{"id":"https://openalex.org/W2006308728","doi":"https://doi.org/10.1172/jci41805","title":"Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors","display_name":"Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors","publication_year":2010,"publication_date":"2010-09-30","ids":{"openalex":"https://openalex.org/W2006308728","doi":"https://doi.org/10.1172/jci41805","mag":"2006308728","pmid":"https://pubmed.ncbi.nlm.nih.gov/20890043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2947219"},"language":"en","primary_location":{"id":"doi:10.1172/jci41805","doi":"https://doi.org/10.1172/jci41805","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci41805","pdf_url":"http://www.jci.org/articles/view/41805/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/41805/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110689687","display_name":"Zhihong Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhihong Wan","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892-1652, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892-1652, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106628038","display_name":"Ning Zhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ning Zhi","raw_affiliation_strings":["Hematology Branch , National Heart, Lung, and Blood Institute , NIH , Bethesda , Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch , National Heart, Lung, and Blood Institute , NIH , Bethesda , Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054283305","display_name":"Susan C. Wong","orcid":"https://orcid.org/0000-0001-7001-5265","observed_orcids":["https://orcid.org/0000-0001-7001-5265"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Wong","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004581558","display_name":"Keyvan Keyvanfar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keyvan Keyvanfar","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052008214","display_name":"Delong Liu","orcid":"https://orcid.org/0000-0003-4502-4949","observed_orcids":["https://orcid.org/0000-0003-4502-4949","https://orcid.org/0000-0001-9956-0857"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I29955533","display_name":"Center for Information Technology","ror":"https://ror.org/03jh5a977","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I29955533"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Delong Liu","raw_affiliation_strings":["Center for Information Technology, NIH, Bethesda, Maryland, USA","Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Information Technology, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I29955533"]},{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050580288","display_name":"Nalini Raghavachari","orcid":"https://orcid.org/0000-0001-8674-1755","observed_orcids":["https://orcid.org/0000-0001-8674-1755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nalini Raghavachari","raw_affiliation_strings":["Gene Expression Core Facility and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Core Facility and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023243366","display_name":"Peter J. Munson","orcid":"https://orcid.org/0000-0003-0824-7887","observed_orcids":["https://orcid.org/0000-0003-0824-7887"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I29955533","display_name":"Center for Information Technology","ror":"https://ror.org/03jh5a977","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I29955533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Munson","raw_affiliation_strings":["Center for Information Technology, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Information Technology, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I29955533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101691895","display_name":"Su Su","orcid":"https://orcid.org/0000-0002-8582-795X","observed_orcids":["https://orcid.org/0000-0002-8582-795X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su Su","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061349997","display_name":"Daniela A. Malide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela Malide","raw_affiliation_strings":["Light Microscopy Core Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Light Microscopy Core Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075319144","display_name":"Sachiko Kajigaya","orcid":"https://orcid.org/0000-0003-1035-3662","observed_orcids":["https://orcid.org/0000-0003-1035-3662"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sachiko Kajigaya","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072063614","display_name":"Neal S. Young","orcid":"https://orcid.org/0009-0007-0999-2519","observed_orcids":["https://orcid.org/0009-0007-0999-2519"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal S. Young","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5106628038"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.6416,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.92776603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"120","issue":"10","first_page":"3530","last_page":"3544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parvovirus-b19","display_name":"parvovirus B19","score":0.9789999723434448},{"id":"https://openalex.org/keywords/erythroid-progenitors","display_name":"erythroid progenitor cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/e2f-transcription-factors","display_name":"E2F transcription factors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8389999866485596},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ns1-protein","display_name":"NS1 protein","score":0.8569999933242798},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5720000267028809},{"id":"https://openalex.org/keywords/e2f4","display_name":"E2F4","score":0.7540000081062317},{"id":"https://openalex.org/keywords/e2f5","display_name":"E2F5","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.796999990940094},{"id":"https://openalex.org/keywords/erythroid-differentiation","display_name":"erythroid differentiation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pure-red-cell-aplasia","display_name":"pure red cell aplasia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/fifth-disease","display_name":"fifth disease","score":0.6010000109672546},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5543943643569946},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.5395293831825256},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5212386250495911},{"id":"https://openalex.org/C2779630601","wikidata":"https://www.wikidata.org/wiki/Q13210344","display_name":"Parvovirus","level":3,"score":0.49092915654182434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4703507721424103},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4421229362487793},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4280267655849457},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4276770353317261},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.41894298791885376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3510696589946747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3328644037246704},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2358229160308838},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18275529146194458},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1231483519077301},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016732","descriptor_name":"Parvovirus B19, Human","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018955","descriptor_name":"CD36 Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050684","descriptor_name":"E2F Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050700","descriptor_name":"E2F5 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050704","descriptor_name":"E2F4 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci41805","doi":"https://doi.org/10.1172/jci41805","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci41805","pdf_url":"http://www.jci.org/articles/view/41805/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2947219","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2947219","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:20890043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20890043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci41805","doi":"https://doi.org/10.1172/jci41805","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci41805","pdf_url":"http://www.jci.org/articles/view/41805/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006308728.pdf","grobid_xml":"https://content.openalex.org/works/W2006308728.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W106241224","https://openalex.org/W1545425202","https://openalex.org/W1554464948","https://openalex.org/W1567405511","https://openalex.org/W1814853484","https://openalex.org/W1967126774","https://openalex.org/W1968371525","https://openalex.org/W1974200066","https://openalex.org/W1975728570","https://openalex.org/W1982260117","https://openalex.org/W1982621971","https://openalex.org/W1983914017","https://openalex.org/W1995875930","https://openalex.org/W1995928415","https://openalex.org/W1999101043","https://openalex.org/W1999523595","https://openalex.org/W2001738143","https://openalex.org/W2003492406","https://openalex.org/W2005983934","https://openalex.org/W2006195578","https://openalex.org/W2011008303","https://openalex.org/W2012013049","https://openalex.org/W2013088842","https://openalex.org/W2024436169","https://openalex.org/W2024999114","https://openalex.org/W2026488617","https://openalex.org/W2027114933","https://openalex.org/W2028619373","https://openalex.org/W2029206805","https://openalex.org/W2039169884","https://openalex.org/W2040164071","https://openalex.org/W2040782212","https://openalex.org/W2043127322","https://openalex.org/W2044651568","https://openalex.org/W2047399907","https://openalex.org/W2048831823","https://openalex.org/W2054343283","https://openalex.org/W2065343028","https://openalex.org/W2070677152","https://openalex.org/W2072453311","https://openalex.org/W2080872281","https://openalex.org/W2081736214","https://openalex.org/W2095621048","https://openalex.org/W2101297848","https://openalex.org/W2102918674","https://openalex.org/W2104049033","https://openalex.org/W2109430139","https://openalex.org/W2116527969","https://openalex.org/W2122462438","https://openalex.org/W2123463963","https://openalex.org/W2125072003","https://openalex.org/W2125983642","https://openalex.org/W2126018089","https://openalex.org/W2133645968","https://openalex.org/W2141076277","https://openalex.org/W2143955085","https://openalex.org/W2144575978","https://openalex.org/W2159099751","https://openalex.org/W2165029623","https://openalex.org/W4212962560","https://openalex.org/W4255007839","https://openalex.org/W7096869818"],"related_works":["https://openalex.org/W7099171088","https://openalex.org/W2068042354","https://openalex.org/W2144575978","https://openalex.org/W2141076277","https://openalex.org/W2980940824","https://openalex.org/W1983083876","https://openalex.org/W2799913103","https://openalex.org/W7058499373","https://openalex.org/W2592055922","https://openalex.org/W7098036640"],"abstract_inverted_index":{"Human":[0],"parvovirus":[1],"B19":[2],"(B19V)":[3],"is":[4,34,58,84],"the":[5,108,129,160,192,213],"only":[6],"human":[7,16,78],"pathogenic":[8],"parvovirus.":[9],"It":[10],"causes":[11],"a":[12,62,74,139],"wide":[13],"spectrum":[14],"of":[15,47,64,111,163,177,216],"diseases,":[17],"including":[18],"fifth":[19],"disease":[20,56],"(erythema":[21],"infectiosum)":[22],"in":[23,30,40,128,191,218],"children":[24],"and":[25,37,68,121,155,167,180,199],"pure":[26],"red":[27],"cell":[28,66,97],"aplasia":[29],"immunocompromised":[31],"patients.":[32],"B19V":[33,49,88,101,106,133,217],"highly":[35,85,219],"erythrotropic":[36],"preferentially":[38],"replicates":[39],"erythroid":[41,200,221],"progenitor":[42],"cells":[43],"(EPCs).":[44],"Current":[45],"understanding":[46],"how":[48],"interacts":[50],"with":[51],"cellular":[52,92],"factors":[53,93,113],"to":[54,61,90,96,119,126],"regulate":[55],"progression":[57,193],"limited,":[59],"due":[60],"lack":[63],"permissive":[65,86,220],"lines":[67],"animal":[69],"models.":[70],"Here,":[71],"we":[72],"employed":[73],"recently":[75],"developed":[76],"primary":[77,130],"CD36(+)":[79,131],"EPC":[80],"culture":[81],"system":[82],"that":[83,94,105],"for":[87,144],"infection":[89],"identify":[91],"lead":[95],"cycle":[98],"arrest":[99,174],"after":[100],"infection.":[102],"We":[103],"found":[104],"exploited":[107],"E2F":[109],"family":[110],"transcription":[112],"by":[114,204],"downregulating":[115],"activating":[116],"E2Fs":[117,124,166],"(E2F1":[118],"E2F3a)":[120],"upregulating":[122],"repressive":[123,165],"(E2F4":[125],"E2F8)":[127],"EPCs.":[132],"nonstructural":[134],"protein":[135],"1":[136],"(NS1)":[137],"was":[138,175],"key":[140],"viral":[141,182],"factor":[142],"responsible":[143],"altering":[145],"E2F1-E2F5":[146],"expression,":[147],"but":[148],"not":[149],"E2F6-E2F8":[150],"expression.":[151],"Interaction":[152],"between":[153],"NS1":[154],"E2F4":[156],"or":[157],"E2F5":[158],"enhanced":[159],"nuclear":[161],"import":[162],"these":[164],"induced":[168],"stable":[169],"G\u2082":[170,173,195],"arrest.":[171],"NS1-induced":[172],"independent":[176],"p53":[178],"activation":[179],"increased":[181],"replication.":[183],"Downstream":[184],"E2F4/E2F5":[185],"targets,":[186],"which":[187],"are":[188],"potentially":[189],"involved":[190],"from":[194],"into":[196,212],"M":[197],"phase":[198],"differentiation,":[201],"were":[202],"identified":[203],"microarray":[205],"analysis.":[206],"These":[207],"findings":[208],"provide":[209],"new":[210],"insight":[211],"molecular":[214],"pathogenesis":[215],"progenitors.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}