{"id":"https://openalex.org/W2006254922","doi":"https://doi.org/10.1117/12.809478","title":"In vivo studies of 144 breast masses by phase contrast diffuse optical tomography","display_name":"In vivo studies of 144 breast masses by phase contrast diffuse optical tomography","publication_year":2009,"publication_date":"2009-02-12","ids":{"openalex":"https://openalex.org/W2006254922","doi":"https://doi.org/10.1117/12.809478","mag":"2006254922"},"language":"en","primary_location":{"id":"doi:10.1117/12.809478","doi":"https://doi.org/10.1117/12.809478","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.809478","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110369290","display_name":"Ruixin Jiang","orcid":"https://orcid.org/0009-0005-0246-1964","observed_orcids":["https://orcid.org/0009-0005-0246-1964"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruixin Jiang","raw_affiliation_strings":["Univ. of Florida (United States)","University of Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida (United States)","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002977387","display_name":"Xiaoping Liang","orcid":"https://orcid.org/0000-0001-5644-3642","observed_orcids":["https://orcid.org/0000-0001-5644-3642"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Liang","raw_affiliation_strings":["Univ. of Florida (United States)","University of Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida (United States)","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004136136","display_name":"Qizhi Zhang","orcid":"https://orcid.org/0000-0002-8544-609X","observed_orcids":["https://orcid.org/0000-0002-8544-609X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qizhi Zhang","raw_affiliation_strings":["Univ. of Florida (United States)","University of Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida (United States)","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029748536","display_name":"Stephen R. Grobmyer","orcid":"https://orcid.org/0000-0002-1163-1348","observed_orcids":["https://orcid.org/0000-0002-1163-1348"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Grobmyer","raw_affiliation_strings":["Univ. of Florida (United States)","University of Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida (United States)","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023887141","display_name":"Laurie L. Fajardo","orcid":"https://orcid.org/0000-0001-6853-4832","observed_orcids":["https://orcid.org/0000-0001-6853-4832"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie L. Fajardo","raw_affiliation_strings":["The Univ. of Iowa (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Univ. of Iowa (United States)","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108510223","display_name":"Huabei Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huabei Jiang","raw_affiliation_strings":["Univ. of Florida (United States)","University of Florida, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Florida (United States)","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida, United States","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10791367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7174","issue":null,"first_page":"71740X","last_page":"71740X"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-mass","display_name":"breast mass","score":0.9520000219345093},{"id":"https://openalex.org/keywords/breast-cancer-diagnosis","display_name":"breast cancer diagnosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/benign-versus-malignant-differentiation","display_name":"benign versus malignant differentiation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tissue-optical-properties","display_name":"tissue optical properties","score":0.6690000295639038},{"id":"https://openalex.org/keywords/refractive-index","display_name":"refractive index","score":0.9869999885559082},{"id":"https://openalex.org/keywords/absorption-coefficient","display_name":"absorption coefficient","score":0.8999999761581421},{"id":"https://openalex.org/keywords/scattering-coefficient","display_name":"scattering coefficient","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5691525936126709},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.5149232149124146},{"id":"https://openalex.org/C145417883","wikidata":"https://www.wikidata.org/wiki/Q5275421","display_name":"Diffuse optical imaging","level":3,"score":0.5097176432609558},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48955807089805603},{"id":"https://openalex.org/C151193507","wikidata":"https://www.wikidata.org/wiki/Q898815","display_name":"Phase contrast microscopy","level":2,"score":0.4790588319301605},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.4749058485031128},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.43018826842308044},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4095570147037506},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.39901942014694214},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3853803277015686},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2019098699092865},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07501950860023499}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.809478","doi":"https://doi.org/10.1117/12.809478","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.809478","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W91942097","https://openalex.org/W2066934908","https://openalex.org/W2035030388","https://openalex.org/W2010387961","https://openalex.org/W2005915049","https://openalex.org/W1963999071","https://openalex.org/W2018927311","https://openalex.org/W2153367996","https://openalex.org/W2187510766","https://openalex.org/W1969127458"],"abstract_inverted_index":{"We":[0],"report":[1],"our":[2,63],"continued":[3],"study":[4,107],"of":[5,38,115,135],"phase-contrast":[6],"diffuse":[7],"optical":[8,41],"tomography":[9],"(PCCDOT)":[10],"for":[11],"evaluating":[12],"its":[13],"fidelity":[14],"in":[15],"distinguishing":[16],"malignant":[17,66,136],"breast":[18,24],"lesions":[19],"form":[20],"benign":[21,91,118],"ones.":[22],"144":[23],"masses":[25,67],"were":[26,51],"examined":[27],"from":[28,32,90],"134":[29],"patients,":[30],"aging":[31],"22~82":[33],"with":[34,55,62],"the":[35,84,97,103,113,121,125,132,141],"mean":[36],"age":[37],"56.":[39],"Tissue":[40],"parameters":[42],"including":[43],"refractive":[44,73],"index,":[45],"and":[46,48,53],"absorption":[47],"scattering":[49],"coefficients,":[50],"obtained":[52],"compared":[54,139],"their":[56,77],"corresponding":[57],"biopsy/pathology":[58],"reports.":[59],"In":[60],"consistent":[61],"previous":[64,104],"study,":[65],"tended":[68],"to":[69,76,87,112,131,140],"have":[70],"a":[71],"decreased":[72],"index":[74],"relative":[75],"surrounding":[78],"normal":[79],"tissue,":[80],"which":[81],"acts":[82],"as":[83],"key":[85],"character":[86],"differentiate":[88],"them":[89],"masses.":[92],"The":[93],"results":[94],"show":[95],"that":[96],"specificity":[98],"is":[99],"improved":[100],"significantly":[101,116],"over":[102],"smaller":[105,142],"scale":[106,143],"(85%":[108],"vs.":[109,128],"70%)":[110],"due":[111,130],"addition":[114],"more":[117],"cases,":[119],"while":[120],"sensitivity":[122],"stays":[123],"about":[124],"same":[126],"(81%":[127],"82%)":[129],"similar":[133],"number":[134],"cases":[137],"used":[138],"study.":[144]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}