{"id":"https://openalex.org/W2006239294","doi":"https://doi.org/10.1186/1471-2172-10-49","title":"Ethanol inhibits LPS-induced signaling and modulates cytokine production in peritoneal macrophages in vivo in a model for binge drinking","display_name":"Ethanol inhibits LPS-induced signaling and modulates cytokine production in peritoneal macrophages in vivo in a model for binge drinking","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2006239294","doi":"https://doi.org/10.1186/1471-2172-10-49","mag":"2006239294","pmid":"https://pubmed.ncbi.nlm.nih.gov/19765273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2761873"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2172-10-49","doi":"https://doi.org/10.1186/1471-2172-10-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-10-49","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-10-49","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-10-49","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048915875","display_name":"Stephen B. Pruett","orcid":"https://orcid.org/0000-0003-4574-5965","observed_orcids":["https://orcid.org/0000-0003-4574-5965"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]},{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen B Pruett","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. Pruett@cvm.msstate.edu","Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, , USA","Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. Pruett@cvm.msstate.edu","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, , USA","institution_ids":["https://openalex.org/I99041443"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063845733","display_name":"Ruping Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruping Fan","raw_affiliation_strings":["Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA","Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, LA, 71130, USA","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA","institution_ids":["https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048915875"],"corresponding_institution_ids":["https://openalex.org/I81020160","https://openalex.org/I99041443"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.8265,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.71393044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6890000104904175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.3093000054359436,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/binge-drinking","display_name":"binge drinking","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tlr4-signaling","display_name":"TLR4 signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9520000219345093},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8420000076293945},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7960000038146973},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.9639999866485596},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nf-kappab-p65-nuclear-translocation","display_name":"p65 nuclear translocation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/alcohol-induced-immunosuppression","display_name":"alcohol-induced immunosuppression","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8093392848968506},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7811880111694336},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7213929295539856},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6071926355361938},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.541661262512207},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5313081741333008},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.49855947494506836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4717346429824829},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.4572451114654541},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.44520702958106995},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4416614770889282},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3975573778152466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35556793212890625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3478412330150604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2849460244178772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27348971366882324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2683055102825165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1471-2172-10-49","doi":"https://doi.org/10.1186/1471-2172-10-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-10-49","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-10-49","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},{"id":"pmid:19765273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19765273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2761873","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2761873/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0785b549a510458d89bb651f1e14ed08","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0785b549a510458d89bb651f1e14ed08","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Immunology, Vol 10, Iss 1, p 49 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2172-10-49","doi":"https://doi.org/10.1186/1471-2172-10-49","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-10-49","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-10-49","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7572002257","display_name":"Mechanisms of Immunosuppression by One Dose of Ethanol","funder_award_id":"R01AA009505","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2006239294.pdf","grobid_xml":"https://content.openalex.org/works/W2006239294.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1549587541","https://openalex.org/W1621475458","https://openalex.org/W1817249348","https://openalex.org/W1825815388","https://openalex.org/W1874466605","https://openalex.org/W1969182317","https://openalex.org/W1978350019","https://openalex.org/W1979674794","https://openalex.org/W1991609774","https://openalex.org/W1992397451","https://openalex.org/W1996909141","https://openalex.org/W2003977454","https://openalex.org/W2004143904","https://openalex.org/W2006563083","https://openalex.org/W2024290077","https://openalex.org/W2030574379","https://openalex.org/W2031514858","https://openalex.org/W2034526634","https://openalex.org/W2062801324","https://openalex.org/W2067030124","https://openalex.org/W2075713296","https://openalex.org/W2081292558","https://openalex.org/W2096704339","https://openalex.org/W2100475731","https://openalex.org/W2105699711","https://openalex.org/W2116498531","https://openalex.org/W2125377111","https://openalex.org/W2135728875","https://openalex.org/W2150864430","https://openalex.org/W2159546356","https://openalex.org/W2159730178","https://openalex.org/W2160853231","https://openalex.org/W2165963707","https://openalex.org/W2167209993","https://openalex.org/W2167314053"],"related_works":["https://openalex.org/W2025121101","https://openalex.org/W1489740257","https://openalex.org/W2024290077","https://openalex.org/W2075713296","https://openalex.org/W2165963707","https://openalex.org/W2045219526","https://openalex.org/W2013278604","https://openalex.org/W2160368373","https://openalex.org/W2043459126","https://openalex.org/W2593911670"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"reports":[2],"indicate":[3],"that":[4,40,318],"ethanol,":[5],"in":[6,11,19,32,36,46,49,68,79,90,122,146,154,193,277,285],"a":[7,204,239,246,333],"binge":[8],"drinking":[9],"model":[10,35],"mice,":[12],"inhibits":[13],"the":[14,22,51,147,175,178,188,219,256,271,295,307],"production":[15,198,328],"of":[16,24,60,117,125,141,149,168,187,191,199,231,249,259,273,294,297,304,329,342],"pro-inflammatory":[17,201],"cytokines":[18,202,260,331],"vivo.":[20,37,91,123],"However,":[21,214,292],"inhibition":[23,248,258,293],"signaling":[25,41,64,212],"through":[26],"TLR4":[27,63,87,211],"has":[28],"not":[29,222,300,338],"been":[30],"investigated":[31],"this":[33,194],"experimental":[34],"Considering":[38],"evidence":[39],"can":[42],"be":[43,266],"very":[44],"different":[45],"vitro":[47,286],"and":[48,77,86,96,112,153,161],"vivo,":[50],"present":[52],"study":[53],"was":[54,221,234,299,310],"conducted":[55],"to":[56,173,203,218,265,281,288,306],"determine":[57,227],"if":[58,228],"effects":[59,190,272],"ethanol":[61,74,84,126,131,192,274,289,319],"on":[62,275],"reported":[65,283],"for":[66,284],"cells":[67,71],"culture":[69,80],"or":[70,103],"removed":[72],"from":[73],"treated":[75],"mice":[76,237],"stimulated":[78],"also":[81],"occur":[82,89],"when":[83],"treatment":[85],"activation":[88,296],"RESULTS:":[92],"Phosphorylated":[93],"p38,":[94],"ERK,":[95],"c-Jun":[97],"(nuclear)":[98],"were":[99,127,156,171,242,279],"quantified":[100],"with":[101,120,238,255,325],"kits":[102],"by":[104,129,132,224],"western":[105],"blot":[106],"using":[107,312],"samples":[108,148],"taken":[109],"15,":[110],"30,":[111],"60":[113],"min":[114,138],"after":[115,164],"stimulation":[116],"peritoneal":[118,150],"macrophages":[119],"lipopolysaccharide":[121,142,165],"Effects":[124],"assessed":[128],"administering":[130],"gavage":[133],"at":[134,158],"6":[135,162],"g/kg":[136],"30":[137],"before":[139,323],"administration":[140],"(LPS).":[143],"Cytokine":[144],"concentrations":[145],"lavage":[151],"fluid":[152],"serum":[155],"determined":[157],"1,":[159],"2,":[160],"hr":[163,322],"administration.":[166],"All":[167],"these":[169],"data":[170],"used":[172],"measure":[174],"area":[176],"under":[177],"concentration":[179],"vs":[180],"time":[181],"curve,":[182],"which":[183,252,336],"provided":[184],"an":[185],"indication":[186],"overall":[189],"system.":[195],"Ethanol":[196],"suppressed":[197],"most":[200],"similar":[205,280],"degree":[206],"as":[207,302],"it":[208],"inhibited":[209,223],"key":[210],"events.":[213],"NF-kappaB":[215,229,250,267,298],"(p65)":[216],"translocation":[217,303],"nucleus":[220,308],"ethanol.":[225,343],"To":[226],"composed":[230],"other":[232],"subunits":[233],"inhibited,":[235],"transgenic":[236,313],"luciferase":[240],"reporter":[241,314],"used.":[243],"This":[244],"revealed":[245],"reproducible":[247],"activity,":[251],"is":[253,263],"consistent":[254],"observed":[257],"whose":[261],"expression":[262],"known":[264],"dependent.":[268],"CONCLUSION:":[269],"Overall,":[270],"signalling":[276],"vivo":[278],"those":[282],"exposure":[287],"and/or":[290],"lipopolysaccharide.":[291],"detected":[301,311],"p65":[305],"but":[309],"mice.":[315],"The":[316],"observation":[317],"given":[320],"24":[321],"dosing":[324],"LPS":[326],"modulated":[327],"some":[330],"indicates":[332],"persistent":[334],"effect":[335],"does":[337],"require":[339],"continued":[340],"presence":[341]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
