{"id":"https://openalex.org/W2006329487","doi":"https://doi.org/10.2174/1381612003400317","title":"Stopping Drug Therapy in Epilepsy","display_name":"Stopping Drug Therapy in Epilepsy","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2006329487","doi":"https://doi.org/10.2174/1381612003400317","mag":"2006329487","pmid":"https://pubmed.ncbi.nlm.nih.gov/10828311"},"language":"en","primary_location":{"id":"doi:10.2174/1381612003400317","doi":"https://doi.org/10.2174/1381612003400317","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612003400317","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065856386","display_name":"Samden D. Lhatoo","orcid":"https://orcid.org/0000-0002-0260-3855","observed_orcids":["https://orcid.org/0000-0002-0260-3855","https://orcid.org/0000-0001-8626-1137"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. Lhatoo","raw_affiliation_strings":["Epilepsy Research Group, Institute of Neurology, University College London, UK. slhatoo@aol.com","Epilepsy Research Group, Institute of Neurology, University College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epilepsy Research Group, Institute of Neurology, University College London, UK. slhatoo@aol.com","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Epilepsy Research Group, Institute of Neurology, University College London, UK","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035657409","display_name":"Josemir W. A. S. Sander","orcid":"https://orcid.org/0000-0001-6041-9661","observed_orcids":["https://orcid.org/0000-0001-6041-9661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.W.A.S. Sander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6771,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69453935,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"8","first_page":"861","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8629999756813049},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.5929999947547913},{"id":"https://openalex.org/keywords/seizure-recurrence","display_name":"seizure recurrence","score":0.609000027179718},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6520000100135803},{"id":"https://openalex.org/keywords/vigabatrin","display_name":"vigabatrin","score":0.972000002861023},{"id":"https://openalex.org/keywords/felbamate","display_name":"felbamate","score":1.0},{"id":"https://openalex.org/keywords/epilepsy-syndromes","display_name":"epilepsy syndromes","score":0.7749999761581421},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/social-stigma","display_name":"social stigma","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8256547451019287},{"id":"https://openalex.org/C2780837902","wikidata":"https://www.wikidata.org/wiki/Q421663","display_name":"Vigabatrin","level":4,"score":0.7798346281051636},{"id":"https://openalex.org/C2781011581","wikidata":"https://www.wikidata.org/wiki/Q421301","display_name":"Felbamate","level":4,"score":0.7755457162857056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5657999515533447},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5296449661254883},{"id":"https://openalex.org/C2778734009","wikidata":"https://www.wikidata.org/wiki/Q55785625","display_name":"Epilepsy syndromes","level":3,"score":0.5160729289054871},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.510190486907959},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4932064414024353},{"id":"https://openalex.org/C2778496695","wikidata":"https://www.wikidata.org/wiki/Q254128","display_name":"Dilemma","level":2,"score":0.46363064646720886},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3638923466205597},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.3477678894996643},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3364447355270386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07755208015441895},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/1381612003400317","doi":"https://doi.org/10.2174/1381612003400317","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612003400317","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:10828311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10828311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:81358","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/81358/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CURR PHARM DESIGN , 6 (8) 861 - 863. (2000)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2014872241","https://openalex.org/W2002828169","https://openalex.org/W4301057417","https://openalex.org/W1982975668","https://openalex.org/W2784219355","https://openalex.org/W2151100253","https://openalex.org/W2071505895","https://openalex.org/W2022660132","https://openalex.org/W1983267827","https://openalex.org/W4410018496"],"abstract_inverted_index":{"In":[0],"most":[1],"of":[2,51,66,96,100,104,110,119,126,133,136],"the":[3,8,23,63,73,79,105,117,127,131,134,154,157],"epilepsies":[4,128],"and":[5,40,68,86,108,130,156],"epileptic":[6],"syndromes,":[7],"decision":[9,24],"to":[10,25,35,37,43],"initiate":[11],"antiepileptic":[12],"drug":[13],"(AED)":[14],"therapy":[15],"is":[16,48,89],"often":[17],"a":[18,33,41,49,55,90,101,140,148],"far":[19],"simpler":[20],"one":[21],"than":[22],"stop":[26],"it.":[27],"The":[28,98],"primary":[29],"factor":[30],"that":[31,57,93],"drives":[32],"patient":[34,155],"want":[36],"discontinue":[38],"therapy,":[39],"doctor":[42],"endorse":[44],"or":[45],"recommend":[46],"this,":[47],"fear":[50],"long-term":[52],"adverse":[53],"events,":[54],"consideration":[56],"may":[58],"be":[59],"entirely":[60],"justified":[61],"as":[62,123],"side":[64],"effects":[65],"vigabatrin":[67],"felbamate":[69],"have":[70],"proved.":[71],"On":[72],"other":[74],"hand,":[75],"seizure":[76,137],"recurrence":[77],"with":[78],"attendant":[80],"implications":[81],"in":[82],"employment,":[83],"driving":[84],"regulations":[85],"social":[87],"stigmatization":[88],"strong":[91],"deterrent":[92],"discourages":[94],"withdrawal":[95],"therapy.":[97],"absence":[99],"clearer":[102],"understanding":[103,125],"natural":[106],"history":[107],"prognosis":[109],"many":[111],"individual":[112],"epilepsy":[113],"syndromes":[114],"somewhat":[115],"hampers":[116],"resolution":[118],"this":[120],"dilemma.":[121],"Hopefully,":[122],"our":[124],"grows":[129],"prediction":[132],"chances":[135],"relapse":[138],"becomes":[139],"more":[141],"precise":[142],"science,":[143],"stopping":[144],"medication":[145],"will":[146],"become":[147],"less":[149],"fraught":[150],"exercise":[151],"for":[152],"both":[153],"doctor.":[158]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
