{"id":"https://openalex.org/W2006129483","doi":"https://doi.org/10.4161/derm.2.2.13509","title":"The role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias","display_name":"The role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2006129483","doi":"https://doi.org/10.4161/derm.2.2.13509","mag":"2006129483","pmid":"https://pubmed.ncbi.nlm.nih.gov/21547103","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081682"},"language":"en","primary_location":{"id":"doi:10.4161/derm.2.2.13509","doi":"https://doi.org/10.4161/derm.2.2.13509","is_oa":false,"landing_page_url":"https://doi.org/10.4161/derm.2.2.13509","pdf_url":null,"source":{"id":"https://openalex.org/S131311902","display_name":"Dermato-Endocrinology","issn_l":"1938-1972","issn":["1938-1972","1938-1980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermato-Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081682","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085486302","display_name":"Randy Linde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1317822957","display_name":"Palo Alto Medical Foundation","ror":"https://ror.org/04rg6e566","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114073160","https://openalex.org/I1317822957"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randy Linde","raw_affiliation_strings":["The Palo Alto Medical Foundation (R.L.) and Stanford University School of Medicine; Palo Alto and Stanford, CA USA","Palo Alto, CA USA","Stanford University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Palo Alto Medical Foundation (R.L.) and Stanford University School of Medicine; Palo Alto and Stanford, CA USA","institution_ids":["https://openalex.org/I1317822957","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Palo Alto, CA USA","institution_ids":[]},{"raw_affiliation_string":"Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101552536","display_name":"Lihong Peng","orcid":"https://orcid.org/0000-0002-3905-7085","observed_orcids":["https://orcid.org/0000-0002-3905-7085"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihong Peng","raw_affiliation_strings":["Stanford University School of Medicine; Palo Alto, CA USA","Palo Alto, CA USA","Stanford University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine; Palo Alto, CA USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Palo Alto, CA USA","institution_ids":[]},{"raw_affiliation_string":"Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032969374","display_name":"Manisha Desai","orcid":"https://orcid.org/0000-0002-6949-2651","observed_orcids":["https://orcid.org/0000-0002-6949-2651","https://orcid.org/0000-0001-9032-8509"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manisha Desai","raw_affiliation_strings":["Stanford University School of Medicine; Palo Alto, CA USA","Palo Alto, CA USA","Stanford University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine; Palo Alto, CA USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Palo Alto, CA USA","institution_ids":[]},{"raw_affiliation_string":"Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036496348","display_name":"David Feldman","orcid":"https://orcid.org/0000-0003-2288-5017","observed_orcids":["https://orcid.org/0000-0003-2288-5017"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Feldman","raw_affiliation_strings":["Stanford University School of Medicine; Palo Alto, CA USA","Palo Alto, CA USA","Stanford University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine; Palo Alto, CA USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Palo Alto, CA USA","institution_ids":[]},{"raw_affiliation_string":"Stanford University School of Medicine","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085486302"],"corresponding_institution_ids":["https://openalex.org/I1317822957","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":1.4357,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.81002365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"2","first_page":"77","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9169999957084656},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/statin-intolerance","display_name":"statin intolerance","score":0.8270000219345093},{"id":"https://openalex.org/keywords/statin-rechallenge","display_name":"statin rechallenge","score":0.8870000243186951},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9070000052452087},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2776598434","wikidata":"https://www.wikidata.org/wiki/Q18035517","display_name":"SLCO1B1","level":5,"score":0.9466713666915894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7379816174507141},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.7362921237945557},{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.6945465207099915},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6537270545959473},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.5615773797035217},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5369460582733154},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5171553492546082},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.47977691888809204},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.474921315908432},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.43500712513923645},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41756346821784973},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.33599162101745605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3359658718109131},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3275994062423706},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2684474587440491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11566665768623352},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10595133900642395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08100757002830505}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4161/derm.2.2.13509","doi":"https://doi.org/10.4161/derm.2.2.13509","is_oa":false,"landing_page_url":"https://doi.org/10.4161/derm.2.2.13509","pdf_url":null,"source":{"id":"https://openalex.org/S131311902","display_name":"Dermato-Endocrinology","issn_l":"1938-1972","issn":["1938-1972","1938-1980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermato-Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2098740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3081682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatoendocrinol","raw_type":"Text"},{"id":"pmid:21547103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21547103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermato-endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2098740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3081682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333491","display_name":"Palo Alto Medical Foundation","ror":"https://ror.org/04rg6e566"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W24049057","https://openalex.org/W27987714","https://openalex.org/W150250458","https://openalex.org/W176130219","https://openalex.org/W633735835","https://openalex.org/W1604547439","https://openalex.org/W1972231896","https://openalex.org/W1974928646","https://openalex.org/W1982499176","https://openalex.org/W1985565845","https://openalex.org/W1990993346","https://openalex.org/W1995773136","https://openalex.org/W2018868115","https://openalex.org/W2024277698","https://openalex.org/W2024936844","https://openalex.org/W2026961817","https://openalex.org/W2031556182","https://openalex.org/W2035139971","https://openalex.org/W2036888384","https://openalex.org/W2053130595","https://openalex.org/W2059078444","https://openalex.org/W2064896297","https://openalex.org/W2065237107","https://openalex.org/W2069510074","https://openalex.org/W2078314427","https://openalex.org/W2079789436","https://openalex.org/W2099665543","https://openalex.org/W2103873642","https://openalex.org/W2111343462","https://openalex.org/W2124070987","https://openalex.org/W2127457459","https://openalex.org/W2131288319","https://openalex.org/W2131552966","https://openalex.org/W2139681313","https://openalex.org/W2140314600","https://openalex.org/W2148546401","https://openalex.org/W2151244893","https://openalex.org/W2157482325","https://openalex.org/W2160936671","https://openalex.org/W2166471219","https://openalex.org/W2170643508","https://openalex.org/W2207307625","https://openalex.org/W2495832169","https://openalex.org/W2727742003","https://openalex.org/W3022181047","https://openalex.org/W4243096964"],"related_works":["https://openalex.org/W2788460682","https://openalex.org/W2005976370","https://openalex.org/W2065237107","https://openalex.org/W2555018223","https://openalex.org/W1984088234","https://openalex.org/W2128803773","https://openalex.org/W2007318427","https://openalex.org/W150250458","https://openalex.org/W7217073067","https://openalex.org/W2028922961"],"abstract_inverted_index":{"Myalgias":[0],"are":[1],"the":[2,11,51,70,118,121,217],"most":[3],"common":[4],"side":[5],"effect":[6,119],"of":[7,40,72,95,120,131,164,185,205,227],"statin":[8,63,109,147],"use":[9],"and":[10,25,111,198],"commonest":[12],"cause":[13,32],"for":[14,54,62,107,142],"discontinuing":[15],"therapy.":[16],"Vitamin":[17],"D":[18,27,87,97,115,137,166,169,177,241],"has":[19,65],"known":[20,30],"physiologic":[21],"functions":[22],"in":[23,50,98,134,167],"muscle":[24,41,74],"vitamin":[26,86,96,114,165,168,176,240],"deficiency":[28],"is":[29,60],"to":[31,38,68,83,105,154,237],"myalgias,":[33,183],"with":[34,77,85,101,180,188,193,208,222],"its":[35],"correction":[36],"leading":[37],"disappearance":[39],"symptoms.":[42,75],"The":[43],"521T>C":[44],"SLCO1B1*5":[45,122,218],"gene":[46,52],"polymorphism":[47],"decreasing":[48],"function":[49],"coding":[53],"a":[55,128,223],"liver":[56],"anion":[57],"transporter":[58],"that":[59,162],"responsible":[61],"uptake":[64],"been":[66,81,140],"found":[67,158,236],"explain":[69],"majority":[71],"statin-associated":[73,78,182],"Patients":[76],"myalgias":[79,102,228],"have":[80],"reported":[82],"improve":[84],"supplementation.":[88],"We":[89],"therefore":[90],"investigated":[91],"(i)":[92],"whether":[93,113],"repletion":[94,163],"deficient":[99,170,178],"patients":[100,133,151,171,179],"could":[103],"lead":[104],"tolerance":[106],"subsequent":[108],"therapy":[110,210],"(ii)":[112],"status":[116,242],"modifies":[117],"genotype":[123,219],"on":[124,146],"myalgia":[125],"risk.":[126],"Using":[127],"retrospective":[129],"cohort":[130],"64":[132],"whom":[135],"25-hydroxyvitamin":[136],"[25(OH)D]":[138],"had":[139],"measured":[141],"any":[143],"reason":[144],"while":[145,216],"therapy,":[148],"including":[149],"46":[150],"who":[152],"consented":[153],"be":[155],"genotyped,":[156],"we":[157],"strong":[159],"evidence":[160],"showing":[161],"improved":[172],"myalgias.":[173],"Of":[174],"21":[175],"intolerable":[181],"14":[184],"15":[186],"rechallenged":[187],"statins":[189],"were":[190],"subsequently":[191],"symptomfree,":[192],"one":[194],"patient":[195],"experiencing":[196],"mild":[197],"tolerable":[199],"symptoms,":[200],"far":[201],"exceeding":[202],"expected":[203],"rates":[204],"acquired":[206],"tolerability":[207],"no":[209],"(p":[211,229,243],"=":[212,230,244],"0.01).":[213],"In":[214],"addition,":[215],"was":[220,234],"associated":[221],"three-fold":[224],"increased":[225],"risk":[226,233],"0.07),":[231],"this":[232],"not":[235],"differ":[238],"by":[239],"0.60).":[245]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}