{"id":"https://openalex.org/W2006314775","doi":"https://doi.org/10.1210/endo.139.1.5682","title":"Cloning of Rabbit TR4 and Its Bone Cell-Specific Activity to Suppress Estrogen Receptor-Mediated Transactivation","display_name":"Cloning of Rabbit TR4 and Its Bone Cell-Specific Activity to Suppress Estrogen Receptor-Mediated Transactivation","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2006314775","doi":"https://doi.org/10.1210/endo.139.1.5682","mag":"2006314775","pmid":"https://pubmed.ncbi.nlm.nih.gov/9421416"},"language":"en","primary_location":{"id":"doi:10.1210/endo.139.1.5682","doi":"https://doi.org/10.1210/endo.139.1.5682","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.139.1.5682","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hideyuki Harada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideyuki Harada","raw_affiliation_strings":["Sumitomo Pharmaceuticals Research Center, Osaka, Japan","Sumitomo Pharmaceuticals Research Center (H.H., M.N., Y.Ko.), Kasugadenaka, Konohana-ku, Osaka, 554"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sumitomo Pharmaceuticals Research Center, Osaka, Japan","institution_ids":[]},{"raw_affiliation_string":"Sumitomo Pharmaceuticals Research Center (H.H., M.N., Y.Ko.), Kasugadenaka, Konohana-ku, Osaka, 554","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044519948","display_name":"Yoshikazu Kuboi","orcid":"https://orcid.org/0000-0002-0782-565X","observed_orcids":["https://orcid.org/0000-0002-0782-565X"]},"institutions":[{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Kuboi","raw_affiliation_strings":["Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156","institution_ids":["https://openalex.org/I127317711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011251507","display_name":"Rika Miki","orcid":"https://orcid.org/0009-0001-6223-2101","observed_orcids":["https://orcid.org/0009-0001-6223-2101"]},"institutions":[{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rika Miki","raw_affiliation_strings":["Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156","institution_ids":["https://openalex.org/I127317711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111633459","display_name":"Chikara Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikara Honda","raw_affiliation_strings":["Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156","institution_ids":["https://openalex.org/I127317711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111529545","display_name":"Shoichi Masushige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127317711","display_name":"Tokyo University of Agriculture","ror":"https://ror.org/05crbcr45","country_code":"JP","type":"education","lineage":["https://openalex.org/I127317711"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoichi Masushige","raw_affiliation_strings":["Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Chemistry (Y.Ku., R.M., C.H., S.M.), Faculty of Agriculture, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo, 156","institution_ids":["https://openalex.org/I127317711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079426104","display_name":"Masashi Nakatsuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masashi Nakatsuka","raw_affiliation_strings":["Sumitomo Pharmaceuticals Research Center (H.H., M.N., Y.Ko.), Kasugadenaka, Konohana-ku, Osaka, 554"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sumitomo Pharmaceuticals Research Center (H.H., M.N., Y.Ko.), Kasugadenaka, Konohana-ku, Osaka, 554","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060969891","display_name":"Yoshihiko Koga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiko Koga","raw_affiliation_strings":["Sumitomo Pharmaceuticals Research Center (H.H., M.N., Y.Ko.), Kasugadenaka, Konohana-ku, Osaka, 554"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sumitomo Pharmaceuticals Research Center (H.H., M.N., Y.Ko.), Kasugadenaka, Konohana-ku, Osaka, 554","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046367290","display_name":"Shigeaki KATO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeaki Kato","raw_affiliation_strings":["CREST (S.K.), Japan Science and Technology Corporation, Honcho, Kawaguchi, Saitama 332, Japan","Institute of Molecular and Cellular Biochemistry (S.K.), University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST (S.K.), Japan Science and Technology Corporation, Honcho, Kawaguchi, Saitama 332, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Institute of Molecular and Cellular Biochemistry (S.K.), University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046367290"],"corresponding_institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I74801974"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.8598,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71476138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"139","issue":"1","first_page":"204","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tr4","display_name":"TR4","score":0.734000027179718},{"id":"https://openalex.org/keywords/orphan-nuclear-receptor","display_name":"orphan nuclear receptor","score":0.8069999814033508},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.6209999918937683},{"id":"https://openalex.org/keywords/bone-cells","display_name":"bone cells","score":0.5590000152587891},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-marrow-cells","display_name":"bone marrow cells","score":0.6800000071525574},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.7490000128746033},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.8160961866378784},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7706785798072815},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6435086727142334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6370545625686646},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.5891668200492859},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5684850811958313},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4412556290626526},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.4385334551334381},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42794013023376465},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24418503046035767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19818460941314697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19021111726760864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13629135489463806},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12723475694656372},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/endo.139.1.5682","doi":"https://doi.org/10.1210/endo.139.1.5682","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.139.1.5682","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.139.1.204","doi":"https://doi.org/10.1210/en.139.1.204","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.139.1.204","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9421416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9421416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W193617093","https://openalex.org/W1545280767","https://openalex.org/W1552563052","https://openalex.org/W1973603230","https://openalex.org/W1979655333","https://openalex.org/W1986276800","https://openalex.org/W1986572126","https://openalex.org/W1995754186","https://openalex.org/W1999420659","https://openalex.org/W2012970553","https://openalex.org/W2016798180","https://openalex.org/W2017581017","https://openalex.org/W2020128265","https://openalex.org/W2026207114","https://openalex.org/W2031110757","https://openalex.org/W2036297795","https://openalex.org/W2037984842","https://openalex.org/W2051625890","https://openalex.org/W2055650366","https://openalex.org/W2056797992","https://openalex.org/W2058134184","https://openalex.org/W2066092624","https://openalex.org/W2068733538","https://openalex.org/W2071263028","https://openalex.org/W2073130464","https://openalex.org/W2073353512","https://openalex.org/W2075786281","https://openalex.org/W2076425895","https://openalex.org/W2082183799","https://openalex.org/W2085124463","https://openalex.org/W2086591488","https://openalex.org/W2097191932","https://openalex.org/W2099551278","https://openalex.org/W2114882367","https://openalex.org/W2134812217","https://openalex.org/W2141568746","https://openalex.org/W2143678523","https://openalex.org/W2152961738","https://openalex.org/W2162822427","https://openalex.org/W2168942231","https://openalex.org/W2172256092","https://openalex.org/W2321613759","https://openalex.org/W4231098641"],"related_works":["https://openalex.org/W4242880593","https://openalex.org/W2158188555","https://openalex.org/W2106182593","https://openalex.org/W2073353512","https://openalex.org/W7095675954","https://openalex.org/W1967185906","https://openalex.org/W2039291115","https://openalex.org/W2051625890","https://openalex.org/W165079118","https://openalex.org/W2122234080"],"abstract_inverted_index":{"To":[0],"clone":[1,38],"a":[2,8,41,71,88,177,252,262],"new":[3],"nuclear":[4,25],"receptor,":[5,191,259],"we":[6,214],"screened":[7],"rabbit":[9,62,72],"heart":[10],"complementary":[11],"DNA":[12],"(cDNA)":[13],"library":[14],"with":[15,108],"degenerate":[16],"oligonucleotide":[17],"probes":[18],"corresponding":[19],"to":[20],"the":[21,35,68,78,161,217,239,244,248,256,267],"DNA-binding":[22],"domain":[23,82],"of":[24,34,44,111,119,133,143,164,171,238,243,255],"receptors,":[26],"which":[27,76,92,120],"is":[28,52],"highly":[29],"conserved":[30],"among":[31],"receptors.":[32],"One":[33],"cDNA":[36,69],"clones,":[37],"23,":[39],"encodes":[40],"novel":[42,253],"protein":[43,60],"596":[45],"amino":[46,84],"acids,":[47],"and":[48,115,127,156,193,199,204],"predicted":[49],"molecular":[50],"mass":[51],"66":[53],"kDa.":[54],"Homology":[55],"search":[56],"analysis":[57,102],"identified":[58],"this":[59],"as":[61,261],"TR4":[63,73,257],"(TR4-0).":[64],"We":[65],"also":[66],"cloned":[67],"encoding":[70],"isoform":[74],"(TR4-1),":[75],"lacks":[77],"putative":[79],"C-terminal":[80],"ligand-binding":[81],"(350":[83],"acids)":[85],"caused":[86],"by":[87],"23-bp":[89],"exon":[90],"deletion,":[91],"probably":[93],"occurred":[94],"during":[95],"messenger":[96],"RNA":[97],"(mRNA)":[98],"splicing.":[99],"Northern":[100],"blot":[101],"showed":[103,139,181],"that":[104,140,182,205,216],"TR4s":[105,218],"are":[106,121,151],"expressed":[107],"two":[109],"kinds":[110],"mRNAs":[112],"(9.0":[113],"kb":[114],"2.8":[116],"kb),":[117],"both":[118,141,150,183],"relatively":[122],"abundant":[123],"in":[124,146,153,197,224,229,266],"brain,":[125],"testis,":[126],"bone.":[128],"RT-PCR":[129],"analysis,":[130],"using":[131,176],"pairs":[132],"primers":[134],"specific":[135],"for":[136],"each":[137],"TR4,":[138],"types":[142],"receptor":[144,188],"express":[145],"various":[147],"tissues.":[148],"Furthermore,":[149],"present":[152,249],"primary":[154],"osteoblasts":[155],"bone":[157,225,263],"marrow":[158],"cells,":[159,226],"though":[160],"mRNA":[162],"levels":[163],"TR4-0":[165,206],"were":[166],"much":[167,208],"higher":[168],"than":[169,211],"those":[170],"TR4-1.":[172,212],"A":[173],"functional":[174],"study,":[175],"transient":[178],"transfection":[179],"assay,":[180],"receptors":[184],"suppressed":[185,220],"retinoid":[186],"X":[187],"(RXR)-retinoid":[189],"acid":[190],"RXR-TR,":[192],"RXR-VDR-mediated":[194],"transactivation":[195,223],"significantly":[196],"COS-1":[198],"osteosarcoma":[200],"cells":[201,235,242],"(UMR-106,":[202],"ROS17/2.8)":[203],"was":[207],"more":[209],"effective":[210],"Unexpectedly,":[213],"found":[215],"effectively":[219],"estrogen":[221,245,268],"receptor-mediated":[222,269],"but":[227],"neither":[228],"kidney":[230],"(COS-1)":[231],"nor":[232],"breast":[233],"cancer":[234],"(MCF-7,":[236],"one":[237],"major":[240],"target":[241],"action).":[246],"Thus,":[247],"study":[250],"shows":[251],"property":[254],"orphan":[258],"acting":[260],"cell-specific":[264],"repressor":[265],"signaling":[270],"pathway.":[271]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}