{"id":"https://openalex.org/W2006136808","doi":"https://doi.org/10.1016/j.ecoenv.2004.10.015","title":"Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals","display_name":"Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals","publication_year":2005,"publication_date":"2005-01-04","ids":{"openalex":"https://openalex.org/W2006136808","doi":"https://doi.org/10.1016/j.ecoenv.2004.10.015","mag":"2006136808","pmid":"https://pubmed.ncbi.nlm.nih.gov/16677909"},"language":"en","primary_location":{"id":"doi:10.1016/j.ecoenv.2004.10.015","doi":"https://doi.org/10.1016/j.ecoenv.2004.10.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2004.10.015","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2006136808"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084876362","display_name":"Beno\u00eet Fraysse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4387154183","display_name":"Institut National de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture","ror":"https://ror.org/01wep6g48","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benoit Fraysse","raw_affiliation_strings":["Laboratoire d'Ecotoxicologie, Cemagref 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Ecotoxicologie, Cemagref 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112857587","display_name":"R. Mons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4387154183","display_name":"Institut National de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture","ror":"https://ror.org/01wep6g48","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raphael Mons","raw_affiliation_strings":["Laboratoire d\u2019Ecotoxicologie, Cemagref, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ecotoxicologie, Cemagref, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019957498","display_name":"Jeanne Garric","orcid":"https://orcid.org/0000-0001-5637-072X","observed_orcids":["https://orcid.org/0000-0001-5637-072X"]},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4387154183","display_name":"Institut National de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture","ror":"https://ror.org/01wep6g48","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jeanne Garric","raw_affiliation_strings":["Laboratoire d\u2019Ecotoxicologie, Cemagref, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ecotoxicologie, Cemagref, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France","institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019957498"],"corresponding_institution_ids":["https://openalex.org/I4210088668","https://openalex.org/I4387154183"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":1.6597,"has_fulltext":false,"cited_by_count":330,"citation_normalized_percentile":{"value":0.80556386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"63","issue":"2","first_page":"253","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.5814999938011169,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemical-toxicity-testing","display_name":"chemical toxicity testing","score":0.7580000162124634},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.5220000147819519},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8220000267028809},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9190000295639038},{"id":"https://openalex.org/keywords/malathion","display_name":"malathion","score":1.0},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hatchability","display_name":"hatchability","score":0.7329999804496765},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7820000052452087},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.8460000157356262},{"id":"https://openalex.org/keywords/spontaneous-movement","display_name":"spontaneous movement","score":0.6819999814033508},{"id":"https://openalex.org/keywords/environmental-risk-assessment","display_name":"environmental risk assessment","score":0.6809999942779541},{"id":"https://openalex.org/keywords/non-target-organisms","display_name":"non-target organisms","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.8783023357391357},{"id":"https://openalex.org/C2777744765","wikidata":"https://www.wikidata.org/wiki/Q2734755","display_name":"Hatching","level":2,"score":0.751907467842102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7346562147140503},{"id":"https://openalex.org/C6047887","wikidata":"https://www.wikidata.org/wiki/Q420811","display_name":"Blastula","level":5,"score":0.658998966217041},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6512730121612549},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.6088323593139648},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5864275693893433},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5685622692108154},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.5079923272132874},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4363408088684082},{"id":"https://openalex.org/C2777289358","wikidata":"https://www.wikidata.org/wiki/Q2371293","display_name":"Oryzias","level":3,"score":0.41244810819625854},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3640870451927185},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.25092604756355286},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.23837459087371826},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.11671996116638184},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.1120612621307373},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.10328009724617004},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10067066550254822},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.098451167345047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09015125036239624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008294","descriptor_name":"Malathion","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013623","descriptor_name":"Tail","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013623","descriptor_name":"Tail","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ecoenv.2004.10.015","doi":"https://doi.org/10.1016/j.ecoenv.2004.10.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2004.10.015","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},{"id":"pmid:16677909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16677909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and environmental safety","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02587487v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-02587487","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ecotoxicology and Environmental Safety, 2006, 63 (2), pp.253-267. &#x27E8;10.1016/j.ecoenv.2004.10.015&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:irsteadoc.irstea.fr:PUB00019062","doi":null,"is_oa":false,"landing_page_url":"https://irsteadoc.irstea.fr/cemoa/PUB00019062","pdf_url":null,"source":{"id":"https://openalex.org/S7407064358","display_name":"Cemadoc (Cemagref / IRSTEA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"16110","raw_type":"Article de revue scientifique \u00e0 comit\u00e9 de lecture"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W50771863","https://openalex.org/W105408941","https://openalex.org/W176379508","https://openalex.org/W594823730","https://openalex.org/W649365077","https://openalex.org/W1027874188","https://openalex.org/W1431804186","https://openalex.org/W1655460658","https://openalex.org/W1964005742","https://openalex.org/W1964236635","https://openalex.org/W1964640165","https://openalex.org/W1965506112","https://openalex.org/W1974022535","https://openalex.org/W1982821820","https://openalex.org/W1990351437","https://openalex.org/W1992906252","https://openalex.org/W1999094990","https://openalex.org/W2001885713","https://openalex.org/W2005159772","https://openalex.org/W2013568102","https://openalex.org/W2017796207","https://openalex.org/W2020108596","https://openalex.org/W2022892895","https://openalex.org/W2024905986","https://openalex.org/W2030618223","https://openalex.org/W2041048602","https://openalex.org/W2041283704","https://openalex.org/W2046018464","https://openalex.org/W2046590898","https://openalex.org/W2046970032","https://openalex.org/W2052723361","https://openalex.org/W2056990554","https://openalex.org/W2058207889","https://openalex.org/W2063916615","https://openalex.org/W2067960605","https://openalex.org/W2079978401","https://openalex.org/W2080004698","https://openalex.org/W2080883474","https://openalex.org/W2086724269","https://openalex.org/W2097600936","https://openalex.org/W2098402445","https://openalex.org/W2104790506","https://openalex.org/W2107735878","https://openalex.org/W2111829591","https://openalex.org/W2115840555","https://openalex.org/W2125349610","https://openalex.org/W2146122103","https://openalex.org/W2161866869","https://openalex.org/W2211096241","https://openalex.org/W2470027073","https://openalex.org/W2521304717","https://openalex.org/W2598528694","https://openalex.org/W2612241851","https://openalex.org/W4251706019","https://openalex.org/W4251768136","https://openalex.org/W4254382607","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2028426134","https://openalex.org/W2904634922","https://openalex.org/W1975743313","https://openalex.org/W6926383101","https://openalex.org/W2376244784","https://openalex.org/W4239808387","https://openalex.org/W4280496606","https://openalex.org/W4293768034","https://openalex.org/W2415387657","https://openalex.org/W2011188574"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}