{"id":"https://openalex.org/W2006198656","doi":"https://doi.org/10.1515/bc.2007.081","title":"Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II","display_name":"Plasminogen-dependent internalization of soluble melanotransferrin involves the low-density lipoprotein receptor-related protein and annexin II","publication_year":2007,"publication_date":"2007-06-16","ids":{"openalex":"https://openalex.org/W2006198656","doi":"https://doi.org/10.1515/bc.2007.081","mag":"2006198656","pmid":"https://pubmed.ncbi.nlm.nih.gov/17570828"},"language":"en","primary_location":{"id":"doi:10.1515/bc.2007.081","doi":"https://doi.org/10.1515/bc.2007.081","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bc.2007.081","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bchm","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2006198656"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028764758","display_name":"Jonathan Michaud\u2010Levesque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159129438","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","ror":"https://ror.org/002rjbv21","country_code":"CA","type":"education","lineage":["https://openalex.org/I159129438","https://openalex.org/I49663120"]},{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan Michaud-Levesque","raw_affiliation_strings":["Laboratoire de M\u00e9decine Mol\u00e9culaire, Service d'H\u00e9mato-Oncologie, H\u00f4pital Ste-Justine, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al H3C 3P8, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de M\u00e9decine Mol\u00e9culaire, Service d'H\u00e9mato-Oncologie, H\u00f4pital Ste-Justine, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al H3C 3P8, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I159129438","https://openalex.org/I2802351361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052978024","display_name":"Michel Demeule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159129438","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","ror":"https://ror.org/002rjbv21","country_code":"CA","type":"education","lineage":["https://openalex.org/I159129438","https://openalex.org/I49663120"]},{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michel Demeule","raw_affiliation_strings":["Laboratoire de M\u00e9decine Mol\u00e9culaire, Service d'H\u00e9mato-Oncologie, H\u00f4pital Ste-Justine, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al H3C 3P8, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de M\u00e9decine Mol\u00e9culaire, Service d'H\u00e9mato-Oncologie, H\u00f4pital Ste-Justine, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al H3C 3P8, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I159129438","https://openalex.org/I2802351361"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074404132","display_name":"Richard B\u00e9liveau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159129438","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al","ror":"https://ror.org/002rjbv21","country_code":"CA","type":"education","lineage":["https://openalex.org/I159129438","https://openalex.org/I49663120"]},{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Richard B\u00e9liveau","raw_affiliation_strings":["Laboratoire de M\u00e9decine Mol\u00e9culaire, Service d'H\u00e9mato-Oncologie, H\u00f4pital Ste-Justine, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al H3C 3P8, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de M\u00e9decine Mol\u00e9culaire, Service d'H\u00e9mato-Oncologie, H\u00f4pital Ste-Justine, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montr\u00e9al H3C 3P8, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I159129438","https://openalex.org/I2802351361"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"EUR","value_usd":0},"apc_paid":null,"fwci":0.2067,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.56115735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":94},"biblio":{"volume":"388","issue":"7","first_page":"747","last_page":"754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.17139999568462372,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasminogen","display_name":"plasminogen","score":0.9800000190734863},{"id":"https://openalex.org/keywords/low-density-lipoprotein-receptor-related-protein","display_name":"low density lipoprotein receptor-related protein","score":0.8539999723434448},{"id":"https://openalex.org/keywords/annexin-a2","display_name":"annexin A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-mediated-internalization","display_name":"receptor-mediated internalization","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":0.7480000257492065},{"id":"https://openalex.org/keywords/aprotinin","display_name":"aprotinin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/receptor-associated-protein","display_name":"receptor-associated protein","score":0.6330000162124634},{"id":"https://openalex.org/keywords/u87-glioblastoma-cells","display_name":"U87 glioblastoma cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/murine-embryonic-fibroblasts","display_name":"murine embryonic fibroblasts","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.872776985168457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6766117215156555},{"id":"https://openalex.org/C30345302","wikidata":"https://www.wikidata.org/wiki/Q14908233","display_name":"Annexin A2","level":4,"score":0.669519305229187},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5175849199295044},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.48734745383262634},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.44537076354026794},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4322115182876587},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42762547731399536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.355937123298645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.347256064414978},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32689476013183594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32240408658981323},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2258642017841339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1922726035118103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15072157979011536},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09447255730628967}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017306","descriptor_name":"Annexin A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026502","descriptor_name":"LDL-Receptor Related Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D026502","descriptor_name":"LDL-Receptor Related Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026502","descriptor_name":"LDL-Receptor Related Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058950","descriptor_name":"Melanoma-Specific Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1515/bc.2007.081","doi":"https://doi.org/10.1515/bc.2007.081","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bc.2007.081","pdf_url":null,"source":{"id":"https://openalex.org/S18118477","display_name":"Biological Chemistry","issn_l":"1431-6730","issn":["1431-6730","1437-4315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bchm","raw_type":"journal-article"},{"id":"pmid:17570828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17570828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6225000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310557","display_name":"BioMarin Pharmaceutical","ror":"https://ror.org/03fmvqd28"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W5525601","https://openalex.org/W1555380614","https://openalex.org/W1582157044","https://openalex.org/W1583346750","https://openalex.org/W1598970150","https://openalex.org/W1605718906","https://openalex.org/W1848059939","https://openalex.org/W1968325920","https://openalex.org/W1968651459","https://openalex.org/W1970708087","https://openalex.org/W1976578829","https://openalex.org/W1981417802","https://openalex.org/W1992854414","https://openalex.org/W2008469349","https://openalex.org/W2011179146","https://openalex.org/W2012295337","https://openalex.org/W2013702238","https://openalex.org/W2017198809","https://openalex.org/W2022631158","https://openalex.org/W2032838825","https://openalex.org/W2053529427","https://openalex.org/W2065791048","https://openalex.org/W2074219629","https://openalex.org/W2080718685","https://openalex.org/W2081059129","https://openalex.org/W2083234898","https://openalex.org/W2088005598","https://openalex.org/W2092616984","https://openalex.org/W2094247513","https://openalex.org/W2097830168","https://openalex.org/W2105789755","https://openalex.org/W2111921653","https://openalex.org/W2135805603","https://openalex.org/W2143975632","https://openalex.org/W2151317721","https://openalex.org/W2395363633","https://openalex.org/W2414435255","https://openalex.org/W2416318431"],"related_works":["https://openalex.org/W4385897908","https://openalex.org/W1848059939","https://openalex.org/W2020714594","https://openalex.org/W1978870841","https://openalex.org/W2044140136","https://openalex.org/W1502389462","https://openalex.org/W2414892569","https://openalex.org/W127156176","https://openalex.org/W2564548957","https://openalex.org/W1972320907"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,8,27,53,58,73,90,94,108,116,133,157,172,178,190],"effect":[3],"of":[4,10,50,60,63,92,96,110,115,136,159,175,180,192],"plasminogen":[5],"(Plg)":[6],"on":[7,107],"internalization":[9,95,187],"recombinant":[11],"soluble":[12],"melanotransferrin":[13],"(sMTf)":[14],"using":[15,151],"U87":[16,85],"human":[17],"glioblastoma":[18],"cells":[19],"and":[20,39,67,84,105,120,153,197],"murine":[21],"embryonic":[22],"fibroblasts":[23],"(MEF)":[24],"deficient":[25],"in":[26,57,65,68,81,89,146,156,177],"low-density":[28],"lipoprotein":[29],"receptor-related":[30],"protein":[31],"(LRP).":[32],"Using":[33],"biospecific":[34],"interaction":[35],"analysis,":[36],"both":[37,61],"Glu-":[38],"Lys-Plg":[40,80],"were":[41],"shown":[42],"to":[43,103],"interact":[44],"with":[45],"immobilized":[46],"sMTf.":[47,137],"The":[48,113],"binding":[49,152,174],"sMTf":[51,97,176,193],"at":[52],"cell":[54],"surface":[55],"increased":[56],"presence":[59,91,158,179],"forms":[62],"Plg":[64],"control":[66,82],"LRP-deficient":[69],"MEF":[70,83],"cells,":[71],"whereas":[72],"uptake":[74,135,154],"was":[75,98],"strongly":[76],"stimulated":[77],"only":[78],"by":[79],"cells.":[86],"In":[87,149],"addition,":[88,150],"Lys-Plg,":[93],"a":[99,125,185],"saturable":[100],"process,":[101],"sensitive":[102],"temperature":[104],"dependent":[106],"integrity":[109],"lysine":[111],"residues.":[112],"addition":[114],"receptor-associated":[117],"protein,":[118],"lactoferrin":[119],"aprotinin,":[121],"as":[122,124],"well":[123],"monoclonal":[126],"antibody":[127],"(mAb)":[128],"directed":[129],"against":[130],"LRP,":[131],"inhibited":[132],"Lys-Plg-dependent":[134],"These":[138],"results":[139,183],"suggest":[140,184],"an":[141],"important":[142],"role":[143],"for":[144,171,189],"LRP":[145],"this":[147],"process.":[148],"assays":[155],"anti-annexin":[160],"II":[161,167,196],"mAb,":[162],"we":[163],"showed":[164],"that":[165],"annexin":[166,195],"might":[168],"be":[169],"responsible":[170],"initial":[173],"Plg.":[181],"Our":[182],"Plg-mediated":[186],"mechanism":[188],"clearance":[191],"via":[194],"LRP.":[198]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}