{"id":"https://openalex.org/W2006346166","doi":"https://doi.org/10.1080/00365520802240255","title":"A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome","display_name":"A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2006346166","doi":"https://doi.org/10.1080/00365520802240255","mag":"2006346166","pmid":"https://pubmed.ncbi.nlm.nih.gov/18618371"},"language":"en","primary_location":{"id":"doi:10.1080/00365520802240255","doi":"https://doi.org/10.1080/00365520802240255","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365520802240255","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083747247","display_name":"Kei Matsueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155463","display_name":"Kohnodai Hospital, National Center for Global Health and Medicine","ror":"https://ror.org/00bky6e07","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210094012","https://openalex.org/I4387155463","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kei Matsueda","raw_affiliation_strings":["International Medical Center of Japan Kohnodai Hospital, Kohnodai, Ichikawa, Chiba 272-8516, Japan. matsueda@imcjk.hosp.go.jp","International Medical Center of Japan Kohnodai Hospital, Ichikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Medical Center of Japan Kohnodai Hospital, Kohnodai, Ichikawa, Chiba 272-8516, Japan. matsueda@imcjk.hosp.go.jp","institution_ids":["https://openalex.org/I4387155463"]},{"raw_affiliation_string":"International Medical Center of Japan Kohnodai Hospital, Ichikawa, Japan","institution_ids":["https://openalex.org/I4387155463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112710975","display_name":"Shigeru Harasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284407","display_name":"Saiseikai Kawaguchi General Hospital","ror":"https://ror.org/03gqch695","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210120601","https://openalex.org/I4405284407"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Harasawa","raw_affiliation_strings":["Saitama-ken Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama-ken Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan","institution_ids":["https://openalex.org/I4405284407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053752434","display_name":"Michio Hongo","orcid":"https://orcid.org/0000-0003-1929-2448","observed_orcids":["https://orcid.org/0000-0003-1929-2448"]},"institutions":[{"id":"https://openalex.org/I4210093896","display_name":"Tohoku University Hospital","ror":"https://ror.org/00kcd6x60","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210093896"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michio Hongo","raw_affiliation_strings":["Tohoku University Hospital, Sendai, Japan","Tohoku Univ. Hospital, Sendai, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tohoku University Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210093896"]},{"raw_affiliation_string":"Tohoku Univ. Hospital, Sendai, Japan;","institution_ids":["https://openalex.org/I4210093896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034905709","display_name":"Nobuo Hiwatashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119531","display_name":"Iwaki Kyoritsu General Hospital","ror":"https://ror.org/022a11m05","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210119531"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Hiwatashi","raw_affiliation_strings":["Iwaki Kyoritsu General Hospital, Iwaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iwaki Kyoritsu General Hospital, Iwaki, Japan","institution_ids":["https://openalex.org/I4210119531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119012045","display_name":"Daisuke Sasaki","orcid":"https://orcid.org/0000-0002-8260-0717","observed_orcids":["https://orcid.org/0000-0002-8260-0717"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Sasaki","raw_affiliation_strings":["Student Health & Counseling Center, Hirosaki University, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Health & Counseling Center, Hirosaki University, Aomori, Japan","institution_ids":["https://openalex.org/I146516829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083747247"],"corresponding_institution_ids":["https://openalex.org/I4387155463"],"apc_list":null,"apc_paid":null,"fwci":8.9174,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.97863944,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"10","first_page":"1202","last_page":"1211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ramosetron","display_name":"ramosetron","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diarrhea-predominant-irritable-bowel-syndrome","display_name":"diarrhea-predominant irritable bowel syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.6610000133514404},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.6809999942779541},{"id":"https://openalex.org/keywords/bowel-habits","display_name":"bowel habits","score":0.9120000004768372},{"id":"https://openalex.org/keywords/symptom-relief","display_name":"symptom relief","score":0.6060000061988831},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6190000176429749},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7089999914169312},{"id":"https://openalex.org/keywords/hard-stools","display_name":"hard stools","score":0.8270000219345093},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.937467098236084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7300722599029541},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6646404266357422},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6551604270935059},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.6394302248954773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.608558177947998},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.5912280082702637},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3740082383155823},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.074614018201828},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/00365520802240255","doi":"https://doi.org/10.1080/00365520802240255","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365520802240255","pdf_url":null,"source":{"id":"https://openalex.org/S55592950","display_name":"Scandinavian Journal of Gastroenterology","issn_l":"0036-5521","issn":["0036-5521","1502-7708"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:18618371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18618371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1486352899","https://openalex.org/W1823088980","https://openalex.org/W1854805108","https://openalex.org/W1904771243","https://openalex.org/W1981220433","https://openalex.org/W1989305728","https://openalex.org/W1991271245","https://openalex.org/W2002062852","https://openalex.org/W2009249793","https://openalex.org/W2017232891","https://openalex.org/W2018343808","https://openalex.org/W2024414619","https://openalex.org/W2040962418","https://openalex.org/W2042335480","https://openalex.org/W2044044822","https://openalex.org/W2058681706","https://openalex.org/W2059036933","https://openalex.org/W2075334766","https://openalex.org/W2076438268","https://openalex.org/W2083665563","https://openalex.org/W2085538087","https://openalex.org/W2097566770","https://openalex.org/W2126547777","https://openalex.org/W2127837438","https://openalex.org/W2127983504","https://openalex.org/W2129860142","https://openalex.org/W2137002278","https://openalex.org/W2138328106","https://openalex.org/W2138976301","https://openalex.org/W2146355677","https://openalex.org/W2147902999","https://openalex.org/W2162602142","https://openalex.org/W2408612426"],"related_works":["https://openalex.org/W2042028186","https://openalex.org/W2017232891","https://openalex.org/W2089464643","https://openalex.org/W4309691139","https://openalex.org/W1901791757","https://openalex.org/W7099474566","https://openalex.org/W2168877909","https://openalex.org/W2588055959","https://openalex.org/W2017242867","https://openalex.org/W2782948580"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Irritable":[1],"bowel":[2,14,47,53,82,104,148,196,203],"syndrome":[3,105,149],"is":[4,183],"characterized":[5],"by":[6],"abdominal":[7,192],"discomfort":[8,194],"and/or":[9],"pain":[10,44],"associated":[11],"with":[12,51,79,94,101,152,169,200],"altered":[13],"habits.":[15],"The":[16,55,157],"neurotransmitter":[17],"serotonin":[18,20,69],"and":[19,45,65,185,195],"type":[21,70],"3":[22,71],"receptors":[23],"that":[24],"are":[25],"extensively":[26],"distributed":[27],"on":[28],"enteric":[29],"neurons":[30],"in":[31,39,49,76,137,163,188,198],"the":[32,41,63,68,107,138,164,170,189],"human":[33],"gastrointestinal":[34],"tract":[35],"play":[36],"a":[37,88,95],"role":[38],"increasing":[40],"sensation":[42],"of":[43,57,67,130,144,146,191],"affecting":[46],"habits":[48,197],"patients":[50,78,100,133,199],"irritable":[52,81,103,147,202],"syndrome.":[54,83,204],"aim":[56],"this":[58],"study":[59,93],"was":[60,173],"to":[61],"evaluate":[62],"efficacy":[64],"safety":[66],"receptor":[72],"antagonist":[73],"ramosetron":[74,116,131,165],"hydrochloride":[75,117,178],"Japanese":[77],"diarrhea-predominant":[80,102,201],"MATERIAL":[84],"AND":[85],"METHODS:":[86],"In":[87],"double-blind,":[89],"placebo-controlled,":[90],"parallel":[91],"group-comparative":[92],"1-week":[96],"run-in":[97],"period,":[98],"539":[99],"meeting":[106],"Rome":[108],"II":[109],"diagnostic":[110],"criteria":[111],"received":[112],"either":[113],"5":[114,179],"microg":[115,180],"(n=270)":[118],"or":[119],"placebo":[120,171],"(n=269)":[121],"once":[122,181],"daily":[123,182],"for":[124,154],"12":[125],"weeks.":[126],"RESULTS:":[127],"Forty-seven":[128],"percent":[129],"hydrochloride-treated":[132,166],"were":[134],"monthly":[135],"responders":[136],"primary":[139],"end-point,":[140],"\"Patient-reported":[141],"global":[142],"assessment":[143],"relief":[145],"symptoms\",":[150],"compared":[151,168],"27%":[153],"placebos":[155],"(p<0.001).":[156],"most":[158],"frequently":[159],"reported":[160],"adverse":[161],"event":[162],"group":[167,172],"hard":[174],"stool.":[175],"CONCLUSIONS:":[176],"Ramosetron":[177],"effective":[184],"well":[186],"tolerated":[187],"treatment":[190],"pain,":[193]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
