United States of America","Department of Medicine, New York University, New York City, New York, United States of America","Division of Comparative Effectiveness and Decision Sciences, Department of Population Health, NYU School of Medicine, New York City, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University, New York City, New York, United States of America; Division of Comparative Effectiveness and Decision Sciences, Department of Population Health, NYU School of Medicine, New York City, New York, United States of America","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, New York University, New York City, New York, United States of America","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Division of Comparative Effectiveness and Decision Sciences, Department of Population Health, NYU School of Medicine, New York City, New York, United States of America","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074444217","display_name":"Denis Saur\u00e9","orcid":"https://orcid.org/0000-0002-8123-5009","observed_orcids":["https://orcid.org/0000-0002-8123-5009"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Denis Saure","raw_affiliation_strings":["Department of Industrial Engineering, University of Chile, Santiago, RM, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, University of Chile, Santiago, RM, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083035521","display_name":"Andrew J. Schaefer","orcid":"https://orcid.org/0000-0002-0379-741X","observed_orcids":["https://orcid.org/0000-0002-0379-741X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Schaefer","raw_affiliation_strings":["Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044763435","display_name":"Kimberly A. Nucifora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Nucifora","raw_affiliation_strings":["Division of Comparative Effectiveness and Decision Sciences, Department of Population Health, NYU School of Medicine, New York City, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Comparative Effectiveness and Decision Sciences, Department of Population Health, NYU School of Medicine, New York City, New York, United States of America","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043740961","display_name":"Mark S. Roberts","orcid":"https://orcid.org/0000-0002-8277-0425","observed_orcids":["https://orcid.org/0000-0002-8277-0425"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark S. Roberts","raw_affiliation_strings":["Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America","Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Health Policy and Management, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043740961"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.6483,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71178307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"9","issue":"6","first_page":"e98354","last_page":"e98354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.09049999713897705,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.7089999914169312},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/treatment-initiation-timing","display_name":"treatment initiation timing","score":0.8939999938011169},{"id":"https://openalex.org/keywords/drug-approval-rates","display_name":"drug approval rates","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cd4-threshold","display_name":"CD4 threshold","score":0.8009999990463257},{"id":"https://openalex.org/keywords/life-expectancy","display_name":"life expectancy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/quality-adjusted-life-expectancy","display_name":"quality-adjusted life expectancy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5659999847412109},{"id":"https://openalex.org/keywords/computer-simulation","display_name":"computer simulation","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.7645940780639648},{"id":"https://openalex.org/C100406419","wikidata":"https://www.wikidata.org/wiki/Q3543802","display_name":"Formulary","level":2,"score":0.6255694627761841},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6122462749481201},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5173434615135193},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4450998604297638},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4266059398651123},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.4148055613040924},{"id":"https://openalex.org/C188353592","wikidata":"https://www.wikidata.org/wiki/Q450586","display_name":"Expectancy theory","level":2,"score":0.4143151044845581},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4062204957008362},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35591959953308105},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18442469835281372},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1601957380771637},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1382666826248169},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.09776180982589722},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003657","descriptor_name":"Decision Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008017","descriptor_name":"Life Expectancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008017","descriptor_name":"Life Expectancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008017","descriptor_name":"Life Expectancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0098354","doi":"https://doi.org/10.1371/journal.pone.0098354","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0098354","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0098354&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:24963883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24963883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:d-scholarship.pitt.edu:23011","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/23011/8/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:3044572","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4070901","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070901","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:open.clemson.edu:industrialeng_pubs-1001","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/industrialeng_pubs/3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications","raw_type":"text"},{"id":"pmh:oai:tigerprints.clemson.edu:industrialeng_pubs-1001","doi":null,"is_oa":true,"landing_page_url":"https://tigerprints.clemson.edu/industrialeng_pubs/3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3e38d09267184c14bdd83f05b752e0c1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3e38d09267184c14bdd83f05b752e0c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 6, p e98354 (2014)","raw_type":"article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/126801","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/126801","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0098354","doi":"https://doi.org/10.1371/journal.pone.0098354","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0098354","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0098354&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2051286483","display_name":null,"funder_award_id":"U24-AA022007","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6149333558","display_name":"The Operations Research Collaboration for Alcohol Abuse and AIDS: ORCAAA","funder_award_id":"4u24aa022007-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6156182886","display_name":null,"funder_award_id":"U24AA022007-01","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6205384076","display_name":null,"funder_award_id":"R01 AA017385","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7649968921","display_name":null,"funder_award_id":"R01AA017385-01","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006366129.pdf","grobid_xml":"https://content.openalex.org/works/W2006366129.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W33567193","https://openalex.org/W1971927429","https://openalex.org/W1982988962","https://openalex.org/W1998151345","https://openalex.org/W2023400389","https://openalex.org/W2054997715","https://openalex.org/W2089695993","https://openalex.org/W2097053191","https://openalex.org/W2132736523","https://openalex.org/W2148241669","https://openalex.org/W2148424072","https://openalex.org/W2153494870","https://openalex.org/W2156458610","https://openalex.org/W2168405519","https://openalex.org/W2482329843","https://openalex.org/W2916981229","https://openalex.org/W2917119881","https://openalex.org/W4236479494","https://openalex.org/W6630897105"],"related_works":["https://openalex.org/W2361229924","https://openalex.org/W61473456","https://openalex.org/W152593571","https://openalex.org/W2531489003","https://openalex.org/W577869515","https://openalex.org/W1997230447","https://openalex.org/W2371337988","https://openalex.org/W2560505042","https://openalex.org/W2322222535","https://openalex.org/W1149264892"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"analyses":[2],"of":[3,11,26,28,47,51,75,86,88,98,100,110,112,143,162,173,177,197,220,279,281,293,318,347],"HIV":[4,12,128,362],"treatment":[5,33,159,327,354],"decisions":[6],"assume":[7],"a":[8,21,70,123,234,243,251],"fixed":[9],"formulary":[10],"drugs.":[13,91],"However,":[14],"new":[15,29,52,89,101,113,144,178,198,282,319],"drugs":[16,30,53,102,145,179,199,222,283,296,321,350],"are":[17],"approved":[18],"nearly":[19],"twice":[20],"year,":[22],"and":[23,61,115,165,184,250,332,356],"the":[24,45,49,55,76,84,95,107,118,140,147,171,174,195,201,277,288,291],"rate":[25,85,97,109,120,278],"availability":[27,50,87,99,111,142,176,196,219,280,317],"may":[31],"affect":[32],"decisions,":[34],"particularly":[35,262],"when":[36],"to":[37,79,82,106,126,151,209,218,264,300],"initiate":[38,80,152],"antiretroviral":[39],"therapy":[40],"(ART).":[41],"OBJECTIVES:":[42],"To":[43],"determine":[44],"impact":[46,172,352],"considering":[48,158,194],"on":[54,155,180],"optimal":[56,77,149,202,326,353],"initiation":[57,160,328,355],"criteria":[58],"for":[59,206,230,303,329,337,360],"ART":[60,81,153,268,295,320,349],"outcomes":[62,216,359],"in":[63,215,248,256,345],"patients":[64,208,232,260,339],"with":[65,233,340],"HIV/AIDS.":[66],"METHODS:":[67],"We":[68,92,134,168],"enhanced":[69],"previously":[71],"described":[72],"simulation":[73],"model":[74,125],"time":[78,150],"incorporate":[83],"antiviral":[90],"assumed":[93],"that":[94],"future":[96,141,175,294,316,348],"would":[103],"be":[104],"similar":[105],"past":[108,119],"drugs,":[114],"we":[116],"estimated":[117],"by":[121,309],"fitting":[122],"statistical":[124],"actual":[127],"drug":[129],"approval":[130],"data":[131],"from":[132],"1982-2010.":[133],"then":[135],"tested":[136],"whether":[137],"or":[138],"not":[139,285],"affected":[146],"model-predicted":[148],"based":[154],"clinical":[156,334,358],"outcomes,":[157,335],"thresholds":[161],"200,":[163],"350,":[164],"500":[166,210],"cells/mm3.":[167,211],"also":[169],"quantified":[170],"life":[181,186],"expectancy":[182,187],"(LE)":[183],"quality-adjusted":[185],"(QALE).":[188],"RESULTS:":[189],"In":[190,273],"base":[191],"case":[192],"analysis,":[193,275],"raised":[200],"starting":[203],"CD4":[204],"threshold":[205],"most":[207,330],"The":[212,315],"predicted":[213],"gains":[214],"due":[217],"pipeline":[221],"were":[223,261],"generally":[224],"small":[225],"(less":[226],"than":[227],"1%),":[228],"but":[229],"young":[231],"high":[235],"viral":[236,342],"load":[237],"could":[238,351],"add":[239],"as":[240,242,310,312],"much":[241,311],"4.9%":[244],"(1.73":[245],"years)":[246],"increase":[247,255,301],"LE":[249],"8%":[252],"(2.43":[253],"QALY)":[254],"QALE,":[257],"because":[258],"these":[259],"likely":[263],"exhaust":[265],"currently":[266],"available":[267],"regimens":[269],"before":[270],"they":[271],"died.":[272],"sensitivity":[274],"increasing":[276,307],"did":[284],"substantially":[286],"alter":[287],"results.":[289],"Lowering":[290],"toxicity":[292,324,346],"had":[297],"greater":[298],"potential":[299],"benefit":[302],"many":[304],"patient":[305],"groups,":[306],"QALE":[308],"10%.":[313],"CONCLUSIONS:":[314],"without":[322],"lower":[323],"raises":[325],"patients,":[331],"improves":[333],"especially":[336],"younger":[338],"higher":[341],"loads.":[343],"Reductions":[344],"improve":[357],"all":[361],"patients.":[363]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}