{"id":"https://openalex.org/W2006227336","doi":"https://doi.org/10.1016/j.drudis.2006.02.004","title":"Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents","display_name":"Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2006227336","doi":"https://doi.org/10.1016/j.drudis.2006.02.004","mag":"2006227336","pmid":"https://pubmed.ncbi.nlm.nih.gov/16580970"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2006.02.004","doi":"https://doi.org/10.1016/j.drudis.2006.02.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2006.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109117260","display_name":"J\u00f6rg Holenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162160","display_name":"Esteve (Spain)","ror":"https://ror.org/04yns5a36","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210162160"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"J\u00f6rg Holenz","raw_affiliation_strings":["Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain. j.holenz@esteve.es","Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain. j.holenz@esteve.es","institution_ids":["https://openalex.org/I4210162160"]},{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210162160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112131141","display_name":"Petrus J. Pauwels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162160","display_name":"Esteve (Spain)","ror":"https://ror.org/04yns5a36","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210162160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Petrus J. Pauwels","raw_affiliation_strings":["Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210162160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046332994","display_name":"Jos\u00e9 Luis D\u0131\u0301az","orcid":"https://orcid.org/0000-0001-8812-4689","observed_orcids":["https://orcid.org/0000-0001-8812-4689"]},"institutions":[{"id":"https://openalex.org/I4210162160","display_name":"Esteve (Spain)","ror":"https://ror.org/04yns5a36","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210162160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luis D\u00edaz","raw_affiliation_strings":["Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210162160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065739569","display_name":"Ramon Merc\u00e8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162160","display_name":"Esteve (Spain)","ror":"https://ror.org/04yns5a36","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210162160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ramon Merc\u00e8","raw_affiliation_strings":["Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210162160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091728921","display_name":"Xavier Codony","orcid":"https://orcid.org/0000-0002-8921-6902","observed_orcids":["https://orcid.org/0000-0002-8921-6902"]},"institutions":[{"id":"https://openalex.org/I4210162160","display_name":"Esteve (Spain)","ror":"https://ror.org/04yns5a36","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210162160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xavier Codony","raw_affiliation_strings":["Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210162160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109965348","display_name":"Helmut Buschmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162160","display_name":"Esteve (Spain)","ror":"https://ror.org/04yns5a36","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210162160"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Helmut Buschmann","raw_affiliation_strings":["Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorios Dr. Esteve S.A., Av. Mare de D\u00e9u de Montserrat 221, E-08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210162160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109117260"],"corresponding_institution_ids":["https://openalex.org/I4210162160"],"apc_list":{"value":4720,"currency":"USD","value_usd":4720},"apc_paid":null,"fwci":1.7965,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.86392405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"7-8","first_page":"283","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.19840000569820404,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1453000009059906,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht6-receptor","display_name":"5-HT6 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.6430000066757202},{"id":"https://openalex.org/keywords/nootropics","display_name":"nootropic drugs","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anti-obesity-effect","display_name":"anti-obesity","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9150000214576721},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7839999794960022},{"id":"https://openalex.org/keywords/pharmacophore-model","display_name":"pharmacophore model","score":0.8230000138282776},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9229999780654907},{"id":"https://openalex.org/keywords/scaffold-hopping","display_name":"scaffold hopping","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.5989999771118164},{"id":"https://openalex.org/keywords/high-throughput-screening-hits","display_name":"high-throughput screening hits","score":0.7080000042915344},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5918911695480347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5316650867462158},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5250991582870483},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4807036519050598},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.4371264576911926},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37854906916618347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31708502769470215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28816577792167664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23332282900810242},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.drudis.2006.02.004","doi":"https://doi.org/10.1016/j.drudis.2006.02.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2006.02.004","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:16580970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16580970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W187576616","https://openalex.org/W1490671687","https://openalex.org/W1524487285","https://openalex.org/W1528274454","https://openalex.org/W1554674965","https://openalex.org/W1769626824","https://openalex.org/W1793522754","https://openalex.org/W1905261961","https://openalex.org/W1906479784","https://openalex.org/W1963976940","https://openalex.org/W1964888279","https://openalex.org/W1965283484","https://openalex.org/W1977773631","https://openalex.org/W1979422515","https://openalex.org/W1984194493","https://openalex.org/W1985254321","https://openalex.org/W1989340714","https://openalex.org/W1991180760","https://openalex.org/W1998570794","https://openalex.org/W2004116204","https://openalex.org/W2005218989","https://openalex.org/W2008145156","https://openalex.org/W2011182878","https://openalex.org/W2011662373","https://openalex.org/W2013095956","https://openalex.org/W2016430454","https://openalex.org/W2019900749","https://openalex.org/W2023235142","https://openalex.org/W2023363102","https://openalex.org/W2026823702","https://openalex.org/W2028541643","https://openalex.org/W2038101767","https://openalex.org/W2040196875","https://openalex.org/W2040793507","https://openalex.org/W2043316922","https://openalex.org/W2045614706","https://openalex.org/W2047905218","https://openalex.org/W2048159519","https://openalex.org/W2048568906","https://openalex.org/W2050416942","https://openalex.org/W2052923849","https://openalex.org/W2053432639","https://openalex.org/W2056391133","https://openalex.org/W2058984805","https://openalex.org/W2064446575","https://openalex.org/W2070473876","https://openalex.org/W2072398405","https://openalex.org/W2072441360","https://openalex.org/W2072704665","https://openalex.org/W2076240748","https://openalex.org/W2076395982","https://openalex.org/W2076977175","https://openalex.org/W2077338272","https://openalex.org/W2080202054","https://openalex.org/W2084216816","https://openalex.org/W2085289341","https://openalex.org/W2089571094","https://openalex.org/W2090457291","https://openalex.org/W2091627684","https://openalex.org/W2095460819","https://openalex.org/W2099128415","https://openalex.org/W2105635867","https://openalex.org/W2119059500","https://openalex.org/W2119114660","https://openalex.org/W2127948169","https://openalex.org/W2130780046","https://openalex.org/W2138547303","https://openalex.org/W2147873829","https://openalex.org/W2159483285","https://openalex.org/W2168256117","https://openalex.org/W2221374601","https://openalex.org/W2271363481","https://openalex.org/W2284531502","https://openalex.org/W2398650533","https://openalex.org/W2420198271","https://openalex.org/W2737040811","https://openalex.org/W2738510767","https://openalex.org/W2752412622","https://openalex.org/W2794812455","https://openalex.org/W2895578304","https://openalex.org/W2950815199","https://openalex.org/W2952068036","https://openalex.org/W2952356266","https://openalex.org/W3162870929","https://openalex.org/W4241804791","https://openalex.org/W4285719527","https://openalex.org/W6631372571","https://openalex.org/W6741077895","https://openalex.org/W7066353931"],"related_works":["https://openalex.org/W2090457291","https://openalex.org/W2468185808","https://openalex.org/W2323481100","https://openalex.org/W1754845536","https://openalex.org/W2601051371","https://openalex.org/W1992687049","https://openalex.org/W2065150812","https://openalex.org/W2203261110","https://openalex.org/W1970926049","https://openalex.org/W2044622062"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
